Pancreatic duct replication is increased with obesity and type 2 diabetes in humans

Diabetologia

Volumn 53, Issue 1, 2010, Pages 21-26

  Butler, A E ^a   Galasso, R ^a   Matveyenko, A ^a   Rizza, R A ^b   Dry, S ^a   Butler, P C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Mayo Clinic   (United States)

Author keywords

DPP IV inhibitor; GLP 1; Obesity; Pancreatic cancer; Pancreatic ductal; Pancreatitis

Indexed keywords

CYTOKERATIN; INSULIN; KI 67 ANTIGEN; ORAL ANTIDIABETIC AGENT;

ADULT; AGED; ARTICLE; AUTOPSY; CELL DIVISION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; LEAN BODY WEIGHT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ADENOCARCINOMA; PANCREAS CELL; PANCREAS DUCT; PANCREATITIS; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ANIMALS; AUTOPSY; BODY MASS INDEX; CELL DIVISION; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; PANCREATIC DUCTS; RATS;

EID: 72449164412     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1556-8     Document Type: Article

References (14)

1. AA Gumbs 2008 Obesity, pancreatitis, and pancreatic cancer Obes Surg 18 1183 1187 10.1007/s11695-008-9599-3 18563497
2. AA Gumbs M Bessler L Milone B Schrope J Chabot 2008 Contribution of obesity to pancreatic carcinogenesis Surg Obes Relat Dis 4 186 193 10.1016/j.soard.2007.11.009 18226981
3. AG Renehan M Tyson M Egger RF Heller M Zwahlen 2008 Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 569 578 10.1016/S0140-6736(08)60269-X 18280327 (Pubitemid 351232031)
4. AV Matveyenko S Dry HI Cox A Moshtaghian T Gurlo R Galasso AE Butler PC Butler 2009 Beneficial endocrine but adverse exocrine effects of sitagliptin in the HIP rat model of type 2 diabetes, interactions with metformin Diabetes 58 1604 1615 10.2337/db09-0058 1:CAS:528:DC%2BD1MXos1Cqu74%3D 19403868
5. AE Butler J Jang T Gurlo MD Carty WC Soeller PC Butler 2004 Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes Diabetes 53 1509 1516 10.2337/diabetes.53.6.1509 1:CAS:528:DC%2BD2cXkslCgs7o%3D 15161755 (Pubitemid 38697663)
6. AV Matveyenko PC Butler 2006 Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes Diabetes 55 2106 2114 10.2337/db05-1672 1:CAS:528:DC%2BD28XmvVChtb4%3D 16804082 (Pubitemid 44509986)
7. S Willemer G Adler 1989 Histochemical and ultrastructural characteristics of tubular complexes in human acute pancreatitis Dig Dis Sci 34 46 55 10.1007/BF01536153 1:STN:280:DyaL1M%2FptVOrtA%3D%3D 2535980 (Pubitemid 19039787)
8. DE Bockman WR Boydston MC Anderson 1982 Origin of tubular complexes in human chronic pancreatitis Am J Surg 144 243 249 10.1016/0002-9610(82)90518-9 1:STN:280:DyaL383lsVehtw%3D%3D 7102934 (Pubitemid 12069114)
9. I Parsa DS Longnecker DG Scarpelli P Pour JK Reddy M Lefkowitz 1985 Ductal metaplasia of human exocrine pancreas and its association with carcinoma Cancer Res 45 1285 1290 1:STN:280:DyaL2M7isVCisg%3D%3D 2982487
10. AE Butler J Janson S Bonner-Weir R Ritzel RA Rizza PC Butler 2003 Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Diabetes 52 102 110 10.2337/diabetes.52.1.102 1:CAS:528: DC%2BD3sXisVaisA%3D%3D 12502499 (Pubitemid 36042113)
11. M Wagner CK Weber F Bressau FR Greten V Stagge M Ebert SD Leach G Adler RM Schmid 2002 Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells Gastroenterology 122 1898 1912 10.1053/gast.2002.33594 1:CAS:528:DC%2BD38Xlt12gsL4%3D 12055597
12. M Wagner FR Greten CK Weber S Koschnick T Mattfeldt W Deppert H Kern G Adler RM Schmid 2001 A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease Genes Dev 15 286 293 10.1101/gad.184701 1:CAS:528:DC%2BD3MXhvVOjuro%3D 11159909 (Pubitemid 32155144)
13. JJ Meier MA Nauck 2006 Incretins and the development of type 2 diabetes Curr Diab Rep 6 194 201 10.1007/s11892-006-0034-7 1:CAS:528:DC%2BD28XmtlKgsrk%3D 16898571
14. G Xu DA Stoffers JF Habener S Bonner-Weir 1999 Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats Diabetes 48 2270 2276 10.2337/diabetes.48.12.2270 1:CAS:528:DyaK1MXnslOqtro%3D 10580413