메뉴 건너뛰기




Volumn 13, Issue 6, 2006, Pages 399-409

Pharmacokinetic consequences of pegylation

Author keywords

PEG; Pegylated Drugs; Pegylation; Pharmacokinetic; Systemic Drug Delivery

Indexed keywords

ACUMEN; ALPHA INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; ASPARAGINASE; ASPARAGINASE MACROGOL; BOVINE SERUM ALBUMIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DOXORUBICIN; DRUG CARRIER; INTERLEUKIN 16; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8 ANTIBODY; LACTOFERRIN; LIPOSOME; MACROGOL; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; METHOTREXATE; NANOPARTICLE; OLIGODEOXYNUCLEOTIDE; PACLITAXEL; PEGADEMASE; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PEGVISOMANT; POLYGLACTIN; POLYLACTIDE; PROTHECAN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STREPTOKINASE; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33749121585     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540600814402     Document Type: Review
Times cited : (245)

References (147)
  • 1
    • 0021248339 scopus 로고
    • Cancer therapy with chemically modified enzymes. I. Antitumor properties of poly ethylene glycol-asparaginase
    • Abuchowski, A., Kazo, G. M., Verhoest, C. R., et al. 1984. Cancer therapy with chemically modified enzymes. I. Antitumor properties of poly ethylene glycol-asparaginase. Cancer Biochem. Biophys. 7:175-186.
    • (1984) Cancer Biochem. Biophys. , vol.7 , pp. 175-186
    • Abuchowski, A.1    Kazo, G.M.2    Verhoest, C.R.3
  • 2
    • 0033214796 scopus 로고    scopus 로고
    • Combination therapy with methotrexate, vincristin, polyethylene glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia
    • Aguayo, A., Cortes, J., Thomas, D., et al. 1999. Combination therapy with methotrexate, vincristin, polyethylene glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia. Cancer 86:1202-1209.
    • (1999) Cancer , vol.86 , pp. 1202-1209
    • Aguayo, A.1    Cortes, J.2    Thomas, D.3
  • 3
    • 0030696871 scopus 로고    scopus 로고
    • Safety aspects of pegylated liposomal doxorubicin in patients with cancer
    • Alberts, D. S., and Garcia, D. J. 1997. Safety aspects of pegylated liposomal doxorubicin in patients with cancer. Drugs 54:30-35.
    • (1997) Drugs , vol.54 , pp. 30-35
    • Alberts, D.S.1    Garcia, D.J.2
  • 4
    • 0001299981 scopus 로고    scopus 로고
    • A branched methoxy 40 kDa poly ethylene glycol (PEG) moiety optimizes the pharmacokinetics (PK) of PEG-interferon α 2a (PEG-IFN) and may explain its enhanced efficacy in chronic hepatitis C (CHC)
    • Algranati, N. E., Sy, S., and Modi, M. 1999. A branched methoxy 40 kDa poly ethylene glycol (PEG) moiety optimizes the pharmacokinetics (PK) of PEG-interferon α 2a (PEG-IFN) and may explain its enhanced efficacy in chronic hepatitis C (CHC). Hepatology 40 (suppl.):190A.
    • (1999) Hepatology , vol.40 , Issue.SUPPL.
    • Algranati, N.E.1    Sy, S.2    Modi, M.3
  • 5
    • 0031281885 scopus 로고    scopus 로고
    • Kinetics of blood component adsorption on poly(D,L-lactic acid) nanoparticles: Evidence of complement C3 component involvement
    • Allemann, E., Gravel, P., Leroux, J. C., et al. 1997. Kinetics of blood component adsorption on poly(D,L-lactic acid) nanoparticles: evidence of complement C3 component involvement. J. Biomed. Mater. Res. 37:229-234.
    • (1997) J. Biomed. Mater. Res. , vol.37 , pp. 229-234
    • Allemann, E.1    Gravel, P.2    Leroux, J.C.3
  • 7
    • 0035086519 scopus 로고    scopus 로고
    • Rationale design of a potent, long lasting form of interferon: A 40 kDa branched poly ethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C
    • Bailon, P., Palleroni, A., Schaffer, C. A., et al. 2001. Rationale design of a potent, long lasting form of interferon: A 40 kDa branched poly ethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C. Bioconjug. Chem. 12:195-202
    • (2001) Bioconjug. Chem. , vol.12 , pp. 195-202
    • Bailon, P.1    Palleroni, A.2    Schaffer, C.A.3
  • 8
    • 0035991963 scopus 로고    scopus 로고
    • Ciprofloxacin in polyethylene glycol-coated liposomes: Efficacy in rat models of acute or chronic Pseudomonas aerations infection
    • Bakker-Woudenberg, I. A. J. M., Kate, M. T. T., Guo, L., et al. 2002. Ciprofloxacin in polyethylene glycol-coated liposomes: efficacy in rat models of acute or chronic Pseudomonas aerations infection. Antimicrob. Agents Chemother. 46:2575-2581.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2575-2581
    • Bakker-Woudenberg, I.A.J.M.1    Kate, M.T.T.2    Guo, L.3
  • 9
    • 0027070540 scopus 로고
    • Body distribution of fully biodegradable [14 C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats
    • Bazile, D. V., Ropert, C., Huve, P. V., et al. 1992. Body distribution of fully biodegradable [14 C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats. Biomaterials 13:1093-1102.
    • (1992) Biomaterials , vol.13 , pp. 1093-1102
    • Bazile, D.V.1    Ropert, C.2    Huve, P.V.3
  • 10
    • 0028916155 scopus 로고
    • Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system
    • Bazile, D., Prud'homme, C., Bassoullet, M. T., et al. 1995. Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system. J. Pharm. Sci. 84:493-498.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 493-498
    • Bazile, D.1    Prud'homme, C.2    Bassoullet, M.T.3
  • 11
    • 0020607315 scopus 로고
    • A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alfa 2-macroglobulin
    • Beauchamp, C. O., Gonias, S. L., Menapace, D. P., et al. 1983. A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alfa 2-macroglobulin. Anal. Biochem. 131:25-33.
    • (1983) Anal. Biochem. , vol.131 , pp. 25-33
    • Beauchamp, C.O.1    Gonias, S.L.2    Menapace, D.P.3
  • 13
    • 0031281253 scopus 로고    scopus 로고
    • Synthesis and characterization of high molecular mass polyethylene glycol-conjugated oligonucleotides
    • Bonora, G. M., Ivanova, E., Zarytova, V., et al. 1997. Synthesis and characterization of high molecular mass polyethylene glycol-conjugated oligonucleotides. Bioconjugate Chem. 8:793-797.
    • (1997) Bioconjugate Chem. , vol.8 , pp. 793-797
    • Bonora, G.M.1    Ivanova, E.2    Zarytova, V.3
  • 14
    • 0004154522 scopus 로고    scopus 로고
    • Brenner, B., and Rector Jr., F. (eds.) Philadelphia: W.B. Saunders Company
    • th ed. Philadelphia: W.B. Saunders Company.
    • (1996) th Ed.
  • 15
    • 0035910880 scopus 로고    scopus 로고
    • Tamoxifen encapsulation within polyethylene glycol-coated nanospheres. A new antiestrogen formulation
    • Brigger, I., Chaminade, P., Marsaud, V., et al. 2001. Tamoxifen encapsulation within polyethylene glycol-coated nanospheres. A new antiestrogen formulation Int. J. Pharm. 214:37-42.
    • (2001) Int. J. Pharm. , vol.214 , pp. 37-42
    • Brigger, I.1    Chaminade, P.2    Marsaud, V.3
  • 16
    • 0031921570 scopus 로고    scopus 로고
    • Surface-modified amikacin liposomes: Organ distribution and interaction with plasma proteins
    • Bucke, W. E., Leitzke, S., Diederichs, J. E., et al. 1998. Surface-modified amikacin liposomes: organ distribution and interaction with plasma proteins. J. Drug Target. 5:99-108.
    • (1998) J. Drug Target. , vol.5 , pp. 99-108
    • Bucke, W.E.1    Leitzke, S.2    Diederichs, J.E.3
  • 17
    • 0037099637 scopus 로고    scopus 로고
    • Treating cancer with PEG Intron: Pharmacokinetic profile and dosing guidelines for an improved interferon-alpha-2b formulation
    • Bukowski, R. M., Tendler, C., Cutler, D., et al. 2002. Treating cancer with PEG Intron: pharmacokinetic profile and dosing guidelines for an improved interferon-alpha-2b formulation. Cancer 95:389-396.
