Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: Implication for viral RNA synthesis

Journal of Virology

Volumn 75, Issue 18, 2001, Pages 8615-8623

  Ranjith Kumar, C T ^a   Gajewski, J ^a   Gutshall, L ^a   Maley, D ^a   Sarisky, R T ^a   Kao, C C ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ENZYME; NUCLEOTIDYLTRANSFERASE; RNA POLYMERASE; VIRUS RNA;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BOVINE DIARRHEA VIRUS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PURIFICATION; FLAVIVIRUS; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; VIRUS GENOME; VIRUS RECOMBINANT;

ANIMALS; CELL LINE; CYTIDINE MONOPHOSPHATE; DIARRHEA VIRUSES, BOVINE VIRAL; FLAVIVIRIDAE; HEPACIVIRUS; HUMANS; RECOMBINATION, GENETIC; RNA NUCLEOTIDYLTRANSFERASES; RNA REPLICASE; RNA, VIRAL; SPODOPTERA; TEMPLATES, GENETIC; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0034881065     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.18.8615-8623.2001     Document Type: Article

References (39)

1. Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli
2. pol)
3. Requirements for the self-directed replication of flock house virus RNA 1
4. Site size of cooperative singlestranded RNA binding by poliovirus RNA-dependent RNA polymerase
5. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
6. Comparison of the replication of positive-stranded RNA viruses of plants and animals
7. Template-independent repair of the 3′ end of cucumber mosaic virus satellite RNA controlled by RNAs 1 and 2 of helper virus
8. In vivo restoration of biologically active 3′ ends of virus-associated RNAs by nonhomologous RNA recombination and replacement of a terminal motif
9. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
10. Tacaribe arenavirus RNA synthesis in vitro is primer dependent and suggests an unusual model for the initiation of genome replication
11. The 5′ ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis
12. Polymerization of nontemplate bases before transcription initiation at the 3′ ends of templates by an RNA-dependent RNA polymerase: An activity involved in 3′ end repair of viral RNAs
13. Structure-function relationships of acid ribonucleases: Lysosomal, vacuolar, and periplasmic enzymes
14. Improved predictions of secondary structures for RNA
15. De novo initiation of RNA synthesis by a recombinant Flaviviridae RNA-dependent RNA polymerase
16. De novo initiation of viral RNA-dependent RNA synthesis
17. Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase
18. Template nucleotide moieties for de novo initiation of RNA synthesis by a recombinant RNA-dependent RNA polymerase
19. RNA synthesis: Strategies for the use of bacteriophage RNA polymerases
20. Analysis of the gene start and gene end signals of human respiratory syncytial virus: Quasi-templated initiation at position 1 of the encoded mRNA
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
22. Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase
23. Biochemical and kinetic analysis of NS5B RNA-dependent RNA polymerase of the hepatitis C virus
24. Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
25. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
26. De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus
27. Synthesis of brome mosaic virus subgenomic RNA in vitro by internal initiation on (-)-sense genomic RNA
28. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
29. A novel 3′-end repair mechanism in an RNA virus
30. pol
31. Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template
32. Telomeric function of the tRNA-like structure of brome mosaic virus RNA
33. Sequence-specific recognition of a subgenomic promoter by a viral RNA polymerase
34. Requirement of 3′-terminal guanosine in (-)-stranded RNA for in vitro replication of cucumber mosaic virus satellite RNA by viral RNA-dependent RNA polymerase
35. RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region
36. Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo
37. Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase
38. Identification and characterization of an RNA-dependent RNA polymerase activity within the nonstructural protein 5B region of Bovine viral diarrhea virus