Chloro-substituted 3-alkylamino-4h-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: Impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 147-154

  Pirotte, Bernard ^a   De Tullio, Pascal ^a   Nguyen, Quynh Anh ^b   Somers, Fabian ^a   Fraikin, Pierre ^a   Florence, Xavier ^a   Wahl, Philip ^c   Hansen, John Bondo ^c,d   Lebrun, Philippe ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c NOVO NORDISK A S   (Denmark)

^d Sound Biotech   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE DERIVATIVE; 6 CHLORO 3 CYCLOBUTYLAMINO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 8 CHLORO 3 ISOPROPYLAMINO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CHLORINE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET CELL; PKA; REACTION ANALYSIS; SMOOTH MUSCLE CONTRACTILITY; STRUCTURE ACTIVITY RELATION; TISSUE SPECIFICITY;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOTHIADIAZINES; CELL LINE; CHLORINE; CYCLIC S-OXIDES; DIAZOXIDE; DRUG EVALUATION, PRECLINICAL; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNELS; RATS; STEREOISOMERISM;

EID: 74849121699     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9010093     Document Type: Article

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