Receptor activity modifying proteins and their potential as drug targets

Progress in Molecular Biology and Translational Science

Volumn 91, Issue C, 2010, Pages 53-79

  Wootten, Denise L ^a   Simms, John ^a   Hay, Debbie L ^b   Christopoulos, Arthur ^a   Sexton, Patrick M ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Adrenomedullin (AM); Amylin (AMY); Calcitonin (CT); Calcitonin gene related peptide (CGRP); Calcitonin receptor (CTR); Calcitonin receptor like receptor (CLR); Drug discovery; G protein coupled receptor (GPCR); Receptor activity modifying proteins (RAMPs)

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; RECEPTOR ACTIVITY MODIFYING PROTEIN; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; GENETICS; GLYCOSYLATION; HUMAN; METABOLISM; MOLECULAR GENETICS; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; DRUG DISCOVERY; GLYCOSYLATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 77957272916     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1877-1173(10)91003-X     Document Type: Chapter

References (92)

1. D.L. Hay, D.R. Poyner, and P.M. Sexton GPCR modulation by RAMPs Pharmacol Ther 109 2006 173 197
2. D.M. Perez, and S.S. Karnik Multiple signaling states of G-protein-coupled receptors Pharmacol Rev 57 2005 147 161
3. E. Jacoby, R. Bouhelal, M. Gerspacher, and K. Seuwen The 7 TM G-protein-coupled receptor target family ChemMedChem 1 2006 761 782
4. L.F. Kolakowski Jr GCRDb: a G-protein-coupled receptor database Recept Channels 2 1994 1 7 (Pubitemid 24216240)
5. G. Milligan, D. Ramsay, G. Pascal, and J.J. Carrillo GPCR dimerisation Life Sci 74 2003 181 188 (Pubitemid 37361076)
6. B. Fluhmann, R. Muff, W. Hunziker, J.A. Fischer, and W. Born A human orphan calcitonin receptor-like structure Biochem Biophys Res Commun 206 1995 341 347
7. F. Njuki, C.G. Nicholl, A. Howard, J.C. Mak, P.J. Barnes, and S.I. Girgis A new calcitonin-receptor-like sequence in rat pulmonary blood vessels Clin Sci (Lond) 85 1993 385 388 (Pubitemid 23308448)
8. D.R. Poyner, P.M. Sexton, I. Marshall, D.M. Smith, R. Quirion, and W. Born International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors Pharmacol Rev 54 2002 233 246 (Pubitemid 34575714)
9. L.M. McLatchie, N.J. Fraser, M.J. Main, A. Wise, J. Brown, and N. Thompson RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor Nature 393 1998 333 339 (Pubitemid 28269699)
10. A. Christopoulos, G. Christopoulos, M. Morfis, M. Udawela, M. Laburthe, and A. Couvineau Novel receptor partners and function of receptor activity-modifying proteins J Biol Chem 278 2003 3293 3297 (Pubitemid 36801242)
11. K.G. Harikumar, J. Simms, G. Christopoulos, P.M. Sexton, and L.J. Miller Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor Biochemistry 48 2009 11773 11785
12. T. Bouschet, S. Martin, and J.M. Henley Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane J Cell Sci 118 2005 4709 4720 (Pubitemid 41646381)
13. T. Bouschet, S. Martin, and J.M. Henley Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPs Trends Pharmacol Sci 29 2008 633 639
14. N. Tilakaratne, K. Smyth, B. Popp, R.J. Summers, and P.M. Sexton Beta-adrenergic receptor properties in SK-N-MC cells are altered by receptor activity modifying proteins (RAMPs) Proceedings of Australian health and medical research congress 2002 2002 Abstract 2145
15. T.H. Kunz, S. Mueller-Steiner, K. Schwerdtfeger, P. Kleinert, H. Troxler, and J.M. Kelm Interaction of receptor-activity-modifying protein1 with tubulin Biochim Biophys Acta 1770 2007 1145 1150 (Pubitemid 47002143)
16. D.L. Hay, S.G. Howitt, A.C. Conner, M. Schindler, D.M. Smith, and D.R. Poyner CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS Br J Pharmacol 140 2003 477 486 (Pubitemid 37330492)
