Disrupting 5-HT2A receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain

Molecular Therapy

Volumn 18, Issue 8, 2010, Pages 1462-1470

  Pichon, Xavier ^a,b   Wattiez, Anne S ^a,b   Becamel, Carine ^c,d,e   Ehrlich, Ingrid ^f   Bockaert, Joel ^c,d,e   Eschalier, Alain ^a,b,g   Marin, Philippe ^c,d,e   Courteix, Christine ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b INSERM   (France)

^c UNIV MONTPELLIER   (France)

^d INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^e CNRS UPR 9023   (France)

^f UNIVERSITY OF TÜBINGEN   (Germany)

^g UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CELL PENETRATING PEPTIDE; FLUOXETINE; PDZ PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SEROTONIN 2A RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; DRUG SENSITIVITY; HYPERALGESIA; MALE; MONOTHERAPY; NEUROPATHIC PAIN; NONHUMAN; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR DENSITY; REPEATED DRUG DOSE; THERAPY RESISTANCE; UPREGULATION;

RATTUS;

EID: 77955174990     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.101     Document Type: Article

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