GPCR-Interacting Proteins, Major Players of GPCR Function

Advances in Pharmacology

Volumn 62, Issue , 2011, Pages 349-380

  Maurice, Pascal ^a,b,c   Guillaume, Jean Luc ^a,b,c   Benleulmi Chaachoua, Abla ^a,b,c   Daulat, Avais M ^a,b,c   Kamal, Maud ^a,b,c   Jockers, Ralf ^a,b,c  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Biosynthesis; Desensitization; G protein coupled receptor; Protein complexes; Recycling; Signaling

Indexed keywords

BETA ARRESTIN 1; BETA ARRESTIN 2; CALCITONIN RECEPTOR LIKE RECEPTOR; CALNEXIN; CALRETICULIN; CHAPERONE; CYTOSKELETON PROTEIN; DOPAMINE RECEPTOR INTERACTING PROTEIN 78; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR INTERACTING PROTEIN; GONADORELIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; MU OPIATE RECEPTOR; PDZ PROTEIN; RAB PROTEIN; RECEPTOR ACTIVITY MODIFYING PROTEIN; RGS PROTEIN; RIBOPHORIN I; UNCLASSIFIED DRUG;

BOOK; CELL SURFACE; COMPLEX FORMATION; ENDOCYTOSIS; HORMONE PROTEIN COMPLEX; HUMAN; INTERNALIZATION; LIFE CYCLE; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR ORGANIZATION; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 80052690010     PISSN: 10543589     EISSN: 15578925     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385952-5.00001-4     Document Type: Chapter

References (177)

1. Abu-Helo A., Simonin F. Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs). Pharmacology and Therapeutics 2010, 126:244-250.
2. Ahn S., Maudsley S., Luttrell L.M., Lefkowitz R.J., Daaka Y. Src-mediated tyrosine phosphorylation of dynamin is required for beta(2)-adrenergic receptor internalization and mitogen-activated protein kinase signaling. The Journal of Biological Chemistry 1999, 274:1185-1188.
3. Airas J.M., Betz H., El Far O. PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding. FEBS Letters 2001, 494:60-63.
4. Angelotti T., Daunt D., Shcherbakova O.G., Kobilka B., Hurt C.M. Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Traffic 2010, 11:560-578.
5. Ango F., Robbe D., Tu J.C., Xiao B., Worley P.F., Pin J.P., Bockaert J., Fagni L. Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Molecular and Cellular Neurosciences 2002, 20:323-329.
6. Arthur J.F., Shen Y., Mu F.T., Leon C., Gachet C., Berndt M.C., Andrews R.K. Calmodulin interacts with the platelet ADP receptor P2Y1. The Biochemical Journal 2006, 398:339-343.
7. Awata H., Huang C., Handlogten M.E., Miller R.T. Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. The Journal of Biological Chemistry 2001, 276:34871-34879.
8. Ayala Yanez R., Conn P.M. Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor. Cell Biochemistry and Function 2010, 28:66-73.
9. Ayoub M.A., Maurel D., Binet V., Fink M., Prezeau L., Ansanay H., Pin J.P. Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. Molecular Pharmacology 2007, 71:1329-1340.
10. Baillie G.S., Houslay M.D. Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Current Opinion in Cell Biology 2005, 17:129-134.
11. Baillie G.S., Sood A., McPhee I., Gall I., Perry S.J., Lefkowitz R.J., Houslay M.D. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:940-945.
12. Baines A.J., Bennett P.M., Carter E.W., Terracciano C. Protein 4.1 and the control of ion channels. Blood Cells, Molecules & Diseases 2009, 42:211-215.
13. Baker E.K., Colley N.J., Zuker C.S. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. The EMBO Journal 1994, 13:4886-4895.
14. Balasubramanian S., Fam S.R., Hall R.A. GABAB receptor association with the PDZ scaffold Mupp 1 alters receptor stability and function. The Journal of Biological Chemistry 2007, 282:4162-4171.
15. Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., Lubbert H., Ullmer C. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. The Journal of Biological Chemistry 2001, 276:12794-12982.
16. Beedle A.M., McRory J.E., Poirot O., Doering C.J., Altier C., Barrere C., Hamid J., Nargeot J., Bourinet E., Zamponi G.W. Agonist-independent modulation of N-type calcium channels by ORL1 receptors. Nature Neuroscience 2004, 7:118-125.
17. Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W. Members of RTP and REEP gene families influence functional bitter taste receptor expression. The Journal of Biological Chemistry 2006, 281:20650-20659.
18. Bermak J.C., Li M., Bullock C., Zhou Q.Y. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nature Cell Biology 2001, 3:492-498.
19. Bernstein L.S., Ramineni S., Hague C., Cladman W., Chidiac P., Levey A.I., Hepler J.R. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. The Journal of Biological Chemistry 2004, 279:21248-21256.
20. Bertaso F., Zhang C., Scheschonka A., de Bock F., Fontanaud P., Marin P., Huganir R.L., Betz H., Bockaert J., Fagni L., Lerner-Natoli M. PICK1 uncoupling from mGluR7a causes absence-like seizures. Nature Neuroscience 2008, 11:940-948.
21. Bilodeau P.S., Urbanowski J.L., Winistorfer S.C., Piper R.C. The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nature Cell Biology 2002, 4:534-539.
22. Binda A.V., Kabbani N., Lin R., Levenson R. D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Molecular Pharmacology 2002, 62:507-513.
23. Bockaert J., Fagni L., Dumuis A., Marin P. GPCR interacting proteins (GIP). Pharmacology and Therapeutics 2004, 103:203-221.
24. Bockaert J., Perroy J., Becamel C., Marin P., Fagni L. GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies. Annual Review of Pharmacology and Toxicology 2010, 50:89-109.
25. Boeuf J., Trigo J.M., Moreau P.H., Lecourtier L., Vogel E., Cassel J.C., Mathis C., Klosen P., Maldonado R., Simonin F. Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. The European Journal of Neuroscience 2009, 30:860-868.
26. Bofill-Cardona E., Kudlacek O., Yang Q., Ahorn H., Freissmuth M., Nanoff C. Binding of calmodulin to the D-2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch. The Journal of Biological Chemistry 2000, 275:32672-32680.
27. Bolger G.B., Baillie G.S., Li X., Lynch M.J., Herzyk P., Mohamed A., Mitchell L.H., McCahill A., Hundsrucker C., Klussmann E., Adams D.R., Houslay M.D. Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. The Biochemical Journal 2006, 398:23-36.
28. Boudin H., Doan A., Xia J., Shigemoto R., Huganir R.L., Worley P., Craig A.M. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron 2000, 28:485-497.
29. Bouschet T., Martin S., Henley J.M. Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane. Journal of Cell Science 2005, 118:4709-4720.
30. Brady A.E., Wang Q., Colbran R.J., Allen P.B., Greengard P., Limbird L.E. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. The Journal of Biological Chemistry 2003, 278:32405-32412.
31. Breton B., Lagace M., Bouvier M. Combining resonance energy transfer methods reveals a complex between the {alpha}2A-adrenergic receptor, G{alpha}i1{beta}1{gamma}2, and GRK2. The FASEB Journal 2010.
32. Bulenger S., Marullo S., Bouvier M. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends in Pharmacological Sciences 2005, 26:131-137.
33. Calebiro D., Nikolaev V.O., Persani L., Lohse M.J. Signaling by internalized G-protein-coupled receptors. Trends in Pharmacological Sciences 2010, 31:221-228.
34. Cariolato L., Cavin S., Diviani D. AKAP-LBC anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation. The Journal of Biological Chemistry 2011, 286:7925-7937.
35. Chapple J.P., Cheetham M.E. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. The Journal of Biological Chemistry 2003, 278:19087-19094.
36. Chen J., Huang Y., Wu H., Ni X., Cheng H., Fan J., Gu S., Gu X., Cao G., Ying K., Mao Y., Lu Y., Xie Y. Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. Journal of Human Genetics 2003, 48:217-221.
37. Chen C., Li J.G., Chen Y., Huang P., Wang Y., Liu-Chen L.Y. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. The Journal of Biological Chemistry 2006, 281:7983-7993.
38. Chung J.J., Okamoto Y., Coblitz B., Li M., Qiu Y., Shikano S. PI3K/Akt signalling-mediated protein surface expression sensed by 14-3-3 interacting motif. The FEBS Journal 2009, 276:5547-5558.
39. Clark A.J., Metherell L.A., Cheetham M.E., Huebner A. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. Trends in Endocrinology and Metabolism 2005, 16:451-457.
