Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine

Journal of Biological Chemistry

Volumn 285, Issue 15, 2010, Pages 11270-11280

  Field, Julie R ^a   Henry, L Keith ^c   Blakely, Randy D ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT MEDICATION; BINDING POCKETS; BIOCHEMICAL STUDIES; BIOTINYLATIONS; CITALOPRAM; CONFORMATIONAL DYNAMICS; DIFFERENTIAL INTERACTION; EXTRACELLULAR DOMAINS; HIGH-RESOLUTION STRUCTURES; HOMOLOGY MODELING; LIGAND RECOGNITION; METHYLENEDIOXYMETHAMPHETAMINE; PLASMA MEMBRANES; PSYCHOSTIMULANTS; SEROTONIN TRANSPORTERS; SITE-SPECIFIC; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE DOMAIN; UNIQUE FEATURES; WILD TYPES;

ACTIVATION ANALYSIS; CELL MEMBRANES; METHANE; SODIUM;

SECURITY OF DATA;

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CITALOPRAM; COCAINE; CYSTEINE; GLYCINE; LEUCINE; PAROXETINE; PSYCHOSTIMULANT AGENT; SERINE; SEROTONIN; SEROTONIN TRANSPORTER; SODIUM ION; THIOMESYLIC ACID METHYL ESTER;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING COMPETITION; BINDING SITE; BIOCHEMISTRY; BIOTINYLATION; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOPLASM; DRUG PROTEIN BINDING; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NERVE ENDING; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SEROTONIN RELEASE; SITE DIRECTED MUTAGENESIS; WILD TYPE;

BIOLOGICAL TRANSPORT; CYTOPLASM; HUMANS; KINETICS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEROTONIN; SEROTONIN AGENTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; WATER;

EID: 77951246287     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.093658     Document Type: Article

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