    • (2002) Cancer , vol.95 , pp. 389-396
    • Bukowski, R.M.1    Tendler, C.2    Cutler, D.3
  • 18
    • 0029783864 scopus 로고    scopus 로고
    • Characterization of poly (ethylene glycol) -modified super oxide dismutase: Comparison of capillary electrophoresis and matrix assisted laser desorption /ionization mass spectroscopy
    • Bullock, J., Chowdhury, S., and Johnston, D. 1996. Characterization of poly (ethylene glycol) -modified super oxide dismutase: comparison of capillary electrophoresis and matrix assisted laser desorption /ionization mass spectroscopy. Anal. Chem. 68:3258-3264.
    • (1996) Anal. Chem. , vol.68 , pp. 3258-3264
    • Bullock, J.1    Chowdhury, S.2    Johnston, D.3
  • 19
    • 0031787927 scopus 로고    scopus 로고
    • Branched polyethylene glycol(bPEG) conjugated antisense oligonucleotides
    • Burcovich, B., Verones, F. M., Zarytova, V., and Bonora, G. M. 1998. Branched polyethylene glycol(bPEG) conjugated antisense oligonucleotides. Nuleos. Nuleot. 17:1567-1570.
    • (1998) Nuleos. Nuleot. , vol.17 , pp. 1567-1570
    • Burcovich, B.1    Verones, F.M.2    Zarytova, V.3    Bonora, G.M.4
  • 20
    • 0027982957 scopus 로고
    • Polymers for delivering peptides and proteins
    • Burnham, N. L. 1994. Polymers for delivering peptides and proteins. Am. J. Hosp. Pharm. 51:210-218.
    • (1994) Am. J. Hosp. Pharm. , vol.51 , pp. 210-218
    • Burnham, N.L.1
  • 21
    • 0035975592 scopus 로고    scopus 로고
    • PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases
    • Calvo, P., Gouritin, B., Brigger, I., et al. 2001. PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases. J. Neuros. Methods 111:151-155.
    • (2001) J. Neuros. Methods , vol.111 , pp. 151-155
    • Calvo, P.1    Gouritin, B.2    Brigger, I.3
  • 22
    • 0034812929 scopus 로고    scopus 로고
    • Long circulating PEGylated polycyanoacrylate nanoparticles as new drug carriers for brain delivery
    • Calvo, P., Gouritin, B., Chacun, H., et al. 2001. Long circulating PEGylated polycyanoacrylate nanoparticles as new drug carriers for brain delivery. Pharm. Res. 18:1157-1166.
    • (2001) Pharm. Res. , vol.18 , pp. 1157-1166
    • Calvo, P.1    Gouritin, B.2    Chacun, H.3
  • 23
    • 0036273993 scopus 로고    scopus 로고
    • Delivery of LMW heparin via surface coated chitosan/peg-alginate microspheres prevents thrombosis
    • Chandy, T., Rao, G. H., Wilson, R. F., and Das, G. S. 2002. Delivery of LMW heparin via surface coated chitosan/peg-alginate microspheres prevents thrombosis. Drug Deliv. 9:87-96.
    • (2002) Drug Deliv. , vol.9 , pp. 87-96
    • Chandy, T.1    Rao, G.H.2    Wilson, R.F.3    Das, G.S.4
  • 24
    • 0032904403 scopus 로고    scopus 로고
    • A pharmacokinetic model for alpha interferon administered subcutaneously
    • Chatelut, E., Rostaing, L., Gregoire, N., et al. 1999. A pharmacokinetic model for alpha interferon administered subcutaneously. Br. J. Clin. Pharmacol. 47:365-371.
    • (1999) Br. J. Clin. Pharmacol. , vol.47 , pp. 365-371
    • Chatelut, E.1    Rostaing, L.2    Gregoire, N.3
  • 25
    • 0034023632 scopus 로고    scopus 로고
    • Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy
    • Cheng, T.-L., Chen, B.-M., Chern, J.-W., et al. 2000. Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy. Bioconjugate Chem. 11:258-266.
    • (2000) Bioconjugate Chem. , vol.11 , pp. 258-266
    • Cheng, T.-L.1    Chen, B.-M.2    Chern, J.-W.3
  • 26
    • 0036131650 scopus 로고    scopus 로고
    • The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides
    • Chirila, T. V., Rakoczy, P. E., Garrett, K. L., et al. 2002. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials 23:321-342.
    • (2002) Biomaterials , vol.23 , pp. 321-342
    • Chirila, T.V.1    Rakoczy, P.E.2    Garrett, K.L.3
  • 27
    • 0034633820 scopus 로고    scopus 로고
    • Polyethylene glycol-derivatized cysteine-substitution variants of recombinant staphylokinase for single bolus treatment of acute myocardial infarction
    • Collen, D., Sinnaeve, P., Demarsin, E., et al. 2000. Polyethylene glycol-derivatized cysteine-substitution variants of recombinant staphylokinase for single bolus treatment of acute myocardial infarction. Cancer 102:1766-1772.
    • (2000) Cancer , vol.102 , pp. 1766-1772
    • Collen, D.1    Sinnaeve, P.2    Demarsin, E.3
  • 28
    • 0031657330 scopus 로고    scopus 로고
    • Camptothecin delivery systems: Enhanced efficacy and tumor accumulation of camptothecin following its conjugation to polyethylene glycol via a glycine linker
    • Conover, C. D., Greenwald, R. B., Pendri, A., et al. 1998. Camptothecin delivery systems: enhanced efficacy and tumor accumulation of camptothecin following its conjugation to polyethylene glycol via a glycine linker. Cancer Chemother. Pharmacol. 42:407-414.
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , pp. 407-414
    • Conover, C.D.1    Greenwald, R.B.2    Pendri, A.3
  • 29
    • 0033512145 scopus 로고    scopus 로고
    • Camptothecin delivery systems: The utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol to create prodrugs
    • Conover, C. D., Greenwald, R. B., Pendri, A., and Shum, K. L. 1999. Camptothecin delivery systems: the utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol to create prodrugs. Anti-Cancer Drug Design 14:499-506.
    • (1999) Anti-Cancer Drug Design , vol.14 , pp. 499-506
    • Conover, C.D.1    Greenwald, R.B.2    Pendri, A.3    Shum, K.L.4
  • 30
    • 0030781081 scopus 로고    scopus 로고
    • Camptothecin delivery systems: The antitumor activity of a camptothecin 20-O-polyethylene glycol ester transport form
    • Conover, C. D., Pendri, A., Lee, C., et al. 1997. Camptothecin delivery systems: the antitumor activity of a camptothecin 20-O-polyethylene glycol ester transport form. Anti Cancer Res. 17:3361-3368.
    • (1997) Anti Cancer Res. , vol.17 , pp. 3361-3368
    • Conover, C.D.1    Pendri, A.2    Lee, C.3
  • 31
    • 3843088940 scopus 로고
    • Monoclonal antibodies for the targeting of drugs: Application to nanoparticles
    • eds. Breimer, D.D., and Speises, P. Amsterdam: Elsevier Sciences Publishers B.V.
    • Couvreur, P., and Aubry, J. 1983. Monoclonal antibodies for the targeting of drugs: application to nanoparticles. In Topics in Pharmaceutical Sciences, eds. Breimer, D.D., and Speises, P., p 305-316. Amsterdam: Elsevier Sciences Publishers B.V.
    • (1983) Topics in Pharmaceutical Sciences , pp. 305-316
    • Couvreur, P.1    Aubry, J.2
  • 32
    • 0001139005 scopus 로고
    • Enzyme-polyethylene glycol adducts: Modified enzymes with unique properties
    • Davis, F. F., Abuchowski, A., Van Es T., et al. 1978. Enzyme-polyethylene glycol adducts: modified enzymes with unique properties. Enzyme Eng. 4:169-173.
    • (1978) Enzyme Eng. , vol.4 , pp. 169-173
    • Davis, F.F.1    Abuchowski, A.2    Van Es, T.3
  • 33
    • 0035850257 scopus 로고    scopus 로고
    • Pegylation enhances protein stability during encapsulation in PLGA microspheres
    • Diwan, M., and Park, T. G. 2001. Pegylation enhances protein stability during encapsulation in PLGA microspheres. J. Control. Rel. 73:233-244.
    • (2001) J. Control. Rel. , vol.73 , pp. 233-244
    • Diwan, M.1    Park, T.G.2
  • 34
    • 0035845748 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-human serum albumin-paclitaxel conjugates: Preparation, characterization, and pharmacokinetics
    • Dosio, F., Arpicco, S., Brusa, P., et al. 2001. Poly(ethylene glycol)-human serum albumin-paclitaxel conjugates: preparation, characterization, and pharmacokinetics. J. Control. Rel. 46:107-117.
