Invading target cells: Multifunctional polymer conjugates as therapeutic nucleic acid carriers

Frontiers of Chemical Engineering in China

Volumn 5, Issue 3, 2011, Pages 275-286

  Lächelt, Ulrich ^a   Wagner, Ernst ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

conjugate; DNA; gene transfer; polymer; RNA; targeting

Indexed keywords

EID: 79960493518     PISSN: 16737369     EISSN: 16737474     Source Type: Journal    
DOI: 10.1007/s11705-011-1203-z     Document Type: Review

References (125)

1. Famulok M, Ackermann D. RNA nanotechnology: inspired by DNA. Nature Nanotechnology, 2010, 5(9): 634-635.
2. Guo P. The emerging field of RNA nanotechnology. Nature Nanotechnology, 2010, 5(12): 833-842.
3. Shir A, Ogris M, Wagner E, Levitzki A. EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLoS Medicine, 2006, 3(1): e6.
4. Schaffert D, Kiss M, Rödl W, Shir A, Levitzki A, Ogris M, Wagner E. Poly(I: C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier. Pharmaceutical Research, 2011, 28(4): 731-741.
5. Shir A, Ogris M, Roedl W, Wagner E, Levitzki A. EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice. Clinical Cancer Research, 2011, 17(5): 1033-1043.
6. Venkataraman S, Dirks R M, Ueda C T, Pierce N A. Selective cell death mediated by small conditional RNAs. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(39): 16777-16782.
7. Ulrich H, Trujillo C A, Nery A A, Alves J M, Majumder P, Resende R R, Martins A H. DNA and RNA aptamers: from tools for basic research towards therapeutic applications. Combinatorial Chemistry & High Throughput Screening, 2006, 9(8): 619-632.
8. Gutsaeva D R, Parkerson J B, Yerigenahally S D, Kurz J C, Schaub R G, Ikuta T, Head C A. Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood, 2011, 117(2): 727-735.
9. Sassanfar M, Szostak J W. An RNA motif that binds ATP. Nature, 1993, 364(6437): 550-553.
10. Ellington A D, Szostak J W. In vitro selection of RNA molecules that bind specific ligands. Nature, 1990, 346(6287): 818-822.
11. Maasch C, Vater A, Buchner K, Purschke W G, Eulberg D, Vonhoff S, Klussmann S. Polyetheylenimine-polyplexes of Spiegelmer NOX-A50 directed against intracellular high mobility group protein A1 (HMGA1) reduce tumor growth in vivo. The Journal of Biological Chemistry, 2010, 285(51): 40012-40018.
12. Dua P, Kim S, Lee D K. Nucleic acid aptamers targeting cell-surface proteins. Methods (San Diego, Calif.), 2011.
13. Keefe A D, Pai S, Ellington A. Aptamers as therapeutics. Nature Reviews. Drug Discovery, 2010, 9(7): 537-550.
14. Li S D, Huang L. Non-viral is superior to viral gene delivery. Journal of Controlled Release: Official Journal of the Controlled Release Society, 2007, 123(3): 181-183.
15. Tamura A, Nagasaki Y. Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles. Nanomedicine (Lond), 2010, 5(7): 1089-1102.
16. Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E, Fernandes J C. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e. V, 2004, 57(1): 1-8.
17. Behr J P. The proton sponge: A trick to enter cells the viruses did not exploit. Chimia, 1997, 51(1-2): 34-36.
18. Kichler A, Leborgne C, Coeytaux E, Danos O. Polyethylenimine-mediated gene delivery: a mechanistic study. The Journal of Gene Medicine, 2001, 3(2): 135-144.
19. von Harpe A, Petersen H, Li Y, Kissel T. Characterization of commercially available and synthesized polyethylenimines for gene delivery. Journal of Controlled Release: Official Journal of the Controlled Release Society, 2000, 69(2): 309-322.
20. Werth S, Urban-Klein B, Dai L, Höbel S, Grzelinski M, Bakowsky U, Czubayko F, Aigner A. A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. Journal of Controlled Release: Official Journal of the Controlled Release Society, 2006, 112(2): 257-270.
21. Cherng J Y, van de Wetering P, Talsma H, Crommelin D J A, Hennink W E. Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharmaceutical Research, 1996, 13(7): 1038-1042.
