Activation of the glp-1 receptor signalling pathway: A relevant strategy to repair a deficient beta-cell mass

Experimental Diabetes Research

Volumn 2011, Issue , 2011, Pages

  Portha, Bernard ^a   Tourrel Cuzin, Cécile ^a   Movassat, Jamileh ^a  

^a Groupe Hospitalier Pitié Salpêtrière   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CD3 ANTIGEN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LISOFYLLINE; LYMPHOCYTE ANTIBODY; METFORMIN; MONOCLONAL ANTIBODY; SITAGLIPTIN; VILDAGLIPTIN; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR;

AMYLASE BLOOD LEVEL; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; DIABETES MELLITUS; DRUG SAFETY; ENZYME ACTIVATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSMOTIC MINIPUMP; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS RESECTION; PANCREATITIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TREATMENT OUTCOME; ANIMAL; CELL TRANSFORMATION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG POTENTIATION; FEMALE; METABOLISM; MIDDLE AGED; PANCREAS TUMOR; RAT;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN-SECRETING CELLS; MIDDLE AGED; PANCREATIC NEOPLASMS; PANCREATITIS; RATS; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION;

EID: 80052766495     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2011/376509     Document Type: Review

References (108)

1. Butler A. E., Janson J., Bonner-Weir S., Ritzel R., Rizza R. A., Butler P. C., β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes Diabetes 2003 52 1 102 110 (Pubitemid 36042113)
2. Robertson R. P., Successful islet transplantation for patients with diabetesfact or fantasy? The New England Journal of Medicine 2000 343 4 289 290 (Pubitemid 30490398)
3. Salehi M., Aulinger B. A., D'Alessio D. A., Targeting -cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins Endocrine Reviews 2008 29 3 367 379 (Pubitemid 351679705)
4. Meier J. J., Butler A. E., Galasso R., Rizza R. A., Butler P. C., Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans Diabetologia 2006 49 11 2689 2696 (Pubitemid 44510793)
5. Meier J. J., Lin J. C., Butler A. E., Galasso R., Martinez D. S., Butler P. C., Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes Diabetologia 2006 49 8 1838 1844 (Pubitemid 44025038)
6. Tillmar L., Carlsson C., Welsh N., Control of insulin mRNA stability in rat pancreatic islets: regulatory role of a 3′ -untranslated region pyrimidine-rich sequence Journal of Biological Chemistry 2002 277 2 1099 1106 (Pubitemid 34968856)
7. Knoch K. P., Meisterfeld R., Kersting S., Bergert H., Altkrger A., Wegbrod C., Jger M., Saeger H. D., Solimena M., cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in cells Cell Metabolism 2006 3 2 123 134
8. Drucker D. J., Philippe J., Mojsov S., Chick W. L., Habener J. F., Glucagon-like peptide 1 stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line Proceedings of the National Academy of Sciences USA 1987 84 3434 3438 (Pubitemid 17085418)
9. Wang X., Cahill C. M., Pineyro M. A., Zhou J., Doyle M. E., Egan J. M., Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells Endocrinology 1999 140 10 4904 4907 (Pubitemid 30666159)
10. Wang X., Zhou J., Doyle M. E., Egan J. M., Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic -cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism Endocrinology 2001 142 5 1820 1827 (Pubitemid 32405938)
11. Stoffers D. A., Kieffer T. J., Hussain M. A., Drucker D. J., Bonner-Weir S., Habener J. F., Egan J. M., Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas Diabetes 2000 49 5 741 748 (Pubitemid 30339989)
12. Ohlsson H., Karlsson K., Edlund T., IPF1, a homeodomain-containing transactivator of the insulin gene The EMBO Journal 1993 12 11 4251 4259 (Pubitemid 23302039)
13. Le Lay J., Stein R., Involvement of PDX-1 in activation of human insulin gene transcription Journal of Endocrinology 2006 188 2 287 294 (Pubitemid 43273816)
14. Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs W. H., Wright C. V. E., White M. F., Arden K. C., Accili D., The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic cell growth Journal of Clinical Investigation 2002 110 12 1839 1847 (Pubitemid 36076491)
