Molecular organization and dynamics of the melatonin MT 1 receptor/RGS20/G i protein complex reveal asymmetry of receptor dimers for RGS and G i coupling

EMBO Journal

Volumn 29, Issue 21, 2010, Pages 3646-3659

  Maurice, Pascal ^a,b   Daulat, Avais M ^a,b,g   Turecek, Rostislav ^c,d   Ivankova Susankova, Klara ^c   Zamponi, Francesco ^e   Kamal, Maud ^a,b   Clement, Nathalie ^a,b   Guillaume, Jean Luc ^a,b   Bettler, Bernhard ^c   Galés, Céline ^b   Delagrange, Philippe ^f   Jockers, Ralf ^a,b  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

^c UNIVERSITY OF BASEL   (Switzerland)

^d INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

^e ECOLE NORMALE SUPÉRIEURE   (France)

^f INSTITUT DE RECHERCHES SERVIER   (France)

^g UNIVERSITY OF TORONTO   (Canada)

Author keywords

G protein; G protein coupled receptor; heterodimerization; molecular organization; RGS

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL KIR3; REGULATOR OF G PROTEIN SIGNALLING 20; RGS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; COMPLEX FORMATION; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

EID: 78149286159     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.236     Document Type: Article

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