Glucagon-like peptide-1 receptor activation modulates pancreatitis- associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice

Diabetes

Volumn 58, Issue 9, 2009, Pages 2148-2161

  Koehler, Jacqueline A ^a   Baggio, Laurie L ^a   Lamont, Benjamin J ^a   Ali, Safina ^a   Drucker, Daniel J ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CERULETIDE; EARLY GROWTH RESPONSE FACTOR 1; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LIRAGLUTIDE; MESSENGER RNA; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN C FOS; SITAGLIPTIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; METABOLIC STRESS; MOUSE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; UPREGULATION;

ANIMALS; CAERULEIN; DIETARY FATS; DISEASE MODELS, ANIMAL; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION; GENES, FOS; GLUCAGON-LIKE PEPTIDE 1; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PANCREAS, EXOCRINE; PANCREATITIS; PEPTIDES; RECEPTORS, GLUCAGON; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; VENOMS;

EID: 70349120958     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0626     Document Type: Article

References (34)

1. Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-165
2. Brubaker PL, Drucker DJ. Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 2004;145:2653-2659
3. Deacon CF. Therapeutic strategies based on glucagon-like peptide 1. Diabetes 2004;53:2181-2189
4. Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696-1705
5. Zhou J, Wang X, Pineyro MA, Egan JM. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 1999;48:2358-2366 (Pubitemid 30395427)
6. Wettergren A, Wojdemann M, Holst JJ. Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. Am J Physiol 1998;275:G984-G992 (Pubitemid 28538952)
7. Wan S, Coleman FH, Travagli RA. Glucagon-like peptide-1 excites pancreas- projecting preganglionic vagal motoneurons. Am J Physiol Gastrointest Liver Physiol 2007;292:G1474-G1482 (Pubitemid 47080600)
8. Ahmad SR, Swann J. Exenatide and rare adverse events. N Engl J Med 2008;358:1970 -1971; discussion 1971-1972
9. Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I, Hale PM, Zdravkovic M, Bode B. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;373:473-481
10. Dore DD, Seeger JD, Arnold Chan K. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin 2009;25:1019-1027
11. Gaisano HY, Gorelick FS. New insights into the mechanisms of pancreatitis. Gastroenterology, 2009 [Epub ahead of print]
12. De Leon DD, Farzad C, Crutchlow MF, Brestelli J, Tobias J, Kaestner KH, Stoffers DA. Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment. Physiol Genomics 2006;24:133-143
13. Gironella M, Folch-Puy E, LeGoffic A, Garcia S, Christa L, Smith A, Tebar L, Hunt SP, Bayne R, Smith AJ, Dagorn JC, Closa D, Iovanna JL. Experimental acute pancreatitis in PAP/HIP knock-out mice. Gut 2007;56:1091-1097 (Pubitemid 47123239)
14. Graf R, Schiesser M, Reding T, Appenzeller P, Sun LK, Fortunato F, Perren A, Bimmler D. Exocrine meets endocrine: pancreatic stone protein and regenerating protein-two sides of the same coin. J Surg Res 2006;133:113-120 (Pubitemid 43765756)
15. Saluja AK, Lerch MM, Phillips PA, Dudeja V. Why does pancreatic overstimulation cause pancreatitis? Annu Rev Physiol 2007;69:249-269
16. Hansotia T, Maida A, Flock G, Yamada Y, Tsukiyama K, Seino Y, Drucker DJ. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J Clin Invest 2007;117:143-152 (Pubitemid 46048461)
17. Pandol SJ, Saluja AK, Imrie CW, Banks PA. Acute pancreatitis: bench to the bedside. Gastroenterology 2007;132:1127-1151
18. Willemer S, Elsasser HP, Adler G. Hormone-induced pancreatitis. Eur Surg Res 1992;1 (Suppl.):29-39
19. Winzell MS, Ahren B. The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 2004;3 (Suppl.):S215-S219 (Pubitemid 39564546)
20. Kowalik AS, Johnson CL, Chadi SA, Weston JY, Fazio EN, Pin CL. Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G1123-G1132
21. Singh VP, Bhagat L, Navina S, Sharif R, Dawra RK, Saluja AK. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion. Gut 2007;56:958-964 (Pubitemid 46999080)
22. Flock G, Baggio LL, Longuet C, Drucker DJ. Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 2007;56:3006-3013 (Pubitemid 350223636)
23. Baggio LL, Huang Q, Cao X, Drucker DJ. The long-acting albumin-exendin-4 GLP-1R agonist CJC-1134 engages central and peripheral mechanisms regulating glucose homeostasis. Gastroenterology 2008;134:1137-1147
24. Thiel G, Cibelli G. Regulation of life and death by the zinc finger transcription factor Egr-1. J Cell Physiol 2002;193:287-292 (Pubitemid 35265949)
25. Ji B, Chen XQ, Misek DE, Kuick R, Hanash S, Ernst S, Najarian R, Logsdon CD. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Physiol Genomics 2003;14:59-72 (Pubitemid 37345215)
26. Yasuda N, Inoue T, Nagakura T, Yamazaki K, Kira K, Saeki T, Tanaka I. Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. Biochem Biophys Res Commun 2002;298:779-784 (Pubitemid 35356808)
27. Singh G, Eng J, Raufman JP. Use of 125I-[Y39]exendin-4 to characterize exendin receptors on dispersed pancreatic acini and gastric chief cells from guinea pig. Regul Pept 1994;53:47-59
28. Kash FF, Wood JG, Solomon T. Glucagon inhibition of cerulein-induced hypertrophy of the exocrine pancreas. Pancreas 1988;3:11-17 (Pubitemid 18225429)
29. Biedzinski TM, Bataille D, Devaux MA, Sarles H. The effect of oxyntomodulin (glucagon-37) and glucagon on exocrine pancreatic secretion in the conscious rat. Peptides 1987;8:967-972
30. Raufman J-P, Singh L, Singh G, Eng J. Truncated glucagon-like peptide-1 interacts with exendin receptors on disperced acini from guinea pig pancreas. Identification of a mammalian homolgue of the reptilian peptide exendin-4. J Biol Chem 1992;267:21432-21437
31. Eng J, Kleinman WA, Singh L, Singh G, Raufman JP. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 1992;267:7402-7405
32. Malhotra R, Singh L, Eng J, Raufman JP. Exendin-4, a new peptide from Heloderma suspectum venom, potentiates cholecystokinin-induced amylase release from rat pancreatic acini. Regul Pept 1992;41:149-156
33. Fehmann HC, Goke B, Weber V, Goke R, Trautmann ME, Richter G, Arnold R. Interaction of glucagon-like peptide-1 (7-36)amide and cholecystokinin- 8 in the endocrine and exocrine rat pancreas. Pancreas 1990;5:361-365
34. Zhang H, Kandil E, Lin YY, Levi G, Zenilman ME. Targeted inhibition of gene expression of pancreatitis-associated proteins exacerbates the severity of acute pancreatitis in rats. Scand J Gastroenterol 2004;39:870-881 (Pubitemid 39215459)