15. Buteau J., Spatz M. L., Accili D., Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic -cell mass Diabetes 2006 55 5 1190 1196 (Pubitemid 44195354)
16. Skoglund G., Hussain M. A., Holz G. G., Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element Diabetes 2000 49 7 1156 1164 (Pubitemid 30439090)
17. Chepurny O. G., Hussain M. A., Holz G. G., Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220 Endocrinology 2002 143 6 2303 2313 (Pubitemid 34521577)
18. Light P. E., Manning Fox J. E., Riedel M. J., Wheeler M. B., Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism Molecular Endocrinology 2002 16 9 2135 2144 (Pubitemid 35013461)
19. Gromada J., Holst J. J., Rorsman P., Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 Pflugers Archiv European Journal of Physiology 1998 435 5 583 594 (Pubitemid 28098639)
20. Nakazaki M., Crane A., Hu M., Seghers V., Ullrich S., Aguilar-Bryan L., Bryan J., cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets Diabetes 2002 51 12 3440 3449 (Pubitemid 35403448)
21. Shiota C., Larsson O., Shelton K. D., Shiota M., Efanov A. M., Hy M., Lindner J., Kooptiwut S., Juntti-Berggren L., Gromada J., Berggren P. O., Magnuson M. A., Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose Journal of Biological Chemistry 2002 277 40 37176 37183
22. De Rooij J., Zwartkruis F. J. T., Verheijen M. H. G., Cool R. H., Nijman S. M. B., Wittinghofer A., Bos J. L., Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Nature 1998 396 6710 474 477 (Pubitemid 28553318)
23. Kawasaki H., Springett G. M., Mochizuki N., Toki S., Nakaya M., Matsuda M., Housman D. E., Graybiel A. M., A family of cAMP-binding proteins that directly activate Rap1 Science 1998 282 5397 2275 2279 (Pubitemid 29004080)
24. Shibasaki T., Sunaga Y., Seino S., Integration of ATP, cAMP, and Ca 2+ signals in insulin granule exocytosis Diabetes 2004 53 3 S59 S62 (Pubitemid 39564523)
25. Kang G., Chepurny O. G., Malester B., Rindler M. J., Rehmann H., Bos J. L., Schwede F., Coetzee W. A., Holz G. G., cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic cells and rat INS-1 cells Journal of Physiology 2006 573 3 595 609 (Pubitemid 43842505)
26. Sonoda N., Imamura T., Yoshizaki T., Babendure J. L., Lu J. C., Olefsky J. M., β-arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic cells Proceedings of the National Academy of Sciences of the United States of America 2008 105 18 6614 6619 (Pubitemid 351754555)
27. MacDonald P. E., Wang X., Xia F., El-Kholy W., Targonsky E. D., Tsushima R. G., Wheeler M. B., Antagonism of rat -cell voltage-dependent K + currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways Journal of Biological Chemistry 2003 278 52 52446 52453 (Pubitemid 38035837)
28. Lester L. B., Langeberg L. K., Scott J. D., Anchoring of protein kinase A facilitates hormone-mediated insulin secretion Proceedings of the National Academy of Sciences of the United States of America 1997 94 26 14942 14947 (Pubitemid 28041479)
29. Fraser L. D. C., Tavalin S. J., Lester L. B., Langeberg L. K., Westphal A. M., Dean R. A., Marrion N. V., Scott J. D., A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events The EMBO Journal 1998 17 8 2261 2272 (Pubitemid 28171911)
30. Hulme J. T., Lin T. W. C., Westenbroek R. E., Scheuer T., Catterall W. A., β-adrenergic regulation requires direct anchoring of PKA to cardiac Ca1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15 Proceedings of the National Academy of Sciences of the United States of America 2003 100 22 13093 13098 (Pubitemid 37340031)
31. Kang G., Joseph J. W., Chepurny O. G., Monaco M., Wheeler M. B., Bos J. L., Schwede F., Genieser H. G., Holz G. G., Epac-selective cAMP analog 8-pCPT- 2′ -O-Me-cAMP as a stimulus for Ca 2+ -induced Ca 2+ release and exocytosis in pancreatic -cells Journal of Biological Chemistry 2003 278 10 8279 8285 (Pubitemid 36800574)
