Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

Journal of Biological Chemistry

Volumn 277, Issue 41, 2002, Pages 38322-38327

  Dhanak, Dashyant ^a   Duffy, Kevin J ^a   Johnston, Victor K ^b   Lin Goerke, Juili ^b   Darcy, Michael ^b   Shaw, Antony N ^b   Gu, Baohua ^b   Silverman, Carol ^b   Gates, Adam T ^b   Nonnemacher, Michael R ^b   Earnshaw, David L ^b   Casper, David J ^a,b   Kaura, Arun ^a,b   Baker, Audrey ^a,b   Greenwood, Cathy ^a,b   Gutshall, Lester L ^a,c   Maley, Derrick ^b   Delvecchio, Alfred ^b,c   Macarron, Ricardo ^a   Hofmann, Glenn A ^b   Alnoah, Zaid ^c   Cheng, Hung Yuan ^b   Chan, George ^a,b   Khandekar, Sanjay ^b   Keenan, Richard M ^b   Sarisky, Robert T ^a,c   more..

^a Department of Medicinal Chemistry   (United States)

^b Metabolic and Viral Diseases Center of Excellence for Drug Discovery   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOASSAY; CATALYSIS; CELLS; DISEASES; ENZYME INHIBITION; RNA; SYNTHESIS (CHEMICAL); VIRUSES;

REPLICATE COMPLEXES;

BIOCHEMISTRY;

BENZO 1,2,4 THIADIAZINE DERIVATIVE; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; RECOMBINANT PROTEIN; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; ENZYME INHIBITION; HEPATITIS C VIRUS; HUMAN; IC 50; PRIORITY JOURNAL; REPLICON; RNA REPLICATION; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION;

CELL LINE; CIRCULAR DICHROISM; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ENZYME STABILITY; HEPACIVIRUS; HUMANS; MOLECULAR STRUCTURE; PROTEIN DENATURATION; RECOMBINANT PROTEINS; RNA; RNA REPLICASE; TEMPERATURE; THIADIAZINES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0037064091     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205566200     Document Type: Article

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