Expression of the GLP-1 receptor in mouse, rat, and human pancreas

Journal of Histochemistry and Cytochemistry

Volumn 56, Issue 9, 2008, Pages 841-851

  Tornehave, Ditte ^a   Kristensen, Peter ^a   Rømer, John ^a   Knudsen, Lotte Bjerre ^a   Heller, R Scott ^b  

^a NOVO NORDISK A S   (Denmark)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

Glucagon; Glucagon like peptide 1 receptor; Immunohistochemistry; Insulin; ISH; Somatostatin

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1; INSULIN; MESSENGER RNA; PANCREAS POLYPEPTIDE; SOMATOSTATIN;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; FEMALE; GENE TARGETING; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PANCREAS; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIVITY AND SPECIFICITY;

ANIMALS; FEMALE; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; PANCREATIC DUCTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; RNA, MESSENGER; SPECIES SPECIFICITY; TISSUE FIXATION;

MUS; RATTUS;

EID: 49749113817     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.2008.951319     Document Type: Article

References (48)

1. Ahren B (2004) Sensory nerves contribute to insulin secretion by glucagon- like peptide-1 in mice. Am J Physiol Regul Integr Comp Physiol 286:R269-272
2. Balkan B, Li X (2000) Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. Am J Physiol Regul Integr Comp Physiol 279:R1449-1454
3. Barnett A (2007) Exenatide. Expert Opin Pharmacother 8:2593-2608
4. Bermúdez-Silva FJ, Suárez J, Baixeras E, Cobo N, Bautista D, Cuesta-Muñoz AL, Fuentes E, et al. (2008) Presence of functional cannabinoid receptors in human endocrine pancreas. Diabetologia 51:476-487
5. Bode HP, Moormann B, Dabew R, Goke B (1999) Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta;-cells independently of protein kinase A. Endocrinology 140:3919-3927
6. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ (2000) in vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004
7. Bullock BP, Heller RS, Habener JF (1996) Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968-2978
8. Bulotta A, Hui H, Anastasi E, Bertolotto C, Boros LG, Di Mario U, Perfetti R (2002) Cultured pancreatic ductal cells undergo cell cycle re- distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J Mol Endocrinol 29:347-360
9. Butler PC, Meier JJ, Butler AE, Bhushan A (2007) The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab 3:758-768
10. Chiba T, Taminato T, Kadowaki S, Abe H, Chihara K, Matsukura S, Goto Y, et al. (1980) Effects of insulin and pancreatic polypeptide on gastric somatostatin release. Diabetes 29:292-295
11. D'Alessio DA, Fujimoto WY, Ensinck JW (1989) Effects of glucagon-like peptide 1-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. Diabetes 38:1534-1538
12. de Koning EJ, Bonner-Weir S, Rabelink TJ (2008) Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci 29:218-227
13. Ding WG, Renström E, Rorsman P, Buschard K, Gromada J (1997) Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism. Diabetes 46:792-800
14. Drucker DJ, Nauck M (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-1705
15. Fehmann HC, Habener JF (1991) Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line. FEBS Lett 279:335-340
16. Gerber PP, Trimble ER, Wollheim CB, Renold AE (1981) Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas. Endocrinology 109:279-283
17. Goke R, Conlon JM (1988) Receptors for glucagon-like peptide-1(7-36) amide on rat insulinoma-derived cells. J Endocrinol 116:357-362
18. Gromada J, Holst JJ, Rorsman P (1998) Cellular-regulation of islet hormone-secretion by the incretin hormone glucagon-like peptide-1. Pflugers Arch 435:583-594
19. Hanley NA, Hanley KP, Miettinen PJ, Otonkoski T (2008) Weighing up beta-cell mass in mice and humans: Self-renewal, progenitors or stem cells? Mol Cell Endocrinol 288:79-85
20. Hansen L, Deacon CF, Orskov C, Holst JJ (1999) Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140: 5356-5363
21. Heller RS, Aponte GW (1995) Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide. Am J Physiol 269:G852-860
22. Heller RS, Kieffer TJ, Habener JF (1996) Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun 223:624-632
23. Heller RS, Kieffer TJ, Habener JF (1997) Insulinotropic glucagon-like peptide 1 receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes 46:785-791
24. Holst JJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87:1409-1439
25. Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV (1983) Autonomic nervous control of pancreatic somatostatin secretion. Am J Physiol 245:E542-548
26. Holz GG, Kuhtreiber WM, Habener JF (1993) Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361:362-365
27. Hörsch D, Goke R, Eissele R, Michel B, Goke B (1997) Reciprocal cellular distribution of glucagon-like peptide-1 (GLP-1) immunoreactivity and GLP-1 receptor mRNA in pancreatic islets of rat. Pancreas 14:290-294
28. Hui H, Wright C, Perfetti R (2001) Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 50:785-796
29. Inui T, Kinoshita Y, Yamaguchi A, Yamatani T, Chiba T (1991) Linkage between capsaicin-stimulated calcitonin gene-related peptide and somatostatin release in rat stomach. Am J Physiol 261:G770-774
30. Kanno T, Gopel SO, Rorsman P, Wakui M (2002) Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet. Neurosci Res 42:79-90
31. Kristensen P, Eriksen J, Dan K (1991) Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization. J Histochem Cytochem 39:341-349
32. Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, et al. (1996) Expression and functional activity of glucagon, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells. Diabetes 45:257-261
33. Nadal A, Quesada I, Soria B (1999) Homologous and heterologous asynchronicity between identified α-, β- and δ-cells within intact islets of Langerhans in the mouse. J Physiol 517:85-93
34. Orskov C, Poulsen SS (1991) Glucagonlike peptide-I-(7-36)-amide receptors only in islets of Langerhans. Autoradiographic survey of extracerebral tissues in rats. Diabetes 40:1292-1296
35. Patton GS, Ipp E, Dobbs RE, Orci L, Vale W, Unger RH (1977) Pancreatic immunoreactive somatostatin release. Proc Natl Acad Sci USA 74:2140-2143
36. Raun K, von Voss P, Knudsen LB (2007) Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs. Obesity (Silver Spring) 15:1710-1716
37. Scrocchi LA, Brown TJ, Maclusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ (1996) Glucose-intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide-1 receptor gene. Nat Med 2:1254-1258
38. Shi SR, Cote RJ, Taylor CR (2001) Antigen retrieval techniques: current perspectives. J Histochem Cytochem 49:931-937
39. Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM (2000) Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748
40. Suga S, Kanno T, Ogawa Y, Takeo T, Kamimura N, Wakui M (2000) cAMP-independent decrease of ATP-sensitive K+ channel activity by GLP-1 in rat pancreatic beta-cells. Pflugers Arch 440:566-572
41. Thorens B (1992) Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89:8641-8645
42. Turner RC, Cull CA, Frighi V, Holman RR (1999) Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 281:2005-2012
43. Vilsbøll T (2007) Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus. Expert Opin Investig Drugs 16:231-237
44. Willesen MG, Kristensen P, Romer J (1999) Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70:306-316
45. Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S (2006) GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract 73:107-110
46. Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
47. Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, et al. (2008) Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132: 197-207
48. Zander M, Madsbad S, Madsen JL, Holst JJ (2002) Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830