Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 3, 2008, Pages 791-800

  Walline, Crystal C ^a   Nichols, David E ^a   Carroll, F Ivy ^b   Barker, Eric L ^a  

^a PURDUE UNIVERSITY   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; ANTIDEPRESSANT AGENT; MUTANT PROTEIN; SEROTONIN ANTAGONIST; SEROTONIN TRANSPORTER; SODIUM; TROPANE DERIVATIVE;

AQUIFEX AEOLICUS; ARTICLE; BINDING KINETICS; BINDING SITE; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DROSOPHILA; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR RECOGNITION; NEUROTRANSMISSION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; RECEPTOR BLOCKING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; THIRD TRANSMEMBRANE HELIX; TRANSPORT KINETICS;

AMPHETAMINES; ANIMALS; ANTIDEPRESSIVE AGENTS; COCAINE; DROSOPHILA; HELA CELLS; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, SECONDARY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44249099473     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.136200     Document Type: Article

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