    • (2001) J. Control. Rel. , vol.46 , pp. 107-117
    • Dosio, F.1    Arpicco, S.2    Brusa, P.3
  • 35
    • 0032725837 scopus 로고    scopus 로고
    • Pegylated recombinant human soluble tumor necrosis factor receptor type (rHu-STNF-RI): A novel high affinity TNF receptor designed for chronic inflammatory disease
    • Edwards, C. K. 1999. Pegylated recombinant human soluble tumor necrosis factor receptor type (rHu-STNF-RI): a novel high affinity TNF receptor designed for chronic inflammatory disease. Ann. Rheum. Dis. 58:I73-I81.
    • (1999) Ann. Rheum. Dis. , vol.58
    • Edwards, C.K.1
  • 36
    • 0035205807 scopus 로고    scopus 로고
    • Pegylated cytokines-potential application in immunotherapy of cancer
    • Eliason, J. F. 2001. Pegylated cytokines-potential application in immunotherapy of cancer.Biodrugs 15:705-711.
    • (2001) Biodrugs , vol.15 , pp. 705-711
    • Eliason, J.F.1
  • 37
    • 0031010296 scopus 로고    scopus 로고
    • Pharmacodynamic and safety results of PEG-Hirudin in healthy volunteers
    • Esslinger, H. V., Haas, S., Maurer, R., et al. 1997. Pharmacodynamic and safety results of PEG-Hirudin in healthy volunteers. Thromb. Haemost. 77:911-919.
    • (1997) Thromb. Haemost. , vol.77 , pp. 911-919
    • Esslinger, H.V.1    Haas, S.2    Maurer, R.3
  • 38
    • 33749135071 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche, Ltd., data on file
    • F. Hoffmann-La Roche, Ltd., data on file.
  • 39
    • 0032126845 scopus 로고    scopus 로고
    • PEGylation of cytokines and other therapeutic proteins and peptides: The importance of biological optimization of coupling techniques
    • Francis, G. E., Fisher, D., Delgado, C., et al. 1998. PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimization of coupling techniques. Int. J. Hematol. 68:1-18.
    • (1998) Int. J. Hematol. , vol.68 , pp. 1-18
    • Francis, G.E.1    Fisher, D.2    Delgado, C.3
  • 40
    • 0035090503 scopus 로고    scopus 로고
    • Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir
    • Fresta, M., Fontana, G., Bucolo, C., et al. 2001. Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir. J. Pharm. Sci., 90:288-297.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 288-297
    • Fresta, M.1    Fontana, G.2    Bucolo, C.3
  • 41
    • 0028337529 scopus 로고
    • Control of in vivo fate of albumin derivatives utilizing combined chemical modification
    • Fujita, T., Nishikawa, M., Ohtsubo, Y., et al. 1994. Control of in vivo fate of albumin derivatives utilizing combined chemical modification. J. Drug Target. 2:157-165.
    • (1994) J. Drug Target. , vol.2 , pp. 157-165
    • Fujita, T.1    Nishikawa, M.2    Ohtsubo, Y.3
  • 42
    • 0030042023 scopus 로고    scopus 로고
    • Liposome longevity and stability in circulation: Effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines
    • Gabizon, A., Chemla, M., Tzemach, D., et al. 1996. Liposome longevity and stability in circulation: effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines J. Drug Target. 3:391-398.
    • (1996) J. Drug Target. , vol.3 , pp. 391-398
    • Gabizon, A.1    Chemla, M.2    Tzemach, D.3
  • 43
    • 0030669086 scopus 로고    scopus 로고
    • Polyethylene glycol-coated liposomal doxorubicin: Rationale for use in solid tumors
    • Gabizon, A., and Martin, F. 1997. Polyethylene glycol-coated liposomal doxorubicin: rationale for use in solid tumors. Drugs 54:15-21.
    • (1997) Drugs , vol.54 , pp. 15-21
    • Gabizon, A.1    Martin, F.2
  • 44
    • 0023630881 scopus 로고
    • The preparation and properties of novel reversible polymer-protein conjugates. 2-methoxy polyethylene (5000) glycoxymethylene-3-methylmaleyl conjugates of plasminogen activators
    • Garman, J., and Kalindjian, S. B. 1987. The preparation and properties of novel reversible polymer-protein conjugates. 2-methoxy polyethylene (5000) glycoxymethylene-3-methylmaleyl conjugates of plasminogen activators. FEBS Lett. 223-361.
    • (1987) FEBS Lett. , pp. 223-361
    • Garman, J.1    Kalindjian, S.B.2
  • 45
    • 0037132508 scopus 로고    scopus 로고
    • PEGylation of microspheres generates a heterogeneous population of particles with differential surface characteristics and biological performance
    • Gbadamosi, J. K., Hunter, A. C., and Moghimi, S. M. 2002. PEGylation of microspheres generates a heterogeneous population of particles with differential surface characteristics and biological performance. FEBS Lett 532:338-344.
    • (2002) FEBS Lett , vol.532 , pp. 338-344
    • Gbadamosi, J.K.1    Hunter, A.C.2    Moghimi, S.M.3
  • 46
    • 0345256596 scopus 로고    scopus 로고
    • Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers
    • Chognot, D., Six, J. L., Leonard, M., et al. 2003. Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers. J. Colloid Interface Sci. 268:441-447.
    • (2003) J. Colloid Interface Sci. , vol.268 , pp. 441-447
    • Chognot, D.1    Six, J.L.2    Leonard, M.3
  • 47
    • 4243339996 scopus 로고    scopus 로고
    • A dose ranging study of PEG-Intron and ribavirin in chronic hepatitis C-safety, efficacy, and virological rational
    • Glue, P., Fang, J., Sabo, R., et al. 1999a. A dose ranging study of PEG-Intron and ribavirin in chronic hepatitis C-safety, efficacy, and virological rational. Hepatology 30:303A.
    • (1999) Hepatology , vol.30
    • Glue, P.1    Fang, J.2    Sabo, R.3
  • 48
    • 0000553168 scopus 로고    scopus 로고
    • PEG-interferon-α 2b: Pharmacokinetics, pharmacodynamics, safety and preliminary efficacy data
    • Glue, P., Rouzier-panis, R., Raffanel, C., et al. 1999b. PEG-interferon-α 2b: pharmacokinetics, pharmacodynamics, safety and preliminary efficacy data. Hepatology 30:189AA.
    • (1999) Hepatology , vol.30
    • Glue, P.1    Rouzier-panis, R.2    Raffanel, C.3
  • 49
    • 18244377180 scopus 로고    scopus 로고
    • Structural and biologic characterization of pegylated recombinant IFN-α-2b
    • Grace, M., Youngster, S., Gitlin, G., et al. 2001. Structural and biologic characterization of pegylated recombinant IFN-α-2b. J. IFN Cytokine Res. 21:1103-1115.
    • (2001) J. IFN Cytokine Res. , vol.21 , pp. 1103-1115
    • Grace, M.1    Youngster, S.2    Gitlin, G.3
  • 50
    • 0028806691 scopus 로고
    • Highly water soluble taxol derivatives. 7-polyethylene glycol carbamates and carbonates
    • Greenwald, R. B., Pendri, A., and Bolikal, D. 1995. Highly water soluble taxol derivatives. 7-polyethylene glycol carbamates and carbonates. J. Org. Chem. 60:331-336.
    • (1995) J. Org. Chem. , vol.60 , pp. 331-336
    • Greenwald, R.B.1    Pendri, A.2    Bolikal, D.3
  • 51
    • 0030071043 scopus 로고    scopus 로고
    • Drug delivery systems: Water soluble taxol 2-poly (ethylene glycol) ester prodrugs-design and in vivo effectiveness
    • Greenwald, R. B., Gilbert, C. W., Pendri, A., et al. 1996a. Drug delivery systems: water soluble taxol 2-poly (ethylene glycol) ester prodrugs-design and in vivo effectiveness. J. Med. Chem. 39:424-431.
    • (1996) J. Med. Chem. , vol.39 , pp. 424-431
    • Greenwald, R.B.1    Gilbert, C.W.2    Pendri, A.3
  • 52
    • 0029948533 scopus 로고    scopus 로고
    • Drug delivery systems: 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms
    • Greenwald, R. B., Pendri, A., Conover, C., et al. 1996b. Drug delivery systems: 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms. J. Med. Chem. 39:1938-1940.
    • (1996) J. Med. Chem. , vol.39 , pp. 1938-1940
    • Greenwald, R.B.1    Pendri, A.2    Conover, C.3
  • 53
    • 0031747452 scopus 로고    scopus 로고
    • Camptothecin-20-PEG ester transport forms: The effect of space groups on antitumor activity
    • Greenwald, R. B., Pendri, A., Conover, C. V., et al. 1998. Camptothecin-20-PEG ester transport forms: the effect of space groups on antitumor activity. Bioorg. Med. Chem. 6:551-562.
