c-Src Tyrosine Kinase Binds the β2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 13240-13247

  Fan, Gao Feng ^a   Shumay, Elena ^a   Malbon, Craig C ^a,b   Wang, Hsien Yu ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL ACTIVATION; CHEMICAL BONDS; MUTAGENESIS;

PHOSPHORYLATION;

ENZYMES;

4 AMINE 5 (4 CHLOROPHENYL) 7 (TERT BUTYL)PYRAZOLO[3,4 D]PYRIMIDINE; BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE INHIBITOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; ANTISENSE OLIGODEOXYNUCLEOTIDE; BETA ADRENERGIC RECEPTOR KINASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYANOIODOPINDOLOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; GREEN FLUORESCENT PROTEIN; ISOPRENALINE; PHOSPHOTYROSINE; PHOTOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE C SRC; PROTEIN-TYROSINE KINASE C-SRC; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CHO CELL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HAMSTER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; REPORTER GENE; SITE DIRECTED MUTAGENESIS; SQUAMOUS CELL CARCINOMA; SRC HOMOLOGY DOMAIN;

ANIMALIA;

ADRENERGIC BETA-AGONISTS; AMINO ACID SUBSTITUTION; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; BINDING SITES; CARCINOMA, SQUAMOUS CELL; CHO CELLS; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; IODOCYANOPINDOLOL; ISOPROTERENOL; LUMINESCENT PROTEINS; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT PROTEINS; SRC HOMOLOGY DOMAINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035918269     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011578200     Document Type: Article

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