SCOPUS 정보 검색 플랫폼

Volumn 19, Issue 16, 2011, Pages 4690-4703

Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors

(7) Das, Debasis a Hong, Jian a Chen, Shu Hui a Wang, Guangyi b Beigelman, Leonid b Seiwert, Scott D b Buckman, Brad O b

a WUXI APPTEC (China)

b InterMune Inc (United States)

Author keywords

Benzoisothiazole; Benzothiadiazine; Benzothiazine; HCV; Hepatitis C; NS5B; Polymerase; Review; Tetramic acid

Indexed keywords

2' DEOXY 2' FLUORO 2' METHYLCYTIDINE; A 837093; A 848837; ABT 072; ABT 333; ANA 598; BENZOTHIADIAZINE DERIVATIVE; BOCEPREVIR; CYCLOBUTANE DERIVATIVE; CYCLOPROPANE DERIVATIVE; DANOPREVIR; FILIBUVIR; ITMN 8020; JTK 109; MERICITABINE; MK 3281; NONSTRUCTURAL PROTEIN 5B; PEGINTERFERON ALPHA; PEGINTERFERON ALPHA PLUS RIBAVIRIN; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE INHIBITOR; TEGOBUVIR; TELAPREVIR; TMC 435350; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANIPREVIR; VCH 222; VCH 759; VCH 916;

ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; AREA UNDER THE CURVE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TOLERABILITY; ENZYME INHIBITION; GENETIC VARIABILITY; HEPATITIS C VIRUS; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; IC 50; MONOTHERAPY; NONHUMAN; OPEN READING FRAME; PLASMA PROTEIN BINDING; REVIEW; STRUCTURE ACTIVITY RELATION; TREATMENT DURATION; VIRUS GENOME; VIRUS REPLICATION;

ANTIVIRAL AGENTS; BENZOTHIADIAZINES; DRUG DISCOVERY; ENZYME INHIBITORS; HEPACIVIRUS; HEPATITIS C; HUMANS; MOLECULAR TARGETED THERAPY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 79961171672 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.06.079 Document Type: Review

Times cited : (32)

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