    • (1998) Bioorg. Med. Chem. , vol.6 , pp. 551-562
    • Greenwald, R.B.1    Pendri, A.2    Conover, C.V.3
  • 54
    • 0032878627 scopus 로고    scopus 로고
    • Drug delivery of anticancer agents: Water soluble 4-poly(ethylene glycol) derivatives of the lignan, podophylotoxin
    • Greenwald, R. B., Conover, C. V., Pendri, A., et al. 1999. Drug delivery of anticancer agents: water soluble 4-poly(ethylene glycol) derivatives of the lignan, podophylotoxin. J. Control. Rel. 61:281-294.
    • (1999) J. Control. Rel. , vol.61 , pp. 281-294
    • Greenwald, R.B.1    Conover, C.V.2    Pendri, A.3
  • 55
    • 23444444512 scopus 로고
    • Biodegradable long-circulating polymeric nanospheres
    • Gref, R., Minamitake, Y., Peracchia, M. T., et al. 1994. Biodegradable long-circulating polymeric nanospheres. Science 263:1600-1603.
    • (1994) Science , vol.263 , pp. 1600-1603
    • Gref, R.1    Minamitake, Y.2    Peracchia, M.T.3
  • 56
    • 0029360414 scopus 로고
    • The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres
    • Gref, R., Domb, A., Quellec, P., et al. 1995. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv. Drug. Deliv. Rev. 16:215-233.
    • (1995) Adv. Drug. Deliv. Rev. , vol.16 , pp. 215-233
    • Gref, R.1    Domb, A.2    Quellec, P.3
  • 57
    • 0343191443 scopus 로고    scopus 로고
    • 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
    • Gref, R., Lück, M., Quellec, P., et al. 2000. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surfaces B: Biointerfaces 18:301-313.
    • (2000) Colloids Surfaces B: Biointerfaces , vol.18 , pp. 301-313
    • Gref, R.1    Lück, M.2    Quellec, P.3
  • 58
    • 18544362355 scopus 로고    scopus 로고
    • Single dose pharmacokinetics and safety of pegylated interferon alfa-2b in patients with chronic renal dysfunction
    • Gupta, S. K., Pittance, A. L., Swan, S. K., et al. 2002. Single dose pharmacokinetics and safety of pegylated interferon alfa-2b in patients with chronic renal dysfunction.J. Clin. Pharamacol. 42:1109-1115.
    • (2002) J. Clin. Pharamacol. , vol.42 , pp. 1109-1115
    • Gupta, S.K.1    Pittance, A.L.2    Swan, S.K.3
  • 59
    • 17844380498 scopus 로고    scopus 로고
    • Pegylation: A novel process for modifying pharmacokinetics
    • Harris, J. M., Martin, N. E., and Modi, M. 2001. Pegylation: a novel process for modifying pharmacokinetics. Clin. Pharmacokinet. 40:539-551.
    • (2001) Clin. Pharmacokinet. , vol.40 , pp. 539-551
    • Harris, J.M.1    Martin, N.E.2    Modi, M.3
  • 61
    • 0033580768 scopus 로고
    • Reducing the immunogenicity and improving the in vivo activity of trichosantin by site directed pegylation
    • He, X. H., Shaw, P. C., and Tam, S. C. 1995. Reducing the immunogenicity and improving the in vivo activity of trichosantin by site directed pegylation. Life Sci. 65:355-368.
    • (1995) Life Sci. , vol.65 , pp. 355-368
    • He, X.H.1    Shaw, P.C.2    Tam, S.C.3
  • 62
    • 0000030786 scopus 로고    scopus 로고
    • Multinational evaluation of the efficacy and safety of once weekly PEG-interferon α-2a (PEG-IFN) in patients with chronic hepatitis C (CHC) with compensation cirrhosis
    • Heathcof, E. J., Shiffman, M. L., Cooksley, G., et al. 1999. Multinational evaluation of the efficacy and safety of once weekly PEG-interferon α-2a (PEG-IFN) in patients with chronic hepatitis C (CHC) with compensation cirrhosis. Hepatology 30(suppl.):316A.
    • (1999) Hepatology , vol.30 , Issue.SUPPL.
    • Heathcof, E.J.1    Shiffman, M.L.2    Cooksley, G.3
  • 63
    • 0029081965 scopus 로고
    • PEG-ADA replacement therapy for adenosine deaminase deficiency: An update after 8.5 years
    • Hershfield, M. S. 1995. PEG-ADA replacement therapy for adenosine deaminase deficiency: an update after 8.5 years. Clin. Immunol. Immunopathol. 76:S228-S232.
    • (1995) Clin. Immunol. Immunopathol. , vol.76
    • Hershfield, M.S.1
  • 64
    • 0009971781 scopus 로고    scopus 로고
    • Biochemistry and poly (ethylene glycol)-modified adenosine deaminase (PEG-ADA)
    • eds. Harris, J.M., and Zolipsky, S., Washington, DC: ACS Books
    • Hershfield, M. S. 1997. Biochemistry and poly (ethylene glycol)-modified adenosine deaminase (PEG-ADA). In Poly (ethylene glycol): Chemistry and Biological Applications, eds. Harris, J.M., and Zolipsky, S., 134-144. Washington, DC: ACS Books.
    • (1997) Poly (Ethylene Glycol): Chemistry and Biological Applications , pp. 134-144
    • Hershfield, M.S.1
  • 65
    • 0025784230 scopus 로고
    • Use of site directed mutagenesis to enhance the epitope shielding effect of covalent modification of protein with poly ethylene glycol
    • Hershfield, M. S., Chaffee, S., Koro-jonson, L., et al. 1991. Use of site directed mutagenesis to enhance the epitope shielding effect of covalent modification of protein with poly ethylene glycol. Proc. Natl. Acad. Sci. USA 88:7185-7189.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7185-7189
    • Hershfield, M.S.1    Chaffee, S.2    Koro-jonson, L.3
  • 66
    • 0028803099 scopus 로고
    • Megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
    • Hokom, M. M., Lacey, D., Kinsler, O., et al. 1995. Megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486-4892.
    • (1995) Blood , vol.86 , pp. 4486-4892
    • Hokom, M.M.1    Lacey, D.2    Kinsler, O.3
  • 67
    • 0030973214 scopus 로고    scopus 로고
    • Pegaspargase: Alternative?
    • 655-656
    • Holle, L. M. 1997. Pegaspargase: alternative? Ann. Pharmacother. 31:616-624, 655-656.
    • (1997) Ann. Pharmacother. , vol.31 , pp. 616-624
    • Holle, L.M.1
  • 68
    • 0036467835 scopus 로고    scopus 로고
    • Blinded, randomized, multicentre study to evaluate single administration PEG filgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer
    • Holmes, F. A., O'Shaughnessy, J. A., Vukelja, S., et al. 2002. Blinded, randomized, multicentre study to evaluate single administration PEG filgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer. J. Clin. Oncol. 20:727-731.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 727-731
    • Holmes, F.A.1    O'Shaughnessy, J.A.2    Vukelja, S.3
  • 69
    • 0033944158 scopus 로고    scopus 로고
    • Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies
    • Hurwitz, E., Klapper, L. N., Wilchek, M. Y., et al. 2000. Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies. Cancer Immunol. Immunother. 49:226-234.
    • (2000) Cancer Immunol. Immunother. , vol.49 , pp. 226-234
    • Hurwitz, E.1    Klapper, L.N.2    Wilchek, M.Y.3
  • 70
    • 0021092177 scopus 로고
    • Adsorption of monoclonal antibodies to polyhexylcyanoacrylate nanoparticles and subsequent immunospecific binding to tumour cells in vitro
    • Illum, L., Jones, P. D. E., Kreuter, J., et al. 1983. Adsorption of monoclonal antibodies to polyhexylcyanoacrylate nanoparticles and subsequent immunospecific binding to tumour cells in vitro. Int. J. Pharm. 17:65-76.
    • (1983) Int. J. Pharm. , vol.17 , pp. 65-76
    • Illum, L.1    Jones, P.D.E.2    Kreuter, J.3
  • 71
    • 0021198790 scopus 로고
    • Tissue distribution of poly(hexyl 2-cyanoacrylate) nanoparticles coated with monoclonal antibodies in mice bearing human tumor xenografts
    • Illum, L., Jones, P. D., Baldwin, R. W., and Davis S. S. 1984. Tissue distribution of poly(hexyl 2-cyanoacrylate) nanoparticles coated with monoclonal antibodies in mice bearing human tumor xenografts. J. Pharmacol. Exp. Ther. 230:733-736.
