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Volumn 3, Issue 3, 2011, Pages 3525-3556

Epigenetics, nervous system tumors, and cancer stem cells

Author keywords

Cancer; Cancer stem cell; Chromatin; Corest; Epigenetic; Glioblastoma multiforme; Nervous system tumor; Non coding RNA; REST

Indexed keywords

ANTINEOPLASTIC AGENT; BIX 01294; DNA METHYLTRANSFERASE 3A; GENOMIC DNA; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MICRORNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

EID: 80053214795     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3033525     Document Type: Review
Times cited : (7)

References (208)
  • 1
    • 57049151436 scopus 로고    scopus 로고
    • Epigenetic principles and mechanisms underlying nervous system functions in health and disease
    • Mehler, M.F. Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog. Neurobiol. 2008, 86, 305-341.
    • (2008) Prog. Neurobiol , vol.86 , pp. 305-341
    • Mehler, M.F.1
  • 2
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes, M.; Esteller, M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 2011, 17, 330-339.
    • (2011) Nat. Med , vol.17 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 3
    • 51649129596 scopus 로고    scopus 로고
    • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    • Mohn, F.; Weber, M.; Rebhan, M.; Roloff, T.C.; Richter, J.; Stadler, M.B.; Bibel, M.; Schubeler, D. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol. Cell 2008, 30, 755-766.
    • (2008) Mol. Cell , vol.30 , pp. 755-766
    • Mohn, F.1    Weber, M.2    Rebhan, M.3    Roloff, T.C.4    Richter, J.5    Stadler, M.B.6    Bibel, M.7    Schubeler, D.8
  • 4
    • 77954842322 scopus 로고    scopus 로고
    • Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes
    • Wu, H.; Coskun, V.; Tao, J.; Xie, W.; Ge, W.; Yoshikawa, K.; Li, E.; Zhang, Y.; Sun, Y.E. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 2010, 329, 444-448.
    • (2010) Science , vol.329 , pp. 444-448
    • Wu, H.1    Coskun, V.2    Tao, J.3    Xie, W.4    Ge, W.5    Yoshikawa, K.6    Li, E.7    Zhang, Y.8    Sun, Y.E.9
  • 7
    • 4043112183 scopus 로고    scopus 로고
    • Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
    • Valinluck, V.; Tsai, H.H.; Rogstad, D.K.; Burdzy, A.; Bird, A.; Sowers, L.C. Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res. 2004, 32, 4100-4108.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4100-4108
    • Valinluck, V.1    Tsai, H.H.2    Rogstad, D.K.3    Burdzy, A.4    Bird, A.5    Sowers, L.C.6
  • 8
    • 77954362183 scopus 로고    scopus 로고
    • Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine
    • Jin, S.G.; Kadam, S.; Pfeifer, G.P. Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. Nucleic Acids Res. 2010, 38, e125.
    • (2010) Nucleic Acids Res , vol.38
    • Jin, S.G.1    Kadam, S.2    Pfeifer, G.P.3
  • 9
    • 79954457998 scopus 로고    scopus 로고
    • Genomewide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
    • Wu, H.; D'Alessio, A.C.; Ito, S.; Wang, Z.; Cui, K.; Zhao, K.; Sun, Y.E.; Zhang, Y. Genomewide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 2011, 25, 679-684.
    • (2011) Genes Dev , vol.25 , pp. 679-684
    • Wu, H.1    D'alessio, A.C.2    Ito, S.3    Wang, Z.4    Cui, K.5    Zhao, K.6    Sun, Y.E.7    Zhang, Y.8
  • 11
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis, S.; Heintz, N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009, 324, 929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 13
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5-hydroxymethylcytosine in the human brain
    • Jin, S.G.; Wu, X.; Li, A.X.; Pfeifer, G.P. Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res. 2011, 39, 5015-5024.
    • (2011) Nucleic Acids Res , vol.39 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3    Pfeifer, G.P.4
  • 14
    • 77952678006 scopus 로고    scopus 로고
    • Epigenetic control of neural precursor cell fate during development
    • Hirabayashi, Y.; Gotoh, Y. Epigenetic control of neural precursor cell fate during development. Nat. Rev. Neurosci. 2010, 11, 377-388.
    • (2010) Nat. Rev. Neurosci , vol.11 , pp. 377-388
    • Hirabayashi, Y.1    Gotoh, Y.2
  • 15
    • 77956405805 scopus 로고    scopus 로고
    • Chromatin remodeling in neural stem cell differentiation
    • Juliandi, B.; Abematsu, M.; Nakashima, K. Chromatin remodeling in neural stem cell differentiation. Curr. Opin. Neurobiol. 2010, 20, 408-415.
    • (2010) Curr. Opin. Neurobiol , vol.20 , pp. 408-415
    • Juliandi, B.1    Abematsu, M.2    Nakashima, K.3
  • 16
  • 17
    • 70449578270 scopus 로고    scopus 로고
    • Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation
    • Abrajano, J.J.; Qureshi, I.A.; Gokhan, S.; Zheng, D.; Bergman, A.; Mehler, M.F. Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation. PLoS one 2009, 4, e7665.
    • (2009) PLoS One , vol.4
    • Abrajano, J.J.1    Qureshi, I.A.2    Gokhan, S.3    Zheng, D.4    Bergman, A.5    Mehler, M.F.6
  • 18
    • 78049293258 scopus 로고    scopus 로고
    • Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions
    • Abrajano, J.J.; Qureshi, I.A.; Gokhan, S.; Molero, A.E.; Zheng, D.; Bergman, A.; Mehler, M.F. Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions. Proc. Natl. Acad. Sci. USA 2010, 107, 16685-16690.
    • (2010) Proc. Natl. Acad. Sci , vol.107 , pp. 16685-16690
    • Abrajano, J.J.1    Qureshi, I.A.2    Gokhan, S.3    Molero, A.E.4    Zheng, D.5    Bergman, A.6    Mehler, M.F.7
  • 19
    • 77950675541 scopus 로고    scopus 로고
    • Histone demethylase LSD1 regulates neural stem cell proliferation
    • Sun, G.; Alzayady, K.; Stewart, R.; Ye, P.; Yang, S.; Li, W.; Shi, Y. Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 2010, 30, 1997-2005.
    • (2010) Mol. Cell. Biol , vol.30 , pp. 1997-2005
    • Sun, G.1    Alzayady, K.2    Stewart, R.3    Ye, P.4    Yang, S.5    Li, W.6    Shi, Y.7
  • 20
    • 69949085080 scopus 로고    scopus 로고
    • Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition
    • Hirabayashi, Y.; Suzki, N.; Tsuboi, M.; Endo, T.A.; Toyoda, T.; Shinga, J.; Koseki, H.; Vidal, M.; Gotoh, Y. Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 2009, 63, 600-613.
    • (2009) Neuron , vol.63 , pp. 600-613
    • Hirabayashi, Y.1    Suzki, N.2    Tsuboi, M.3    Endo, T.A.4    Toyoda, T.5    Shinga, J.6    Koseki, H.7    Vidal, M.8    Gotoh, Y.9
  • 23
    • 33747706117 scopus 로고    scopus 로고
    • Non-coding RNAs in the nervous system
    • Mehler, M.F.; Mattick, J.S. Non-coding RNAs in the nervous system. J. Physiol. 2006, 575, 333-341.