40. Daaka Y., Luttrell L.M., Lefkowitz R.J. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997, 390:88-91.
41. Daulat A.M., Maurice P., Froment C., Guillaume J.L., Broussard C., Monsarrat B., Delagrange P., Jockers R. Purification and identification of G protein-coupled receptor protein complexes under native conditions. Molecular & Cellular Proteomics 2007, 6:835-844.
42. Daulat A.M., Maurice P., Jockers R. Recent methodological advances in the discovery of GPCR-associated protein complexes. Trends in Pharmacological Sciences 2009, 30:72-78.
43. Davare M.A., Avdonin V., Hall D.D., Peden E.M., Burette A., Weinberg R.J., Horne M.C., Hoshi T., Hell J.W. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science 2001, 293:98-101.
44. Decaillot F.M., Rozenfeld R., Gupta A., Devi L.A. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:16045-16050.
45. Defea K. Beta-arrestins and heterotrimeric G-proteins: Collaborators and competitors in signal transduction. British Journal of Pharmacology 2008, 153(Suppl. 1):S298-S309.
46. Dev K.K., Nakajima Y., Kitano J., Braithwaite S.P., Henley J.M., Nakanishi S. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. The Journal of Neuroscience 2000, 20:7252-7257.
47. Ding Y., Zhang L., Goodwin J.S., Wang Z., Liu B., Zhang J., Fan G.H. Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1 infection. Experimental Cell Research 2008, 314:590-602.
48. Discher D., Parra M., Conboy J.G., Mohandas N. Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1. The Journal of Biological Chemistry 1993, 268:7186-7195.
49. Dooley R., Baumgart S., Rasche S., Hatt H., Neuhaus E.M. Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. The FEBS Journal 2009, 276:7279-7290.
50. Dunham J.H., Hall R.A. Enhancement of the surface expression of G protein-coupled receptors. Trends in Biotechnology 2009, 27:541-545.
51. Dupre D.J., Hebert T.E. Biosynthesis and trafficking of seven transmembrane receptor signalling complexes. Cellular Signalling 2006, 18:1549-1559.
52. Dupre D.J., Robitaille M., Rebois R.V., Hebert T.E. The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annual Review of Pharmacology and Toxicology 2009, 49:31-56.
53. El Far O., Airas J., Wischmeyer E., Nehring R.B., Karschin A., Betz H. Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1. The European Journal of Neuroscience 2000, 12:4215-4221.
54. Enz R. The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. FEBS Letters 2002, 514:184-188.
55. Esseltine J.L., Dale L.B., Ferguson S.S. Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: Evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization. Molecular Pharmacology 2011, 79:175-184.
56. Fam S.R., Paquet M., Castleberry A.M., Oller H., Lee C.J., Traynelis S.F., Smith Y., Yun C.C., Hall R.A. P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:8042-8047.
57. Fan G., Shumay E., Malbon C.C., Wang H. c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization. The Journal of Biological Chemistry 2001, 276:13240-13247.
58. Fan G.F., Shumay E., Wang H.Y., Malbon C.C. The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta(2)-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization. The Journal of Biological Chemistry 2001, 276:24005-24014.
59. Feng G.J., Kellett E., Scorer C.A., Wilde J., White J.H., Milligan G. Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation. The Journal of Biological Chemistry 2003, 278:33400-33407.
60. Ferreira P.A., Nakayama T.A., Pak W.L., Travis G.H. Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. Nature 1996, 383:637-640.
61. Francke F., Ward R.J., Jenkins L., Kellett E., Richter D., Milligan G., Bachner D. Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization. The Journal of Biological Chemistry 2006, 281:32496-32507.
62. Fraser I.D.C., Cong M., Kim J., Rollins E.N., Daaka Y., Lefkowitz R.J., Scott J.D. Assembly of an A kinase-anchoring protein-2-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Current Biology 2000, 10:409-412.
63. Gage R.M., Matveeva E.A., Whiteheart S.W., von Zastrow M. Type I PDZ ligands are sufficient to promote rapid recycling of G protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. The Journal of Biological Chemistry 2005, 280:3305-3313.
64. Gales C., Rebois R.V., Hogue M., Trieu P., Breit A., Hebert T.E., Bouvier M. Real-time monitoring of receptor and G-protein interactions in living cells. Nature Methods 2005, 2:177-184.
