The Mechanism of a Neurotransmitter:Sodium Symporter-Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

Molecular Cell

Volumn 30, Issue 6, 2008, Pages 667-677

  Shi, Lei ^a   Quick, Matthias ^b,c   Zhao, Yongfang ^b   Weinstein, Harel ^a   Javitch, Jonathan A ^b,c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

MOLNEURO; PROTEINS

Indexed keywords

COTRANSPORTER; LEUCINE; NEUROTRANSMITTER; NEUROTRANSMITTER:SODIUM SYMPORTER; PSYCHOSTIMULANT AGENT; SODIUM ION; TRICYCLIC ANTIDEPRESSANT AGENT;

ALLOSTERISM; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; MOLECULAR DYNAMICS; NEUROTRANSMISSION; PROKARYOTE; SIMULATION; SODIUM TRANSPORT;

BINDING SITES; BLOOD PLATELETS; CELL COMMUNICATION; COMPUTER SIMULATION; HUMANS; KINETICS; LEUCINE; MODELS, MOLECULAR; MUTAGENESIS; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SODIUM; SODIUM CHLORIDE;

EUKARYOTA; PROKARYOTA;

EID: 44949086583     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2008.05.008     Document Type: Article

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