    • (2006) J. Physiol , vol.575 , pp. 333-341
    • Mehler, M.F.1    Mattick, J.S.2
  • 25
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol, J.; Loedige, I.; Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 2010, 11, 597-610.
    • (2010) Nat. Rev. Genet , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 27
    • 34248162440 scopus 로고    scopus 로고
    • Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs
    • Ponjavic, J.; Ponting, C.P.; Lunter, G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res 2007, 17, 556-565.
    • (2007) Genome Res , vol.17 , pp. 556-565
    • Ponjavic, J.1    Ponting, C.P.2    Lunter, G.3
  • 30
    • 27944464131 scopus 로고    scopus 로고
    • Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome
    • Washietl, S.; Hofacker, I.L.; Lukasser, M.; Huttenhofer, A.; Stadler, P.F. Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome. Nat. Biotechnol. 2005, 23, 1383-1390.
    • (2005) Nat. Biotechnol , vol.23 , pp. 1383-1390
    • Washietl, S.1    Hofacker, I.L.2    Lukasser, M.3    Huttenhofer, A.4    Stadler, P.F.5
  • 33
    • 15944402920 scopus 로고    scopus 로고
    • Small regulatory RNAs in mammals
    • Spec No
    • Mattick, J.S.; Makunin, I.V. Small regulatory RNAs in mammals. Hum. Mol. Genet. 2005, 14 Spec No 1, R121-R132.
    • (2005) Hum. Mol. Genet , vol.14 , Issue.1
    • Mattick, J.S.1    Makunin, I.V.2
  • 34
    • 77952581350 scopus 로고    scopus 로고
    • Long non-coding RNAs in nervous system function and disease
    • Qureshi, I.A.; Mattick, J.S.; Mehler, M.F. Long non-coding RNAs in nervous system function and disease. Brain Res. 2010, 1338, 20-35.
    • (2010) Brain Res , vol.1338 , pp. 20-35
    • Qureshi, I.A.1    Mattick, J.S.2    Mehler, M.F.3
  • 35
    • 60349120914 scopus 로고    scopus 로고
    • Long non-coding RNAs: Insights into functions
    • Mercer, T.R.; Dinger, M.E.; Mattick, J.S. Long non-coding RNAs: Insights into functions. Nat. Rev. Genet. 2009, 10, 155-159.
    • (2009) Nat Rev. Genet , vol.10 , pp. 155-159
    • Mercer, T.R.1    Dinger, M.E.2    Mattick, J.S.3
  • 38
    • 63649138643 scopus 로고    scopus 로고
    • Mir-124 regulates adult neurogenesis in the subventricular zone stem cell niche
    • Cheng, L.C.; Pastrana, E.; Tavazoie, M.; Doetsch, F. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat. Neurosci. 2009, 12, 399-408.
    • (2009) Nat. Neurosci , vol.12 , pp. 399-408
    • Cheng, L.C.1    Pastrana, E.2    Tavazoie, M.3    Doetsch, F.4
  • 42
    • 45449092537 scopus 로고    scopus 로고
    • Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation
    • Tochitani, S.; Hayashizaki, Y. Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation. Biochem. Biophys. Res. Commun. 2008, 372, 691-696.
    • (2008) Biochem. Biophys. Res. Commun , vol.372 , pp. 691-696
    • Tochitani, S.1    Hayashizaki, Y.2
  • 44
    • 77952293063 scopus 로고    scopus 로고
    • Functions and regulation of RNA editing by ADAR deaminases
    • Nishikura, K. Functions and regulation of RNA editing by ADAR deaminases. Annu. Rev. Biochem. 2010, 79, 321-349.
    • (2010) Annu. Rev. Biochem , vol.79 , pp. 321-349
    • Nishikura, K.1
  • 45
    • 70350131063 scopus 로고    scopus 로고
    • Enhancing non-coding RNA information content with ADAR editing
    • St Laurent, G., 3rd; Savva, Y.A.; Reenan, R. Enhancing non-coding RNA information content with ADAR editing. Neurosci. Lett. 2009, 466, 89-98.
    • (2009) Neurosci. Lett , vol.466 , pp. 89-98
    • St Laurent III, G.1    Savva, Y.A.2    Reenan, R.3
  • 46
    • 67649130153 scopus 로고    scopus 로고
    • ADAR1 and ADAR2 expression and editing activity during forebrain development
    • Jacobs, M.M.; Fogg, R.L.; Emeson, R.B.; Stanwood, G.D. ADAR1 and ADAR2 expression and editing activity during forebrain development. Dev. Neurosci. 2009, 31, 223-237.
    • (2009) Dev. Neurosci , vol.31 , pp. 223-237
    • Jacobs, M.M.1    Fogg, R.L.2    Emeson, R.B.3    Stanwood, G.D.4
  • 47
    • 0029775644 scopus 로고    scopus 로고
    • RED2, a brain-specific member of the RNA-specific adenosine deaminase family
    • Melcher, T.; Maas, S.; Herb, A.; Sprengel, R.; Higuchi, M.; Seeburg, P.H. RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J. Biol. Chem. 1996, 271, 31795-31798.
    • (1996) J. Biol. Chem , vol.271 , pp. 31795-31798
    • Melcher, T.1    Maas, S.2    Herb, A.3    Sprengel, R.4    Higuchi, M.5    Seeburg, P.H.6
  • 48
    • 34249724360 scopus 로고    scopus 로고
    • Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease
    • Mehler, M.F.; Mattick, J.S. Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol. Rev. 2007, 87, 799-823.
    • (2007) Physiol. Rev , vol.87 , pp. 799-823
    • Mehler, M.F.1    Mattick, J.S.2
  • 50
    • 66349122954 scopus 로고    scopus 로고
    • Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing
    • Li, J.B.; Levanon, E.Y.; Yoon, J.K.; Aach, J.; Xie, B.; Leproust, E.; Zhang, K.; Gao, Y.; Church, G.M. Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science 2009, 324, 1210-1213.
    • (2009) Science , vol.324 , pp. 1210-1213
    • Li, J.B.1    Levanon, E.Y.2    Yoon, J.K.3    Aach, J.4    Xie, B.5    Leproust, E.6    Zhang, K.7    Gao, Y.8    Church, G.M.9
  • 51
    • 12344300804 scopus 로고    scopus 로고
    • Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome
    • Athanasiadis, A.; Rich, A.; Maas, S. Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol. 2004, 2, e391.
    • (2004) PLoS Biol , vol.2
    • Athanasiadis, A.1    Rich, A.2    Maas, S.3
  • 52
    • 77954313452 scopus 로고    scopus 로고
    • ADAR editing in double-stranded UTRs and other noncoding RNA sequences
    • Hundley, H.A.; Bass, B.L. ADAR editing in double-stranded UTRs and other noncoding RNA sequences. Trends Biochem. Sci. 2010, 35, 377-383.
