Assembly of an A kinase-anchoring protein-β2-adrenergic receptor complex facilitates receptor phosphorylation and signaling

Current Biology

Volumn 10, Issue 7, 2000, Pages 409-412

  Fraser, Iain D C ^a   Cong, Mei ^b   Kim, Jihee ^c   Rollins, Emily N ^a   Daaka, Yehia ^c   Lefkowitz, Robert J ^b   Scott, John D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0034611757     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00419-X     Document Type: Article

References (24)

1. Benovic J.L., Pike L.J., Cerione R.A., Staniszewski C., Yoshimasa T., Caron M.G., Lefkowitz R.J. Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. J Biol Chem. 260:1985;7094-7101.
2. Pitcher J., Lohse M.J., Codina J., Caron M.G., Lefkowitz R.J. Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry. 31:1992;3193-3197.
3. Lefkowitz R.J. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem. 273:1998;18677-18680.
4. Daaka Y., Luttrell L.M., Lefkowitz R.J. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390:1997;88-91.
5. Zou Y., Komuro I., Yamazaki T., Kudoh S., Uozumi H., Kadowaki T., Yazaki Y. Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. J Biol Chem. 274:1999;9760-9770.
6. Hausken Z.E., Coghlan V.M., Scott J.D. Overlay, ligand blotting and band-shift techniques to study kinase anchoring. Clegg R.A. Protein Targeting Protocols. 1998;47-64 Humana Press, Totowa, NJ.
7. Coghlan V.M., Perrino B.A., Howard M., Langeberg L.K., Gallatin W.M., Scott J.D. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science. 267:1995;108-112.
8. Klauck T.M., Faux M.C., Labudda K., Langeberg L.K., Jaken S., Scott J.D. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science. 271:1996;1589-1592.
9. Shih M., Lin F., Scott J.D., Wang H.Y., Malbon C.C. Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. J Biol Chem. 274:1999;1588-1595.
10. Ferguson S.S., Barak L.S., Zhang J., Caron M.G. G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. Can J Physiol Pharmacol. 74:1996;1095-1110.
11. Hall R.A., Premont R.T., Lefkowitz R.J. Heptahelical receptor signaling: beyond the G protein paradigm. J Cell Biol. 145:1999;927-932.
12. Dohlman H.G., Thorner J., Caron M.G., Lefkowitz R.J. Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem. 60:1991;653-688.
13. Strulovici B., Cerione R.A., Kilpatrick B.F., Caron M.G., Lefkowitz R.J. Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. Science. 225:1984;837-840.
14. Carr D.W., Stofko-Hahn R.E., Fraser I.D.C., Cone R.D., Scott J.D. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins: characterization of AKAP79. J Biol Chem. 24:1992;16816-16823.
15. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron. 19:1997;. 185-196.
16. Li Y., Ndubuka C., Rubin C.S. A kinase anchor protein 75 targets regulatory (RII) subunits of cAMP-dependent protein kinase II to the cortical actin cytoskeleton in non-neuronal cells. J Biol Chem. 271:1996;16862-16869.
17. Dell'Acqua M.L., Faux M.C., Thorburn J., Thorburn A., Scott J.D. Membrane targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate. EMBO J. 17:1998;2246-2260.
18. Fraser I.D., Scott J.D. Modulation of ion channels: a "current" view of AKAPs. Neuron. 23:1999;423-426.
19. Harada H., Becknell B., Wilm M., Mann M., Huang L.J., Taylor S.S., Scott J.D., Korsmeyer S.J. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell. 3:1999;413-422.
20. Lester L.B., Langeberg L.K., Scott J.D. Anchoring of PKA is required for cAMP-mediated insulin secretion. Proc Natl Acad Sci USA. 94:1997;14942-14947.
21. Luo X., Zeng W., Xu X., Popov S., Davignon I., Wilkie T.M.et al. Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells. J Biol Chem. 274:1999;17684-17690.
22. Luttrell L.M., Ferguson S.S., Daaka Y., Miller W.E., Maudsley S., Della Rocca G.J.et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 283:1999;655-661.
23. Nauert J.B., Klauck T.M., Langeberg L.K., Scott J.D. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Curr Biol. 7:1997;52-62.
24. Gordon T., Grove B., Loftus J.C., O'Toole T., McMillan R., Lindstrom J., Ginsberg M.H. Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. J Clin Invest. 90:1992;992-999.