17. J. Roh, C.L. Chang, A. Bhalla, C. Klein, and S.Y. Hsu Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes J Biol Chem 279 2004 7264 7274 (Pubitemid 38248876)
18. P.M. Sexton, G. Christopoulos, A. Christopoulos, E.S. Nylen, R.H. Snider Jr., and K.L. Becker Procalcitonin has bioactivity at calcitonin receptor family complexes: potential mediator implications in sepsis Crit Care Med 36 2008 1637 1640 (Pubitemid 351620662)
19. T. Katafuchi, K. Hamano, and N. Minamino Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides Biochem Biophys Res Commun 313 2004 74 79 (Pubitemid 37524027)
20. N.J. Fraser, A. Wise, J. Brown, L.M. McLatchie, M.J. Main, and S.M. Foord The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor Mol Pharmacol 55 1999 1054 1059 (Pubitemid 29252372)
21. T.J. Fitzsimmons, X. Zhao, and S.A. Wank The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function J Biol Chem 278 2003 14313 14320 (Pubitemid 36799981)
22. M. Udawela, G. Christopoulos, N. Tilakaratne, A. Christopoulos, A. Albiston, and P.M. Sexton Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors Mol Pharmacol 69 2006 1984 1989 (Pubitemid 43894317)
23. T. Qi, G. Christopoulos, R.J. Bailey, A. Christopoulos, P.M. Sexton, and D.L. Hay Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function Mol Pharmacol 74 2008 1059 1071
24. M. Udawela, D.L. Hay, and P.M. Sexton The receptor activity modifying protein family of G protein coupled receptor accessory proteins Semin Cell Dev Biol 15 2004 299 308 (Pubitemid 38581998)
25. S. Steiner, R. Muff, R. Gujer, J.A. Fischer, and W. Born The transmembrane domain of receptor-activity-modifying protein 1 is essential for the functional expression of a calcitonin gene-related peptide receptor Biochemistry 41 2002 11398 11404
26. M. Udawela, G. Christopoulos, M. Morfis, A. Christopoulos, S. Ye, and N. Tilakaratne A critical role for the short intracellular C terminus in receptor activity-modifying protein function Mol Pharmacol 70 2006 1750 1760
27. M. Flahaut, B.C. Rossier, and D. Firsov Respective roles of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP) in cell surface expression of CRLR/RAMP heterodimeric receptors J Biol Chem 277 2002 14731 14737 (Pubitemid 34952544)
28. S. Hilairet, S.M. Foord, F.H. Marshall, and M. Bouvier Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins J Biol Chem 276 2001 29575 29581 (Pubitemid 37452056)
29. K. Kuwasako, Y. Shimekake, M. Masuda, K. Nakahara, T. Yoshida, and M. Kitaura Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling J Biol Chem 275 2000 29602 29609 (Pubitemid 32043838)
30. K. Kuwasako, Y.N. Cao, C.P. Chu, S. Iwatsubo, T. Eto, and K. Kitamura Functions of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and adrenomedullin receptors J Biol Chem 281 2006 7205 7213 (Pubitemid 43847487)
31. J.M. Bomberger, N. Parameswaran, C.S. Hall, N. Aiyar, and W.S. Spielman Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking J Biol Chem 280 2005 9297 9307 (Pubitemid 40409622)
32. G.S. Cottrell, B. Padilla, S. Pikios, D. Roosterman, M. Steinhoff, and E.F. Grady Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1 J Biol Chem 282 2007 12260 12271 (Pubitemid 47100722)
33. J.M. Bomberger, W.S. Spielman, C.S. Hall, E.J. Weinman, and N. Parameswaran Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1 J Biol Chem 280 2005 23926 23935 (Pubitemid 40884881)
34. S. Hilairet, C. Belanger, J. Bertrand, A. Laperriere, S.M. Foord, and M. Bouvier Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin J Biol Chem 276 2001 42182 42190 (Pubitemid 37371126)
35. M. Morfis, N. Tilakaratne, S.G. Furness, G. Christopoulos, T.D. Werry, and A. Christopoulos Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors Endocrinology 149 2008 5423 5431