    • (2010) Trends Biochem. Sci , vol.35 , pp. 377-383
    • Hundley, H.A.1    Bass, B.L.2
  • 55
    • 48749110103 scopus 로고    scopus 로고
    • Calciumpermeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons
    • Whitney, N.P.; Peng, H.; Erdmann, N.B.; Tian, C.; Monaghan, D.T.; Zheng, J.C. Calciumpermeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons. FASEB J. 2008, 22, 2888-2900.
    • (2008) FASEB J , vol.22 , pp. 2888-2900
    • Whitney, N.P.1    Peng, H.2    Erdmann, N.B.3    Tian, C.4    Monaghan, D.T.5    Zheng, J.C.6
  • 56
    • 70350126990 scopus 로고    scopus 로고
    • Regulation of non-coding RNA networks in the nervous system-- what's the REST of the story?
    • Qureshi, I.A.; Mehler, M.F. Regulation of non-coding RNA networks in the nervous system-- what's the REST of the story? Neurosci. Lett. 2009, 466, 73-80.
    • (2009) Neurosci. Lett , vol.466 , pp. 73-80
    • Qureshi, I.A.1    Mehler, M.F.2
  • 57
    • 71849119231 scopus 로고    scopus 로고
    • Nuclear organization in the 3D space of the nucleus - cause or consequence?
    • Nunez, E.; Fu, X.D.; Rosenfeld, M.G. Nuclear organization in the 3D space of the nucleus - cause or consequence? Curr. Opin. Genet. Dev. 2009, 19, 424-436.
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 424-436
    • Nunez, E.1    Fu, X.D.2    Rosenfeld, M.G.3
  • 59
    • 33846283384 scopus 로고    scopus 로고
    • Dynamic genome architecture in the nuclear space: Regulation of gene expression in three dimensions
    • Lanctot, C.; Cheutin, T.; Cremer, M.; Cavalli, G.; Cremer, T. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nat. Rev. Genet. 2007, 8, 104-115.
    • (2007) Nat. Rev. Genet , vol.8 , pp. 104-115
    • Lanctot, C.1    Cheutin, T.2    Cremer, M.3    Cavalli, G.4    Cremer, T.5
  • 60
    • 77956651480 scopus 로고    scopus 로고
    • Differentiation and large scale spatial organization of the genome
    • Joffe, B.; Leonhardt, H.; Solovei, I. Differentiation and large scale spatial organization of the genome. Curr. Opin. Genet. Dev. 2010, 20, 562-569.
    • (2010) Curr. Opin. Genet. Dev , vol.20 , pp. 562-569
    • Joffe, B.1    Leonhardt, H.2    Solovei, I.3
  • 61
    • 77957606554 scopus 로고    scopus 로고
    • Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: Implications for neurological disease states
    • Qureshi, I.A.; Mehler, M.F. Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease states. Ann. N.Y. Acad. Sci. 2010, 1204, E20-E37.
    • (2010) Ann. N.Y. Acad. Sci , vol.1204
    • Qureshi, I.A.1    Mehler, M.F.2
  • 62
    • 78349288865 scopus 로고    scopus 로고
    • Higher-order genome organization in human disease
    • doi:10.1101/cshperspect.a000794
    • Misteli, T. Higher-order genome organization in human disease. Cold Spring Harb. Perspect. Biol. 2010, doi:10.1101/cshperspect.a000794.
    • (2010) Cold Spring Harb. Perspect. Biol
    • Misteli, T.1
  • 64
    • 1842855742 scopus 로고    scopus 로고
    • Nuclear organization in differentiating oligodendrocytes
    • Nielsen, J.A.; Hudson, L.D.; Armstrong, R.C. Nuclear organization in differentiating oligodendrocytes. J. Cell Sci. 2002, 115, 4071-4079.
    • (2002) J. Cell Sci , vol.115 , pp. 4071-4079
    • Nielsen, J.A.1    Hudson, L.D.2    Armstrong, R.C.3
  • 65
    • 69149102249 scopus 로고    scopus 로고
    • Mir-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination
    • Lin, S.T.; Fu, Y.H. miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination. Dis. Model. Mech. 2009, 2, 178-188.
    • (2009) Dis. Model. Mech , vol.2 , pp. 178-188
    • Lin, S.T.1    Fu, Y.H.2
  • 66
    • 79251551942 scopus 로고    scopus 로고
    • Adult-onset autosomal dominant leukodystrophy: Linking nuclear envelope to myelin
    • Lin, S.T.; Ptacek, L.J.; Fu, Y.H. Adult-onset autosomal dominant leukodystrophy: linking nuclear envelope to myelin. J. Neurosci. 2011, 31, 1163-1166.
    • (2011) J. Neurosci , vol.31 , pp. 1163-1166
    • Lin, S.T.1    Ptacek, L.J.2    Fu, Y.H.3
  • 67
    • 77950510166 scopus 로고    scopus 로고
    • Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: Results from RTOG 9704
    • Manuyakorn, A.; Paulus, R.; Farrell, J.; Dawson, N.A.; Tze, S.; Cheung-Lau, G.; Hines, O.J.; Reber, H.; Seligson, D.B.; Horvath, S.; et al. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J. Clin. Oncol. 2010, 28, 1358-1365.
    • (2010) J. Clin. Oncol , vol.28 , pp. 1358-1365
    • Manuyakorn, A.1    Paulus, R.2    Farrell, J.3    Dawson, N.A.4    Tze, S.5    Cheung-Lau, G.6    Hines, O.J.7    Reber, H.8    Seligson, D.B.9    Horvath, S.10
  • 71
    • 55949134303 scopus 로고    scopus 로고
    • DNA methylomes, histone codes and miRNAs: Tying it all together
    • Guil, S.; Esteller, M. DNA methylomes, histone codes and miRNAs: Tying it all together. Int. J. Biochem. Cell Biol. 2009, 41, 87-95.
    • (2009) Int. J. Biochem. Cell Biol , vol.41 , pp. 87-95
    • Guil, S.1    Esteller, M.2
  • 73
    • 75149163987 scopus 로고    scopus 로고
    • Conserved long Nonco ing RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells
    • Sheik Mohamed, J.; Gaughwin, P.M.; Lim, B.; Robson, P.; Lipovich, L. Conserved long Nonco ing RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA 2010, 16, 324-337.
    • (2010) RNA , vol.16 , pp. 324-337
    • Sheik, M.J.1    Gaughwin, P.M.2    Lim, B.3    Robson, P.4    Lipovich, L.5
  • 74
    • 79952255050 scopus 로고    scopus 로고
    • Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5
    • Hawkins, P.G.; Morris, K.V. Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5. Transcription 2010, 1, 165-175.
    • (2010) Transcription , vol.1 , pp. 165-175
    • Hawkins, P.G.1    Morris, K.V.2
  • 76
    • 78651397147 scopus 로고    scopus 로고
    • Large non-coding RNAs: Missing links in cancer
    • Huarte, M.; Rinn, J.L. Large non-coding RNAs: Missing links in cancer? Hum. Mol. Genet. 2010, 19, R152-R161.
