The association of NHERF adaptor proteins with G protein-coupled receptors and receptor tyrosine kinases

Annual Review of Physiology

Volumn 68, Issue , 2006, Pages 491-505

  Weinman, Edward J ^a   Hall, Randy A ^b   Friedman, Peter A ^c   Liu Chen, Lee Yuan ^d   Shenolikar, Shirish ^e  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Growth factor receptors; Hormone receptors; Multiple protein complexes; PDZ adaptor proteins

Indexed keywords

ADAPTOR PROTEIN; BETA 2 ADRENERGIC RECEPTOR; CARRIER PROTEIN; CYTOSKELETON PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EZRIN; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR; ION CHANNEL; KAPPA OPIATE RECEPTOR; MERLIN; MOESIN; PARATHYROID HORMONE RECEPTOR; PDZ PROTEIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; RADIXIN; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR 1; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; KIDNEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; SMALL INTESTINE;

ANIMALS; HUMANS; PHOSPHOPROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, OPIOID, KAPPA; RECEPTORS, PARATHYROID HORMONE; SODIUM-HYDROGEN ANTIPORTER;

EID: 33646009701     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.68.040104.131050     Document Type: Review

References (55)

1. Voltz JW, Weinman EJ, Shenolikar S. 2001. Expanding the role of NHERF, a PDZ domain containing adaptor to growth regulation. Oncogene 20:6309-14
2. Shenolikar S, Voltz JW, Cunningham R, Weinman EJ. 2004. Regulation of ion transport by the NHERF family of PDZ proteins. Physiology 19:48-54
3. Shenolikar S, Weinman EJ. 2001. NHERF: Targeting and trafficking membrane proteins. Am. J. Physiol. Renal Physiol. 280:F389-95
4. + exchanger. Annu. Rev. Physiol. 55:289-304
5. + exchanger 3 (NHE3) is dependent on the presence but not the phosphorylation of NHERF. J. Biol. Chem. 274:24753-58
6. Lamprecht G, Weinman EJ, Yun C-HC. 1998. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J. Biol. Chem. 273:29972-78
7. + exchanger, NHE3, requires an associated regulatory protein. Proc. Natl. Acad. Sci. USA 94:3010-15
8. + exchanger. J. Clin. Invest. 95:2143-49
9. + exchanger requires a dissociable phosphoprotein co-factor. J. Clin. Invest. 92:1781-86
10. Custer M, Spindler B, Verrey F, Murer H, Biber J. 1997. Identification of a new gene product (diphor-1) regulated by dietary phosphate. Am. J. Physiol. Renal Physiol. 273:F801-6
11. Fouassier L, Yun CC, Fitz JG, Doctor RB. 2000. Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions. J. Biol. Chem. 275:25039-45
12. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, et al. 2003. PDZK1: I. A major scaffolder in brush borders of proximal tubular cells. Kidney Int. 64:1733-45
13. Lau AG, Hall RA. 2001. Oligomerization of NHERF-1 and NHERF-2 PDZ domains: differential regulation by association with receptor carboxyl-termini and by phosphorylation. Biochemistry 40:8572-80
14. Shenolikar S, Minkoff CM, Steplock D, Chuckeree C, Liu M-Z, Weinman EJ. 2001. N-terminal PDZ domain is required for NHERF dimerization. FEBS Lett. 489:233-36
15. + exchange. Nature 392:626-30
16. + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417:858-61
17. Sneddon WB, Syme CA, Bisello A, Magyar CE, Rochi MD, et al. 2003. Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J. Biol. Chem. 278:43787-96
18. + exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. J. Biol. Chem. 277:27545-52
19. + exchanger regulatory factor potentiates receptor activity. Mol. Cell Biol. 20:8352-63
20. + exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol. Biol. Cell 15:5470-80
21. + exchanger regulatory factor family of PDZ proteins. Proc. Natl. Acad. Sci. USA 95:8496-501
22. Weinman EJ, Steplock D, Tate K, Hall RA, Spurney RF, Shenolikar S. 1998. Structure-function of the Na/H exchanger regulatory factor (NHE-RF). J. Clin. Invest. 101:2199-206
23. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M. 1999. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor. Nature 401:286-90
24. Gage RM, Kim KA, Cao TT, von Zastrow M. 2001. A transplantable sorting signal that is sufficient to mediate rapid recycling of G protein-coupled receptors. J. Biol. Chem. 276:44712-20
25. Gage RM, Matveeva EA, Whiteheart SW, von Zastrow M. 2005. Type I PDZ ligands are sufficient to promote rapid recycling of G protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. J. Biol. Chem. 280:3305-13
