-
1
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA 2005 A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54:1763-1769
-
(2005)
Diabetes
, vol.54
, pp. 1763-1769
-
-
Herold, K.C.1
Gitelman, S.E.2
Masharani, U.3
Hagopian, W.4
Bisikirska, B.5
Donaldson, D.6
Rother, K.7
Diamond, B.8
Harlan, D.M.9
Bluestone, J.A.10
-
2
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA 2002 Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346:1692-1698
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
3
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L 2005 Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 352:2598-2608
-
(2005)
N Engl J Med
, vol.352
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
Mathieu, C.4
Kaufman, L.5
Hale, G.6
Gorus, F.7
Goldman, M.8
Walter, M.9
Candon, S.10
Schandene, L.11
Crenier, L.12
De Block, C.13
Seigneurin, J.M.14
De Pauw, P.15
Pierard, D.16
Weets, I.17
Rebello, P.18
Bird, P.19
Berrie, E.20
Frewin, M.21
Waldmann, H.22
Bach, J.F.23
Pipeleers, D.24
Chatenoud, L.25
more..
-
4
-
-
0023849461
-
Factors associated with early remission of type I diabetes in children treated with cyclosporine
-
Bougneres PF, Carel JC, Castano L, Boitard C, Gardin JP, Landais P, Hors J, Mihatsch MJ, Paillard M, Chaussain JL, Bach JF 1988 Factors associated with early remission of type I diabetes in children treated with cyclosporine. N Engl J Med 318:663-670
-
(1988)
N Engl J Med
, vol.318
, pp. 663-670
-
-
Bougneres, P.F.1
Carel, J.C.2
Castano, L.3
Boitard, C.4
Gardin, J.P.5
Landais, P.6
Hors, J.7
Mihatsch, M.J.8
Paillard, M.9
Chaussain, J.L.10
Bach, J.F.11
-
5
-
-
7444228521
-
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
-
Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD 2004 Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27:2628-2635
-
(2004)
Diabetes Care
, vol.27
, pp. 2628-2635
-
-
Buse, J.B.1
Henry, R.R.2
Han, J.3
Kim, D.D.4
Fineman, M.S.5
Baron, A.D.6
-
6
-
-
0038497464
-
Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
-
Kolterman OG, Buse JB, Fineman MS, Gaines E, Heintz S, Bicsak TA, Taylor K, Kim D, Aisporna M, Wang Y, Baron AD 2003 Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 88:3082-3089
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3082-3089
-
-
Kolterman, O.G.1
Buse, J.B.2
Fineman, M.S.3
Gaines, E.4
Heintz, S.5
Bicsak, T.A.6
Taylor, K.7
Kim, D.8
Aisporna, M.9
Wang, Y.10
Baron, A.D.11
-
7
-
-
0037414781
-
Glucagon-like peptide-1 receptor signaling modulates β-cell apoptosis
-
Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ 2003 Glucagon-like peptide-1 receptor signaling modulates β-cell apoptosis. J Biol Chem 278:471-478
-
(2003)
J Biol Chem
, vol.278
, pp. 471-478
-
-
Li, Y.1
Hansotia, T.2
Yusta, B.3
Ris, F.4
Halban, P.A.5
Drucker, D.J.6
-
8
-
-
0345374580
-
GLP-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
-
Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R 2003 GLP-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 144:5149-5158
-
(2003)
Endocrinology
, vol.144
, pp. 5149-5158
-
-
Farilla, L.1
Bulotta, A.2
Hirshberg, B.3
Li Calzi, S.4
Khoury, N.5
Noushmehr, H.6
Bertolotto, C.7
Di Mario, U.8
Harlan, D.M.9
Perfetti, R.10
-
9
-
-
0033513455
-
Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
-
Xu G, Stoffers DA, Habener JF, Bonner-Weir S 1999 Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
10
-
-
0034032317
-
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
-
Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM 2000 Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748
-
(2000)
Diabetes
, vol.49
, pp. 741-748
-
-
Stoffers, D.A.1
Kieffer, T.J.2
Hussain, M.A.3
Drucker, D.J.4
Bonner-Weir, S.5
Habener, J.F.6
Egan, J.M.7
-
11
-
-
0037341252
-
Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
-
Stoffers DA, Desai BM, DeLeon DD, Simmons RA 2003 Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 52:734-740
-
(2003)
Diabetes
, vol.52
, pp. 734-740
