An efficient, asymmetric solid-phase synthesis of benzothiadiazine- substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2205-2208

  Evans, Karen A ^a   Chai, Deping ^a   Graybill, Todd L ^a   Burton, George ^a   Sarisky, Robert T ^a   Lin Goerke, Juili ^a   Johnston, Victor K ^a   Rivero, Ralph A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

HCV polymerase inhibitors; Hepatitis C; Solid phase synthesis

Indexed keywords

BENZOTHIADIAZINE DERIVATIVE; RNA POLYMERASE; TETRAMIC ACID DERIVATIVE;

AMINATION; ARTICLE; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; CYCLIZATION; DIECKMANN REACTION; DRUG SYNTHESIS; HEPATITIS C VIRUS; NONHUMAN; RNA ANALYSIS; SOLID; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; BENZOTHIADIAZINES; CATALYSIS; CYCLIZATION; DRUG RESISTANCE, VIRAL; HEPACIVIRUS; HEPATITIS C; HUMANS; INHIBITORY CONCENTRATION 50; PYRROLIDINONES; RNA REPLICASE;

HEPATITIS C VIRUS;

EID: 33644810532     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.034     Document Type: Article

References (18)

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