Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions

RNA

Volumn 14, Issue 3, 2008, Pages 577-583

  Zhang, Kexiong ^a   Wang, Qiaoqiao ^a   Xie, Yanhua ^a   Mor, Gil ^a   Sega, Emanuela ^b   Low, Philip S ^b   Huang, Yingqun ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Folate receptor; Gene therapy; siRNA delivery

Indexed keywords

CELL SURFACE RECEPTOR; FOLATE RECEPTOR; NUCLEIC ACID BASE; OLIGODEOXYNUCLEOTIDE; SMALL INTERFERING RNA; BIRC5 PROTEIN, HUMAN; CARRIER PROTEIN; CD51 ANTIGEN; FOLATE BINDING PROTEIN; FOLATE-BINDING PROTEIN; LIGAND; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; NUCLEIC ACID; OLIGODEOXYRIBONUCLEOTIDE; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; DRUG UPTAKE; GENE DELIVERY SYSTEM; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; RNA INTERFERENCE; CELL LINE; CHEMISTRY; GENE THERAPY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE PAIRING; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; GENE SILENCING; GENE THERAPY; HUMANS; INTEGRIN ALPHAV; LIGANDS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NUCLEIC ACIDS; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, CELL SURFACE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 40449099069     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.739308     Document Type: Article

References (19)

1. Aronov, O., Horowitz, A.T., Gabizon, A., and Gibson, D. 2003. Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies. Bioconjug. Chem. 14: 563-574.
2. Cao, Q., Cai, W., Li, T., Yang, Y., Chen, K., Xing, L., and Chen, X. 2006. Combination of integrin siRNA and irradiation for breast cancer therapy. Biochem. Biophys. Res. Commun. 351: 726-732.
3. Chu, T.C., Twu, K.Y., Ellington, A.D., and Levy, M. 2006. Aptamer mediated siRNA delivery. Nucleic Acids Res. 34: 71-76. doi: 10.1093/nar/gkl388.
4. Guo, S., Huang, F., and Guo, P. 2006. Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells. Gene Ther. 13: 814-820.
5. Hu-Lieskovan, S., Heidel, J.D., Bartlett, D.W., Davis, M.E., and Triche, T.J. 2005. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 65: 8984-8992.
6. Kariko, K., Bhuyan, P., Capodici, J., and Weissman, D. 2004. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 172: 6545-6549.
7. Kumar, C.C. 2003. Integrin avb3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr. Drug Targets 4: 123-131.
8. Leamon, C.P. and Low, P.S. 2001. Folate-mediated targeting: From diagnostics to drug and gene delivery. Drug Discov. Today 6: 44-51.
9. McNamara II., J.O., Andrechek, E.R., Wang, Y., Viles, K.D., Rempel, R.E., Gilboa, E., Sullenger, B.A., and Giangrande, P.H. 2006. Cell-type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol. 24: 1005-1015.
10. Parker, N., Turk, M.J., Westrick, E., Lewis, J.D., Low, P.S., and Leamon, C.P. 2005. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal. Biochem. 338: 284-293.
11. Paulos, C.M., Varghese, B., Widmer, W.R., Breur, G.J., Vlashi, E., and Low, P.S. 2006. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res. Ther. 8: R77. doi: 10.1186/ar1944.
12. Qiao, R., Yan, W., Lum, H., and Malek, A.B. 1995. Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: Comparison with thrombin response. Am. J. Physiol. 269: 110-117.
13. Schiffelers, R.M., Ansari, A., Xu, J., Zhou, Q., Tang, Q., Storm, G., Molema, G., Lu, P.Y., Scaria, P.V., and Woodle, M.C. 2004. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 32: 141-110. doi: 10.1093/nar/gnh140.
14. Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H., and Williams, B.R. 2003. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5: 834-839.
15. Song, E., Zhu, P., Lee, S.-K., Chowdhury, D., Kussman, S., Dykxhoorn, D.M., Feng, Y., Palliser, D., Weiner, D.B., Shankar, P., et al. 2005. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23: 709-717.
16. Temming, K., Schiffelers, R.M., Molema, G., and Kok, R.J. 2005. RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumor vasculature. Drug Resist. Updat. 8: 381-402.
17. Turk, M.J., Waters, D.J., and Low, P.S. 2004. Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinoma. Cancer Lett. 213: 165-172.
18. Weikert, S., Schrader, M., Krause, H., Schulze, W., Muller, M., and Miller, K. 2005. The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes. Cancer Lett. 223: 331-337.
19. Yang, J., Chen, H., Vlahov, I.R., Cheng, J.-X., and Low, P.S. 2006. Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging. Proc. Natl. Acad. Sci. 103: 13872-13877.