36. R. Muff, N. Buhlmann, J.A. Fischer, and W. Born An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3 Endocrinology 140 1999 2924 2927 (Pubitemid 32245175)
37. N. Tilakaratne, G. Christopoulos, E.T. Zumpe, S.M. Foord, and P.M. Sexton Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment J Pharmacol Exp Ther 294 2000 61 72 (Pubitemid 30434671)
38. G. Christopoulos, K.J. Perry, M. Morfis, N. Tilakaratne, Y. Gao, and N.J. Fraser Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product Mol Pharmacol 56 1999 235 242 (Pubitemid 29309833)
39. M.A. Prado, B. Evans-Bain, and I.M. Dickerson Receptor component protein (RCP): a member of a multi-protein complex required for G-protein-coupled signal transduction Biochem Soc Trans 30 2002 460 464 (Pubitemid 35001577)
40. I.M. Dickerson, and S.C. Loiseau CGRP-receptor: a multi-protein complex required for G protein-coupled signal transduction, Poster 19 Fifth annual joint meeting Great Lakes GPCR retreat, Nov 57, 2004 2004 Poster 19
41. M. Flahaut, C. Pfister, B.C. Rossier, and D. Firsov N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor Biochemistry 42 2003 10333 10341 (Pubitemid 37052055)
42. T. Choksi, D.L. Hay, S. Legon, D.R. Poyner, S. Hagner, and S.R. Bloom Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines Br J Pharmacol 136 2002 784 792 (Pubitemid 34785721)
43. K. Tsujikawa, K. Yayama, T. Hayashi, H. Matsushita, T. Yamaguchi, and T. Shigeno Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice Proc Natl Acad Sci USA 104 2007 16702 16707 (Pubitemid 350211080)
44. Z. Zhang, C.S. Winborn, B. Marquez de Prado, and A.F. Russo Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion J Neurosci 27 2007 2693 2703 (Pubitemid 46393588)
45. R. Dackor, K. Fritz-Six, O. Smithies, and K. Caron Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age J Biol Chem 282 2007 18094 18099 (Pubitemid 47100252)
46. K.L. Fritz-Six, W.P. Dunworth, M. Li, and K.M. Caron Adrenomedullin signaling is necessary for murine lymphatic vascular development J Clin Invest 118 2008 40 50
47. Y. Ichikawa-Shindo, T. Sakurai, A. Kamiyoshi, H. Kawate, N. Iinuma, and T. Yoshizawa The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity J Clin Invest 118 2008 29 39
48. C. Cueille, E. Pidoux, M.C. de Vernejoul, R. Ventura-Clapier, and J.M. Garel Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure Biochem Biophys Res Commun 294 2002 340 346 (Pubitemid 34694100)
49. K. Totsune, K. Takahashi, H.S. Mackenzie, O. Murakami, Z. Arihara, and M. Sone Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor- like receptor (CRLR) in the hearts of rats with congestive heart failure Clin Sci (Lond) 99 2000 541 546 (Pubitemid 32014561)
50. E. Oie, L.E. Vinge, A. Yndestad, C. Sandberg, H.K. Grogaard, and H. Attramadal Induction of a myocardial adrenomedullin signaling system during ischemic heart failure in rats Circulation 101 2000 415 422 (Pubitemid 30067399)
51. Y.F. Qi, Y.R. Shi, D.F. Bu, Y.Z. Pang, and C.S. Tang Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia Peptides 24 2003 463 468
52. T. Nishikimi, X. Wang, K. Akimoto, K. Tadokoro, Y. Mori, and Y. Ishikawa Alteration of renal adrenomedullin and its receptor system in the severely hypertensive rat: effect of diuretic Regul Pept 124 2005 89 98 (Pubitemid 39488345)
53. K. Mishima, J. Kato, K. Kuwasako, T. Imamura, K. Kitamura, and T. Eto Angiotensin II modulates gene expression of adrenomedullin receptor components in rat cardiomyocytes Life Sci 73 2003 1629 1635 (Pubitemid 36869004)
54. T. Nishikimi, F. Yoshihara, A. Kanazawa, I. Okano, T. Horio, and N. Nagaya Role of increased circulating and renal adrenomedullin in rats with malignant hypertension Am J Physiol Regul Integr Comp Physiol 281 2001 R2079 R2087 (Pubitemid 33776688)