22. van de Wetering P, Cherng J Y, Talsma H, Hennink W E. Relation between transfection efficiency and cytotoxicity of poly(2-(dimethylamino)ethyl methacrylate)/plasmid complexes. Journal of Controlled Release, 1997, 49(1): 59-69.
23. van de Wetering P, Cherng J Y, Talsma H, Crommelin D J, Hennink W E. 2-(Dimethylamino)ethyl methacrylate based (co) polymers as gene transfer agents. Journal of Controlled Release: Official Journal of the Controlled Release Society, 1998, 53(1-3): 145-153.
24. Xu F J, Li H, Li J, Zhang Z, Kang E T, Neoh K G. Pentablock copolymers of poly(ethylene glycol), poly((2-dimethyl amino) ethyl methacrylate) and poly(2-hydroxyethyl methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene delivery. Biomaterials, 2008, 29(20): 3023-3033.
25. Krämer M, Stumbé J F, Grimm G, Kaufmann B, Krüger U, Weber M, Haag R. Dendritic polyamines: simple access to new materials with defined treelike structures for application in nonviral gene delivery. Chembiochem: a European Journal of Chemical Biology, 2004, 5(8): 1081-1087.
26. Esfand R, Tomalia D A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discovery Today, 2001, 6(8): 427-436.
27. Hartmann L. Polymers for control freaks: sequence-defined poly (amidoamine)s and their biomedical applications. Macromolecular Chemistry and Physics, 2011, 212(1): 8-13.
28. Hartmann L, Krause E, Antonietti M, Börner H G. Solid-phase supported polymer synthesis of sequence-defined, multifunctional poly(amidoamines). Biomacromolecules, 2006, 7(4): 1239-1244.
29. Hartmann L, Häfele S, Peschka-Süss R, Antonietti M, Börner H G. Tailor-made poly(amidoamine)s for controlled complexation and condensation of DNA. Chemistry, 2008, 14(7): 2025-2033.
30. Schaffert D, Badgujar N, Wagner E. Novel Fmoc-polyamino acids for solid-phase synthesis of defined polyamidoamines. Organic Letters, 2011, 13(7): 1586-1589.
31. Burke R S, Pun S H. Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver. Bioconjugate Chemistry, 2008, 19(3): 693-704.
32. Edinger D, Wagner E. Bioresponsive polymers for the delivery of therapeutic nucleic acids. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 2011, 3(1): 33-46.
33. Itaka K, Harada A, Yamasaki Y, Nakamura K, Kawaguchi H, Kataoka K. In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. The Journal of Gene Medicine, 2004, 6(1): 76-84.
34. Oupický D, Parker A L, Seymour L W. Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors. Journal of the American Chemical Society, 2002, 124(1): 8-9.
35. Neu M, Germershaus O, Mao S, Voigt K H, Behe M, Kissel T. Crosslinked nanocarriers based upon poly(ethylene imine) for systemic plasmid delivery: in vitro characterization and in vivo studies in mice. Journal of Controlled Release: Official Journal of the Controlled Release Society, 2007, 118(3): 370-380.
36. Miyata K, Kakizawa Y, Nishiyama N, Harada A, Yamasaki Y, Koyama H, Kataoka K. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. Journal of the American Chemical Society, 2004, 126(8): 2355-2361.
37. Russ V, Fröhlich T, Li Y, Halama A, Ogris M, Wagner E. Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes. The journal of gene medicine, 2010, 12(2): 180-193.
38. Hamidi M, Azadi A, Rafiei P. Pharmacokinetic consequences of pegylation. Drug Delivery, 2006, 13(6): 399-409.
39. Itaka K, Yamauchi K, Harada A, Nakamura K, Kawaguchi H, Kataoka K. Polyion complex micelles from plasmid DNA and poly (ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials, 2003, 24(24): 4495-4506.
40. Venkataraman S, Ong W L, Ong Z Y, Joachim Loo S C, Ee P L, Yang Y Y. The role of PEG architecture and molecular weight in the gene transfection performance of PEGylated poly(dimethylaminoethyl methacrylate) based cationic polymers. Biomaterials, 2011, 32(9): 2369-2378.
41. Lai T C, Bae Y, Yoshida T, Kataoka K, Kwon G S. pH-sensitive multi-PEGylated block copolymer as a bioresponsive pDNA delivery vector. Pharmaceutical Research, 2010, 27(11): 2260-2273.