65. Gavarini S., Becamel C., Altier C., Lory P., Poncet J., Wijnholds J., Bockaert J., Marin P. Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. Molecular Biology of the Cell 2006, 17:4619-4631.
66. Ge X., Loh H.H., Law P.Y. mu-Opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I. Molecular Pharmacology 2009, 75:1307-1316.
67. Gee H.Y., Kim Y.W., Jo M.J., Namkung W., Kim J.Y., Park H.W., Kim K.S., Kim H., Baba A., Yang J., Kim E., Kim K.H., Lee M.G. Synaptic scaffolding molecule binds to and regulates vasoactive intestinal polypeptide type-1 receptor in epithelial cells. Gastroenterology 2009, 137:607-617. 617.e1-4.
68. Georgoussi Z., Leontiadis L., Mazarakou G., Merkouris M., Hyde K., Hamm H. Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling. Cellular Signalling 2006, 18:771-782.
69. Guillaume J.L., Daulat A.M., Maurice P., Levoye A., Migaud M., Brydon L., Malpaux B., Borg-Capra C., Jockers R. The PDZ protein mupp 1 promotes Gi coupling and signaling of the Mt1 melatonin receptor. The Journal of Biological Chemistry 2008, 283:16762-16771.
70. Hague C., Bernstein L.S., Ramineni S., Chen Z., Minneman K.P., Hepler J.R. Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop. The Journal of Biological Chemistry 2005, 280:27289-27295.
71. Hall R.A., Premont R.T., Chow C.W., Blitzer J.T., Pitcher J.A., Claing A., Stoffel R.H., Barak L.S., Shenolikar S., Weinman E.J., Grinstein S., Lefkowitz R.J. The beta(2)-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature 1998, 392:626-630.
72. Hammad M.M., Dupre D.J. Chaperones contribute to G protein coupled receptor oligomerization, but do not participate in assembly of the G protein with the receptor signaling complex. Journal of Molecular Signaling 2010, 5:16.
73. Hammad M.M., Kuang Y.Q., Yan R., Allen H., Dupre D.J. Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer. The Journal of Biological Chemistry 2010, 285:34653-34664.
74. He J., Bellini M., Inuzuka H., Xu J., Xiong Y., Yang X., Castleberry A.M., Hall R.A. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. The Journal of Biological Chemistry 2006, 281:2820-2827.
75. Hjalm G., MacLeod R.J., Kifor O., Chattopadhyay N., Brown E.M. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. The Journal of Biological Chemistry 2001, 276:34880-34887.
76. Hu L.Y.A., Tang Y.T., Miller W.E., Cong M., Lau A.G., Lefkowitz R.J., Hall R.A. Beta 1-adrenergic receptor association with PSD-95-Inhibition of receptor internalization and facilitation of beta(1)-adrenergic receptor interaction with N-methyl-d-aspartate receptors. The Journal of Biological Chemistry 2000, 275:38659-38666.
77. Ilegems E., Iwatsuki K., Kokrashvili Z., Benard O., Ninomiya Y., Margolskee R.F. REEP2 enhances sweet receptor function by recruitment to lipid rafts. The Journal of Neuroscience 2010, 30:13774-13783.
78. Jeanneteau F., Guillin O., Diaz J., Griffon N., Sokoloff P. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. Molecular Biology of the Cell 2004, 15:4926-4937.
79. Ji S.P., Zhang Y., Van Cleemput J., Jiang W., Liao M., Li L., Wan Q., Backstrom J.R., Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nature Medicine 2006, 12:324-329.
80. Jones K.A., Borowsky B., Tamm J.A., Gerald C. GABAb receptors function as a heterotrimeric assembly of the subunits GABAbR1 and GAGbR2. Nature 1998, 396:674-679.
81. Kim O.J., Ariano M.A., Lazzarini R.A., Levine M.S., Sibley D.R. Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization. The Journal of Neuroscience 2002, 22:5920-5930.
82. Kim K.M., Gainetdinov R.R., Laporte S.A., Caron M.G., Barak L.S. G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. The Journal of Biological Chemistry 2005, 280:12774-12780.
83. Klenk C., Vetter T., Zurn A., Vilardaga J.P., Friedman P.A., Wang B., Lohse M.J. Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor. The Journal of Biological Chemistry 2010, 285:30355-30362.