26. Bello-Reuss E. 1980. Effect of catecholamines on fluid reabsorption by the isolated proximal convoluted tubule. Am. J. Physiol. Renal Physiol. 238:F347-52
27. Weinman EJ, Sansom SC, Knight TF, Senekjian HO. 1982. Alpha and beta adrenergic agonists stimulate water absorption in the rat proximal tubule. J. Membr. Biol. 69:107-11
28. Short DB, Trotter KW, Reczek D, Kreda SM, Bretscher A, et al. 1998. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J. Biol. Chem. 273:19797-801
29. Wang S, Raab RW, Schatz PJ, Guggino WB, Li M. 1998. Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR). FEBS Lett. 427:103-8
30. Naren AP, Cobb B, Li CY, Roy K, Nelson D, et al. 2003. A macromolecular complex of β2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proc. Natl. Acad. Sci. USA 100:342-46
31. Taouil K, Hinnrasky J, Hologne C, Corlieu P, Klossek JM, Puchelle E. 2003. Stimulation of β2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway. J. Biol. Chem. 278:17320-27
32. o proteins. J. Biol Chem. 279:25002-9
33. Sheng M, Sala C. 2001. PDZ domains and the organization of supramolecular complexes. Annu. Rev. Neurosci. 24:1-29
34. Heydorn A, Sondergaard BP, Ersboll B, Holst B, Nielsen FC, et al. 2004. A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP5 0), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J. Biol. Chem. 279:54291-303
35. Li J-G, Benovic JL, Liu-Chen L-Y. 2000. Mechanisms of agonist-induced down-regulation of the human κ-opioid receptor: internalization is required for down-regulation. Mol. Pharmacol. 58:795-801
36. Reczek D, Berryman M, Bretscher A. 1997. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J. Cell Biol. 139:169-79
37. Hatzoglou A, Bakogeorgou E, Papakonstanti E, Stournaras C, Emmanouel DS, Castanas E. 1996. Identification and characterization of opioid and somatostatin binding sites in the opossum kidney (OK) cell line and their effect on growth. J. Cell Biochem. 63:410-21
38. Weinman EJ, Steplock D, Shenolikar S. 2001. Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex. Kidney Int. 60:450-54
39. Brown EM, Segre GV, Goldring SR. 1996. Serpentine receptors for parathyroid hormone, calcitonin and extracellular calcium ions. Baillieres Clin. Endocrinol. Metab. 10:123-61
40. Birnbaumer L. 1992. Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits. Cell 71:1069-72
41. Sneddon WB, Syme CA, Bisello A, Magyar CE, Weinman EJ, Friedman PA. 2003. PTH receptor internalization by inactive PTH fragments. Regulation by NHERF1 (EBP50). J. Bone Miner. Res. 18:837
42. Sneddon WB, Bisello A, Magyar CE, Willick GE, Syme CA, et al. 2004. Ligand-selective dissociation of activation and internalization of the parathyroid hormone receptor. Conditional efficacy of PTH peptide fragments. Endocrinology 145:2815-23
43. 2+ channels in renal epithelial cells by parathyroid hormone. Nature 347:388-91
44. Sneddon WB, Bisello A, Friedman PA. 2002. PTH receptor desensitization accompanies receptor activation and not internalization. J. Bone Miner. Res. 17(Suppl. 1):S216
45. + exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol. Endocrinol. 11:2355-64
46. Seedorf K, Millauer B, Kostka G, Schlessinger J, Ullrich A. 1992. Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates. Mol. Cell Biol. 12:4347-56
47. +-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem. J. 376:505-10
48. James MF, Beauchamp RL, Manchanda N, Kazlauskas A, Ramesh V. 2004. A NHERF binding site links the βPDGFR to the cytoskeleton and regulates cell spreading and migration. J. Cell Sci. 117:2951-61
49. + exchanger regulatory factor. J. Biol. Chem. 279:41775-82
50. q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50). J. Biol. Chem. 277:40751-59
51. + exchanger 3 (NHE3) requires an NHE3-E3KARP-α-actinin-4 complex for oligomerization and endocytosis. J. Biol. Chem. 277:23714-24
52. Sitaraman SV, Wang L, Wong M, Bruewer M, Hobert M, et al. 2002. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and ezrin upon agonist stimulation. J. Biol. Chem. 277:33188-95
53. Oh YS, Jo NW, Choi JW, Kim HS, Seo SW, et al. 2004. NHERF2 specifically interacts with LPA(2) receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-β3 activation. Mol. Cell Biol. 11:5069-79
54. Hirakawa T, Galet C, Kishi M, Ascoli M. 2003. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. J. Biol. Chem. 278:49348-57
55. Bomberger JM, Spielman WS, Hall CS, Weinman EJ, Parameswaran N. 2005. RAMP isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1. J. Biol. Chem. 280:23926-35