Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol

Journal of Neuroscience

Volumn 28, Issue 34, 2008, Pages 8604-8614

  Zhang, Chuan Sheng ^a   Bertaso, Federica ^b   Eulenburg, Volker ^a   Lerner Natoli, Mireille ^b   Herin, Greta Ann ^a   Bauer, Liane ^a   Bockaert, Joel ^b   Fagni, Laurent ^b   Betz, Heinrich ^a   Scheschonka, Astrid ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b CNRS   (France)

Author keywords

Metabotropic glutamate receptor 7; Pentylenetetrazol; PICK1; PKC signaling; Synaptic clustering; Working memory

Indexed keywords

ALANINE; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 7A; PENTETRAZOLE; PROTEIN KINASE C; PROTEIN KINASE C 1; UNCLASSIFIED DRUG; CARRIER PROTEIN; CONVULSANT AGENT; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; ISOPROTEIN; LIGAND; METABOTROPIC RECEPTOR; NUCLEAR PROTEIN; PRKCABP PROTEIN, MOUSE;

AMINO ACID SUBSTITUTION; AMNESIA; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXON; IMMUNOPRECIPITATION; MOTOR COORDINATION; MOUSE; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; OOCYTE; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SEIZURE; SIGNAL TRANSDUCTION; SPATIAL MEMORY; WORKING MEMORY; XENOPUS LAEVIS; ANIMAL; ANIMAL BEHAVIOR; BRAIN; CELL CULTURE; CEREBELLUM; CHEMICALLY INDUCED DISORDER; DEPTH PERCEPTION; DRUG ANTAGONISM; GENETIC PREDISPOSITION; GENETICS; MEMORY DISORDER; METABOLISM; MUTATION; NERVE CELL INHIBITION; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN MOTIF; SYNAPSE; SYNAPTOSOME; TRANSGENIC MOUSE;

AMINO ACID MOTIFS; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CARRIER PROTEINS; CELLS, CULTURED; CEREBELLUM; CONVULSANTS; GENETIC PREDISPOSITION TO DISEASE; GLUTAMATES; GLUTAMIC ACID; LIGANDS; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MUTATION; NEURAL INHIBITION; NUCLEAR PROTEINS; OOCYTES; PENTYLENETETRAZOLE; PRESYNAPTIC TERMINALS; PROTEIN ISOFORMS; PROTEIN KINASE C; RECEPTORS, METABOTROPIC GLUTAMATE; SEIZURES; SIGNAL TRANSDUCTION; SPACE PERCEPTION; SYNAPSES; XENOPUS LAEVIS;

EID: 51649112473     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0628-08.2008     Document Type: Article

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