84. Krebs M.P., Holden D.C., Joshi P., Clark C.L., Lee A.H., Kaushal S. Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue. Journal of Molecular Biology 2010, 395:1063-1078.
85. Kurogi M., Nagatomo K., Kubo Y., Saitoh O. Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs. NeuroReport 2009, 20:1134-1139.
86. Labasque M., Reiter E., Becamel C., Bockaert J., Marin P. Physical interaction of calmodulin with the 5-HT2C receptor C-terminus is essential for G protein-independent, arrestin-dependent, receptor signaling. Molecular Biology of the Cell 2008, 19:4640-4650.
87. Langer I., Tikhonova I.G., Boulegue C., Esteve J.P., Vatinel S., Ferrand A., Moroder L., Robberecht P., Fourmy D. Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor. Molecular Pharmacology 2009, 75:502-513.
88. Leclerc P.C., Auger-Messier M., Lanctot P.M., Escher E., Leduc R., Guillemette G. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology 2002, 143:4702-4710.
89. Lee F.J., Pei L., Moszczynska A., Vukusic B., Fletcher P.J., Liu F. Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. The EMBO Journal 2007, 26:2127-2136.
90. Lee S.J., Ritter S.L., Zhang H., Shim H., Hall R.A., Yun C.C. MAGI-3 competes with NHERF-2 to negatively regulate LPA(2) receptor signaling in colon cancer cells. Gastroenterology 2011, 140, 924-934.
91. Lefkowitz R.J., Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 2005, 308:512-517.
92. Leontiadis L.J., Papakonstantinou M.P., Georgoussi Z. Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling. Cellular Signalling 2009, 21:1218-1228.
93. Li M., Bermak J.C., Wang Z.W., Zhou Q.Y. Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280). Molecular Pharmacology 2000, 57:446-452.
94. Li M., Li C., Weingarten P., Bunzow J.R., Grandy D.K., Zhou Q.Y. Association of dopamine D(3) receptors with actin-binding protein 280 (ABP-280). Biochemical Pharmacology 2002, 63:859-863.
95. Lin R., Karpa K., Kabbani N., Goldman-Rakic P., Levenson R. Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:5258-5263.
96. Liu Y., Buck D.C., Macey T.A., Lan H., Neve K.A. Evidence that calmodulin binding to the dopamine D2 receptor enhances receptor signaling. Journal of Receptor and Signal Transduction Research 2007, 27:47-65.
97. Liu Y., Buck D.C., Neve K.A. Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: Role in D2 receptor function. Molecular Pharmacology 2008, 74:371-378.
98. Liu F., Wan Q., Pristupa Z.B., Yu X.M., Wang Y.T., Niznik H.B. Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors. Nature 2000, 403:274-280.
99. Lu D., Yan H., Othman T., Rivkees S.A. Cytoskeletal protein 4.1G is a binding partner of the metabotropic glutamate receptor subtype 1 alpha. Journal of Neuroscience Research 2004, 78:49-55.
100. Luo W., Wang Y., Reiser G. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. The Journal of Biological Chemistry 2007, 282:30246-30255.
101. Luo W., Wang Y., Reiser G. Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. Journal of Neurochemistry 2011, 117, 71-81.
102. Lynch M.J., Baillie G.S., Mohamed A., Li X., Maisonneuve C., Klussmann E., van Heeke G., Houslay M.D. RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. The Journal of Biological Chemistry 2005, 280:33178-33189.
103. Marchese A., Benovic J.L. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. The Journal of Biological Chemistry 2001, 276:45509-45512.
104. Martini L., Thompson D., Kharazia V., Whistler J.L. Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology 2010, 35:1363-1373.
105. Maurice P., Daulat A.M., Broussard C., Mozo J., Clary G., Hotellier F., Chafey P., Guillaume J.L., Ferry G., Boutin J.A., Delagrange P., Camoin L., Jockers R. A generic approach for the purification of signaling complexes that specifically interact with the carboxy-terminal domain of G protein-coupled receptors. Molecular & Cellular Proteomics 2008, 7:1556-1569.
106. Maurice P., Daulat A.M., Turecek R., Ivankova-Susankova K., Zamponi F., Kamal M., Clement N., Guillaume J.L., Bettler B., Gales C., Delagrange P., Jockers R. Molecular organization and dynamics of the melatonin MT receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling. The EMBO Journal 2010, 29:3646-3659.
107. McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J., Thompson N., Solari R., Lee M.G., Foord S.M. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 1998, 393:333-339.
108. Metherell L.A., Chapple J.P., Cooray S., David A., Becker C., Ruschendorf F., Naville D., Begeot M., Khoo B., Nurnberg P., Huebner A., Cheetham M.E., Clark A.J. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nature Genetics 2005, 37:166-170.
109. Milligan G. G protein-coupled receptor hetero-dimerization: Contribution to pharmacology and function. British Journal of Pharmacology 2009, 158:5-14.
110. Misra U.K., Pizzo S.V. Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages. Journal of Cellular Biochemistry 2008, 104:96-104.
111. Mizrachi D., Segaloff D.L. Intracellularly located misfolded glycoprotein hormone receptors associate with different chaperone proteins than their cognate wild-type receptors. Molecular Endocrinology 2004, 18:1768-1777.
112. Mukhopadhyay S., Wen X., Chih B., Nelson C.D., Lane W.S., Scales S.J., Jackson P.K. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes & Development 2010, 24:2180-2193.
113. Murdoch H., Feng G.J., Bachner D., Ormiston L., White J.H., Richter D., Milligan G. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail. The Journal of Biological Chemistry 2005, 280:8208-8220.
114. Namkung Y., Dipace C., Javitch J.A., Sibley D.R. G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor. The Journal of Biological Chemistry 2009, 284:15038-15051.
115. Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G., Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R., Lewis D.L. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Molecular Pharmacology 2007, 72:1557-1566.
116. Nobles M., Benians A., Tinker A. Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:18706-18711.
117. O'Connor V., El Far O., Bofill-Cardona E., Nanoff C., Freissmuth M., Karschin A., Airas J.M., Betz H., Boehm S. Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. Science 1999, 286:1180-1184.
118. Oh Y.S., Jo N.W., Choi J.W., Kim H.S., Seo S.W., Kang K.O., Hwang J.I., Heo K., Kim S.H., Kim Y.H., Kim I.H., Kim J.H., Banno Y., Ryu S.H., Suh P.G. NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Molecular and Cellular Biology 2004, 24:5069-5079.
119. Paasche J.D., Attramadal T., Kristiansen K., Oksvold M.P., Johansen H.K., Huitfeldt H.S., Dahl S.G., Attramadal H. Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors. Molecular Pharmacology 2005, 67:1581-1590.
120. Paquet M., Asay M.J., Fam S.R., Inuzuka H., Castleberry A.M., Oller H., Smith Y., Yun C.C., Traynelis S.F., Hall R.A. The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. The Journal of Biological Chemistry 2006, 281:29949-29961.
121. Parent A., Laroche G., Hamelin E., Parent J.L. RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2). Traffic 2008, 9:394-407.
122. Parker L.L., Backstrom J.R., Sanders-Bush E., Shieh B.H. Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1. The Journal of Biological Chemistry 2003, 278:21576-21583.
123. Penela P., Murga C., Ribas C., Lafarga V., Mayor F.Jr. The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. British Journal of Pharmacology 2010, 160:821-832.
124. Perroy J., El Far O., Bertaso F., Pin J.P., Betz H., Bockaert J., Fagni L. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. The EMBO Journal 2002, 21:2990-2999.
125. Pi M., Spurney R.F., Tu Q., Hinson T., Quarles L.D. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology 2002, 143:3830-3838.
126. Pichon X., Wattiez A.S., Becamel C., Ehrlich I., Bockaert J., Eschalier A., Marin P., Courteix C. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Molecular Therapy 2010, 18:1462-1470.
127. Premont R.T., Gainetdinov R.R. Physiological roles of G protein-coupled receptor kinases and arrestins. Annual Review of Physiology 2007, 69:511-534.
128. Raveh A., Cooper A., Guy-David L., Reuveny E. Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase. Cell 2010, 143:750-760.
129. Reid H.M., Mulvaney E.P., Turner E.C., Kinsella B.T. Interaction of the human prostacyclin receptor with Rab11: Characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation. The Journal of Biological Chemistry 2010, 285:18709-18726.
130. Reiter E., Lefkowitz R.J. GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling. Trends in Endocrinology and Metabolism 2006, 17:159-165.
131. Ritter S.L., Hall R.A. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews. Molecular Cell Biology 2009, 10:819-830.