    • (2010) Hum. Mol. Genet , vol.19
    • Huarte, M.1    Rinn, J.L.2
  • 77
    • 77952888433 scopus 로고    scopus 로고
    • The DNA methylome of glioblastoma multiforme
    • Martinez, R.; Esteller, M. The DNA methylome of glioblastoma multiforme. Neurobiol. Dis. 2010, 39, 40-46.
    • (2010) Neurobiol. Dis , vol.39 , pp. 40-46
    • Martinez, R.1    Esteller, M.2
  • 82
    • 79251536531 scopus 로고    scopus 로고
    • Comprehensive Analysis of MGMT Promoter Methylation: Correlation with MGMT Expression and Clinical Response in GBM
    • Shah, N.; Lin, B.; Sibenaller, Z.; Ryken, T.; Lee, H.; Yoon, J.G.; Rostad, S.; Foltz, G. Comprehensive Analysis of MGMT Promoter Methylation: Correlation with MGMT Expression and Clinical Response in GBM. PLoS one 2011, 6, e16146.
    • (2011) PLoS One , vol.6
    • Shah, N.1    Lin, B.2    Sibenaller, Z.3    Ryken, T.4    Lee, H.5    Yoon, J.G.6    Rostad, S.7    Foltz, G.8
  • 83
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455, 1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 85
    • 13144290928 scopus 로고    scopus 로고
    • Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    • Yu, J.; Zhang, H.; Gu, J.; Lin, S.; Li, J.; Lu, W.; Wang, Y.; Zhu, J. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. BMC Cancer 2004, 4, 65.
    • (2004) BMC Cancer , vol.4 , pp. 65
    • Yu, J.1    Zhang, H.2    Gu, J.3    Lin, S.4    Li, J.5    Lu, W.6    Wang, Y.7    Zhu, J.8
  • 86
    • 73949090337 scopus 로고    scopus 로고
    • High incidence of MGMT and RARbeta promoter methylation in primary glioblastomas: Association with histopathological characteristics, inflammatory mediators and clinical outcome
    • Piperi, C.; Themistocleous, M.S.; Papavassiliou, G.A.; Farmaki, E.; Levidou, G.; Korkolopoulou, P.; Adamopoulos, C.; Papavassiliou, A.G. High incidence of MGMT and RARbeta promoter methylation in primary glioblastomas: association with histopathological characteristics, inflammatory mediators and clinical outcome. Mol. Med. 2010, 16, 1-9.
    • (2010) Mol. Med , vol.16 , pp. 1-9
    • Piperi, C.1    Themistocleous, M.S.2    Papavassiliou, G.A.3    Farmaki, E.4    Levidou, G.5    Korkolopoulou, P.6    Adamopoulos, C.7    Papavassiliou, A.G.8
  • 89
    • 54249136806 scopus 로고    scopus 로고
    • MicroRNA-21 targets a network of key tumorsuppressive pathways in glioblastoma cells
    • Papagiannakopoulos, T.; Shapiro, A.; Kosik, K.S. MicroRNA-21 targets a network of key tumorsuppressive pathways in glioblastoma cells. Cancer Res. 2008, 68, 8164-8172.
    • (2008) Cancer Res , vol.68 , pp. 8164-8172
    • Papagiannakopoulos, T.1    Shapiro, A.2    Kosik, K.S.3
  • 90
    • 78649647583 scopus 로고    scopus 로고
    • Investigation gene and microRNA expression in glioblastoma
    • Dong, H.; Siu, H.; Luo, L.; Fang, X.; Jin, L.; Xiong, M. Investigation gene and microRNA expression in glioblastoma. BMC Genomics 2010, 11 (Suppl. 3), S16.
    • (2010) BMC Genomics , vol.11 , Issue.SUPPL. 3
    • Dong, H.1    Siu, H.2    Luo, L.3    Fang, X.4    Jin, L.5    Xiong, M.6
  • 91
    • 52949127993 scopus 로고    scopus 로고
    • Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells
    • Korneev, S.A.; Korneeva, E.I.; Lagarkova, M.A.; Kiselev, S.L.; Critchley, G.; O'Shea, M. Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells. RNA 2008, 14, 2030-2037.
    • (2008) RNA , vol.14 , pp. 2030-2037
    • Korneev, S.A.1    Korneeva, E.I.2    Lagarkova, M.A.3    Kiselev, S.L.4    Critchley, G.5    O'Shea, M.6
  • 93
    • 77449126878 scopus 로고    scopus 로고
    • Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns
    • Grinchuk, O.V.; Jenjaroenpun, P.; Orlov, Y.L.; Zhou, J.; Kuznetsov, V.A. Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns. Nucleic Acids Res 2010, 38, 534-547.
    • (2010) Nucleic Acids Res , vol.38 , pp. 534-547
    • Grinchuk, O.V.1    Jenjaroenpun, P.2    Orlov, Y.L.3    Zhou, J.4    Kuznetsov, V.A.5
  • 95
    • 0035807807 scopus 로고    scopus 로고
    • Underediting of glutamate receptor GluR-B mRNA in malignant gliomas
    • Maas, S.; Patt, S.; Schrey, M.; Rich, A. Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc. Natl. Acad. Sci. USA 2001, 98, 14687-14692.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14687-14692
    • Maas, S.1    Patt, S.2    Schrey, M.3    Rich, A.4
  • 98
    • 0034925182 scopus 로고    scopus 로고
    • Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors
    • Dong, S.M.; Pang, J.C.; Poon, W.S.; Hu, J.; To, K.F.; Chang, A.R.; Ng, H.K. Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors. J. Neuropathol. Exp. Neurol. 2001, 60, 808-816.
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , pp. 808-816
    • Dong, S.M.1    Pang, J.C.2    Poon, W.S.3    Hu, J.4    To, K.F.5    Chang, A.R.6    Ng, H.K.7
  • 100
    • 79954553605 scopus 로고    scopus 로고
    • Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma
    • Cogdell, D.; Chung, W.; Liu, Y.; McDonald, J.M.; Aldape, K.; Issa, J.P.; Fuller, G.N.; Zhang, W. Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma. Chin. J. Cancer 2011, 30, 247-253.
    • (2011) Chin. J. Cancer , vol.30 , pp. 247-253
    • Cogdell, D.1    Chung, W.2    Liu, Y.3    McDonald, J.M.4    Aldape, K.5    Issa, J.P.6    Fuller, G.N.7    Zhang, W.8
  • 101
    • 78449275473 scopus 로고    scopus 로고
    • KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells
    • Pang, J.C.; Li, K.K.; Lau, K.M.; Ng, Y.L.; Wong, J.; Chung, N.Y.; Li, H.M.; Chui, Y.L.; Lui, V.W.; Chen, Z.P.; et al. KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. Brain Pathol. 2010, 20, 1021-1032.
