TgCRND8 amyloid precursor protein transgenic mice exhibit an altered γ-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation

Biochemistry

Volumn 46, Issue 36, 2007, Pages 10317-10327

  Van Vickie, Gregory D ^a   Esh, Chera L ^a   Kalback, Walter M ^a   Patton, R Lyle ^a   Luehrs, Dean C ^a   Kokjohn, Tyler A ^a,b   Fifield, Frederick G ^c   Fraser, Paul E ^d   Westaway, David ^d   McLaurin, Joanne ^d   Lopez, John ^e   Brune, Daniel ^e   Newel, Amanda J ^a   Poston, Marissa ^a   Beach, Thomas G ^a   Roher, Alex E ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

^c Sun Health Boswell Hospital   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DISEASES; ELECTRON MICROSCOPY; IMMUNOLOGY; MASS SPECTROMETRY; MORPHOLOGY; PATHOLOGY; RATS;

AMYLOIDS; IMMUNOTHERAPEUTIC MODULATION; PARENCHYMAL DEPOSITS; TRANSGENIC MICE;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTIBODY; GAMMA SECRETASE; AMYLOID; SECRETASE; THIAZOLE DERIVATIVE; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNIZATION; IMMUNOMODULATION; IMMUNOPRECIPITATION; IMMUNOTHERAPY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSGENICS; VACCINATION; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; SENILE PLAQUE; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALIA; MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IMMUNOTHERAPY; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; SENILE PLAQUES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THIAZOLES;

EID: 35148869239     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700951u     Document Type: Article

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