Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid β peptide clearance in primary neurons

Journal of Biological Chemistry

Volumn 279, Issue 29, 2004, Pages 30259-30264

  Hama, Emi ^a   Shirotani, Keiro ^a   Iwata, Nobuhisa ^a   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; DEGRADATION; ENZYMES; LIPIDS; NEUROLOGY; OPTIMIZATION;

CORTICAL NEURONS; ENDOPLASMIC RETICULUM; NEPRILYSIN CHIMERIC PROTEINS;

PROTEINS;

AMYLOID BETA PROTEIN; BETA GALACTOSIDE ALPHA2,6 SIALYLTRANSFERASE NEPRILYSIN; GROWTH ASSOCIATED PROTEIN 43 NEPRILYSIN; MEMBRANE METALLOENDOPEPTIDASE; SEC12 NEPRILYSIN; TRANSFERRIN RECEPTOR NEPRILYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOSOME; LIPID MEMBRANE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN TARGETING; TRANS GOLGI NETWORK;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; BLOTTING, WESTERN; BRAIN; CELL LINE; CRICETINAE; CYTOPLASM; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GAP-43 PROTEIN; GOLGI APPARATUS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MEMBRANE MICRODOMAINS; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; NEPRILYSIN; NEURONS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SIALYLTRANSFERASES; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 3142721151     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401891200     Document Type: Article

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