    • (1984) J. Pharmacol. Exp. Ther. , vol.230 , pp. 733-736
    • Illum, L.1    Jones, P.D.2    Baldwin, R.W.3    Davis, S.S.4
  • 72
    • 0034955441 scopus 로고    scopus 로고
    • Development of systems for targeting the regional lymph nodes for diagnostic imaging
    • Illum, L., Church, A. E., Butterworth, M. D., et al. 2001. Development of systems for targeting the regional lymph nodes for diagnostic imaging. Pharm Res. 18:640-645.
    • (2001) Pharm Res. , vol.18 , pp. 640-645
    • Illum, L.1    Church, A.E.2    Butterworth, M.D.3
  • 73
    • 33749128113 scopus 로고    scopus 로고
    • New formulation of interferon in treatment of hepatitis: Peginterferon alfa-2b (pegintron)
    • 12-15,CP1
    • Imaz, I. A. 2002. New formulation of interferon in treatment of hepatitis: peginterferon alfa-2b (pegintron). Farm. Hosp. Spain 133:9-10, 12-15, CP1.
    • (2002) Farm. Hosp. Spain , vol.133 , pp. 9-10
    • Imaz, I.A.1
  • 74
    • 0034866792 scopus 로고    scopus 로고
    • Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors
    • Ishida, O., Maruyama, K., Tanahashi, H., et al. 2001. Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors. Pharm. Res. 18:1042-1048.
    • (2001) Pharm. Res. , vol.18 , pp. 1042-1048
    • Ishida, O.1    Maruyama, K.2    Tanahashi, H.3
  • 75
    • 0030801601 scopus 로고    scopus 로고
    • Oral delivery of insulin by using surface coating liposomes: Improvement of stability of insulin in GI tract
    • Iwanaga, K., Ono, S., Narioka, K., et al. 1997. Oral delivery of insulin by using surface coating liposomes: improvement of stability of insulin in GI tract. Int. J. Pharm. 157:73-80.
    • (1997) Int. J. Pharm. , vol.157 , pp. 73-80
    • Iwanaga, K.1    Ono, S.2    Narioka, K.3
  • 76
    • 0027998163 scopus 로고
    • Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates
    • Jaschke, A., Furste, J. P., Nordhoff, E., et al. 1994. Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates. Nuleic Acids Res. 22:4810-4817.
    • (1994) Nuleic Acids Res. , vol.22 , pp. 4810-4817
    • Jaschke, A.1    Furste, J.P.2    Nordhoff, E.3
  • 77
    • 0027390310 scopus 로고
    • Automated incorporation of polyethylene glycol into synthetic oligonuleotides
    • Jaschke, A., Furste, J. P., Cech, D., and Erdmann, V. A. 1993. Automated incorporation of polyethylene glycol into synthetic oligonuleotides. Tetrahedron Lett. 34:301-304.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 301-304
    • Jaschke, A.1    Furste, J.P.2    Cech, D.3    Erdmann, V.A.4
  • 78
    • 0027253357 scopus 로고
    • The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of proteins to enhancing their therapeutic potential
    • Katre, N. V. 1993. The conjugation of proteins with polyethylene glycol and other polymers: altering properties of proteins to enhancing their therapeutic potential. Adv. Drug Del. Rev. 10:91-114.
    • (1993) Adv. Drug Del. Rev. , vol.10 , pp. 91-114
    • Katre, N.V.1
  • 79
    • 0028949238 scopus 로고
    • Atachability, binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5′-terminal with poly(ethylene glycol)
    • Kawaguchi, T., Asakawa, H., Tashiro, T., et al. 1995. Atachability, binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5′-terminal with poly(ethylene glycol). Biol. Pharm. Bull. 18:474-576.
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 474-576
    • Kawaguchi, T.1    Asakawa, H.2    Tashiro, T.3
  • 80
    • 0036128917 scopus 로고    scopus 로고
    • Pegylated recombinant human epidermal growth factor (rhEGF) for sustained release from biodegradable PLGA microspheres
    • Kim, T. H., Lee, H. and Park, T. G. 2002. Pegylated recombinant human epidermal growth factor (rhEGF) for sustained release from biodegradable PLGA microspheres. Biomaterials 23:2311-2317.
    • (2002) Biomaterials , vol.23 , pp. 2311-2317
    • Kim, T.H.1    Lee, H.2    Park, T.G.3
  • 81
    • 0029759584 scopus 로고    scopus 로고
    • Characterization and stability of N- Terminally PEGylated rhG-CSF
    • Kinstler, O. B., Brems, D. N., Lauren, S. L., et al. 1996. Characterization and stability of N- terminally PEGylated rhG-CSF. Pharm. Res. 13:996-1002.
    • (1996) Pharm. Res. , vol.13 , pp. 996-1002
    • Kinstler, O.B.1    Brems, D.N.2    Lauren, S.L.3
  • 82
    • 0023683508 scopus 로고
    • Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
    • Knauf, M. J., Bell, D. P., Hirtzer, P., et al. 1988. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers. J. Biol. Chem. 263:15064-15070.
    • (1988) J. Biol. Chem. , vol.263 , pp. 15064-15070
    • Knauf, M.J.1    Bell, D.P.2    Hirtzer, P.3
  • 84
    • 0035858379 scopus 로고    scopus 로고
    • Improvements in protein PEGylation: Pegylated interferons for treatment of hepatitis C
    • Kozlowski, A., and Harris, J. M. 2001. Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C. J. Control. Rel. 72:217-224.
    • (2001) J. Control. Rel. , vol.72 , pp. 217-224
    • Kozlowski, A.1    Harris, J.M.2
  • 85
    • 0002042385 scopus 로고
    • Sorptive properties of antibodies onto cyanoacrylic nanoparticles
    • Kubiak, C., Manil, L., and Couvreur, P. 1988. Sorptive properties of antibodies onto cyanoacrylic nanoparticles. Int J Pharm 41:181-187.
    • (1988) Int J Pharm , vol.41 , pp. 181-187
    • Kubiak, C.1    Manil, L.2    Couvreur, P.3
  • 86
    • 0035839192 scopus 로고    scopus 로고
    • Microscopic localization of PEG-liposomes in a rat model of focal infection
    • Laverman, P., Dams, E. Th. M., Storm, G., et al. 2001. Microscopic localization of PEG-liposomes in a rat model of focal infection. J. Control. Rel. 75:347-355.
    • (2001) J. Control. Rel. , vol.75 , pp. 347-355
    • Laverman, P.1    Dams, E.Th.M.2    Storm, G.3
  • 87
    • 0000981509 scopus 로고    scopus 로고
    • Preparation and characterization of polyethylene-glycol-modified salmon calcitonins
    • Lee, K. C., Tak, K. K., Park, M. O., et al. 1999. Preparation and characterization of polyethylene-glycol-modified salmon calcitonins. Pharm. Dev. Tech. 4:269-275.
    • (1999) Pharm. Dev. Tech. , vol.4 , pp. 269-275
    • Lee, K.C.1    Tak, K.K.2    Park, M.O.3
  • 88
    • 0345504113 scopus 로고    scopus 로고
    • Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: A comparison of conjugation chemistries and compounds
    • Lee, L. S., Conover, C., Shi, C., et al. 1999. Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: a comparison of conjugation chemistries and compounds. Bioconjug. Chem. 10:973-981.
    • (1999) Bioconjug. Chem. , vol.10 , pp. 973-981
    • Lee, L.S.1    Conover, C.2    Shi, C.3
  • 89
    • 0037142255 scopus 로고    scopus 로고
    • Liposome clearance in mice: The effect of a separate and combined presence of surface charge and polymer coating
    • Levchenko, T. S., Rammohan, R., Lukyanov, A. N., et al. 2002. Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating. Int. J. Pharm. 240:95-102.
    • (2002) Int. J. Pharm. , vol.240 , pp. 95-102
    • Levchenko, T.S.1    Rammohan, R.2    Lukyanov, A.N.3
  • 90
    • 2942538210 scopus 로고    scopus 로고
    • Protein carboxyl amidation increases the potential extent of protein poly ethylene glycol conjugation
    • Li, S., Yang, Z., Sun, X., et al. 2004. Protein carboxyl amidation increases the potential extent of protein poly ethylene glycol conjugation. Anal. Biochem. 330:204-271.
    • (2004) Anal. Biochem. , vol.330 , pp. 204-271
    • Li, S.1    Yang, Z.2    Sun, X.3
  • 91
    • 0035795022 scopus 로고    scopus 로고
    • PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats
    • Li, Y., Pei, Y., Zhang, X., et al. 2001. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J. Control. Rel. 71:203-211.