32. Tsuboi T., da Silva Xavier G., Holz G. G., Jouaville L. S., Thomas A. P., Rutter G. A., Glucagon-like peptide-1 mobilizes intracellular Ca 2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 -cells Biochemical Journal 2003 369 2 287 299 (Pubitemid 36174198)
33. Kim B. J., Park K. H., Yim C. Y., Takasawa S., Okamoto H., Im M. J., Kim U. H., Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca 2+ signal that is essential for insulin secretion in mouse pancreatic islets Diabetes 2008 57 4 868 878
34. Kato I., Yamamoto Y., Fujimura M., Noguchi N., Takasawa S., Okamoto H., CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion Journal of Biological Chemistry 1999 274 4 1869 1872
35. Lester L. B., Faux M. C., Nauert J. B., Scott J. D., Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation Endocrinology 2001 142 3 1218 1227 (Pubitemid 32202832)
36. Lonart G., Schoch S., Kaeser P. S., Larkin C. J., Sdhof T. C., Linden D. J., Phosphorylation of RIM1 by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses Cell 2003 115 1 49 60 (Pubitemid 37255317)
37. Wang Y., Okamoto M., Schmitz F., Hofmann K., Sdhof T. C., Rim is a putative rab3 effector in regulating synaptic-vesicle fusion Nature 1997 388 6642 593 598 (Pubitemid 27340010)
38. Betz A., Thakur P., Junge H. J., Ashery U., Rhee J. S., Scheuss V., Rosenmund C., Rettig J., Brose N., Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming Neuron 2001 30 1 183 196 (Pubitemid 32441686)
39. Ozaki N., Shibasaki T., Kashima Y., Miki T., Takahashi K., Ueno H., Sunaga Y., Yano H., Matsuura Y., Iwanaga T., Takai Y., Seino S., cAMP-GEFII is a direct target of cAMP in regulated exocytosis Nature Cell Biology 2000 2 11 805 811
40. Kwan E. P., Xie L., Sheu L., Ohtsuka T., Gaisano H. Y., Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1-mediated rescue of exocytotic defects in Munc13-1-deficient pancreatic -cells Diabetes 2007 56 10 2579 2588 (Pubitemid 47523266)
41. Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S., Piccolo, a Ca 2+ sensor in pancreatic -cells: involvement of cAMP-GEFII Rim2 Piccolo complex in cAMP-dependent exocytosis Journal of Biological Chemistry 2002 277 52 50497 50502 (Pubitemid 36042206)
42. Pipeleers D. G., Schuit F. C., In't Veld P. A., Interplay of nutrients and hormones in the regulation of insulin release Endocrinology 1985 117 3 824 833 (Pubitemid 15019999)
43. Cornu M., Modi H., Kawamori D., Kulkarni R. N., Joffraud M., Thorens B., Glucagon-like peptide-1 increases -cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression Journal of Biological Chemistry 2010 285 14 10538 10545
44. Holz G. G., Kuhtreiber W. M., Habener J. F., Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(737) Nature 1993 361 6410 362 365 (Pubitemid 23041630)
45. Peyot M.-L., Gray J. P., Lamontagne J., Smith P. J. S., Holz G. G., Madiraju S. R. M., Prentki M., Heart E., Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic -cells PLoS One 2009 4 7
46. Portha B., Lacraz G., Kergoat M., Homo-Delarche F., Giroix M. H., Bailbé D., Gangnerau M. N., Dolz M., Tourrel-Cuzin C., Movassat J., The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes? Molecular and Cellular Endocrinology 2009 297 1-2 73 85
47. Dolz M., Movassat J., Fradet M., cAMP-secretion coupling is impaired in the diabetic GK/par beta-cells. A defect counteracted by GLP-1. submitted
48. Dachicourt N., Serradas P., Bailbé D., Kergoat M., Doaré L., Portha B., Glucagon-like peptide-1(736)-amide confers glucose sensitivity to previously glucose-incompetent -cells in diabetic rats: in vivo and in vitro studies Journal of Endocrinology 1997 155 2 369 376 (Pubitemid 27475832)
49. Buteau J., Foisy S., Joly E., Prentki M., Glucagon-like peptide 1 induces pancreatic -cell proliferation via transactivation of the epidermal growth factor receptor Diabetes 2003 52 1 124 132 (Pubitemid 36042116)
50. Drucker D. J., Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis Molecular Endocrinology 2003 17 2 161 171 (Pubitemid 36183142)
51. Li Y., Cao X., Li L. X., Brubaker P. L., Edlund H., Drucker D. J., β-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1 Diabetes 2005 54 2 482 491
