Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 627-632

  Stansfield, Ian ^a   Ercolani, Caterina ^a   Mackay, Angela ^a   Conte, Immacolata ^a   Pompei, Marco ^a   Koch, Uwe ^a   Gennari, Nadia ^a   Giuliano, Claudio ^a   Rowley, Michael ^a   Narjes, Frank ^a  

^a Biologia Molecolare P Angeletti SpA   (Italy)

Author keywords

Allosteric inhibitors; Hepatitis C virus; NS5B polymerase; Pre clinical candidate; Tetracyclic indoles

Indexed keywords

AMPHOLYTE; INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 5B;

AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; HEPATITIS C VIRUS; HUMAN; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; HYDROLYSIS; INDOLES; MODELS, CHEMICAL; NITROGEN; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 58549117277     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.068     Document Type: Article

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