Targeting of the β2-adrenoceptor increases nonviral gene delivery to pulmonary epithelial cells in vitro and lungs in vivo

Journal of Controlled Release

Volumn 135, Issue 3, 2009, Pages 234-241

  Elfinger, Markus ^a,b   Geiger, Johannes ^a,b   Hasenpusch, Günther ^a   Üzgün, Senta ^a,b   Sieverling, Nathalie ^c   Aneja, Manish K ^a   Maucksch, Christof ^a,b   Rudolph, Carsten ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c FRAUNHOFER INSTITUTE FOR APPLIED POLYMER RESEARCH   (Germany)

Author keywords

2 adrenoceptor; Aerosol; Clenbuterol; Gene delivery; Lung; Polyethylenimine

Indexed keywords

AEROSOL DELIVERIES; ALVEOLAR EPITHELIAL CELLS; BOVINE SERUM ALBUMINS; CELLULAR UPTAKES; CLENBUTEROL; EPITHELIAL CELLS; GENE DELIVERY; GENE VECTORS; IN-VITRO; IN-VIVO; LUNG; MOLAR RATIOS; NON-VIRAL; NON-VIRAL GENE DELIVERIES; POLYETHYLENIMINE; TRANSFECTION EFFICIENCIES; TRANSFER EFFICIENCIES;

ATMOSPHERIC AEROSOLS; BIOLOGICAL ORGANS; BODY FLUIDS; CELLS; GENE EXPRESSION; LIGANDS; NUCLEIC ACIDS; VECTORS; ZETA POTENTIAL;

GENE TRANSFER;

BETA 2 ADRENERGIC RECEPTOR; BOVINE SERUM ALBUMIN; CLENBUTEROL; FLUORESCEIN; POLYETHYLENEIMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BRONCHUS MUCOSA; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; DRUG UPTAKE; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE TRANSFER; GENE VECTOR; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN TARGETING; ZETA POTENTIAL;

ANIMALS; CELL LINE; CELL LINE, TUMOR; EPITHELIAL CELLS; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; LUNG; MICE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 63649115668     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.01.012     Document Type: Article

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