52. Trmper A., Trmper K., Hrsch D., Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in (INS-1)-cells Journal of Endocrinology 2002 174 2 233 246
53. Buteau J., Foisy S., Rhodes C. J., Carpenter L., Biden T. J., Prentki M., Protein kinase C activation mediates glucagon-like peptide-1induced pancreatic -cell proliferation Diabetes 2001 50 10 2237 2243 (Pubitemid 33641907)
54. Buteau J., Roduit R., Susini S., Prentki M., Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells Diabetologia 1999 42 7 856 864 (Pubitemid 29325077)
55. Demeterco C., Beattie G. M., Dib S. A., Lopez A. D., Hayek A., A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth Journal of Clinical Endocrinology and Metabolism 2000 85 10 3892 3897
56. Movassat J., Beattie G. M., Lopez A. D., Hayek A., Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells Journal of Clinical Endocrinology and Metabolism 2002 87 10 4775 4781 (Pubitemid 35247075)
57. Xie T., Chen M., Zhang Q.-H., Ma Z., Weinstein L. S., cell-specific deficiency of the stimulatory G protein -subunit Gs leads to reduced cell mass and insulin-deficient diabetes Proceedings of the National Academy of Sciences of the United States of America 2007 104 49 19601 19606
58. Jhala U. S., Canettieri G., Screaton R. A., Kulkarni R. N., Krajewski S., Reed J., Walker J., Lin X., White M., Montminy M., cAMP promotes pancreatic -cell survival via CREB-mediated induction of IRS2 Genes and Development 2003 17 13 1575 1580 (Pubitemid 36828785)
59. Friedrichsen B. N., Neubauer N., Lee Y. C., Gram V. K., Blume N., Petersen J. S., Nielsen J. H., Mldrup A., Stimulation of pancreatic -cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways Journal of Endocrinology 2006 188 3 481 492
60. Kim M.-J., Kang J.-H., Park Y. G., Ryu G. R., Ko S. H., Jeong I.-K., Koh K.-H., Rhie D.-J., Yoon S. H., Hahn S. J., Kim M.-S., Jo Y.-H., Exendin-4 induction of cyclin D1 expression in INS-1 -cells: involvement of cAMP-responsive element Journal of Endocrinology 2006 188 3 623 633
61. Lupi R., Mancarella R., Del Guerra S., Bugliani M., Del Prato S., Boggi U., Mosca F., Filipponi F., Marchetti P., Effects of exendin-4 on islets from type 2 diabetes patients Diabetes, Obesity and Metabolism 2008 10 6 515 519 (Pubitemid 351639096)
62. Liu Z., Habener J. F., Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation Journal of Biological Chemistry 2008 283 13 8723 8735
63. Tanabe K., Liu Z., Patel S., Doble B. W., Li L., Cras-Méneur C., Martinez S. C., Welling C. M., White M. F., Bernal-Mizrachi E., Woodgett J. R., Permutt M. A., Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biology 2008 6 2, article e37
64. Figeac F., Uzan B., Faro M., Chelali N., Portha B., Movassat J., Neonatal growth and regeneration of -cells are regulated by the Wnt/ -catenin signaling in normal and diabetic rats American Journal of Physiology 2010 298 2 E245 E256
65. Farilla L., Hongxiang H., Bertolotto C., Kang E., Bulotta A., Mario U. D. I., Perfetti R., Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats Endocrinology 2002 143 11 4397 4408 (Pubitemid 35239574)
66. Kim W., Egan J. M., The role of incretins in glucose homeostasis and diabetes treatment Pharmacological Reviews 2008 60 4 470 512
67. Li Y., Hansotia T., Yusta B., Ris F., Halban P. A., Drueker D. J., Glucagon-like peptide-1 receptor signaling modulates cell apoptosis Journal of Biological Chemistry 2003 278 1 471 478 (Pubitemid 36043598)
68. Yusta B., Baggio L. L., Estall J. L., Koehler J. A., Holland D. P., Li H., Pipeleers D., Ling Z., Drucker D. J., GLP-1 receptor activation improves cell function and survival following induction of endoplasmic reticulum stress Cell Metabolism 2006 4 5 391 406 (Pubitemid 44752565)
69. Tsunekawa S., Yamamoto N., Tsukamoto K., Itoh Y., Kaneko Y., Kimura T., Ariyoshi Y., Miura Y., Oiso Y., Niki I., Protection of pancreatic -cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies Journal of Endocrinology 2007 193 1 65 74 (Pubitemid 46638533)
70. Buteau J., El-Assaad W., Rhodes C. J., Mosenberg L., Joly E., Prentki M., Glucagon-like peptide-1 prevents beta cell glucolipotoxicity Diabetologia 2004 47 5 806 815 (Pubitemid 38756992)
