Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors

Journal of Medicinal Chemistry

Volumn 50, Issue 13, 2007, Pages 3153-3157

  Francotte, Pierre ^a   De Tullio, Pascal ^a   Goffin, Eric ^a   Dintilhac, Gaëlle ^a   Graindorge, Emmanuel ^a   Fraikin, Pierre ^a   Lestage, Pierre ^b   Danober, Laurence ^b   Thomas, Jean Yves ^b   Caignard, Daniel Henri ^b   Pirotte, Bernard ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1, DIOXIDE DERIVATIVE; 4 ETHYL 7 FLUORO 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; OOCYTE; RAT; REACTION ANALYSIS; RECOGNITION; STRUCTURE ANALYSIS; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; COGNITION; CYCLIC S-OXIDES; DRUG DESIGN; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; NOREPINEPHRINE; OOCYTES; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECOGNITION (PSYCHOLOGY); RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES; XENOPUS;

EID: 34347213071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070120i     Document Type: Article

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