42. Tamura A, Oishi M, Nagasaki Y. Enhanced cytoplasmic delivery of siRNA using a stabilized polyion complex based on PEGylated nanogels with a cross-linked polyamine structure. Biomacromolecules, 2009, 10(7): 1818-1827.
43. Meyer M, Dohmen C, Philipp A, Kiener D, Maiwald G, Scheu C, Ogris M, Wagner E. Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate. Molecular Pharmaceutics, 2009, 6(3): 752-762.
44. Takae S, Miyata K, Oba M, Ishii T, Nishiyama N, Itaka K, Yamasaki Y, Koyama H, Kataoka K. PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. Journal of the American Chemical Society, 2008, 130(18): 6001-6009.
45. Hatakeyama H, Akita H, Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Advanced Drug Delivery Reviews, 2011, 63(3): 152-160.
46. Dash P R, Read M L, Fisher K D, Howard K A, Wolfert M, Oupicky D, Subr V, Strohalm J, Ulbrich K, Seymour L W. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. The Journal of Biological Chemistry, 2000, 275(6): 3793-3802.
47. Oupicky D, Ogris M, Howard K A, Dash P R, Ulbrich K, Seymour L W. Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Molecular Therapy: the Journal of the American Society of Gene Therapy, 2002, 5(4): 463-472.
48. Ito T, Yoshihara C, Hamada K, Koyama Y. DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice. Biomaterials, 2010, 31(10): 2912-2918.
49. Hornof M, de la Fuente M, Hallikainen M, Tammi R H, Urtti A. Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells. The Journal of Gene Medicine, 2008, 10(1): 70-80.
50. Kircheis R, Wightman L, Schreiber A, Robitza B, Rössler V, Kursa M, Wagner E. Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Therapy, 2001, 8(1): 28-40.
51. Kircheis R, Schüller S, Brunner S, Ogris M, Heider K H, Zauner W, Wagner E. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. Journal of Gene Medicine, 1999, 1(2): 111-120.
52. Li S D, Chono S, Huang L. Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Molecular Therapy, 2008, 16(5): 942-946.
53. Li S D, Huang L. Surface-modified LPD nanoparticles for tumor targeting. Annals of the New York Academy of Sciences, 2006, 1082(1): 1-8.
54. Hong M S, Lim S J, Oh Y K, Kim C K. pH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system. Journal of Pharmacy and Pharmacology, 2002, 54(1): 51-58.
55. Miller C R, Bondurant B, McLean S D, McGovern K A, O'Brien D F. Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. Biochemistry, 1998, 37(37): 12875-12883.
56. O'Riordan C R, Lachapelle A, Delgado C, Parkes V, Wadsworth S C, Smith A E, Francis G E. PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo. Human Gene Therapy, 1999, 10(8): 1349-1358.
57. Croyle M A, Yu Q C, Wilson J M. Development of a rapid method for the PEGylation of adenoviruses with enhanced transduction and improved stability under harsh storage conditions. Human Gene Therapy, 2000, 11(12): 1713-1722.
58. Wolfert M A, Schacht E H, Toncheva V, Ulbrich K, Nazarova O, Seymour LW. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Human Gene Therapy, 1996, 7(17): 2123-2133.
59. Erbacher P, Bettinger T, Belguise-Valladier P, Zou S, Coll J L, Behr J P, Remy J S. Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI). Journal of Gene Medicine, 1999, 1(3): 210-222.
60. Kursa M, Walker G F, Roessler V, Ogris M, Roedl W, Kircheis R, Wagner E. Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjugate Chemistry, 2003, 14(1): 222-231.
61. Kasper J C, Schaffert D, Ogris M, Wagner E, Friess W. Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability-A step closer from promising technology to application. Journal of Controlled Release, 2011, 151(3): 246-255.
62. Kasper J C, Schaffert D, Ogris M, Wagner E, Friess W. The establishment of an up-scaled micro-mixer method allows the standardized and reproducible preparation of well-defined plasmid/LPEI polyplexes. European Journal of Pharmaceutics and Biopharmaceutics, 2011, 77(1): 182-185.
