Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies

Proteins: Structure, Function and Bioinformatics

Volumn 74, Issue 3, 2009, Pages 630-642

  Kaufmann, Kristian W ^a   Dawson, Eric S ^a   Henry, L Keith ^a,b   Field, Julie R ^a   Blakely, Randy D ^a   Meiler, Jens ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

Comparative modeling; Leucine transporter; ROSETTALIGAND; Sodium and chloride dependent neurotransmitter transporters; Support vector machine substitution sensitivity map

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER; TRYPTAMINE DERIVATIVE; DROSOPHILA PROTEIN; DRUG DERIVATIVE; LIGAND; TRYPTAMINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPUTER SIMULATION; DROSOPHILA; HUMAN; MOLECULAR DOCKING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ENZYME SPECIFICITY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SEQUENCE ALIGNMENT; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; TRYPTAMINES;

EID: 59849093622     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22178     Document Type: Article

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