Folate-mediated targeting: From diagnostics to drug and gene delivery

Drug Discovery Today

Volumn 6, Issue 1, 2001, Pages 44-51

  Leamon, Christopher P ^a   Low, Philip S ^b  

^a Endocyte Inc   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; DEFEROXAMINE; FOLIC ACID; FOLIC ACID DERIVATIVE; GALLIUM 67; IODINE 125; LIPOSOME; OLIGONUCLEOTIDE; PENTETATE INDIUM IN 111; RADIOISOTOPE; RECEPTOR; TECHNETIUM 99M;

CANCER; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONJUGATE; DRUG TARGETING; GENE TARGETING; GENE THERAPY; HUMAN; RADIODIAGNOSIS; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 0035135353     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01594-4     Document Type: Review

References (80)

1. The biological chemistry of folate receptors
2. Receptor-mediated folate accumulation is regulated by the cellular folate content
3. Folate receptors
4. Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development
5. Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein
6. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues
7. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines
8. Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis
9. The folate receptor in central nervous system malignancies of childhood
10. Patterns of antigen distribution in human carcinomas
11. Trophoblast and ovarian cancer antigen LK26
12. Overexpression of folate binding protein in ovarian cancers
13. High-affinity folate binding in human choroid plexus
14. Measurement of endosome pH following folate receptor-mediated endocytosis
15. Potocytosis: sequestration and transport of small molecules by caveolae
16. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells
17. Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis
18. 67Ga-deferoxamine-folate, a potential radiopharmaceutical for tumor imaging
19. Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of Gallium-67-deferoxamine-folate
20. Indium-111-DTPA-folate as a potential folate-receptor-targeted radiopharmaceutical
21. 99mTc-ethylenedicysteine-folate: a new tumor imaging agent. Synthesis, labeling and evaluation in animals
22. 99mTc-HYNIC-folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging
23. 99mTc-OXA-folate show uptake of both isomers in folate-receptor (+) KB cell lines
24. Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor
25. Folate-maytansinoids: target-selective drugs of low molecular weight
26. Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells
27. Targeted delivery of antisense oligodeoxynucleotides by LPDII
28. Targeted delivery of antisense oligodeoxynucleotides formulated in a novel lipidic vector
29. Folate-mediated targeting of antisense oligonucleotides to ovarian cancer cells
30. Multi-unit ribozyme-mediated cleavage of bcr-abl mRNA in myeloid leukemias
31. Folic acid targeting of protein conjugates into ascites tumor cells from ovarian cancer patients
32. Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug
33. Cytotoxicity of momordin - folate conjugates in cultured human cells
34. Cytotoxicity of folate-pseudomonas exotoxin conjugates toward tumor cells
35. Selective targeting of malignant cells with cytotoxin-folate conjugates
36. Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis
37. Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells
38. Targeting tumor cells with bispecific antibodies and T cells
39. Bispecific agents target endogenous murine T cells against human tumor xenografts
40. Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis
41. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro
42. Peptide-mediated release of folate-targeted liposome contents from endosomal compartments
43. Diplasmenylcholine-folate liposomes: An efficient vehicle for intracellular drug delivery
44. Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: in vitro studies
45. Folate receptor-mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression
46. Transfection of folate-polylysine DNA complexes: evidence for lysosomal delivery
47. Targeted gene delivery by tropism-modified adenoviral vectors
48. Folate copolymer-mediated transfection of cultured cells
49. Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy
50. Enhanced folate receptor-mediated gene therapy using a novel pH-sensitive lipid formulation
51. Somatostatin receptor imaging of neuroendocrine tumors with indium-111 pentetreotide (Octreoscan)
52. Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors
53. 131I-labelled chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot study
54. Immunoscintigraphy with three-step monoclonal pretargeting technique in diagnosis of uveal melanoma: preliminary results
55. A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples
56. In vivo tumor targeting of a recombinant single-chain antigen-binding protein
57. Imaging of folate receptors with I-125-labeled folate using a small animal imaging system built with plastic scintillating optical fibers
58. 111In]In-DTPA-Folate, a folate-receptor-targeted radiopharmaceutical
59. Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli
60. Folate-mediated drug delivery: effect of alternative conjugation chemistry
61. Folate-mediated targeting of therapeutic and imaging agents to cancers
62. Folate-targeted non-viral DNA vectors for cancer gene therapy
63. Cationic liposome-mediated transfection
64. Efficient lipid-mediated transfection of DNA into primary rat hepatocytes
65. Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity
66. Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes
67. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
68. DNA condensation by protamine and arginine-rich peptides: analysis of toroid stability using single DNA molecules
69. Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes
70. Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration
71. Systemic p53 gene therapy in combination with radiation results in human tumor regression
72. In vivo fate of folate-BSA in non-tumor- and tumor-bearing mice
73. Dosimetric analysis of chimeric monoclonal antibody cMOv18 IgG in ovarian carcinoma patients after intraperitoneal and intravenous administration
74. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
75. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule
76. Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule
77. Biophysical basis of glomerular permselectivity
78. Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression
79. Development of a specific radioimmunoassay for the placental folate receptor and related high-affinity folate binding proteins in human tissues