63. Zhang X, Pan S R, Hu H M, Wu G F, Feng M, Zhang W, Luo X. Poly(ethylene glycol)-block-polyethylenimine copolymers as carriers for gene delivery: effects of PEG molecular weight and PEGylation degree. Journal of Biomedical Materials Research. Part A, 2008, 84A(3): 795-804.
64. Walker G F, Fella C, Pelisek J, Fahrmeir J, Boeckle S, Ogris M, Wagner E. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Molecular Therapy, 2005, 11(3): 418-425.
65. Fella C, Walker G F, Ogris M, Wagner E. Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding. European Journal of Pharmaceutical Sciences, 2008, 34(4-5): 309-320.
66. Knorr V, Ogris M, Wagner E. An acid sensitive ketal-based polyethylene glycol-oligoethylenimine copolymer mediates improved transfection efficiency at reduced toxicity. Pharmaceutical Research, 2008, 25(12): 2937-2945.
67. Knorr V, Allmendinger L, Walker G F, Paintner F F, Wagner E. An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes. Bioconjugate Chemistry, 2007, 18(4): 1218-1225.
68. Li W, Huang Z, MacKay J A, Grube S, Szoka F C Jr. Low-pHsensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. The Journal of Gene Medicine, 2005, 7(1): 67-79.
69. Hatakeyama H, Akita H, Kogure K, Oishi M, Nagasaki Y, Kihira Y, Ueno M, Kobayashi H, Kikuchi H, Harashima H. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Therapy, 2007, 14(1): 68-77.
70. Ikeda Y, Taira K. Ligand-targeted delivery of therapeutic siRNA. Pharmaceutical Research, 2006, 23(8): 1631-1640.
71. Thurnher M, Wagner E, Clausen H, Mechtler K, Rusconi S, Dinter A, Birnstiel M L, Berger E G, Cotten M. Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. Glycobiology, 1994, 4(4): 429-435.
72. Spänkuch B, Steinhauser I, Wartlick H, Kurunci-Csacsko E, Strebhardt K I, Langer K. Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles. Neoplasia (New York, N. Y.), 2008, 10(3): 223-234.
73. Saul J M, Annapragada A V, Bellamkonda R V. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. Journal of Controlled Release, 2006, 114(3): 277-287.
74. Moffatt S, Papasakelariou C, Wiehle S, Cristiano R. Successful in vivo tumor targeting of prostate-specific membrane antigen with a highly efficient J591/PEI/DNA molecular conjugate. Gene Therapy, 2006, 13(9): 761-772.
75. de Bruin K, Ruthardt N, von Gersdorff K, Bausinger R, Wagner E, Ogris M, Bräuchle C. Cellular dynamics of EGF receptor-targeted synthetic viruses. Molecular Therapy, 2007, 15(7): 1297-1305.
76. Wolschek M F, Thallinger C, Kursa M, Rössler V, Allen M, Lichtenberger C, Kircheis R, Lucas T, Willheim M, Reinisch W, Gangl A, Wagner E, Jansen B. Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology (Baltimore, Md.), 2002, 36(5): 1106-1114.
77. Elfinger M, Pfeifer C, Uezguen S, Golas M M, Sander B, Maucksch C, Stark H, Aneja M K, Rudolph C. Self-assembly of ternary insulin-polyethylenimine (PEI)-DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells. Biomacromolecules, 2009, 10(10): 2912-2920.
78. Furgeson D Y, Chan W S, Yockman J W, Kim S W. Modified linear polyethylenimine-cholesterol conjugates for DNA complexation. Bioconjugate Chemistry, 2003, 14(4): 840-847.
79. Thomas M, Kularatne S A, Qi L, Kleindl P, Leamon C P, Hansen M J, Low P S. Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues. Annals of the New York Academy of Sciences, 2009, 1175(1): 32-39.
80. Xia W, Low P S. Folate-targeted therapies for cancer. Journal of Medicinal Chemistry, 2010, 53(19): 6811-6824.
81. Wang S, Lee R J, Cauchon G, Gorenstein D G, Low P S. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci USA, 1995, 92(0027-8424): 3318-3322.
82. Kularatne S A, Low P S. Targeting of nanoparticles: folate receptor. Methods in Molecular Biology (Clifton, N. J.), 2010, 624: 249-265.
83. Zhang K, Wang Q, Xie Y, Mor G, Sega E, Low P S, Huang Y. Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions. RNA (New York), 2008, 14(3): 577-583.