    • (2010) Brain Pathol , vol.20 , pp. 1021-1032
    • Pang, J.C.1    Li, K.K.2    Lau, K.M.3    Ng, Y.L.4    Wong, J.5    Chung, N.Y.6    Li, H.M.7    Chui, Y.L.8    Lui, V.W.9    Chen, Z.P.10
  • 105
    • 15944374306 scopus 로고    scopus 로고
    • Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16
    • Fuller, G.N.; Su, X.; Price, R.E.; Cohen, Z.R.; Lang, F.F.; Sawaya, R.; Majumder, S. Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol. Cancer Ther. 2005, 4, 343-349.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 343-349
    • Fuller, G.N.1    Su, X.2    Price, R.E.3    Cohen, Z.R.4    Lang, F.F.5    Sawaya, R.6    Majumder, S.7
  • 107
    • 33644518372 scopus 로고    scopus 로고
    • Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation
    • Su, X.; Gopalakrishnan, V.; Stearns, D.; Aldape, K.; Lang, F.F.; Fuller, G.; Snyder, E.; Eberhart, C.G.; Majumder, S. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol. Cell. Biol. 2006, 26, 1666-1678.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 1666-1678
    • Su, X.1    Gopalakrishnan, V.2    Stearns, D.3    Aldape, K.4    Lang, F.F.5    Fuller, G.6    Snyder, E.7    Eberhart, C.G.8    Majumder, S.9
  • 108
    • 78649849473 scopus 로고    scopus 로고
    • REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions
    • Qureshi, I.A.; Gokhan, S.; Mehler, M.F. REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions. Cell Cycle 2010, 9, 4477-4486.
    • (2010) Cell Cycle , vol.9 , pp. 4477-4486
    • Qureshi, I.A.1    Gokhan, S.2    Mehler, M.F.3
  • 110
    • 65249186793 scopus 로고    scopus 로고
    • The miR-17/92 polycistron is upregulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehogtreated cerebellar neural precursors
    • Northcott, P.A.; Fernandez, L.A.; Hagan, J.P.; Ellison, D.W.; Grajkowska, W.; Gillespie, Y.; Grundy, R.; Van Meter, T.; Rutka, J.T.; Croce, C.M.; et al. The miR-17/92 polycistron is upregulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehogtreated cerebellar neural precursors. Cancer Res. 2009, 69, 3249-3255.
    • (2009) Cancer Res , vol.69 , pp. 3249-3255
    • Northcott, P.A.1    Fernandez, L.A.2    Hagan, J.P.3    Ellison, D.W.4    Grajkowska, W.5    Gillespie, Y.6    Grundy, R.7    van Meter, T.8    Rutka, J.T.9    Croce, C.M.10
  • 112
    • 79953172603 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions
    • Buckley, P.G.; Das, S.; Bryan, K.; Watters, K.M.; Alcock, L.; Koster, J.; Versteeg, R.; Stallings, R.L. Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions. Int. J. Cancer 2011, 128, 2296-2305.
    • (2011) Int. J. Cancer , vol.128 , pp. 2296-2305
    • Buckley, P.G.1    Das, S.2    Bryan, K.3    Watters, K.M.4    Alcock, L.5    Koster, J.6    Versteeg, R.7    Stallings, R.L.8
  • 113
    • 0141885092 scopus 로고    scopus 로고
    • Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma
    • Yang, Q.W.; Liu, S.; Tian, Y.; Salwen, H.R.; Chlenski, A.; Weinstein, J.; Cohn, S.L. Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. Cancer Res. 2003, 63, 6299-6310.
    • (2003) Cancer Res , vol.63 , pp. 6299-6310
    • Yang, Q.W.1    Liu, S.2    Tian, Y.3    Salwen, H.R.4    Chlenski, A.5    Weinstein, J.6    Cohn, S.L.7
  • 114
    • 0036532064 scopus 로고    scopus 로고
    • Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation
    • van Noesel, M.M.; van Bezouw, S.; Salomons, G.S.; Voute, P.A.; Pieters, R.; Baylin, S.B.; Herman, J.G.; Versteeg, R. Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation. Cancer Res. 2002, 62, 2157-2161.
    • (2002) Cancer Res , vol.62 , pp. 2157-2161
    • van Noesel, M.M.1    van Bezouw, S.2    Salomons, G.S.3    Voute, P.A.4    Pieters, R.5    Baylin, S.B.6    Herman, J.G.7    Versteeg, R.8
  • 115
    • 0035866396 scopus 로고    scopus 로고
    • Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
    • Eggert, A.; Grotzer, M.A.; Zuzak, T.J.; Wiewrodt, B.R.; Ho, R.; Ikegaki, N.; Brodeur, G.M. Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res. 2001, 61, 1314-1319.
    • (2001) Cancer Res , vol.61 , pp. 1314-1319
    • Eggert, A.1    Grotzer, M.A.2    Zuzak, T.J.3    Wiewrodt, B.R.4    Ho, R.5    Ikegaki, N.6    Brodeur, G.M.7
  • 117
    • 78751567948 scopus 로고    scopus 로고
    • Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors
    • Shahi, M.H.; Schiapparelli, P.; Afzal, M.; Sinha, S.; Rey, J.A.; Castresana, J.S. Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors. Tumour Biol. 2011, 32, 113-127.
    • (2011) Tumour Biol , vol.32 , pp. 113-127
    • Shahi, M.H.1    Schiapparelli, P.2    Afzal, M.3    Sinha, S.4    Rey, J.A.5    Castresana, J.S.6
  • 124
    • 33846922849 scopus 로고    scopus 로고
    • Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas
    • Abe, M.; Westermann, F.; Nakagawara, A.; Takato, T.; Schwab, M.; Ushijima, T. Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Lett. 2007, 247, 253-258.
    • (2007) Cancer Lett , vol.247 , pp. 253-258
    • Abe, M.1    Westermann, F.2    Nakagawara, A.3    Takato, T.4    Schwab, M.5    Ushijima, T.6
  • 125
    • 46249114389 scopus 로고    scopus 로고
    • Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis
    • Abe, M.; Watanabe, N.; McDonell, N.; Takato, T.; Ohira, M.; Nakagawara, A.; Ushijima, T. Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology 2008, 74, 50-60.
    • (2008) Oncology , vol.74 , pp. 50-60
    • Abe, M.1    Watanabe, N.2    McDonell, N.3    Takato, T.4    Ohira, M.5    Nakagawara, A.6    Ushijima, T.7
  • 126
    • 0030596533 scopus 로고    scopus 로고
    • Decrease in neuron-restrictive silencer factor (NRSF) mRNA levels during differentiation of cultured neuroblastoma cells
    • Nishimura, E.; Sasaki, K.; Maruyama, K.; Tsukada, T.; Yamaguchi, K. Decrease in neuron-restrictive silencer factor (NRSF) mRNA levels during differentiation of cultured neuroblastoma cells. Neurosci. Lett. 1996, 211, 101-104.
    • (1996) Neurosci. Lett , vol.211 , pp. 101-104
    • Nishimura, E.1    Sasaki, K.2    Maruyama, K.3    Tsukada, T.4    Yamaguchi, K.5
  • 127
    • 0032846641 scopus 로고    scopus 로고
    • Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
    • Palm, K.; Metsis, M.; Timmusk, T. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res. Mol. Brain Res. 1999, 72, 30-39.
    • (1999) Brain Res. Mol. Brain Res , vol.72 , pp. 30-39
    • Palm, K.1    Metsis, M.2    Timmusk, T.3
  • 128
    • 0034458424 scopus 로고    scopus 로고
    • Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma
    • Lee, J.H.; Chai, Y.G.; Hersh, L.B. Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma. J. Mol. Neurosci. 2000, 15, 205-214.
