Tumor-associated methylation of the putative tumor suppressor ajap1 gene and association between decreased ajap1 expression and shorter survival in patients with glioma

Chinese Journal of Cancer

Volumn 30, Issue 4, 2011, Pages 254-263

  Cogdell, David ^a   Chung, Woonbok ^a   Liu, Yuexin ^a   Matthew McDonald, J ^a   Aldape, Kenneth ^a   Issa, Jean Pierre J ^a   Fuller, Gregory N ^a   Zhang, Wei ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

1p36; AJAP1(Shrew1); Epigenetics; Glioblastoma; Methylation; Survival; The cancer genome atlas

Indexed keywords

AJAP1 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; AJAP1 PROTEIN, HUMAN; CELL ADHESION MOLECULE;

AJAP1 GENE; ARTICLE; BIOINFORMATICS; CANCER CELL; CANCER PATIENT; CANCER SURVIVAL; CELL ADHESION; CELL MIGRATION; CLINICAL ARTICLE; CPG ISLAND; DNA METHYLATION; GENE DELETION; GENE EXPRESSION; GENETIC ASSOCIATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; OLIGODENDROGLIOMA; PROMOTER REGION; TUMOR SUPPRESSOR GENE; ASTROCYTOMA; CENTRAL NERVOUS SYSTEM TUMOR; DOWN REGULATION; GENETICS; METABOLISM; PATHOLOGY; SURVIVAL RATE; TUMOR CELL LINE;

ASTROCYTOMA; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; GENE DELETION; GLIOBLASTOMA; HUMANS; OLIGODENDROGLIOMA; PROMOTER REGIONS, GENETIC; SURVIVAL RATE;

EID: 79954553605     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.011.10025     Document Type: Article

References (26)

1. Dammann R, Li C, Yoon JH, et al. Epigenetic inactivation of a ras association domain family protein from the lung tumour suppressor locus 3p21.3 [J]. Nat Genet, 2000,25(3):315-319.
2. Esteller M, Toyota M, Sanchez-Cespedes M, et al. Inactivation of the DNA repair gene O-6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis [J]. Cancer Res, 2000,60(9):2368-2371.
3. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma [J]. Proc Natl Acad Sci USA, 1998,95 (12):6870-6875.
4. Merlo A, Herman JG, Mao L, et al. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers [J]. Nat Med, 1995,1(7):686-692.
5. Surawicz TS, McCarthy BJ, Kupelian V, et al. Descriptive epidemiology of primary brain and CNS tumors: results from the central brain tumor registry of the United States, 1990-1994 [J]. Neuro Oncol, 1999,1(1):14-25.
6. Bello MJ, Leone PE, Vaquera J, et al. Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumors [J]. Int J Cancer, 1995,64(3):207-210.
7. Bello MJ, Vaquera J, de Campos JM, et al. Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors [J]. Int J Cancer, 1994,57(2):172-175.
8. Husemann K, Wolter M, Buschges R, et al. Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors [J]. J Neuropathol Exp Neurol, 1999,58(10):1041-1050.
9. Nigro JM, Takahashi MA, Ginzinger DG, et al. Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay [J]. Am J Pathol, 2001,158(4):1253-1262.
10. Reifenberger J, Reifenberger G, Liu L, et al. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p [J]. Am J Pathol, 1994,145(5):1175-1190.
11. Smith JS, Alderete B, Minn Y, et al. Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype [J]. Oncogene, 1999,18 (28):4144-4152.
12. luchi T, Namba H, Iwadate Y, et al. Identification of the small interstitial deletion at chromosome band 1p34-p35 and its association with poor outcome in oligodendroglial tumors [J]. Genes Chromosomes Cancer, 2002,35(2):170-175.
13. McDonald JM, Dunmire V, Taylor E, et al. Attenuated expression of DFFB is a hallmark of oligodendrogliomas with 1p-allelic loss [J]. Mol Cancer, 2005,4:35.
14. Dong Z, Pang JS, Ng MH, et al. Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours [J]. Br J Cancer, 2004,91(6):1105-1111.
15. McDonald JM, Dunlap S, Cogdell D, et al. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration [J]. Cancer Biol Ther, 2006,5(3): 300-304.
16. Schreiner A, Ruonala M, Jakob V, et al. Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147 [J]. Mol Biol Cell, 2007,18(4):1272-1281.
17. Ernst A, Hofmann S, Ahmadi R, et al. Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival [J]. Clin Cancer Res, 2009,15(21):6541-6550.
18. REMBRANDT. National cancer institute. Rembrandt home page, http://rembrandt.nci.nih.gov. 2005. Accessed 2010 December 21.
19. Kraus JA, Koopmann J, Kaskel P, et al. Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma [J]. J Neuropathol Exp Neurol, 1995,54(1):91-95.
20. Cottrell SE, Laird PW. Sensitive detection of DNA methylation [J]. Ann N Y Acad Sci, 2003,983:120-130.
21. Chung W, Kwabi-Addo B, Ittmann M, et al. Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling [J]. PLoS One, 2008,3(4):e2079.
22. Dong SM, Pang JC, Poon WS, et al. Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors [J]. J Neuropathol Exp Neurol, 2001,60 (8):808-816.
23. Hong C, Bollen AW, Costello JF. The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas [J]. Cancer Res, 2003,63(22):7600-7605.
24. Watanabe T, Nakamura M, Yonekawa Y, et al. Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas [J]. Ada Neuropathol, 2001,101(3):185-189.
25. Wolter M, Reifenberger J, Blaschke B, et al. Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes [J]. J Neuropathol Exp Neurol, 2001,60(12):1170-1180.
26. Madhavan S, Zenklusen JC, Kotliarov Y, et al. Rembrandt: helping personalized medicine become a reality through integrative translational research [J]. Mol Cancer Res, 2009,7 (2):157-167.