84. Elfinger M, Geiger J, Hasenpusch G, Uzgün S, Sieverling N, Aneja M K, Maucksch C, Rudolph C. Targeting of the beta(2)-adrenoceptor increases nonviral gene delivery to pulmonary epithelial cells in vitro and lungs in vivo. Journal of Controlled Release, 2009, 135(3): 234-241.
85. Geiger J, Aneja M K, Hasenpusch G, Yüksekdag G, Kummerlöwe G, Luy B, Romer T, Rothbauer U, Rudolph C. Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues. Biomaterials, 2010, 31(10): 2903-2911.
86. Li S D, Chen Y C, Hackett M J, Huang L. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Molecular Therapy, 2008, 16(1): 163-169.
87. Li S D, Huang L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Molecular Pharmaceutics, 2006, 3(5): 579-588.
88. Oishi M, Kataoka K, Nagasaki Y. pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector. Bioconjugate Chemistry, 2006, 17(3): 677-688.
89. Oishi M, Nagatsugi F, Sasaki S, Nagasaki Y, Kataoka K. Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages. ChemBioChem, 2005, 6(4): 718-725.
90. Zauner W, Ogris M, Wagner E. Polylysine-based transfection systems utilizing receptor-mediated delivery. Advanced Drug Delivery Reviews, 1998, 30(1-3): 97-113.
91. Oba M, Fukushima S, Kanayama N, Aoyagi K, Nishiyama N, Koyama H, Kataoka K. Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins. Bioconjugate Chemistry, 2007, 18(5): 1415-1423.
92. Taratula O, Garbuzenko O B, Kirkpatrick P, Pandya I, Savla R, Pozharov V P, He H, Minko T. Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. Journal of Controlled Release, 2009, 140(3): 284-293.
93. Han L, Huang R, Li J, Liu S, Huang S, Jiang C. Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer. Biomaterials, 2011, 32(4): 1242-1252.
94. Klutz K, Schaffert D, Willhauck M J, Grünwald G K, Haase R, Wunderlich N, Zach C, Gildehaus F J, Senekowitsch-Schmidtke R, Göke B, Wagner E, Ogris M, Spitzweg C. Epidermal growth factor receptor-targeted (131)I-therapy of liver cancer following systemic delivery of the sodium iodide symporter gene. Molecular Therapy, 2011, 19(4): 676-685.
95. Herbst R S. Review of epidermal growth factor receptor biology. International Journal of Radiation Oncology, Biology, Physics, 2004, 59(2, Suppl): S21-S26.
96. Li Z, Zhao R, Wu X, Sun Y, Yao M, Li J, Xu Y, Gu J. Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics. The FASEB Journal, 2005, 19(14): 1978-1985.
97. Leamon C P, Low P S. Folate-mediated targeting: from diagnostics to drug and gene delivery. Drug Discovery Today, 2001, 6(1): 44-51.
98. Ross J F, Chaudhuri P K, Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer, 1994, 73(9): 2432-2443.
99. Hwa Kim S, Hoon Jeong J, Chul Cho K, Wan Kim S, Gwan Park T. Target-specific gene silencing by siRNA plasmid DNA complexed with folate-modified poly(ethylenimine). Journal of Controlled Release, 2005, 104(1): 223-232.
100. Bellocq N C, Pun S H, Jensen G S, Davis M E. Transferrin-containing, cyclodextrin polymer-based particles for tumortargeted gene delivery. Bioconjugate Chemistry, 2003, 14(6): 1122-1132.
101. Thorstensen K, Romslo I. The transferrin receptor: its diagnostic value and its potential as therapeutic target. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, 1993, 53(s215): 113-120.
102. Gatter K C, Brown G, Trowbridge I S, Woolston R E, Mason D Y. Transferrin receptors in human tissues: their distribution and possible clinical relevance. Journal of Clinical Pathology, 1983, 36(5): 539-545.
103. Davis M E, Zuckerman J E, Choi C H, Seligson D, Tolcher A, Alabi C A, Yen Y, Heidel J D, Ribas A. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature, 2010, 464(7291): 1067-1070.
