Enzymatic characteristics of I213T mutant presenilin-1/γ-secretase in cell models and knock-in mouse brains: Familial Alzheimer disease-linked mutation impairs γ-site cleavage of amyloid precursor protein C-terminal fragment β

Journal of Biological Chemistry

Volumn 283, Issue 24, 2008, Pages 16488-16496

  Shimojo, Masafumi ^a,b   Sahara, Naruhiko ^a   Mizoroki, Tatsuya ^a   Funamoto, Satoru ^c   Morishima Kawashima, Maho ^d   Kudo, Takashi ^e   Takeda, Masatoshi ^e   Ihara, Yasuo ^c   Ichinose, Hiroshi ^b   Takashima, Akihiko ^a,f  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c DOSHISHA UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^f NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIOCHEMISTRY;

ALZHEIMER DISEASES; AMYLOID PRECURSOR PROTEINS; CATALYTIC RATES; CLEAVAGE REACTIONS; ENZYMATIC ANALYSES; IN CELLS; KINETICS ANALYSES; MOLECULAR MECHANISMS; MOUSE BRAINS; MUTANT ALLELES; PRESENILIN; SECRETASE; TERMINAL FRAGMENTS;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN 43; AMYLOID BETA PROTEIN 45; AMYLOID BETA PROTEIN 46; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN;

ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME KINETICS; FAMILIAL DISEASE; GENE MUTATION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOLOGICAL MODEL; BRAIN; CHEMISTRY; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENETICS; HOMOZYGOTE; HUMAN; KINETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; TRANSGENIC MOUSE;

MUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HOMOZYGOTE; HUMANS; KINETICS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUTATION; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY;

EID: 47749093936     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801279200     Document Type: Article

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