Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter

Molecular Pharmacology

Volumn 50, Issue 4, 1996, Pages 957-965

  Barker, Eric L ^a   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 5 HYDROXYTRYPTOPHAN; COCAINE; DESIPRAMINE; DEXAMPHETAMINE; DRUG BINDING PROTEIN; IMIPRAMINE; NORTRIPTYLINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BINDING SITES; CARRIER PROTEINS; DNA, COMPLEMENTARY; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NERVE TISSUE PROTEINS; NEUROTRANSMITTER UPTAKE INHIBITORS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PHENYLALANINE; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECIES SPECIFICITY; SYMPORTERS; TRANSFECTION;

EID: 0029860223     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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