    • (2001) J. Control. Rel. , vol.71 , pp. 203-211
    • Li, Y.1    Pei, Y.2    Zhang, X.3
  • 92
    • 0345862570 scopus 로고    scopus 로고
    • A clinical phase IB study of PEG-hemoglobin in patients receiving palliative fractioned radiation for solid tumors
    • Lusting, R., Byhardt, R., Diab, S., et al. 1999. A clinical phase IB study of PEG-hemoglobin in patients receiving palliative fractioned radiation for solid tumors. J. Clin. Oncol. 17:1750.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1750
    • Lusting, R.1    Byhardt, R.2    Diab, S.3
  • 93
    • 0022713439 scopus 로고
    • Isobutyl cyanoacrylate nanoparticles as a solid phase for an efficient immunoradiometric assay
    • Manil, L., Roblot-Treupel, L., and Couvreur P. 1986. Isobutyl cyanoacrylate nanoparticles as a solid phase for an efficient immunoradiometric assay. Biomaterials 7:212-216.
    • (1986) Biomaterials , vol.7 , pp. 212-216
    • Manil, L.1    Roblot-Treupel, L.2    Couvreur, P.3
  • 95
    • 0032824375 scopus 로고    scopus 로고
    • Possibility of active targeting to tumor tissues with liposomes
    • Maruyama, K., Ishida, O., Takizawa, T., and Moribe, K. 1999. Possibility of active targeting to tumor tissues with liposomes. Adv. Drug Deliv. Rev. 40:89-102
    • (1999) Adv. Drug Deliv. Rev. , vol.40 , pp. 89-102
    • Maruyama, K.1    Ishida, O.2    Takizawa, T.3    Moribe, K.4
  • 96
    • 0042831216 scopus 로고    scopus 로고
    • Therapeutic advantages of pegylation of interferon alpha in chronic hepatitis C
    • Medina, J., Garcia Buey, L., Moreno Monteagudo, J. A., et al. 2003. Therapeutic advantages of pegylation of interferon alpha in chronic hepatitis C. Rev. Esp. Enferm. Dig. 95:561-574.
    • (2003) Rev. Esp. Enferm. Dig. , vol.95 , pp. 561-574
    • Medina, J.1    Garcia Buey, L.2    Moreno Monteagudo, J.A.3
  • 97
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi, S. M., Hunter, A. C., and Murray, J. C. 2001. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53:283-318.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 98
    • 0037067136 scopus 로고    scopus 로고
    • Chemical camouflage of nanospheres with a poorly reactive surface: Towards development of stealth and target-specific nanocarriers
    • Moghimi, S. M. 2002. Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers. Biochim. Biophys. Acta. 1590:131-139.
    • (2002) Biochim. Biophys. Acta , vol.1590 , pp. 131-139
    • Moghimi, S.M.1
  • 99
    • 0038243775 scopus 로고    scopus 로고
    • Pegfilgrastim: Using pegylation technology to improve neutropenia support in cancer patients
    • Molineux, G. 2003. Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients. Anticancer Drugs 14:259-264.
    • (2003) Anticancer Drugs , vol.14 , pp. 259-264
    • Molineux, G.1
  • 100
    • 0029167706 scopus 로고
    • A branched monomethoxypoly (ethylene glycol) for protein modification
    • Monfardini, C., Schiavon, O., Caliceti, P., et al. 1995. A branched monomethoxypoly (ethylene glycol) for protein modification. Bioconjug. Chem. 6:62-69.
    • (1995) Bioconjug. Chem. , vol.6 , pp. 62-69
    • Monfardini, C.1    Schiavon, O.2    Caliceti, P.3
  • 101
    • 0034913652 scopus 로고    scopus 로고
    • Filgrastim(rmetHuG-CSF) in the 21st century: SD/01
    • Morstyn, G., Foote, M., Walker, T., and Molineux, G. 2001. Filgrastim(rmetHuG-CSF) in the 21st century: SD/01. Acta Haematol. 105:151-155.
    • (2001) Acta Haematol. , vol.105 , pp. 151-155
    • Morstyn, G.1    Foote, M.2    Walker, T.3    Molineux, G.4
  • 102
    • 0035889833 scopus 로고    scopus 로고
    • Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules
    • Mosqueira, V. C., Legrand, P., Gulik, A., et al. 2001. Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules. Biomaterials 22:2967-2979.
    • (2001) Biomaterials , vol.22 , pp. 2967-2979
    • Mosqueira, V.C.1    Legrand, P.2    Gulik, A.3
  • 103
    • 0030944064 scopus 로고    scopus 로고
    • Tumor accumulation of poly(ethylene glycol) with different with molecular weights after i.v. injection
    • Murakami, Y., Tabata, Y., and Ikada, Y. 1997. Tumor accumulation of poly(ethylene glycol) with different with molecular weights after i.v. injection. Drug Del. 4:23-32.
    • (1997) Drug Del. , vol.4 , pp. 23-32
    • Murakami, Y.1    Tabata, Y.2    Ikada, Y.3
  • 104
    • 0029683637 scopus 로고    scopus 로고
    • Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects
    • Nieforth, K.A,, Nadeau, R., Patel, I.H., et al. 1996. Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects. Clin. Pharmacol. Ther. 59:636-646.
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 636-646
    • Nieforth, K.A.1    Nadeau, R.2    Patel, I.H.3
  • 105
    • 0031959490 scopus 로고    scopus 로고
    • Early phase tumor accumulation of macromolecules: A great difference in clearance rate between tumor and normal tissues
    • Noguchi, Y., Wan, J., Duncan, R., et al. 1998. Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jap. J. Cancer 89:397-416.
    • (1998) Jap. J. Cancer , vol.89 , pp. 397-416
    • Noguchi, Y.1    Wan, J.2    Duncan, R.3
  • 108
    • 0040688671 scopus 로고    scopus 로고
    • A double-blind, multicentre, randomized, parallel dose-comparison study of six regimens of 5KDa, linear peginterferon α-2a compared with roferon-ain patients with chronic hepatitis C
    • December 6, 1999, Maui, Hawaii
    • O'Brien, C., Pockros, P., Reddy, R., et al. 1999. A double-blind, multicentre, randomized, parallel dose-comparison study of six regimens of 5KDa, linear peginterferon α-2a compared with roferon-ain patients with chronic hepatitis C. International Conference on Therapies for Viral Hepatitis December 6, 1999, Maui, Hawaii.
    • (1999) International Conference on Therapies for Viral Hepatitis
    • O'Brien, C.1    Pockros, P.2    Reddy, R.3
  • 109
    • 0000869770 scopus 로고    scopus 로고
    • A phase I study of PEG-camptothecin(PEG-CPT) in patients with advanced solid tumors: A novel formulation for an insoluble but active agent
    • Ochoa, L., Tolcher, A. W., Rizzo, J., et al. 2000. A phase I study of PEG-camptothecin(PEG-CPT) in patients with advanced solid tumors: a novel formulation for an insoluble but active agent. J. Clin. Oncol. 19:198a.
    • (2000) J. Clin. Oncol. , vol.19
    • Ochoa, L.1    Tolcher, A.W.2    Rizzo, J.3
  • 110
    • 0037462992 scopus 로고    scopus 로고
    • PEGylated nanoparticles for biological and pharmaceutical applications
    • Otsuka, H., Nagasaki, Y., and Kataoka, K. 2003. PEGylated nanoparticles for biological and pharmaceutical applications. Adv. Drug Deliv. Rev. 55:403-419.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 403-419
    • Otsuka, H.1    Nagasaki, Y.2    Kataoka, K.3
  • 111
    • 0031901771 scopus 로고    scopus 로고
    • Combined use of carboxyldirected protein pegylation and vector-mediated blood-brain barrier drug delivery system optimized brain uptake of brain derived neurotrophic factor following intravenous administration
    • Pardridge, W. M., Wu, D., and Sakane, T. 1998. Combined use of carboxyldirected protein pegylation and vector-mediated blood-brain barrier drug delivery system optimized brain uptake of brain derived neurotrophic factor following intravenous administration. Pharm. Res. 15:576-582.
    • (1998) Pharm. Res. , vol.15 , pp. 576-582
    • Pardridge, W.M.1    Wu, D.2    Sakane, T.3
  • 112
    • 0042820354 scopus 로고    scopus 로고
    • Pegylation of interferon alfa: Structural and pharmacokinetic properties
    • Pedder, S. C. 2003. Pegylation of interferon alfa: structural and pharmacokinetic properties. Semin Liver Dis. 23suppl. 1:19-22.