104. Davis M E. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Molecular Pharmaceutics, 2009, 6(3): 659-668.
105. Quan C Y, Chang C, Wei H, Chen C S, Xu X D, Cheng S X, Zhang X Z, Zhuo R X. Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide for effective cell uptake and drug release. Nanotechnology, 2009, 20(33): 335101.
106. Kakimoto S, Moriyama T, Tanabe T, Shinkai S, Nagasaki T. Dualligand effect of transferrin and transforming growth factor alpha on polyethyleneimine-mediated gene delivery. Journal of Controlled Release, 2007, 120(3): 242-249.
107. Wagner E, Cotten M, Foisner R, Birnstiel M L. Transferrinpolycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88(10): 4255-4259.
108. Han L, Huang R, Liu S, Huang S, Jiang C. Peptide-conjugated PAMAM for targeted doxorubicin delivery to transferrin receptor overexpressed tumors. Molecular Pharmaceutics, 2010, 7(6): 2156-2165.
109. Xia H, Anderson B, Mao Q, Davidson B L. Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium. Journal of Virology, 2000, 74(23): 11359-11366.
110. Li D, Tang G P, Li J Z, Kong Y, Huang H L, Min L J, Zhou J, Shen F P, Wang Q Q, Yu H. Dual-targeting non-viral vector based on polyethylenimine improves gene transfer efficiency. Journal of Biomaterials Science. Polymer Edition, 2007, 18(5): 545-560.
111. Suh W, Han S O, Yu L, Kim SW. An angiogenic, endothelial-cell-targeted polymeric gene carrier. Molecular Therapy, 2002, 6(5): 664-672.
112. Bai M, Campisi L, Freimuth P. Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2. Journal of Virology, 1994, 68(9): 5925-5932.
113. Nie Y, Schaffert D, Rödl W, Ogris M, Wagner E, Günther M. Dualtargeted polyplexes: One step towards a synthetic virus for cancer gene therapy. Journal of Controlled Release, 2011, DOI: 10. 1016/j. jconrel. 2011. 02. 028.
114. Wagner E. Effects of membrane-active agents in gene delivery. Journal of Controlled Release, 1998, 53(1-3): 155-158.
115. Curiel D T, Agarwal S, Wagner E, Cotten M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88(19): 8850-8854.
116. Meyer M, Philipp A, Oskuee R, Schmidt C, Wagner E. Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery. Journal of the American Chemical Society, 2008, 130(11): 3272-3273.
117. Meyer M, Zintchenko A, Ogris M, Wagner E. A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential. The Journal of Gene Medicine, 2007, 9(9): 797-805.
118. Wagner E, Plank C, Zatloukal K, Cotten M, Birnstiel M L. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89(17): 7934-7938.
119. Plank C, Zatloukal K, Cotten M, Mechtler K, Wagner E. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetraantennary galactose ligand. Bioconjugate Chemistry, 1992, 3(6): 533-539.
120. Roy R, Jerry D J, Thayumanavan S. Virus-inspired approach to nonviral gene delivery vehicles. Biomacromolecules, 2009, 10(8): 2189-2193.
121. Wang H, Liu K, Chen K J, Lu Y, Wang S, Lin WY, Guo F, Kamei K, Chen Y C, Ohashi M, Wang M, Garcia M A, Zhao X Z, Shen C K, Tseng H R. A rapid pathway toward a superb gene delivery system: programming structural and functional diversity into a supramolecular nanoparticle library. ACS Nano, 2010, 4(10): 6235-6243.
122. Kleemann E, Neu M, Jekel N, Fink L, Schmehl T, Gessler T, Seeger W, Kissel T. Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. Journal of Controlled Release, 2005, 109(1-3): 299-316.
123. Pun S H, Bellocq N C, Liu A, Jensen G, Machemer T, Quijano E, Schluep T, Wen S, Engler H, Heidel J, Davis M E. Cyclodextrinmodified polyethylenimine polymers for gene delivery. Bioconjugate Chemistry, 2004, 15(4): 831-840.
124. Sletten E M, Bertozzi C R. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angewandte Chemie (International ed. in English), 2009, 48(38): 6974-6998.
125. Navath R S, Menjoge A R, Wang B, Romero R, Kannan S, Kannan R M. Amino acid-functionalized dendrimers with heterobifunctional chemoselective peripheral groups for drug delivery applications. Biomacromolecules, 2010, 11(6): 1544-1563.