Dopamine transporter: Transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition

Molecular Pharmacology

Volumn 56, Issue 2, 1999, Pages 434-447

  Lin, Zhicheng ^a   Wang, Wenfei ^a   Kopajtic, Theresa ^a   Revay, Randal S ^a   Uhl, George R ^a,b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ALANINE; COCAINE DERIVATIVE; DOPAMINE; DOPAMINE TRANSPORTER; PHENYLALANINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; DOPAMINE UPTAKE; DRUG PROTEIN BINDING; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032801143     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.2.434     Document Type: Article

References (40)

1. Baker EL, Perlman MA, Adkins EM, Houlihan WJ, Peristupa ZB, Niznik HB and Blakely RD (1998) High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis: An aromatic residue in transmembrane domain 1 dictates species-selective recognition of citalopram and mazindol. J Biol Chem 273:19459-19468.
2. Baldock C, Rafferty JB, Sedelnikova SE, Baker PJ, Stuitie AR, Slabas AR, Hawkes TR and Rice DW (1996) A mechanism of drug addiction revealed by structural study of enoyl reductase. Science (Wash DC) 274:2107-2110.
3. Bergman J, Madras BK, Johnson SE and Spealman RD (1989) Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther 251:150-155.
4. Buck KJ and Amara SG (1994) Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 91:12584-12588.
5. Buck KJ and Amara SG (1995) Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants. Mol Pharmacol 46:1030-1037.
6. Burley SK and Petsko GA (1986) Aromatic-aromatic interactions in proteins. Science (Wash DC) 229:23-28.
7. Carroll FI, Lewin AH, Boja JW and Kuhar MJ (1992) Cocaine receptor: Biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter. J Med Chem 35:969-981.
8. Chen J-G, Sachpatzidis A and Rudnick G (1997) The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding. J Biol Chem 272:28321-28327.
9. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
10. Donovan DM, Vandenbergh DJ, Perry MP, Bird GS, Ingersoll R, Nanthakumar E and Uhl GR (1995) Human and mouse dopamine transporter genes: Conservation of 5′-flanking sequence elements and gene structures. Mol Brain Res 30:327-335.
11. Dougherty DA (1996) Cation-π interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp. Science (Wash DC) 271:163-168.
12. Edvardsen O and Dahl SG (1994) A putative model of the dopamine transporter. Brain Res Mol Brain Res 27:265-274.
13. Giros B, Wang Y-M, Suter S, McLeskey SB, Pifl C and Caron MG (1994) Delineation of discrete domains for substrate cocaine and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J Biol Chem 269:15985-15988.
14. Grigorieff N, Ceska TA, Downing KH, Baldwin JM and Henderson R (1996) Electro-crystallographic refinement of the structure of bacteriorhodopsin. J Mol Biol 259:393-421.
15. Horn AS (1973) Structure-activity relations for the inhibition of catecholamine uptake into synaptosomes from noradrenaline and dopaminergic neurones in rat brain homogenates. Br J Pharmacol 47:332-338.
16. Horn AS (1978) Characteristics of neuronal dopamine uptake. Adv Biochem Psychopharmacol 19:25-34.
17. Javitch JA, Ballesteros JA, Weinstein H and Chen J (1998) A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. Biochemistry 37:998-1006.
18. Kilty JE, Lorang D and Amara SG (1991) Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science (Wash DC) 254:578-579.
19. +: Uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA. Ann Neurol 32:109-111.
20. Kitayama S, Shimada S, Xu H, Markham L, Donovan DM and Uhl GR (1992b) Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci USA 89:7782-7785.
21. Lieske SF, Yang B, Eldefrawi ME, MacKerell AD Jr and Wright J (1998) (-)-3β-Substituted ecyonine methyl esters as inhibitors for cocaine binding and dopamine uptake. J Med Chem 41:864-876.
22. Meiergerd SM, McElvain JS and Schenk JO (1994) Effects of cocaine and repeated cocaine followed by withdrawal: Alterations of dopaminergic transporter turnover with no changes in kinetics of substrate recognition. Biochem Pharmacol 47:1627-1634.
23. Mitsuhata C, Kitayama S, Monta K, Vandenbergh D, Uhl GR and Dohi T (1998) Tyrosine-533 of rat dopamine transporter: Involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. Brain Res Mol Brain Res 56:84-88.
24. Nirenberg MJ, Chan J, Pohorille A, Vaughan RA, Uhl GR, Kuhar MJ and Pickel VM (1997a) The dopamine transporter: Comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. J Neurosci 17:6899-6907.
25. Nirenberg MJ, Chan J, Vaughan RA, Uhl GR, Kuhar MJ and Pickel VM (1997b) Immunogold localization of the dopamine transporter: An ultrastructural study of the rat ventral tegmental area. J Neurosci 17:5255-5262.
26. Pfenning MA and Richelson E (1990) Methods for studying receptors with cultured cells of nervous tissue origin, in Methods in Neurotransmitter Receptor Analysis (Yamamura HI, Enna SJ and Kuhar MJ eds) pp 147-175, Raven Press, New York.
27. Povlock SL and Schenk JO (1997) A multisubstrate kinetic mechanism of dopamine transport in the nucleus accumbens and its inhibition by cocaine. J Neurochem 69:1093-1105.
28. Ritz MC, Cone EJ and Kuhar MJ (1990) Cocaine-inhibition of ligand binding at dopamine, norepinephrine, and serotonin transporters; a structure-activity study. Life Sci 46:635-645.
29. Ritz MC, Lamb RJ, Goldberg SR and Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (Wash DC) 237:1219-1223.
30. Rudnick G (1997) Mechanisms of biogenic amine neurotransmitter transporters, in Neurotransmitter Transporters: Structure, Function, and Regulation (Reith EA ed) pp 73-100, Humana Press, Totawa, NJ.
31. Self DW and Nestler EJ (1995) Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci 18:463-495.
32. Shimada S, Kitayama S, Lin C-L, Patel A, Nanthankumar E, Gregor P, Kuhar MJ and Uhl GR (1991) Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science (Wash DC) 254:576-578.
33. Strader CD, Fong TM, Graziano MP and Tota MR (1995) The family of G-protein-coupled receptors. FASEB J 9:745-754.
34. UhI GR and Johnson PS (1994) Neurotransmitter transporters: Three important gene families for neuronal function. J Exp Biol 196:229-236.
35. Uhl GR, Lin Z, Metzger T and Dar DE (1998) Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development. Methods Enzymol 296:456-465.
36. Vandenbergh DJ, Persico AM and Uhl GR (1992) A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially dimorphic TaqI RFLP. Brain Res Mol Brain Res 15:161-166.
37. Vaughan R, Uhl GR and Kuhar MJ (1993) Recognition of dopamine transporters of antipeptide antibodies. Mol Cell Neurosci 4:209-215.
38. Wang S, Clemmons A, Strader C and Bayne M (1998) Evidence for hydrophobic interaction between galanin and the GalR1 galanin receptor and GalR1-mediated ligand internalization: Fluorescent probing with a fluorescein-galanin. Biochemistry 37:9528-9535.
39. Wang JB, Moriwaki A and Uhl GR (1995) Dopamine transporter cysteine mutants: Second extracellular loop cysteines are required for transporter expression. J Neurochem 64:1416-1419.
40. Yeates TO, Komiyo H, Chirino A, Rees DC, Allen JP and Feher G (1988) Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: Protein-cofactor (bacteriochlorophyll, bacteriopheophytin, and carotenoid) interactions. Proc Natl Acad Sci USA 85:7993-7997.