    • (2003) Semin Liver Dis. , vol.23 , Issue.1 SUPPL. , pp. 19-22
    • Pedder, S.C.1
  • 113
    • 0031857631 scopus 로고    scopus 로고
    • Antitumor activity of paclitaxel -2′-glycinate conjugated to poly(ethylene glycol): A water-soluble prodrug
    • Pendri, C., Conover, C. D., and Greenwald, R. B. 1998. Antitumor activity of paclitaxel -2′-glycinate conjugated to poly(ethylene glycol): a water-soluble prodrug. Anti-Cancer Drug Design 13:387-395.
    • (1998) Anti-Cancer Drug Design , vol.13 , pp. 387-395
    • Pendri, C.1    Conover, C.D.2    Greenwald, R.B.3
  • 114
    • 0032588348 scopus 로고    scopus 로고
    • Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting
    • Peracchia, M. T., Fattal, E., Desmaele, D., et al. 1999. Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting. J.Control. Rel. 60:121-128.
    • (1999) J. Control. Rel. , vol.60 , pp. 121-128
    • Peracchia, M.T.1    Fattal, E.2    Desmaele, D.3
  • 115
    • 0022003369 scopus 로고
    • A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function
    • Rajagopalan, S., Gonias, S. L., and Pizzo, S. V. 1985. A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. J. Clin. Invest. 75:413-419.
    • (1985) J. Clin. Invest. , vol.75 , pp. 413-419
    • Rajagopalan, S.1    Gonias, S.L.2    Pizzo, S.V.3
  • 116
    • 0033928514 scopus 로고    scopus 로고
    • Controlled-release, pegylation, liposomal formulations: New mechanisms in the delivery of injectable drugs
    • Reddy, K. R. 2000. Controlled-release, pegylation, liposomal formulations: new mechanisms in the delivery of injectable drugs. Ann. Pharmacother. 34:915-923.
    • (2000) Ann. Pharmacother. , vol.34 , pp. 915-923
    • Reddy, K.R.1
  • 117
    • 0032846127 scopus 로고    scopus 로고
    • Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles
    • Riley, T., Govender, T., Stolnik, S., et al. 1999. Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles. Colloids Surfaces B: Biointerfaces 16:147-159.
    • (1999) Colloids Surfaces B: Biointerfaces , vol.16 , pp. 147-159
    • Riley, T.1    Govender, T.2    Stolnik, S.3
  • 119
    • 0031081070 scopus 로고    scopus 로고
    • Interactions of poly(lactic acid) and poly(lactic acid-co-ethylene oxide) nanoparticles with the plasma factors of the coagulation system
    • Sahli, H., Tapon-Bretaudiere, J., Fischer, A. M., et al. 1997. Interactions of poly(lactic acid) and poly(lactic acid-co-ethylene oxide) nanoparticles with the plasma factors of the coagulation system. Biomaterials 18:281-288.
    • (1997) Biomaterials , vol.18 , pp. 281-288
    • Sahli, H.1    Tapon-Bretaudiere, J.2    Fischer, A.M.3
  • 120
    • 0342697550 scopus 로고    scopus 로고
    • Site specific modification of enzymatically synthesized RNA: Transcription initiation and Diels Alder reaction
    • Seelig, B., and Jasche, A. 1997. Site specific modification of enzymatically synthesized RNA: transcription initiation and Diels Alder reaction. Tetrahedran Lett. 38:7729-7732.
    • (1997) Tetrahedran Lett. , vol.38 , pp. 7729-7732
    • Seelig, B.1    Jasche, A.2
  • 121
    • 0036402578 scopus 로고    scopus 로고
    • Polyethylene glycol-liposomal doxorubicin
    • Sharp, M., Easthope, S. E., Keating, G. M., and Lamb, H. M. 2002. Polyethylene glycol-liposomal doxorubicin. Drugs 62:2089-2126.
    • (2002) Drugs , vol.62 , pp. 2089-2126
    • Sharp, M.1    Easthope, S.E.2    Keating, G.M.3    Lamb, H.M.4
  • 122
    • 0000211888 scopus 로고    scopus 로고
    • A controlled, randomized, multicentre, ascending dose phase II trial of pegylated interferon α-2a(PEG) vs. standard interferon α-2a(IFNα) for treatment of chronic hepatitis C
    • Shiffman, M., Pockros, P. J., Reddy, R. K., et al. 1999. A controlled, randomized, multicentre, ascending dose phase II trial of pegylated interferon α-2a(PEG) vs. standard interferon α-2a(IFNα) for treatment of chronic hepatitis C. Gastroenterology 116:1275.
    • (1999) Gastroenterology , vol.116 , pp. 1275
    • Shiffman, M.1    Pockros, P.J.2    Reddy, R.K.3
  • 123
    • 84907035691 scopus 로고
    • Preparation of long-acting superoxide dismutase using high molecular weight polyethylene glycol(41,000-72,000 daltons)
    • Somack, R., Saifer, M. G., and Williams, L. D. 1991. Preparation of long-acting superoxide dismutase using high molecular weight polyethylene glycol(41,000-72,000 daltons). Free Radic. Res. Commun. 12-13:553-562.
    • (1991) Free Radic. Res. Commun. , vol.12-13 , pp. 553-562
    • Somack, R.1    Saifer, M.G.2    Williams, L.D.3
  • 124
    • 0028116078 scopus 로고
    • Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers
    • Stolnik, S., Dunn, S. E., Garnett, M. C., et al. 1994. Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharm. Res. 11:1800-1808.
    • (1994) Pharm. Res. , vol.11 , pp. 1800-1808
    • Stolnik, S.1    Dunn, S.E.2    Garnett, M.C.3
  • 125
    • 0000030258 scopus 로고    scopus 로고
    • Combination therapy with peginterferon α-2a(PEG-IFN) and ribavirin in the treatment of patients with chronic hepatitis C(CHC): A phase II open-label study
    • Sulkowski, M., Reindollar, R., and Yu, J. 1999. Combination therapy with peginterferon α-2a(PEG-IFN) and ribavirin in the treatment of patients with chronic hepatitis C(CHC): a phase II open-label study. Hepatology 30:197A.
    • (1999) Hepatology , vol.30
    • Sulkowski, M.1    Reindollar, R.2    Yu, J.3
  • 126
    • 10744223928 scopus 로고    scopus 로고
    • In vitro efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol and pyridoxal 5′ phosphate supplementation
    • Sun, X., Yang, Z., Li, S., et al. 2003. In vitro efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol and pyridoxal 5′ phosphate supplementation. Cancer Res. 63:8377-8383.
    • (2003) Cancer Res. , vol.63 , pp. 8377-8383
    • Sun, X.1    Yang, Z.2    Li, S.3
  • 127
    • 0034690311 scopus 로고    scopus 로고
    • Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant
    • Trainer, P. J., et al. 2000. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N. Engl. J. Med. 342:1171-1177.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1171-1177
    • Trainer, P.J.1
  • 128
    • 0029058648 scopus 로고
    • Molecular design of hybrid tumour necrosis factor alfa with polyethylene glycol increases its anti-tumour potency
    • Tsutsumi, Y., Kihira, T., Tsunoda, S., et al. 1995. Molecular design of hybrid tumour necrosis factor alfa with polyethylene glycol increases its anti-tumour potency. Br. J. Cancer 71:963-968.
    • (1995) Br. J. Cancer , vol.71 , pp. 963-968
    • Tsutsumi, Y.1    Kihira, T.2    Tsunoda, S.3
  • 129
    • 0031043579 scopus 로고    scopus 로고
    • PEGylation of interleukin-6 effectively increases its thrombopoietic potency
    • Tsutsumi, Y., Tsunoda, S., Kamada, H., et al. 1997. PEGylation of interleukin-6 effectively increases its thrombopoietic potency. Thromb. Haemost. 77:168-173.
    • (1997) Thromb. Haemost. , vol.77 , pp. 168-173
    • Tsutsumi, Y.1    Tsunoda, S.2    Kamada, H.3
  • 130
    • 0029091362 scopus 로고
    • Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
    • Verrecchia, T., Spenlehauer, G., Bazile, D. V., et al. 1995. Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers. J. Control. Rel. 36:49-61.
    • (1995) J. Control. Rel. , vol.36 , pp. 49-61
    • Verrecchia, T.1    Spenlehauer, G.2    Bazile, D.V.3
  • 131
    • 0033398692 scopus 로고    scopus 로고
    • Oligonucleotide conjugated to linear and branched high molecular weight polyethylene glycol as substrates for RNAse H
    • Vorobjev, P. E., Zarytova, V. F., and Bonora, G. M. 1999. Oligonucleotide conjugated to linear and branched high molecular weight polyethylene glycol as substrates for RNAse H. Nucleos. Nucleot. 18:2745-2750.
