Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 3887-3890

  Hutchinson, Douglas K ^a   Rosenberg, Teresa ^a   Klein, Larry L ^a   Bosse, Todd D ^a   Larson, Daniel P ^a   He, Wenping ^a   Jiang, Wen W ^a   Kati, Warren M ^a   Kohlbrenner, William E ^a   Liu, Yaya ^a   Masse, Sherie V ^a   Middleton, Tim ^a   Molla, Akhteruzzaman ^a   Montgomery, Debra A ^a   Beno, David W A ^a   Stewart, Kent D ^a   Stoll, Vincent S ^a   Kempf, Dale J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antiviral; HCV; HCV NS5B polymerase; Hepatitis C

Indexed keywords

BENZOTHIADIAZINE DERIVATIVE; ENZYME INHIBITOR; NONSTRUCTURAL PROTEIN 5B;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C VIRUS; NONHUMAN; RAT; VIRUS INHIBITION;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; GENOTYPE; INFUSIONS, INTRAVENOUS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; RATS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RATTUS;

EID: 47149103056     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.043     Document Type: Article

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