Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8363-8374

  Sinning, Steffen ^a   Musgaard, Maria ^b   Jensen, Marie ^b   Severinsen, Kasper ^a   Celik, Leyla ^b,c   Koldsø, Heidi ^b   Meyer, Tine ^b   Bols, Mikael ^b,d   Jensen, Henrik Helligsø ^b   Schiøtt, Birgit ^b   Wiborg, Ove ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c YALE UNIVERSITY   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC AMINES; BINDING MODES; COMPETITIVE INHIBITION; COMPLEMENTATION; CONTACT POINTS; DOCKING CALCULATIONS; EXPERIMENTAL METHODS; EXTRACELLULAR; HUMAN SEROTONIN TRANSPORTER (HSERT); INDUCED FIT; INHIBITION MECHANISMS; SALT BRIDGES; SEROTONIN TRANSPORTERS; STRUCTURAL MODELS; SUBSTRATE BINDING; SUBSTRATE-BINDING SITES; TRICYCLIC ANTIDEPRESSANTS;

AMINO ACIDS; BACTERIOLOGY; LIGANDS; MODEL STRUCTURES; MOLECULAR ORIENTATION; SULFUR COMPOUNDS;

BINDING ENERGY;

10 HYDROXYIMIPRAMINE; 2 HYDROXYIMIPRAMINE; ALANINE; ALIPHATIC AMINE; AMINO ACID TRANSPORTER; ASPARTIC ACID; CIANOPRAMINE; CLOMIPRAMINE; DESIPRAMINE; DICYANOIMIPRAMINE; DINORIMIPRAMINE; IMIPRAMINE; LIGAND; PHENYLALANINE; SEROTONIN TRANSPORTER; THREONINE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMIPRAMINE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; LEUCINE; SEROTONIN; SLC6A4 PROTEIN, HUMAN; TRITIUM;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; BINDING COMPETITION; BINDING SITE; CELL CULTURE; CHEMICAL MODEL; CHEMISTRY; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; KIDNEY; METABOLISM; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS);

ALANINE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ASPARTIC ACID; BINDING SITES; BINDING, COMPETITIVE; CELLS, CULTURED; HUMANS; IMIPRAMINE; KIDNEY; LEUCINE; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TRITIUM;

EID: 77950887681     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.045401     Document Type: Article

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