55. Y.N. Cao, K. Kitamura, J. Kato, K. Kuwasako, K. Ito, and H. Onitsuka Chronic salt loading upregulates expression of adrenomedullin and its receptors in adrenal glands and kidneys of the rat Hypertension 42 2003 369 372 (Pubitemid 37093487)
56. T.J. Stachniak, and T.L. Krukoff Receptor activity modifying protein 2 distribution in the rat central nervous system and regulation by changes in blood pressure J Neuroendocrinol 15 2003 840 850
57. K. Tadokoro, T. Nishikimi, Y. Mori, X. Wang, K. Akimoto, and H. Matsuoka Altered gene expression of adrenomedullin and its receptor system and molecular forms of tissue adrenomedullin in left ventricular hypertrophy induced by malignant hypertension Regul Pept 112 2003 71 78 (Pubitemid 36351605)
58. X. Wang, T. Nishikimi, K. Akimoto, K. Tadokoro, Y. Mori, and N. Minamino Upregulation of ligand, receptor system, and amidating activity of adrenomedullin in left ventricular hypertrophy of severely hypertensive rats: effects of angiotensin-converting enzyme inhibitors and diuretic J Hypertens 21 2003 1171 1181 (Pubitemid 36667872)
59. T. Nagae, M. Mukoyama, A. Sugawara, K. Mori, K. Yahata, and M. Kasahara Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy Biochem Biophys Res Commun 270 2000 89 93 (Pubitemid 30440397)
60. I. Mrquez-Rodas, F. Longo, R. Aras-Lpez, J. Blanco-Rivero, E. Diguez, and T. Tejerina Aldosterone increases RAMP1 expression in mesenteric arteries from spontaneously hypertensive rats Regul Pept 134 2006 61 66 (Pubitemid 43297850)
61. K. Hiragushi, J. Wada, J. Eguchi, T. Matsuoka, A. Yasuhara, and I. Hashimoto The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats Kidney Int 65 2004 540 550 (Pubitemid 38130648)
62. C. Thota, P.R. Gangula, Y.L. Dong, and C. Yallampalli Changes in the expression of calcitonin receptor-like receptor, receptor activity-modifying protein (RAMP) 1, RAMP2, and RAMP3 in rat uterus during pregnancy, labor, and by steroid hormone treatments Biol Reprod 69 2003 1432 1437 (Pubitemid 37173882)
63. Y.L. Dong, K.E. Green, S. Vegiragu, G.D. Hankins, E. Martin, and M. Chauhan Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies J Clin Endocrinol Metab 90 2005 2336 2343 (Pubitemid 40586282)
64. Y. Ono, I. Okano, M. Kojima, K. Okada, and K. Kangawa Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis Biochem Biophys Res Commun 271 2000 197 202 (Pubitemid 30444877)
65. T. Kitamuro, K. Takahashi, K. Totsune, M. Nakayama, O. Murakami, and W. Hida Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells Peptides 22 2001 1795 1801 (Pubitemid 34062796)
66. X. Qing, J. Svaren, and I.M. Keith mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung Am J Physiol Lung Cell Mol Physiol 280 2001 L547 L554 (Pubitemid 32473206)
67. S. Kusano, M. Kukimoto-Niino, R. Akasaka, M. Toyama, T. Terada, and M. Shirouzu Crystal structure of the human receptor activity-modifying protein 1 extracellular domain Protein Sci 17 2008 1907 1914
68. J. Simms, D.L. Hay, M. Wheatley, and D.R. Poyner Characterization of the structure of RAMP1 by mutagenesis and molecular modeling Biophys J 91 2006 662 669
69. K. Kuwasako, K. Kitamura, T. Uemura, Y. Nagoshi, J. Kato, and T. Eto The function of extracellular cysteines in the human adrenomedullin receptor Hypertens Res 26 Suppl. 2003 S25 S31 (Pubitemid 36372313)
70. S. Steiner, W. Born, J.A. Fischer, and R. Muff The function of conserved cysteine residues in the extracellular domain of human receptor-activity- modifying protein FEBS Lett 555 2003 285 290 (Pubitemid 37486042)
71. D. Koller, L.M. Ittner, R. Muff, K. Husmann, J.A. Fischer, and W. Born Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor J Biol Chem 279 2004 20387 20391 (Pubitemid 38623485)
72. M. Heroux, M. Hogue, S. Lemieux, and M. Bouvier Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1 J Biol Chem 282 2007 31610 31620 (Pubitemid 350044900)
