High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol

Journal of Biological Chemistry

Volumn 273, Issue 31, 1998, Pages 19459-19468

  Barker, Eric L ^b   Perlman, Melody A ^a   Adkins, Erika M ^a   Houlihan, William J ^c   Pristupa, Zdenek B ^d   Niznik, Hyman B ^d   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c DREW UNIVERSITY   (United States)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; COCAINE; FLUOXETINE; IMIPRAMINE; MAZINDOL; PAROXETINE; SEROTONIN ANTAGONIST; SEROTONIN TRANSPORTER;

AMINE TRANSPORT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEROTONIN UPTAKE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CITALOPRAM; DROSOPHILA; DROSOPHILA PROTEINS; HELA CELLS; HUMANS; MAZINDOL; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; RECOMBINANT FUSION PROTEINS; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRANSFECTION;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0032584587     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.31.19459     Document Type: Article

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