    • (2000) J. Mol. Neurosci , vol.15 , pp. 205-214
    • Lee, J.H.1    Chai, Y.G.2    Hersh, L.B.3
  • 129
    • 77950859070 scopus 로고    scopus 로고
    • Mir-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro
    • Chen, H.; Shalom-Feuerstein, R.; Riley, J.; Zhang, S.D.; Tucci, P.; Agostini, M.; Aberdam, D.; Knight, R.A.; Genchi, G.; Nicotera, P.; et al. miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro. Biochem. Biophys. Res. Commun. 2010, 394, 921-927.
    • (2010) Biochem. Biophys. Res. Commun , vol.394 , pp. 921-927
    • Chen, H.1    Shalom-Feuerstein, R.2    Riley, J.3    Zhang, S.D.4    Tucci, P.5    Agostini, M.6    Aberdam, D.7    Knight, R.A.8    Genchi, G.9    Nicotera, P.10
  • 130
    • 34249946434 scopus 로고    scopus 로고
    • The interplay between microRNAs and the neurotrophin receptor tropomyosinrelated kinase C controls proliferation of human neuroblastoma cells
    • Laneve, P.; Di Marcotullio, L.; Gioia, U.; Fiori, M.E.; Ferretti, E.; Gulino, A.; Bozzoni, I.; Caffarelli, E. The interplay between microRNAs and the neurotrophin receptor tropomyosinrelated kinase C controls proliferation of human neuroblastoma cells. Proc. Natl. Acad. Sci. USA 2007, 104, 7957-7962.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 7957-7962
    • Laneve, P.1    di Marcotullio, L.2    Gioia, U.3    Fiori, M.E.4    Ferretti, E.5    Gulino, A.6    Bozzoni, I.7    Caffarelli, E.8
  • 131
    • 78649832226 scopus 로고    scopus 로고
    • A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation
    • Laneve, P.; Gioia, U.; Andriotto, A.; Moretti, F.; Bozzoni, I.; Caffarelli, E. A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation. Nucleic Acids Res. 2010, 38, 6895-6905.
    • (2010) Nucleic Acids Res , vol.38 , pp. 6895-6905
    • Laneve, P.1    Gioia, U.2    Andriotto, A.3    Moretti, F.4    Bozzoni, I.5    Caffarelli, E.6
  • 138
    • 0034610395 scopus 로고    scopus 로고
    • Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
    • Roberts, C.W.; Galusha, S.A.; McMenamin, M.E.; Fletcher, C.D.; Orkin, S.H. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc. Natl. Acad. Sci. USA 2000, 97, 13796-13800.
    • (2000) Proc. Natl. Acad. Sci , vol.97 , pp. 13796-13800
    • Roberts, C.W.1    Galusha, S.A.2    McMenamin, M.E.3    Fletcher, C.D.4    Orkin, S.H.5
  • 139
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D.; Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3, 730-737.
    • (1997) Nat. Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 140
    • 77956611048 scopus 로고    scopus 로고
    • Brain tumor stem cells: The cancer stem cell hypothesis writ large
    • Dirks, P.B. Brain tumor stem cells: The cancer stem cell hypothesis writ large. Mol. Oncol. 2010, 4, 420-430.
    • (2010) Mol. Oncol , vol.4 , pp. 420-430
    • Dirks, P.B.1
  • 142
    • 78449298442 scopus 로고    scopus 로고
    • Cancer stem cells in the central nervous system-A critical review
    • Prestegarden, L.; Enger, P.O. Cancer stem cells in the central nervous system-A critical review. Cancer Res. 2010, 70, 8255-8258.
    • (2010) Cancer Res , vol.70 , pp. 8255-8258
    • Prestegarden, L.1    Enger, P.O.2
  • 147
    • 65649086790 scopus 로고    scopus 로고
    • Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit downregulation of caspase-8 by promoter methylation
    • Cancers 2011, 3 3553
    • Capper, D.; Gaiser, T.; Hartmann, C.; Habel, A.; Mueller, W.; Herold-Mende, C.; von Deimling, A.; Siegelin, M.D. Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit downregulation of caspase-8 by promoter methylation. Acta Neuropathol. 2009, 117, 445-456. Cancers 2011, 3 3553
    • (2009) Acta Neuropathol , vol.117 , pp. 445-456
    • Capper, D.1    Gaiser, T.2    Hartmann, C.3    Habel, A.4    Mueller, W.5    Herold-Mende, C.6    von Deimling, A.7    Siegelin, M.D.8
  • 148
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee, J.; Son, M.J.; Woolard, K.; Donin, N.M.; Li, A.; Cheng, C.H.; Kotliarova, S.; Kotliarov, Y.; Walling, J.; Ahn, S.; et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008, 13, 69-80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3    Donin, N.M.4    Li, A.5    Cheng, C.H.6    Kotliarova, S.7    Kotliarov, Y.8    Walling, J.9    Ahn, S.10
  • 152
    • 78149309989 scopus 로고    scopus 로고
    • Analysis of stemness gene expression and CD133 abnormal methylation in neuroblastoma cell lines
    • Schiapparelli, P.; Enguita-German, M.; Balbuena, J.; Rey, J.A.; Lazcoz, P.; Castresana, J.S. Analysis of stemness gene expression and CD133 abnormal methylation in neuroblastoma cell lines. Oncol. Rep. 2010, 24, 1355-1362.
    • (2010) Oncol. Rep , vol.24 , pp. 1355-1362
    • Schiapparelli, P.1    Enguita-German, M.2    Balbuena, J.3    Rey, J.A.4    Lazcoz, P.5    Castresana, J.S.6
  • 154
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader, J.E. Cells of origin in cancer. Nature 2011, 469, 314-322.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 156
    • 80052404953 scopus 로고    scopus 로고
    • Cancer epigenetics: From disruption of differentiation programs to the emergence of cancer stem cells
    • doi:10.1101/sqb.2010.75.007
    • Scaffidi, P.; Misteli, T. Cancer epigenetics: From disruption of differentiation programs to the emergence of cancer stem cells. Cold Spring Harb. Symp. Quant. Biol. 2010, doi:10.1101/sqb.2010.75.007.
    • (2010) Cold Spring Harb. Symp. Quant. Biol
    • Scaffidi, P.1    Misteli, T.2
  • 157
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: the next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 158
    • 77951203798 scopus 로고    scopus 로고
    • The transcriptional repressor REST/NRSF modulates hedgehog signaling
    • Gates, K.P.; Mentzer, L.; Karlstrom, R.O.; Sirotkin, H.I. The transcriptional repressor REST/NRSF modulates hedgehog signaling. Dev. Biol. 2010, 340, 293-305.
    • (2010) Dev. Biol , vol.340 , pp. 293-305
    • Gates, K.P.1    Mentzer, L.2    Karlstrom, R.O.3    Sirotkin, H.I.4
  • 159
    • 0142059234 scopus 로고    scopus 로고
    • The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord
    • Nishihara, S.; Tsuda, L.; Ogura, T. The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem. Biophys. Res. Commun. 2003, 311, 55-63.