71. Ferdaoussi M., Abdelli S., Yang J. Y., Cornu M., Niederhauser G., Favre D., Widmann C., Regazzi R., Thorens B., Waeber G., Abderrahmani A., Exendin-4 protects -cells from interleukin-1 -induced apoptosis by interfering with the c-Jun NH-terminal kinase pathway Diabetes 2008 57 5 1205 1215
72. Blandino-Rosano M., Perez-Arana G., Mellado-Gil J. M., Segundo C., Aguilar-Diosdado M., Anti-proliferative effect of pro-inflammatory cytokines in cultured cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide -1 Journal of Molecular Endocrinology 2008 41 1-2 35 44
73. Tornehave D., Kristensen P., Rmer J., Knudsen L. B., Heller R. S., Expression of the GLP-1 receptor in mouse, rat, and human pancreas Journal of Histochemistry and Cytochemistry 2008 56 9 841 851
74. Xu G., Kaneto H., Lopez-Avalos M. D., Weir G. C., Bonner-Weir S., GLP-1/exendin-4 facilitates -cell neogenesis in rat and human pancreatic ducts Diabetes Research and Clinical Practice 2006 73 1 107 110 (Pubitemid 43765553)
75. Zhou J., Montrose-Rafizadeh C., Janczewski A. M., Pineyro M. A., Sollott S. J., Wang Y., Egan J. M., Glucagon-like peptide-1 does not mediate amylase release from AR42J cells Journal of Cellular Physiology 1999 181 3 470 478 (Pubitemid 29513416)
76. Zhou J., Wang X., Pineyro M. A., Egan J. M., Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells Diabetes 1999 48 12 2358 2366 (Pubitemid 30395427)
77. Yew K. H., Hembree M., Prasadan K., Preuett B., McFall C., Benjes C., Crowley A., Sharp S., Tulachan S., Mehta S., Tei E., Gittes G., Cross-talk between bone morphogenetic protein and transforming growth factor- signaling is essential for exendin-4-induced insulin-positive differentiation of AR42J cells Journal of Biological Chemistry 2005 280 37 32209 32217 (Pubitemid 41361828)
78. Tei E., Mehta S., Tulachan S. S., Yew H., Hembree M., Preuett B., Snyder C. L., Yamataka A., Miyano T., Gittes G. K., Synergistic endocrine induction by GLP-1 and TGF- in the developing pancreas Pancreas 2005 31 2 138 141 (Pubitemid 41077142)
79. Mashima H., Ohnishi H., Wakabayashi K., Mine T., Miyagawa J. I., Hanafusa T., Seno M., Yamada H., Kojima I., Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells Journal of Clinical Investigation 1996 97 7 1647 1654 (Pubitemid 26105476)
80. Zhou J., Pineyro M. A., Wang X., Doyle M. E., Egan J. M., Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3 transcription factors Journal of Cellular Physiology 2002 192 3 304 314 (Pubitemid 34827607)
81. Hui H., Wright C., Perfetti R., Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells Diabetes 2001 50 4 785 796 (Pubitemid 32242635)
82. Rolin B., Larsen M. O., Gotfredsen C. F., Deacon C. F., Carr R. D., Wilken M., Knudsen L. B., The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases -cell mass in diabetic mice American Journal of Physiology 2002 283 4 E745 E752
83. Tourrel C., Bailbé D., Meile M. J., Kergoat M., Portha B., Glucagon-like peptide-1 and exendin-4 stimulate -cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age Diabetes 2001 50 7 1562 1570 (Pubitemid 33639596)
84. Tourrel C., Bailbe D., Lacorne M., Meile M.-J., Kergoat M., Portha B., Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the -cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4 Diabetes 2002 51 5 1443 1452 (Pubitemid 34826610)
85. Wang Q., Brubaker P., Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice Diabetologia 2002 45 9 1263 1273
86. Xu G., Stoffers D. A., Habener J. F., Bonner-Weir S., Exendin-4 stimulates both -cell replication and neogenesis, resulting in increased -cell mass and improved glucose tolerance in diabetic rats Diabetes 1999 48 12 2270 2276 (Pubitemid 30395416)
87. Stoffers D. A., Desai B. M., DeLeon D. D., Simmons R. A., Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat Diabetes 2003 52 3 734 740 (Pubitemid 36323581)
88. Egan J. M., Bulotta A., Hui H., Perfetti R., GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells Diabetes/Metabolism Research and Reviews 2003 19 2 115 123 (Pubitemid 36417195)