132. Sachdev P., Menon S., Kastner D.B., Chuang J.Z., Yeh T.Y., Conde C., Caceres A., Sung C.H., Sakmar T.P. G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth. The EMBO Journal 2007, 26:2621-2632.
133. Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell 2004, 119:679-691.
134. Saito M., Sugai M., Katsushima Y., Yanagisawa T., Sukegawa J., Nakahata N. Increase in cell-surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G. The Biochemical Journal 2005, 392:75-81.
135. Sanchez-Laorden B.L., Herraiz C., Valencia J.C., Hearing V.J., Jimenez-Cervantes C., Garcia-Borron J.C. Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi. Journal of Cellular Physiology 2009, 220:640-654.
136. Schmid E.M., McMahon H.T. Integrating molecular and network biology to decode endocytosis. Nature 2007, 448:883-888.
137. Schwarze S.R., Ho A., Vocero-Akbani A., Dowdy S.F. In vivo protein transduction: Delivery of a biologically active protein into the mouse. Science 1999, 285:1569-1572.
138. Scott M.G., Benmerah A., Muntaner O., Marullo S. Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated pits in living cells. The Journal of Biological Chemistry 2002, 277:3552-3559.
139. Seachrist J.L., Ferguson S.S. Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases. Life Sciences 2003, 74:225-235.
140. Sheng M., Hoogenraad C.C. The postsynaptic architecture of excitatory synapses: A more quantitative view. Annual Review of Biochemistry 2007, 76:823-847.
141. Shenoy S.K., Lefkowitz R.J. Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. The Biochemical Journal 2003, 375:503-515.
142. Shih M.L., Lin F.B., Scott J.D., Wang H.Y., Malbon C.C. Dynamic complexes of beta(2)-adrenergic receptors with protein kinases and phosphatases and the role of gravin. The Journal of Biological Chemistry 1999, 274:1588-1595.
143. Smith F.D., Oxford G.S., Milgram S.L. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. The Journal of Biological Chemistry 1999, 274:19894-19900.
144. Stepanchick A., Breitwieser G.E. The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway. Biochemical and Biophysical Research Communications 2010, 395:136-140.
145. Sugai M., Saito M., Sukegawa I., Katsushima Y., Kinouchi Y., Nakahata N., Shimosegawa T., Yanagisawa T., Sukegawa J. PTH/PTH-related protein receptor interacts directly with Tctex-1 through its COOH terminus. Biochemical and Biophysical Research Communications 2003, 311:24-31.
146. Sun P., Wang J., Gu W., Cheng W., Jin G.Z., Friedman E., Zheng J., Zhen X. PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation. Cell Research 2009, 19:612-624.
147. Tai A.W., Chuang J.Z., Bode C., Wolfrum U., Sung C.H. Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Cell 1999, 97:877-887.
148. Takesono A., Cismowski M.J., Ribas C., Bernard M., Chung P., Hazard S., Duzic E., Lanier S.M. Receptor-independent activators of heterotrimeric G-protein signaling pathways. The Journal of Biological Chemistry 1999, 274:33202-33205.
149. Tao Y.X. Inactivating mutations of G protein-coupled receptors and diseases: Structure-function insights and therapeutic implications. Pharmacology and Therapeutics 2006, 111:949-973.
150. Tao J., Wang H.Y., Malbon C.C. Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor. The EMBO Journal 2003, 22:6419-6429.
151. Thompson D., Whistler J.L. Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1. The Journal of Biological Chemistry 2011, 286:1598-1608.
152. Turner J.H., Raymond J.R. Interaction of calmodulin with the serotonin 5-hydroxytryptamine2A receptor. A putative regulator of G protein coupling and receptor phosphorylation by protein kinase C. The Journal of Biological Chemistry 2005, 280:30741-30750.
153. Ullmer C., Schmuck K., Figge A., Lubbert H. Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Letters 1998, 424:63-68.
154. Valiquette M., Bonin H., Hnatowich M., Caron M.G., Lefkowitz R.J., Bouvier M. Involvement of tyrosine residues located in the carboxyl tail of the human β2-adrenergic receptor in agonist-induced down-regulation of the receptor. Proceedings of the National Academy of Sciences of the United States of America 1990, 87:5089-5093.
155. von Zastrow M. Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway. Life Sciences 2003, 74:217-224.