-
-
Stoffers, D.A.1
Desai, B.M.2
DeLeon, D.D.3
Simmons, R.A.4
-
12
-
-
0037312829
-
Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy
-
De Leon DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA 2003 Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes 52:365-371
-
(2003)
Diabetes
, vol.52
, pp. 365-371
-
-
De Leon, D.D.1
Deng, S.2
Madani, R.3
Ahima, R.S.4
Drucker, D.J.5
Stoffers, D.A.6
-
13
-
-
0036224872
-
Impaired β-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose
-
Greenbaum CJ, Prigeon RL, D'Alessio DA 2002 Impaired β-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. Diabetes 51:951-957
-
(2002)
Diabetes
, vol.51
, pp. 951-957
-
-
Greenbaum, C.J.1
Prigeon, R.L.2
D'Alessio, D.A.3
-
14
-
-
15044357070
-
Glycaemic effects of incretins in type 1 diabetes mellitus: A concise review, with emphasis on studies in humans
-
Dupre J 2005 Glycaemic effects of incretins in type 1 diabetes mellitus: a concise review, with emphasis on studies in humans. Regul Pept 128:149-157
-
(2005)
Regul Pept
, vol.128
, pp. 149-157
-
-
Dupre, J.1
-
15
-
-
1842598583
-
Glucagon-like peptide 1 improved glycemic control in type 1 diabetes
-
Behme MT, Dupre J, McDonald TJ 2003 Glucagon-like peptide 1 improved glycemic control in type 1 diabetes. BMC Endocr Disord 3:3
-
(2003)
BMC Endocr Disord
, vol.3
, pp. 3
-
-
Behme, M.T.1
Dupre, J.2
McDonald, T.J.3
-
16
-
-
0029033945
-
Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM
-
Dupre J, Behme MT, Hramiak IM, McFarlane P, Williamson MP, Zabel P, McDonald TJ 1995 Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM. Diabetes 44:626-630
-
(1995)
Diabetes
, vol.44
, pp. 626-630
-
-
Dupre, J.1
Behme, M.T.2
Hramiak, I.M.3
McFarlane, P.4
Williamson, M.P.5
Zabel, P.6
McDonald, T.J.7
-
17
-
-
3042737844
-
Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4
-
Ogawa N, List JF, Habener JF, Maki T 2004 Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. Diabetes 53:1700-1705
-
(2004)
Diabetes
, vol.53
, pp. 1700-1705
-
-
Ogawa, N.1
List, J.F.2
Habener, J.F.3
Maki, T.4
-
18
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud L, Thervet E, Primo J, Bach JF 1994 Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 91:123-127
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 123-127
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
19
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
Chatenoud L, Primo J, Bach JF 1997 CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 158:2947-2954
-
(1997)
J Immunol
, vol.158
, pp. 2947-2954
-
-
Chatenoud, L.1
Primo, J.2
Bach, J.F.3
-
20
-
-
33845523340
-
Effects of autoimmunity and immune therapy on β-cell turnover in type 1 diabetes
-
Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC 2006 Effects of autoimmunity and immune therapy on β-cell turnover in type 1 diabetes. Diabetes 55:3238-3245
-
(2006)
Diabetes
, vol.55
, pp. 3238-3245
-
-
Sherry, N.A.1
Kushner, J.A.2
Glandt, M.3
Kitamura, T.4
Brillantes, A.M.5
Herold, K.C.6
-
21
-
-
0032728536
-
Immunocytochemical localization of glucose transporter-2 (GLUT-2) in pancreatic islets and islet cell tumors
-
Tomita T 1999 Immunocytochemical localization of glucose transporter-2 (GLUT-2) in pancreatic islets and islet cell tumors. Endocr Pathol 10:213-221
-
(1999)
Endocr Pathol
, vol.10
, pp. 213-221
-
-
Tomita, T.1
-
22
-
-
0037237655
-
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
-
Trudeau JD, Kelly-Smith C, Verchere CB, Elliott JF, Dutz JP, Finegood DT, Santamaria P, Tan R 2003 Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 111:217-223
-
(2003)
J Clin Invest
, vol.111
, pp. 217-223
-
-
Trudeau, J.D.1
Kelly-Smith, C.2
Verchere, C.B.3
Elliott, J.F.4
Dutz, J.P.5
Finegood, D.T.6
Santamaria, P.7
Tan, R.8
-
23
-
-
0031059346
-
A new culture method for human pancreatic islets using a biopore membrane insert
-
