메뉴 건너뛰기




Volumn 28, Issue 4, 2011, Pages 731-741

Poly(I:C)-Mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier

Author keywords

epidermal growth factor; polyplex; receptor mediated delivery; RNA delivery; tumor targeting

Indexed keywords

DOUBLE STRANDED RNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MACROGOL; MELITTIN; POLYETHYLENEIMINE; POLYINOSINIC POLYCYTIDYLIC ACID;

EID: 79955604155     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0225-4     Document Type: Article
Times cited : (73)

References (53)
  • 2
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • DOI 10.1038/nrd1088
    • R Duncan 2003 The dawning era of polymer therapeutics Nat Rev Drug Discov 2 347 360 12750738 10.1038/nrd1088 1:CAS:528:DC%2BD3sXjslamtb0%3D (Pubitemid 37361705)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.5 , pp. 347-360
    • Duncan, R.1
  • 3
    • 33748290173 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Non-viral gene therapy by systemic delivery
    • DOI 10.1038/sj.gt.3302838, PII 3302838
    • SD Li L Huang 2006 Gene therapy progress and prospects: non-viral gene therapy by systemic delivery Gene Ther 13 1313 1319 16953249 10.1038/sj.gt.3302838 1:CAS:528:DC%2BD28XptVClsLg%3D (Pubitemid 44323687)
    • (2006) Gene Therapy , vol.13 , Issue.18 , pp. 1313-1319
    • Li, S.-D.1    Huang, L.2
  • 4
    • 33751012721 scopus 로고    scopus 로고
    • Recent developments in the application of plasmid DNA-based vectors and small interfering RNA therapeutics for cancer
    • DOI 10.1089/hum.2006.17.1062
    • M Meyer E Wagner 2006 Recent developments in the application of plasmid DNA-based vectors and small interfering RNA therapeutics for cancer Hum Gene Ther 17 1062 1076 17032153 10.1089/hum.2006.17.1062 1:CAS:528:DC%2BD28Xht1Smt7rK (Pubitemid 44749709)
    • (2006) Human Gene Therapy , vol.17 , Issue.11 , pp. 1062-1076
    • Meyer, M.1    Wagner, E.2
  • 5
    • 22144447455 scopus 로고    scopus 로고
    • Design and development of polymers for gene delivery
    • DOI 10.1038/nrd1775
    • DW Pack AS Hoffman S Pun PS Stayton 2005 Design and development of polymers for gene delivery Nat Rev Drug Discov 4 581 593 16052241 10.1038/nrd1775 1:CAS:528:DC%2BD2MXmsFGjtbo%3D (Pubitemid 40975711)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.7 , pp. 581-593
    • Pack, D.W.1    Hoffman, A.S.2    Pun, S.3    Stayton, P.S.4
  • 6
    • 48949098577 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Synthetic polymer-based systems
    • 18528432 10.1038/gt.2008.105 1:CAS:528:DC%2BD1cXptlyhsLY%3D
    • D Schaffert E Wagner 2008 Gene therapy progress and prospects: synthetic polymer-based systems Gene Ther 15 1131 1138 18528432 10.1038/gt.2008.105 1:CAS:528:DC%2BD1cXptlyhsLY%3D
    • (2008) Gene Ther , vol.15 , pp. 1131-1138
    • Schaffert, D.1    Wagner, E.2
  • 7
    • 57149141399 scopus 로고    scopus 로고
    • The silent (r)evolution of polymeric nucleic acid therapeutics
    • 18679773 10.1007/s11095-008-9689-x 1:CAS:528:DC%2BD1cXhsVeqsrjI
    • E Wagner 2008 The silent (r)evolution of polymeric nucleic acid therapeutics Pharm Res 25 2920 2923 18679773 10.1007/s11095-008-9689-x 1:CAS:528:DC%2BD1cXhsVeqsrjI
    • (2008) Pharm Res , vol.25 , pp. 2920-2923
    • Wagner, E.1
  • 8
    • 76649098887 scopus 로고    scopus 로고
    • Lipid-like materials for low-dose, in vivo gene silencing
    • 20080679 10.1073/pnas.0910603106 1:CAS:528:DC%2BC3cXhvFSnsr0%3D
    • KT Love KP Mahon CG Levins KA Whitehead W Querbes JR Dorkin, et al. 2010 Lipid-like materials for low-dose, in vivo gene silencing Proc Natl Acad Sci USA 107 1864 1869 20080679 10.1073/pnas.0910603106 1:CAS:528:DC%2BC3cXhvFSnsr0%3D
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1864-1869
    • Love, K.T.1    Mahon, K.P.2    Levins, C.G.3    Whitehead, K.A.4    Querbes, W.5    Dorkin, J.R.6
  • 9
    • 32044465218 scopus 로고    scopus 로고
    • EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice
    • DOI 10.1371/journal.pmed.0030006, e6
    • A Shir M Ogris E Wagner A Levitzki 2006 EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice PLoS Med 3 e6 16318410 10.1371/journal.pmed.0030006 (Pubitemid 43200638)
    • (2006) PLoS Medicine , vol.3 , Issue.1 , pp. 125-135
    • Shir, A.1    Ogris, M.2    Wagner, E.3    Levitzki, A.4
  • 10
    • 0034924636 scopus 로고    scopus 로고
    • Different strategies for formation of PEGylated EGF-conjugated PEI/DNA complexes for targeted gene delivery
    • DOI 10.1021/bc0001488
    • T Blessing M Kursa R Holzhauser R Kircheis E Wagner 2001 Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery Bioconjug Chem 12 529 537 11459457 10.1021/bc0001488 1:CAS:528:DC%2BD3MXksFemu70%3D (Pubitemid 32696226)
    • (2001) Bioconjugate Chemistry , vol.12 , Issue.4 , pp. 529-537
    • Blessing, T.1    Kursa, M.2    Holzhauser, R.3    Kircheis, R.4    Wagner, E.5
  • 12
    • 27644481173 scopus 로고    scopus 로고
    • C- versus N-terminally linked melittin-polyethylenimine conjugates: The site of linkage strongly influences activity of DNA polyplexes
    • DOI 10.1002/jgm.783
    • S Boeckle E Wagner M Ogris 2005 C- versus N-terminally linked melittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes J Gene Med 7 1335 1347 15945120 10.1002/jgm.783 1:CAS:528:DC%2BD2MXht1Wkt7nE (Pubitemid 41555439)
    • (2005) Journal of Gene Medicine , vol.7 , Issue.10 , pp. 1335-1347
    • Boeckle, S.1    Wagner, E.2    Ogris, M.3
  • 13
    • 41449109039 scopus 로고    scopus 로고
    • Breathing life into polycations: Functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery
    • DOI 10.1021/ja710344v
    • M Meyer A Philipp R Oskuee C Schmidt E Wagner 2008 Breathing life into polycations: functionalization with ph-responsive endosomolytic peptides and polyethylene glycol enables sirna delivery J Am Chem Soc 130 3272 3273 18288843 10.1021/ja710344v 1:CAS:528:DC%2BD1cXitFegtbw%3D (Pubitemid 351456015)
    • (2008) Journal of the American Chemical Society , vol.130 , Issue.11 , pp. 3272-3273
    • Meyer, M.1    Philipp, A.2    Oskuee, R.3    Schmidt, C.4    Wagner, E.5
  • 14
    • 57149137351 scopus 로고    scopus 로고
    • Systemic delivery of DNA or sirna mediated by linear polyethylenimine (l-PEI) does not induce an inflammatory response
    • 18709489 10.1007/s11095-008-9693-1 1:CAS:528:DC%2BD1cXhsVeqs7zP
    • ME Bonnet P Erbacher AL Bolcato-Bellemin 2008 Systemic delivery of DNA or sirna mediated by linear polyethylenimine (l-PEI) does not induce an inflammatory response Pharm Res 25 2972 2982 18709489 10.1007/s11095-008-9693-1 1:CAS:528:DC%2BD1cXhsVeqs7zP
    • (2008) Pharm Res , vol.25 , pp. 2972-2982
    • Bonnet, M.E.1    Erbacher, P.2    Bolcato-Bellemin, A.L.3
  • 15
    • 0030729180 scopus 로고    scopus 로고
    • ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo
    • S Ferrari E Moro A Pettenazzo JP Behr F Zacchello M Scarpa 1997 Exgen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo Gene Ther 4 1100 1106 9415317 10.1038/sj.gt.3300503 1:CAS:528: DyaK2sXmsFaitLw%3D (Pubitemid 27469941)
    • (1997) Gene Therapy , vol.4 , Issue.10 , pp. 1100-1106
    • Ferrari, S.1    Moro, E.2    Pettenazzo, A.3    Behr, J.P.4    Zacchello, F.5    Scarpa, M.6
  • 16
    • 0035408714 scopus 로고    scopus 로고
    • Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo
    • DOI 10.1002/jgm.187
    • L Wightman R Kircheis V Rossler S Carotta R Ruzicka M Kursa, et al. 2001 Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo J Gene Med 3 362 372 11529666 10.1002/jgm.187 1:STN:280:DC%2BD3Mvoslagsw%3D%3D (Pubitemid 33691776)
    • (2001) Journal of Gene Medicine , vol.3 , Issue.4 , pp. 362-372
    • Wightman, L.1    Kircheis, R.2    Rossler, V.3    Garotta, S.4    Ruzicka, R.5    Kursa, M.6    Wagner, E.7
  • 18