    • (2003) Biochem. Biophys. Res. Commun , vol.311 , pp. 55-63
    • Nishihara, S.1    Tsuda, L.2    Ogura, T.3
  • 161
    • 74149083175 scopus 로고    scopus 로고
    • Prb, a local chromatin organizer with global possibilities
    • Longworth, M.S.; Dyson, N.J. pRb, a local chromatin organizer with global possibilities. Chromosoma 2010, 119, 1-11.
    • (2010) Chromosoma , vol.119 , pp. 1-11
    • Longworth, M.S.1    Dyson, N.J.2
  • 162
    • 77049094890 scopus 로고    scopus 로고
    • Chromatin regulation and non-coding RNAs at mammalian telomeres
    • Schoeftner, S.; Blasco, M.A. Chromatin regulation and non-coding RNAs at mammalian telomeres. Semin. Cell Dev. Biol. 2010, 21, 186-193.
    • (2010) Semin. Cell Dev. Biol , vol.21 , pp. 186-193
    • Schoeftner, S.1    Blasco, M.A.2
  • 164
    • 85011937494 scopus 로고    scopus 로고
    • Implications on telomere biology, replicative senescence and cancer
    • Caslini, C. Transcriptional regulation of telomeric non-coding RNA
    • Caslini, C. Transcriptional regulation of telomeric non-coding RNA: Implications on telomere biology, replicative senescence and cancer. RNA Biol. 2010, 7, 18-22.
    • (2010) RNA Biol , vol.7 , pp. 18-22
    • Caslini, C.1
  • 165
    • 79957451421 scopus 로고    scopus 로고
    • Epigenetic regulation of key vascular genes and growth factors
    • Turunen, M.P.; Yla-Herttuala, S. Epigenetic regulation of key vascular genes and growth factors. Cardiovasc. Res. 2011, 90, 441-446.
    • (2011) Cardiovasc. Res , vol.90 , pp. 441-446
    • Turunen, M.P.1    Yla-Herttuala, S.2
  • 167
    • 68249139817 scopus 로고    scopus 로고
    • MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC
    • Sasayama, T.; Nishihara, M.; Kondoh, T.; Hosoda, K.; Kohmura, E. MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int. J. Cancer 2009, 125, 1407-1413.
    • (2009) Int. J. Cancer , vol.125 , pp. 1407-1413
    • Sasayama, T.1    Nishihara, M.2    Kondoh, T.3    Hosoda, K.4    Kohmura, E.5
  • 169
    • 79955836034 scopus 로고    scopus 로고
    • Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    • Yang, Z.; Zhou, L.; Wu, L.M.; Lai, M.C.; Xie, H.Y.; Zhang, F.; Zheng, S.S. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann. Surg. Oncol. 2011, 18, 1243-1250.
    • (2011) Ann. Surg. Oncol , vol.18 , pp. 1243-1250
    • Yang, Z.1    Zhou, L.2    Wu, L.M.3    Lai, M.C.4    Xie, H.Y.5    Zhang, F.6    Zheng, S.S.7
  • 172
    • 74449093175 scopus 로고    scopus 로고
    • Histone deacetylases and the immunological network: Implications in cancer and inflammation
    • Villagra, A.; Sotomayor, E.M.; Seto, E. Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene 2010, 29, 157-173.
    • (2010) Oncogene , vol.29 , pp. 157-173
    • Villagra, A.1    Sotomayor, E.M.2    Seto, E.3
  • 173
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson, R.J.; Rich, J.N. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat. Rev. Cancer 2007, 7, 733-736.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 174
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • Fan, X.; Khaki, L.; Zhu, T.S.; Soules, M.E.; Talsma, C.E.; Gul, N.; Koh, C.; Zhang, J.; Li, Y.M.; Maciaczyk, J.; et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010, 28, 5-16.
    • (2010) Stem Cells , vol.28 , pp. 5-16
    • Fan, X.1    Khaki, L.2    Zhu, T.S.3    Soules, M.E.4    Talsma, C.E.5    Gul, N.6    Koh, C.7    Zhang, J.8    Li, Y.M.9    Maciaczyk, J.10
  • 175
    • 67650660754 scopus 로고    scopus 로고
    • The Notch signaling pathway: Transcriptional regulation at Notch target genes
    • Borggrefe, T.; Oswald, F. The Notch signaling pathway: Transcriptional regulation at Notch target genes. Cell. Mol. Life Sci. 2009, 66, 1631-1646.
    • (2009) Cell. Mol. Life Sci , vol.66 , pp. 1631-1646
    • Borggrefe, T.1    Oswald, F.2
  • 180
    • 40749128979 scopus 로고    scopus 로고
    • IGF2: Epigenetic regulation and role in development and disease
    • Chao, W.; D'Amore, P.A. IGF2: Epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev. 2008, 19, 111-120.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 111-120
    • Chao, W.1    D'amore, P.A.2
  • 181
    • 78149340134 scopus 로고    scopus 로고
    • Do neural cells communicate with endothelial cells via secretory exosomes and microvesicles
    • 2009
    • Smalheiser, N.R. Do neural cells communicate with endothelial cells via secretory exosomes and microvesicles? Cardiovasc. Psychiatry Neurol. 2009, 2009, 383086.
    • (2009) Cardiovasc. Psychiatry Neurol , pp. 383086
    • Smalheiser, N.R.1
  • 182
    • 58249121980 scopus 로고    scopus 로고
    • Temozolomide and carmustine cause largescale heterochromatin reorganization in glioma cells
    • Papait, R.; Magrassi, L.; Rigamonti, D.; Cattaneo, E. Temozolomide and carmustine cause largescale heterochromatin reorganization in glioma cells. Biochem. Biophys. Res. Commun. 2009, 379, 434-439.
    • (2009) Biochem. Biophys. Res. Commun , vol.379 , pp. 434-439
    • Papait, R.1    Magrassi, L.2    Rigamonti, D.3    Cattaneo, E.4
  • 183
    • 70349751583 scopus 로고    scopus 로고
    • Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology
    • Csoka, A.B.; Szyf, M. Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology. Med. Hypotheses 2009, 73, 770-780.
    • (2009) Med. Hypotheses , vol.73 , pp. 770-780
    • Csoka, A.B.1    Szyf, M.2
  • 184
    • 63449086968 scopus 로고    scopus 로고
    • Epigenetic mechanisms in glioblastoma multiforme
    • Nagarajan, R.P.; Costello, J.F. Epigenetic mechanisms in glioblastoma multiforme. Semin. Cancer Biol. 2009, 19, 188-197.
    • (2009) Semin. Cancer Biol , vol.19 , pp. 188-197
    • Nagarajan, R.P.1    Costello, J.F.2
  • 185
    • 30644474460 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
    • Greiner, D.; Bonaldi, T.; Eskeland, R.; Roemer, E.; Imhof, A. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat. Chem. Biol. 2005, 1, 143-145.
    • (2005) Nat. Chem. Biol , vol.1 , pp. 143-145
    • Greiner, D.1    Bonaldi, T.2    Eskeland, R.3    Roemer, E.4    Imhof, A.5
  • 187
    • 33745187327 scopus 로고    scopus 로고
    • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications
    • Lee, M.G.; Wynder, C.; Schmidt, D.M.; McCafferty, D.G.; Shiekhattar, R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem. Biol. 2006, 13, 563-567.
