Relation between transfection efficiency and cytotoxicity of poly(2-dimethylamino)ethyl methacrylate)/plasmid complexes

Journal of Controlled Release

Volumn 49, Issue 1, 1997, Pages 59-69

  Van De Wetering, Petra ^a   Cherng, Jong Yuh ^a   Talsma, Herre ^a   Hennink, Wim E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

galactosidase; Cytotoxicity; DNA; Poly(2 (dimethylamino)ethyl methacrylate); Transfection

Indexed keywords

CHLOROQUINE; DIETHYLAMINOETHYLDEXTRAN; LIPOFECTIN; POLYLYSINE; POLYMETHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; GENE TARGETING; INCUBATION TIME; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PLASMID; PRIORITY JOURNAL; SERUM;

EID: 0030805317     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00059-X     Document Type: Article

References (31)

1. Jolly D. Viral systems for gene therapy. Cancer Gene Ther. 1:1994;51-64.
2. Behr J.P. Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy. Bioconjugate Chem. 5:1994;382-389.
3. Gao X., Huang L. Cationic liposomes and polymers for gene transfer. J. Liposome Res. 3:1993;17-30.
4. Wagner E., Zenke M., Cotten M., Beug H., Birnstiel M. Transferrin-polycation conjugates as carriers for DNA-uptake into cells. Proc. Natl. Acad. Sci. U.S.A. 87:1990;3410-3414.
5. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., Behr J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine. Proc. Natl. Acad. Sci. U.S.A. 92:1995;7297-7301.
6. Haensler J., Szoka F.C. Jr. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4:1993;372-379.
7. Behr J.P., Demeneix B., Loeffler J.P., Perez-Mutul J. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc. Natl. Acad. Sci. U.S.A. 86:1989;6982-6986.
8. Zhou X., Klibanov A., Huang L. Lipophilic polylysines mediate efficient DNA transfection in mammalian cells. Biochim. Biophys. Acta. 1065:1991;8-14.
9. Lee R.J., Huang L. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem. 271:1996;8481-8487.
10. Cherng J.-Y., van de Wetering P., Talsma H., Crommelin D.J.A., Hennink W.E. Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res. 13:1996;1038-1042.
11. ε-branching at lysine during solid-phase peptide synthesis. J. Am. Chem. Soc. 95:1973;3757-3763.
12. Daly W.H., Poché D. The preparation of N-carboxyanhydrides of a-amino acids using bis(trichloromethyl)carbonate. Tetrahedron Lett. 29:1988;5859-5862.
13. Fasman G.D., Idelson M., Blout E.R. The synthesis and conformation of high molecular weight poly-ε-carbobenzyloxy-L-lysine and poly-L-lysine·HCl. J. Am. Chem. Soc. 83:1961;709-712.
14. E. Daniel and E. Katchalski, The hydrodynamic behaviour and molecular configuration of poly-ε, N-carbobenzoxy-L-lysine in dimethylformamide solution, in: M.A. Stahmann (Ed.), Polyamino Acids, Polypeptides and Proteins, The University of Wisconsin Press, Madison, 1962, pp. 183-193.
15. Yaron A., Berger A. The determination of the molecular weight of poly-L-lysine. Biochim. Biophys. Acta. 69:1963;397-399.
16. Bout A., Valerio D., Scholte B.J. In vivo transfer and expression of the LacZ gene in the mouse lung. Exp. Lung Res. 19:1993;193-202.
17. Hamilton T.C., Young R.C., McKoy W.M., Grotzinger K.R., Green J.A., Chu E.W., Whang-Penn J., Rogan A.M., Green W.R., Ozols R.F. Characterization of a human ovarian carcinoma cell line (NIH: OVCAR-3) with androgen and estrogen receptors. Cancer Res. 43:1983;5379-5389.
18. G. Odian, Principles of Polymerization, 3rd ed., John Wiley, New York, 1991.
19. Kabanov A.V., Astafieva I.V., Maksimova I.V., Lukanidin E.M., Georgiev G.P., Kabanov V.A. Efficient transformation of mammalian cells using DNA interpolyelectrolyte complexes with carbon chain polycations. Bioconjugate Chem. 4:1993;448-454.
20. Gao X., Huang L. A novel cationic liposome reagent for effective transfection of mammalian cells. Biochem. Biophys. Res. Commun. 179:1991;280-285.
21. Curiel D.T., Agarwal S., Wagner E., Cotten M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. U.S.A. 88:1991;8850-8854.
22. Felgner P.L., Gadek Y.R., Holm M., Roman R., Chan H.W., Wenz M., Northrop J.P., Ringold G.M., Danielson M. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. U.S.A. 84:1987;7413-7417.
23. Cotten M., Längle-Rouault F., Kirlappos H., Wagner E., Mechtler K., Zenke M., Beug M., Birnstiel M.L. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl. Acad. Sci. U.S.A. 87:1990;4033-4037.
24. Gao X., Huang L. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry. 35:1996;1027-1036.
25. Wolfert M.A., Seymour L.W. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of complexes formed with DNA. Gene Therapy. 3:1996;269-273.
26. Arnold L.J. Jr., Dagan A., Gutheil J., Kaplan N.O. Antineoplastic activity of poly(L-lysine) with some ascites tumor cells. Proc. Natl. Acad. Sci. U.S.A. 76:1979;3246-3250.
27. Zabner J., Fasbender A.J., Moninger T., Poellinger K.A., Welsh M.J. Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. 270:1995;18997-19007.
28. Zhou X., Huang L. DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim. Biophys. Acta. 1189:1994;195-203.
29. Friend D.S., Papahadjopoulos D., Debs R.J. Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim. Biophys. Acta. 1278:1996;41-50.
30. Morgan D.M.L., Clover J., Pearson J.D. Effects of synthetic polycations on leucine incorporation, lactate dehydrogenase release, and morphology of human umbilical vein endothelial cells. J. Cell Sci. 91:1988;231-238.
31. Planck C., Oberhauser B., Mechtler K., Koch C., Wagner E. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 269:1994;12918-12924.