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48649108863
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All structures are arbitrarily drawn as one of several possible tautomers.
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All structures are arbitrarily drawn as one of several possible tautomers.
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19
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44149118393
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Li L.-S., Zhou Y., Murphy D.E., Stankovic N., Zhao J., Dragovich P.S., Bertolini T., Sun Z., Ayida B., Tran C.V., Ruebsam F., Webber S.E., Shah A.M., Tsan M., Showalter R.E., Patel R., LeBrun L.A., Bartkowski D.M., Nolan T.G., Norris D.A., Kamran R., Brooks J., Sergeeva M.V., Kirkovsky L., Zhao Q., and Kissinger C.R. Bioorg. Med. Chem. Lett. 18 (2008) 3446
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Sergeeva, M.V.18
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44649152230
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48649090847
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Related benzothiazine-containing NS5B inhibitors have been reported by others as well. Intermediates 7, 8, 10, 11, and 12 were prepared as described in: Blake, F. J. et al. U.S. Patent Application US20060040972, 2006.
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Related benzothiazine-containing NS5B inhibitors have been reported by others as well. Intermediates 7, 8, 10, 11, and 12 were prepared as described in: Blake, F. J. et al. U.S. Patent Application US20060040972, 2006.
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26
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48649085246
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2 at pH 7.6, and an inhibitor concentration of 2-10 mM. Diffraction data were collected to a resolution of 2.1 Å for compound 3a. The crystal structure discussed in this Letter has been deposited in the Protein Databank (http://www.rcsb.org) with entry code: 3CWJ. Full structure determination details are given in the PDB entry.
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2 at pH 7.6, and an inhibitor concentration of 2-10 mM. Diffraction data were collected to a resolution of 2.1 Å for compound 3a. The crystal structure discussed in this Letter has been deposited in the Protein Databank (http://www.rcsb.org) with entry code: 3CWJ. Full structure determination details are given in the PDB entry.
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27
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48649107871
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The reduced stability of 5b toward monkey liver microsomes relative to 5a may also have contributed to the lower bioavailability of the former compound.
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The reduced stability of 5b toward monkey liver microsomes relative to 5a may also have contributed to the lower bioavailability of the former compound.
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