Hober C, Benhamou PY, Watt PC, Watanabe Y, Nomura Y, Stein E, Brunicardi FC, Mullen Y 1997 A new culture method for human pancreatic islets using a biopore membrane insert. Pancreas 14:199-204
-
(1997)
Pancreas
, vol.14
, pp. 199-204
-
-
Hober, C.1
Benhamou, P.Y.2
Watt, P.C.3
Watanabe, Y.4
Nomura, Y.5
Stein, E.6
Brunicardi, F.C.7
Mullen, Y.8
-
24
-
-
0028800753
-
Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice
-
Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GC 1995 Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes 44:104-111
-
(1995)
Diabetes
, vol.44
, pp. 104-111
-
-
Davalli, A.M.1
Ogawa, Y.2
Scaglia, L.3
Wu, Y.J.4
Hollister, J.5
Bonner-Weir, S.6
Weir, G.C.7
-
25
-
-
0032910989
-
Increased β-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
-
Sreenan S, Pick AJ, Levisetti M, Baldwin AC, Pugh W, Polonsky KS 1999 Increased β-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48:989-996
-
(1999)
Diabetes
, vol.48
, pp. 989-996
-
-
Sreenan, S.1
Pick, A.J.2
Levisetti, M.3
Baldwin, A.C.4
Pugh, W.5
Polonsky, K.S.6
-
26
-
-
33748319404
-
Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-exendin) transgenic mice
-
Baggio LL, Holland D, Wither J, Drucker DJ 2006 Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-exendin) transgenic mice. Diabetes 55:1562-1570
-
(2006)
Diabetes
, vol.55
, pp. 1562-1570
-
-
Baggio, L.L.1
Holland, D.2
Wither, J.3
Drucker, D.J.4
-
27
-
-
0034680105
-
Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
-
Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P 2000 Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406:739-742
-
(2000)
Nature
, vol.406
, pp. 739-742
-
-
Amrani, A.1
Verdaguer, J.2
Serra, P.3
Tafuro, S.4
Tan, R.5
Santamaria, P.6
-
28
-
-
0037478632
-
+ T cells in autoimmune diabetes
-
+ T cells in autoimmune diabetes. Proc Natl Acad Sci USA 100:8384-8388
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8384-8388
-
-
Lieberman, S.M.1
Evans, A.M.2
Han, B.3
Takaki, T.4
Vinnitskaya, Y.5
Caldwell, J.A.6
Serreze, D.V.7
Shabanowitz, J.8
Hunt, D.F.9
Nathenson, S.G.10
Santamaria, P.11
DiLorenzo, T.P.12
-
30
-
-
0141796312
-
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
-
Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L 2003 TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9:1202-1208
-
(2003)
Nat Med
, vol.9
, pp. 1202-1208
-
-
Belghith, M.1
Bluestone, J.A.2
Barriot, S.3
Megret, J.4
Bach, J.F.5
Chatenoud, L.6
-
31
-
-
33646392755
-
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
-
Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M 2006 Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 116:1371-1381
-
(2006)
J Clin Invest
, vol.116
, pp. 1371-1381
-
-
Bresson, D.1
Togher, L.2
Rodrigo, E.3
Chen, Y.4
Bluestone, J.A.5
Herold, K.C.6
von Herrath, M.7
-
32
-
-
24644479189
-
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
-
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D 2005 Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest 115:2454-2461
-
(2005)
J Clin Invest
, vol.115
, pp. 2454-2461
-
-
Turvey, S.E.1
Swart, E.2
Denis, M.C.3
Mahmood, U.4
Benoist, C.5
Weissleder, R.6
Mathis, D.7
-
33
-
-
0032908654
-
Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
-
Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M 1999 Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 48:1026-1034
-
(1999)
Diabetes
, vol.48
, pp. 1026-1034
-
-
Young, A.A.1
Gedulin, B.R.2
Bhavsar, S.3
Bodkin, N.4
Jodka, C.5
Hansen, B.6
Denaro, M.7
-
34
-
-
0034602252
-
Sustained expression of exendin-4 does not perturb glucose homeostasis, β-cell mass, or food intake in metallothionein-preproexendin transgenic mice
-
Baggio L, Adatia F, Bock T, Brubaker PL, Drucker DJ 2000 Sustained expression of exendin-4 does not perturb glucose homeostasis, β-cell mass, or food intake in metallothionein-preproexendin transgenic mice. J Biol Chem 275:34471-34477
-
(2000)
J Biol Chem
, vol.275
, pp. 34471-34477
-
-
Baggio, L.1
Adatia, F.2
Bock, T.3
Brubaker, P.L.4
Drucker, D.J.5
|