156. Wang B., Ardura J.A., Romero G., Yang Y., Hall R.A., Friedman P.A. Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits. The Journal of Biological Chemistry 2010, 285:26976-26986.
157. Wang H., Bedford F.K., Brandon N.J., Moss S.J., Olsen R.W. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature 1999, 397:69-72.
158. Wang Q., Limbird L.E. Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3. The Journal of Biological Chemistry 2002, 277:50589-50596.
159. Wang D.X., Sadee W., Quillan J.M. Calmodulin binding to G protein-coupling domain of opioid receptors. The Journal of Biological Chemistry 1999, 274:22081-22088.
160. Wang B., Yang Y., Abou-Samra A.B., Friedman P.A. NHERF1 regulates parathyroid hormone receptor desensitization: Interference with beta-arrestin binding. Molecular Pharmacology 2009, 75:1189-1197.
161. Wang X., Zeng W., Soyombo A.A., Tang W., Ross E.M., Barnes A.P., Milgram S.L., Penninger J.M., Allen P.B., Greengard P., Muallem S. Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nature Cell Biology 2005, 7:405-411.
162. Wang Q., Zhao J., Brady A.E., Feng J., Allen P.B., Lefkowitz R.J., Greengard P., Limbird L.E. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 2004, 304:1940-1944.
163. Ward R.J., Jenkins L., Milligan G. Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin. Journal of Neurochemistry 2009, 109:182-192.
164. Weinman E.J., Hall R.A., Friedman P.A., Liu-Chen L.Y., Shenolikar S. The association of NHERF adaptor proteins with G protein-coupled receptors and receptor tyrosine kinases. Annual Review of Physiology 2006, 68:491-505.
165. Wootten D.L., Simms J., Hay D.L., Christopoulos A., Sexton P.M. Receptor activity modifying proteins and their potential as drug targets. Progress in Molecular Biology and Translational Science 2010, 91:53-79.
166. Wu N., Hanson S.M., Francis D.J., Vishnivetskiy S.A., Thibonnier M., Klug C.S., Shoham M., Gurevich V.V. Arrestin binding to calmodulin: A direct interaction between two ubiquitous signaling proteins. Journal of Molecular Biology 2006, 364:955-963.
167. Xia Z., Gray J.A., Compton-Toth B.A., Roth B.L. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. The Journal of Biological Chemistry 2003, 278:21901-21908.
168. Xiao K., McClatchy D.B., Shukla A.K., Zhao Y., Chen M., Shenoy S.K., Yates J.R., Lefkowitz R.J. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:12011-12016.
169. Xu J., Paquet M., Lau A.G., Wood J.D., Ross C.A., Hall R.A. Beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. The Journal of Biological Chemistry 2001, 276:41310-41317.
170. Yang X., Zheng J., Xiong Y., Shen H., Sun L., Huang Y., Sun C., Li Y., He J. Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3. FEBS Letters 2010, 584:2207-2212.
171. Yeh T.Y., Peretti D., Chuang J.Z., Rodriguez-Boulan E., Sung C.H. Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. Traffic 2006, 7:1495-1502.
172. Yu N., Erb L., Shivaji R., Weisman G.A., Seye C.I. Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells. Circulation Research 2008, 102:581-588.
173. Zhang C.S., Bertaso F., Eulenburg V., Lerner-Natoli M., Herin G.A., Bauer L., Bockaert J., Fagni L., Betz H., Scheschonka A. Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol. The Journal of Neuroscience 2008, 28:8604-8614.
174. Zhang M., Breitwieser G.E. High affinity interaction with filamin A protects against calcium-sensing receptor degradation. The Journal of Biological Chemistry 2005, 280:11140-11146.
175. Zhang J., Vinuela A., Neely M.H., Hallett P.J., Grant S.G., Miller G.M., Isacson O., Caron M.G., Yao W.D. Inhibition of the dopamine D1 receptor signaling by PSD-95. The Journal of Biological Chemistry 2007, 282:15778-15789.
176. Zhang H., Wang D., Sun H., Hall R.A., Yun C.C. MAGI-3 regulates LPA-induced activation of Erk and RhoA. Cellular Signalling 2007, 19:261-268.
177. Zimmerman B., Simaan M., Lee M.H., Luttrell L.M., Laporte S.A. c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cellular Signalling 2009, 21:103-110.