89. Klinger S., Poussin C., Debril M. B., Dolci W., Halban P. A., Thorens B., Increasing GLP-1-induced -cell proliferation by silencing the negative regulators of signaling cAMP response element modulator- and DUSP14 Diabetes 2008 57 3 584 593
90. Ahmad S. R., Swann J., Exenatide and rare adverse events The New England Journal of Medicine 2008 358 18 1970 1971 (Pubitemid 351620133)
91. Koehler J. A., Baggio L. L., Lamont B. J., Ali S., Drucker D. J., Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice Diabetes 2009 58 9 2148 2161
92. Dore D. D., Seeger J. D., Chan K. A., Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide Current Medical Research and Opinion 2009 25 4 1019 1027
93. Matveyenko A. V., Dry S., Cox H. I., Moshtaghian A., Gurlo T., Galasso R., Butler A. E., Butler P. C., Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin Diabetes 2009 58 7 1604 1615
94. Nachnani J. S., Bulchandani D. G., Nookala A., Herndon B., Molteni A., Pandya P., Taylor R., Quinn T., Weide L., Alba L. M., Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas Diabetologia 2010 53 1 153 159
95. Butler A. E., Galasso R., Matveyenko A., Rizza R. A., Dry S., Butler P. C., Pancreatic duct replication is increased with obesity and type 2 diabetes in humans Diabetologia 2010 53 1 21 26
96. Donath M. Y., Schumann D. M., Faulenbach M., Ellingsgaard H., Perren A., Ehses J. A., Islet inflammation in type 2 diabetes: from metabolic stress to therapy Diabetes care 2008 31 supplement 2 S161 S164
97. Zhang J., Tokui Y., Yamagata K., Kozawa J., Sayama K., Iwahashi H., Okita K., Miuchi M., Konya H., Hamaguchi T., Namba M., Shimomura I., Miyagawa J. I., Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes Diabetologia 2007 50 9 1900 1909 (Pubitemid 47222856)
98. Yang Z., Chen M., Carter J. D., Nunemaker C. S., Garmey J. C., Kimble S. D., Nadler J. L., Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes Biochemical and Biophysical Research Communications 2006 344 3 1017 1022
99. Ogawa N., List J. F., Habener J. F., Maki T., Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4 Diabetes 2004 53 7 1700 1705 (Pubitemid 38857027)
100. Sherry N. A., Chen W., Kushner J. A., Glandt M., Tang Q., Tsai S., Santamaria P., Bluestone J. A., Brillantes A.-M. B., Herold K. C., Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of -cells Endocrinology 2007 148 11 5136 5144 (Pubitemid 350012634)
101. Kim S. J., Nian C., Doudet D. J., Mcintosh C. H. S., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation Diabetes 2009 58 3 641 651
102. Pugazhenthi U., Velmurugan K., Tran A., Mahaffey G., Pugazhenthi S., Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients Diabetologia 2010 53 11 2357 2368
103. Pérez-Arana G., Blandino-Rosano M., Prada-Oliveira A., Aguilar-Diosdado M., Segundo C., Decrease in -cell proliferation precedes apoptosis during diabetes development in bio-breeding/worcester rat: beneficial role of exendin-4 Endocrinology 2010 151 6 2538 2546
104. Brubaker P. L., Drucker D. J., Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system Endocrinology 2004 145 6 2653 2659 (Pubitemid 38686211)
105. Thyssen S., Arany E., Hill D. J., Ontogeny of regeneration of -cells in the neonatal rat after treatment with streptozotocin Endocrinology 2006 147 5 2346 2356
106. Nie Y., Nakashima M., Brubaker P. L., Li Q. L., Perfetti R., Jansen E., Zambre Y., Pipeleers D., Friedman T. C., Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats Journal of Clinical Investigation 2000 105 7 955 965 (Pubitemid 30203068)
107. Wideman R. D., Yu I. L. Y., Webber T. D., Verchere C. B., Johnson J. D., Cheung A. T., Kieffer T. J., Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1) Proceedings of the National Academy of Sciences of the United States of America 2006 103 36 13468 13473 (Pubitemid 44380131)
108. Wideman R. D., Covey S. D., Webb G. C., Drucker D. J., Kieffer T. J., A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted -cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice Diabetes 2007 56 11 2744 2752 (Pubitemid 350044917)