73. T. Qi, J. Simms, R.J. Bailey, M. Wheatley, D.L. Rathbone, and D.L. Hay Structure-function analysis of RAMP1-RAMP3 chimeras Biochemistry 49 2009 522 531
74. E.T. Zumpe, N. Tilakaratne, N.J. Fraser, G. Christopoulos, S.M. Foord, and P.M. Sexton Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product Biochem Biophys Res Commun 267 2000 368 372 (Pubitemid 30072558)
75. K. Kuwasako, K. Kitamura, Y. Nagoshi, Y.N. Cao, and T. Eto Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity J Biol Chem 278 2003 22623 22630 (Pubitemid 36830320)
76. K. Kuwasako, K. Kitamura, K. Ito, T. Uemura, Y. Yanagita, and J. Kato The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors J Biol Chem 276 2001 49459 49465 (Pubitemid 37370660)
77. K. Kuwasako, K. Kitamura, H. Onitsuka, T. Uemura, Y. Nagoshi, and J. Kato Rat RAMP domains involved in adrenomedullin binding specificity FEBS Lett 519 2002 113 116 (Pubitemid 34522002)
78. J. Simms, D.L. Hay, R.J. Bailey, G. Konycheva, G. Bailey, and M. Wheatley Structure-function analysis of RAMP1 by alanine mutagenesis Biochemistry 48 2009 198 205
79. J.J. Mallee, C.A. Salvatore, B. LeBourdelles, K.R. Oliver, J. Longmore, and K.S. Koblan Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists J Biol Chem 277 2002 14294 14298 (Pubitemid 34968045)
80. J. Barwell, P.S. Miller, D. Donnelly, and D.R. Poyner Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor Peptides 31 2009 170 176
81. C.R. Grace, M.H. Perrin, M.R. DiGruccio, C.L. Miller, J.E. Rivier, and W.W. Vale NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor Proc Natl Acad Sci USA 101 2004 12836 12841
82. C.R. Grace, M.H. Perrin, J. Gulyas, M.R. Digruccio, J.P. Cantle, and J.E. Rivier Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand Proc Natl Acad Sci USA 104 2007 4858 4863 (Pubitemid 47186141)
83. C. Parthier, M. Kleinschmidt, P. Neumann, R. Rudolph, S. Manhart, and D. Schlenzig Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor Proc Natl Acad Sci USA 104 2007 13942 13947 (Pubitemid 350003317)
84. H. Doods, K. Arndt, K. Rudolf, and S. Just CGRP antagonists: unravelling the role of CGRP in migraine Trends Pharmacol Sci 28 2007 580 587 (Pubitemid 350026615)
85. D.L. Hay, G. Christopoulos, A. Christopoulos, and P.M. Sexton Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l- piperazinyl]carbonyl]pentyl]amino]-1-[(3, 5-dibromo-4-hydroxyphenyl)methyl]-2- oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptorsthe role of receptor activity modifying protein 1 Mol Pharmacol 70 2006 1984 1991 (Pubitemid 44771914)
86. C.A. Salvatore, J.J. Mallee, I.M. Bell, C.B. Zartman, T.M. Williams, and K.S. Koblan Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor Biochemistry 45 2006 1881 1887
87. P.S. Miller, J. Barwell, D.R. Poyner, M.J. Wigglesworth, S.L. Garland, and D. Donnelly Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74 Biochem Biophys Res Commun 391 2009 437 442
88. S. Benemei, P. Nicoletti, J.A. Capone, and P. Geppetti Pain pharmacology in migraine: focus on CGRP and CGRP receptors Neurol Sci 28 Suppl 2 2007 S89 S93 (Pubitemid 46813633)
89. H. Yin, J.S. Slusky, B.W. Berger, R.S. Walters, G. Vilaire, and R.I. Litvinov Computational design of peptides that target transmembrane helices Science 315 2007 1817 1822 (Pubitemid 46580135)
90. G. Ryan, T.A. Briscoe, and L. Jobe Review of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes Drug Des Devel Ther 2 2009 203 214
91. S.D. Robinson, J.F. Aitken, R.J. Bailey, D.R. Poyner, and D.L. Hay Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3 J Pharmacol Exp Ther 331 2009 513 521
92. S. Pidasheva, L. Canaff, W.F. Simonds, S.J. Marx, and G.N. Hendy Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia Hum Mol Genet 14 2005 1679 1690 (Pubitemid 40895520)