    • (1999) Nucleos. Nucleot. , vol.18 , pp. 2745-2750
    • Vorobjev, P.E.1    Zarytova, V.F.2    Bonora, G.M.3
  • 132
    • 0034609586 scopus 로고    scopus 로고
    • Identification of major positional isomers of pegylated IFNalfa-2b
    • Wang, Y., Youngster, S. Bausch, J., et al. 2000. Identification of major positional isomers of pegylated IFNalfa-2b. Biochemistry 39:10634-10040.
    • (2000) Biochemistry , vol.39 , pp. 10634-110040
    • Wang, Y.1    Youngster, S.2    Bausch, J.3
  • 133
    • 0021196014 scopus 로고
    • Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection
    • Wills, R. J., Dennis, S., Speigel, H. E., et al. 1984. Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection. Clin. Pharmacol. Ther. 35:722-727.
    • (1984) Clin. Pharmacol. Ther. , vol.35 , pp. 722-727
    • Wills, R.J.1    Dennis, S.2    Speigel, H.E.3
  • 134
    • 0027655290 scopus 로고
    • Protected thiol-polyethylene glycol: A new activated polymer for reversible protein modification
    • Woghiren, C., Sharma, B., and Stein, S. 1993. Protected thiol-polyethylene glycol: a new activated polymer for reversible protein modification. Bioconjug. Chem. 3:314.
    • (1993) Bioconjug. Chem. , vol.3 , pp. 314
    • Woghiren, C.1    Sharma, B.2    Stein, S.3
  • 135
    • 0001369293 scopus 로고    scopus 로고
    • Single-dose safety/tolerability and pharmacokinetic/pharmacodynamics (PK/PD) following administration of ascending subcutaneous doses of pegylated interferon (PEG-IFN) and interferon α-2a (IFN α-2a) to healthy subjects
    • [abstract]
    • Xu, Z-X., Patel, I., and Joubert, P. 1998. Single-dose safety/tolerability and pharmacokinetic/pharmacodynamics (PK/PD) following administration of ascending subcutaneous doses of pegylated interferon (PEG-IFN) and interferon α-2a (IFN α-2a) to healthy subjects [abstract]. Hepatology 28 Suppl.: 702.
    • (1998) Hepatology , vol.28 , Issue.SUPPL. , pp. 702
    • Xu, Z.-X.1    Patel, I.2    Joubert, P.3
  • 136
    • 0028337034 scopus 로고
    • Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice
    • Yamaoka, T., Tabata, Y., and Ikada, Y. 1994. Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice. J. Pharm. Sci. 83:601-606.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 601-606
    • Yamaoka, T.1    Tabata, Y.2    Ikada, Y.3
  • 137
    • 0029117871 scopus 로고
    • The use of polyethylene glycol modified interleukin-2(PEG-IL-2) in the treatment of patients with metastatic renal cell carcinoma and melanoma. A phase I study and randomized prospective study comparing IL-2 alone versus IL-2 combined with PEG-IL-2
    • Yang, J. C., Topalian, S. L. Schwartzentruber, D. J., et al. 1995. The use of polyethylene glycol modified interleukin-2(PEG-IL-2) in the treatment of patients with metastatic renal cell carcinoma and melanoma. A phase I study and randomized prospective study comparing IL-2 alone versus IL-2 combined with PEG-IL-2.Cancer 76:687-694.
    • (1995) Cancer , vol.76 , pp. 687-694
    • Yang, J.C.1    Topalian, S.L.2    Schwartzentruber, D.J.3
  • 138
    • 0034529891 scopus 로고    scopus 로고
    • Pharmacokinetic deposition of polyethylene glycol modified salmon calcitonins in rats
    • Yoo, S. D., Jun, H., Shin, B. S., et al. 2000. Pharmacokinetic deposition of polyethylene glycol modified salmon calcitonins in rats. Chem. Pharm. Bull. 48:1921-1924.
    • (2000) Chem. Pharm. Bull. , vol.48 , pp. 1921-1924
    • Yoo, S.D.1    Jun, H.2    Shin, B.S.3
  • 139
    • 0028304405 scopus 로고
    • Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
    • Yuan, F., Leuning, M., Huang, S. K., et al. 1994 . Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res. 54:3352-3356.
    • (1994) Cancer Res. , vol.54 , pp. 3352-3356
    • Yuan, F.1    Leuning, M.2    Huang, S.K.3
  • 140
    • 0029360545 scopus 로고
    • Chemistry of polyethylene glycol conjugates with biologically active molecules
    • Zalipsky, S. 1995. Chemistry of polyethylene glycol conjugates with biologically active molecules. Adv. Drug Deliv. Rev. 16:157-182.
    • (1995) Adv. Drug Deliv. Rev. , vol.16 , pp. 157-182
    • Zalipsky, S.1
  • 141
    • 0001039302 scopus 로고
    • Attachment of drugs to polyethylene glycols
    • Zalipsky, S., Gilon, C., and Zilkha, A. 1985. Attachment of drugs to polyethylene glycols. Eur. Polym. J. 19:1177-1183.
    • (1985) Eur. Polym. J. , vol.19 , pp. 1177-1183
    • Zalipsky, S.1    Gilon, C.2    Zilkha, A.3
  • 142
    • 0002938723 scopus 로고
    • Use of functionalized poly(ethylene glycol)s for modification of polypeptides
    • ed. Harris, J. M., New York: Plenum Press
    • Zalipsky, S., and Lee, C. 1992. Use of functionalized poly(ethylene glycol)s for modification of polypeptides, In Poly(ethylene glycol) Chemistry: Biotechnical and Biomedical Applications ed. Harris, J. M., 347-370. New York: Plenum Press.
    • (1992) Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications , pp. 347-370
    • Zalipsky, S.1    Lee, C.2
  • 143
    • 0034017403 scopus 로고    scopus 로고
    • Involvement of neutrophilic granulocytes in the uptake of biodegradable non-stealth and stealth nanoparticles in guinea pig
    • Zambaux, M. F., Faivre-Fiorina, B., Bonneau, F., et al. 2000. Involvement of neutrophilic granulocytes in the uptake of biodegradable non-stealth and stealth nanoparticles in guinea pig. Biomaterials 21:975-980.
    • (2000) Biomaterials , vol.21 , pp. 975-980
    • Zambaux, M.F.1    Faivre-Fiorina, B.2    Bonneau, F.3
  • 144
    • 0003246250 scopus 로고    scopus 로고
    • Evaluation of the safety and efficacy of once-weekly peginterfron α-2a (PEGASYS™) for chronic hepatitis C: A multinational randomized study
    • May 1-4, 2000. Rotterdam, the Netherlands
    • Zeuzem, S., Feinman, S.V., Rasenack, J., et al. 2000. Evaluation of the safety and efficacy of once-weekly peginterfron α-2a (PEGASYS™) for chronic hepatitis C: a multinational randomized study. The European Association for the Study of the Liver, May 1-4, 2000. Rotterdam, the Netherlands.
    • (2000) The European Association for the Study of the Liver
    • Zeuzem, S.1    Feinman, S.V.2    Rasenack, J.3
  • 145
    • 0035216905 scopus 로고    scopus 로고
    • PegIFN alfa-2a(40 kDa) monotherapy: A novel agent for chronic hepatitis C therapy
    • Zeuzem, S., Heathcote, J. E., Martin, N., et al. 2001. PegIFN alfa-2a(40 kDa) monotherapy: a novel agent for chronic hepatitis C therapy. Expert Opin. Investig. Drugs 10:2201-2213.
    • (2001) Expert Opin. Investig. Drugs , vol.10 , pp. 2201-2213
    • Zeuzem, S.1    Heathcote, J.E.2    Martin, N.3
  • 146
    • 0034725772 scopus 로고    scopus 로고
    • 20-O-acylcamptothecin derivatives: Evidence for lacton stabilization
    • Zhao, H., Lee, C., Sai, P., et al., 2000. 20-O-acylcamptothecin derivatives: evidence for lacton stabilization. J. Org. Chem. 65:4601-4606.
    • (2000) J. Org. Chem. , vol.65 , pp. 4601-4606
    • Zhao, H.1    Lee, C.2    Sai, P.3
  • 147
    • 0345909485 scopus 로고    scopus 로고
    • Novel degradable poly(ethylene glycol) esters for drug delivery
    • eds. Harris, J. M., and Zolipsky, S., Washington, DC: ACS Books
    • Zhao, X., and Harris, J. M. 1997. Novel degradable poly(ethylene glycol) esters for drug delivery, In Poly (ethylene glycol): Chemistry and Biological Applications eds. Harris, J. M., and Zolipsky, S., 458-482. Washington, DC: ACS Books.
    • (1997) Poly (Ethylene Glycol): Chemistry and Biological Applications , pp. 458-482
    • Zhao, X.1    Harris, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.