The GK rat beta-cell: A prototype for the diseased human beta-cell in type 2 diabetes?

Molecular and Cellular Endocrinology

Volumn 297, Issue 1-2, 2009, Pages 73-85

  Portha, B ^a   Lacraz, G ^a   Kergoat, M ^b   Homo Delarche, F ^a   Giroix, M H ^a   Bailbe D ^a   Gangnerau, M N ^a   Dolz, M ^a   Tourrel Cuzin, C ^a   Movassat, J ^a  

^a CNRS   (France)

^b Merck KGaA France   (France)

Author keywords

Beta cell; Development; Epigenetic; Genetic; GK rat; Glucotoxicity; Inflammation; Insulin secretion; Metabolic programming; Neogenesis; Oxidative stress; Type 2 diabetes

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; DISEASE MODEL; GENE LOCUS; GOTO KAKIZAKI RAT; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN RELEASE; MICROENVIRONMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; HUMANS; INSULIN-SECRETING CELLS; RATS;

EID: 57649174792     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.06.013     Document Type: Article

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