    • (2006) Chem. Biol , vol.13 , pp. 563-567
    • Lee, M.G.1    Wynder, C.2    Schmidt, D.M.3    McCafferty, D.G.4    Shiekhattar, R.5
  • 188
    • 34147173308 scopus 로고    scopus 로고
    • Trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1
    • Schmidt, D.M.; McCafferty, D.G. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 2007, 46, 4408-4416.
    • (2007) Biochemistry , vol.46 , pp. 4408-4416
    • Schmidt, D.M.1    McCafferty, D.G.2
  • 189
    • 77949421463 scopus 로고    scopus 로고
    • Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
    • Culhane, J.C.; Wang, D.; Yen, P.M.; Cole, P.A. Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J. Am. Chem. Soc. 2010, 132, 3164-3176.
    • (2010) J. Am. Chem. Soc , vol.132 , pp. 3164-3176
    • Culhane, J.C.1    Wang, D.2    Yen, P.M.3    Cole, P.A.4
  • 190
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J.; Yang, X.; Zhuang, L.; Jiang, X.; Chen, W.; Lee, P.L.; Karuturi, R.K.; Tan, P.B.; Liu, E.T.; Yu, Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007, 21, 1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6    Karuturi, R.K.7    Tan, P.B.8    Liu, E.T.9    Yu, Q.10
  • 191
    • 59049083922 scopus 로고    scopus 로고
    • Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression
    • Tariq, M.; Nussbaumer, U.; Chen, Y.; Beisel, C.; Paro, R. Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. Proc. Natl. Acad. Sci. USA 2009, 106, 1157-1162.
    • (2009) Proc. Natl. Acad. Sci , vol.106 , pp. 1157-1162
    • Tariq, M.1    Nussbaumer, U.2    Chen, Y.3    Beisel, C.4    Paro, R.5
  • 192
    • 70649102209 scopus 로고    scopus 로고
    • Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target
    • Rigamonti, D.; Mutti, C.; Zuccato, C.; Cattaneo, E.; Contini, A. Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target. Curr. Pharm. Des. 2009, 15, 3958-3967.
    • (2009) Curr. Pharm. Des , vol.15 , pp. 3958-3967
    • Rigamonti, D.1    Mutti, C.2    Zuccato, C.3    Cattaneo, E.4    Contini, A.5
  • 193
    • 43749108844 scopus 로고    scopus 로고
    • SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease
    • Leone, S.; Mutti, C.; Kazantsev, A.; Sturlese, M.; Moro, S.; Cattaneo, E.; Rigamonti, D.; Contini, A. SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease. Bioorg. Med. Chem. 2008, 16, 5695-5703.
    • (2008) Bioorg. Med. Chem , vol.16 , pp. 5695-5703
    • Leone, S.1    Mutti, C.2    Kazantsev, A.3    Sturlese, M.4    Moro, S.5    Cattaneo, E.6    Rigamonti, D.7    Contini, A.8
  • 194
    • 34548302039 scopus 로고    scopus 로고
    • Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators
    • Rigamonti, D.; Bolognini, D.; Mutti, C.; Zuccato, C.; Tartari, M.; Sola, F.; Valenza, M.; Kazantsev, A.G.; Cattaneo, E. Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators. J. Biol. Chem. 2007, 282, 24554-24562.
    • (2007) J. Biol. Chem , vol.282 , pp. 24554-24562
    • Rigamonti, D.1    Bolognini, D.2    Mutti, C.3    Zuccato, C.4    Tartari, M.5    Sola, F.6    Valenza, M.7    Kazantsev, A.G.8    Cattaneo, E.9
  • 197
    • 78649366866 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease
    • Gupta, S.K.; Bang, C.; Thum, T. Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease. Circ. Cardiovasc. Genet. 2010, 3, 484-488.
    • (2010) Circ. Cardiovasc. Genet , vol.3 , pp. 484-488
    • Gupta, S.K.1    Bang, C.2    Thum, T.3
  • 198
    • 77955316898 scopus 로고    scopus 로고
    • Biomarkers: MicroRNAs under the spotlight in inflammatory arthritis
    • Buckland, J. Biomarkers: microRNAs under the spotlight in inflammatory arthritis. Nat. Rev. Rheumatol. 2010, 6, 436.
    • (2010) Nat. Rev. Rheumatol , vol.6 , pp. 436
    • Buckland, J.1
  • 200
    • 77954315865 scopus 로고    scopus 로고
    • MicroRNAs as biomarkers in rheumatic diseases
    • Alevizos, I.; Illei, G.G. MicroRNAs as biomarkers in rheumatic diseases. Nat. Rev. Rheumatol. 2010, 6, 391-398.
    • (2010) Nat. Rev. Rheumatol , vol.6 , pp. 391-398
    • Alevizos, I.1    Illei, G.G.2
  • 201
    • 77952583639 scopus 로고    scopus 로고
    • MicroRNAs as biomarkers for CNS cancer and other disorders
    • De Smaele, E.; Ferretti, E.; Gulino, A. MicroRNAs as biomarkers for CNS cancer and other disorders. Brain Res. 2010, 1338, 100-111.
    • (2010) Brain Res , vol.1338 , pp. 100-111
    • de Smaele, E.1    Ferretti, E.2    Gulino, A.3
  • 202
    • 78651311799 scopus 로고    scopus 로고
    • MicroRNAs: Macro challenges on understanding human biological functions and neurological diseases
    • Santos-Reboucas, C.B.; Pimentel, M.M. MicroRNAs: Macro challenges on understanding human biological functions and neurological diseases. Curr. Mol. Med. 2010, 10, 692-704.
    • (2010) Curr. Mol. Med , vol.10 , pp. 692-704
    • Santos-Reboucas, C.B.1    Pimentel, M.M.2
  • 203
    • 41249102422 scopus 로고    scopus 로고
    • MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion
    • Jeyaseelan, K.; Lim, K.Y.; Armugam, A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 2008, 39, 959-966.
    • (2008) Stroke , vol.39 , pp. 959-966
    • Jeyaseelan, K.1    Lim, K.Y.2    Armugam, A.3
  • 206
    • 77956901498 scopus 로고    scopus 로고
    • The promise of microRNA replacement therapy
    • Bader, A.G.; Brown, D.; Winkler, M. The promise of microRNA replacement therapy. Cancer Res. 2010, 70, 7027-7030.
    • (2010) Cancer Res , vol.70 , pp. 7027-7030
    • Bader, A.G.1    Brown, D.2    Winkler, M.3
  • 207
    • 77953689096 scopus 로고    scopus 로고
    • Emergence of chemical biology approaches to the RNAi/miRNA pathway
    • Li, Y.; He, C.; Jin, P. Emergence of chemical biology approaches to the RNAi/miRNA pathway. Chem. Biol. 2010, 17, 584-589.
    • (2010) Chem. Biol , vol.17 , pp. 584-589
    • Li, Y.1    He, C.2    Jin, P.3


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