Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 1930-1933

  Burton, George ^a   Ku, Thomas W ^a   Carr, Thomas J ^a   Kiesow, Terry ^a   Sarisky, Robert T ^a   Lin Goerke, Juili ^a   Hofmann, Glenn A ^a   Slater, Martin J ^b   Haigh, David ^b   Dhanak, Dashyant ^a   Johnson, Victor K ^a   Parry, Nigel R ^b   Thommes, Pia ^b  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

HCV NS5B; HCV replicon; Hepatitis C virus; N Acyl pyrrolidines; RNA dependent RNA polymerase; SAR

Indexed keywords

ANTIVIRUS AGENT; PYRROLIDINE DERIVATIVE; RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; DRUG ACTIVITY; ENZYME INHIBITION; HUMAN CYTOMEGALOVIRUS; REPLICON; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PYRROLIDINES; REPLICON; RNA REPLICASE; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 33847658827     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.034     Document Type: Article

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