    • 0018115212 scopus 로고
    • Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent
    • J Carlsson H Drevin R Axen 1978 Protein thiolation and reversible protein-protein conjugation. N-succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent 90 Biochem J 173 723 737 708370 1:CAS:528: DyaE1MXhvVWktb0%3D (Pubitemid 9010965)
    • (1978) Biochemical Journal , vol.173 , Issue.3 , pp. 723-737
    • Carlsson, J.1    Drevin, H.2    Axen, R.3
  • 19
    • 33750337504 scopus 로고    scopus 로고
    • Synthesis, characterization, and gene transfer application of poly(ethylene glycol-b-ethylenimine) with high molar mass polyamine block
    • DOI 10.1021/bm060499a
    • B Brissault A Kichler C Leborgne O Danos H Cheradame J Gau, et al. 2006 Synthesis, characterization, and gene transfer application of poly(ethylene glycol-b-ethylenimine) with high molar mass polyamine block Biomacromolecules 7 2863 2870 17025363 10.1021/bm060499a 1:CAS:528:DC%2BD28Xptleluro%3D (Pubitemid 44615271)
    • (2006) Biomacromolecules , vol.7 , Issue.10 , pp. 2863-2870
    • Brissault, B.1    Kichler, A.2    Leborgne, C.3    Danos, O.4    Cheradame, H.5    Gau, J.6    Auvray, L.7    Guis, C.8
  • 20
    • 0037419724 scopus 로고    scopus 로고
    • Spectrophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations
    • DOI 10.1016/S0731-7085(02)00571-X, PII S073170850200571X
    • F Ungaro G De Rosa A Miro F Quaglia 2003 Spectrophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations J Pharm Biomed Anal 31 143 149 12560058 10.1016/S0731-7085(02)00571-X 1:CAS:528:DC%2BD3sXmsFWqtg%3D%3D (Pubitemid 36120628)
    • (2003) Journal of Pharmaceutical and Biomedical Analysis , vol.31 , Issue.1 , pp. 143-149
    • Ungaro, F.1    De Rosa, G.2    Miro, A.3    Quaglia, F.4
  • 21
    • 0016636179 scopus 로고
    • An improved 2, 4, 6-trinitrobenzenesulfonic acid method for the determination of amines
    • 1137089 10.1016/0003-2697(75)90431-5 1:CAS:528:DyaE2MXhsFWlsbc%3D
    • SL Snyder PZ Sobocinski 1975 An improved 2, 4, 6-trinitrobenzenesulfonic acid method for the determination of amines Anal Biochem 64 284 288 1137089 10.1016/0003-2697(75)90431-5 1:CAS:528:DyaE2MXhsFWlsbc%3D
    • (1975) Anal Biochem , vol.64 , pp. 284-288
    • Snyder, S.L.1    Sobocinski, P.Z.2
  • 22
    • 33749013859 scopus 로고    scopus 로고
    • Gene carriers based on hexanediol diacrylate linked oligoethylenimine: Effect of chemical structure of polymer on biological properties
    • DOI 10.1021/bc060133v
    • J Kloeckner S Bruzzano M Ogris E Wagner 2006 Gene carriers based on hexanediol diacrylate linked oligoethylenimine: effect of chemical structure of polymer on biological properties Bioconjug Chem 17 1339 1345 16984145 10.1021/bc060133v 1:CAS:528:DC%2BD28XptFait74%3D (Pubitemid 44455343)
    • (2006) Bioconjugate Chemistry , vol.17 , Issue.5 , pp. 1339-1345
    • Kloeckner, J.1    Bruzzano, S.2    Ogris, M.3    Wagner, E.4
  • 24
    • 0014124597 scopus 로고
    • Inducers of interferon and host resistance. Ii. Multistranded synthetic polynucleotide complexes
    • 5233831 10.1073/pnas.58.3.1004 1:CAS:528:DyaF2sXltFGltLs%3D
    • AK Field AA Tytell GP Lampson MR Hilleman 1967 Inducers of interferon and host resistance. Ii. Multistranded synthetic polynucleotide complexes Proc Natl Acad Sci USA 58 1004 1010 5233831 10.1073/pnas.58.3.1004 1:CAS:528: DyaF2sXltFGltLs%3D
    • (1967) Proc Natl Acad Sci USA , vol.58 , pp. 1004-1010
    • Field, A.K.1    Tytell, A.A.2    Lampson, G.P.3    Hilleman, M.R.4
  • 25
    • 3242707528 scopus 로고    scopus 로고
    • In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine
    • DOI 10.1002/jgm.470
    • K Itaka A Harada Y Yamasaki K Nakamura H Kawaguchi K Kataoka 2004 In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine J Gene Med 6 76 84 14716679 10.1002/jgm.470 1:CAS:528:DC%2BD2cXhvVGgtrY%3D (Pubitemid 40228005)
    • (2004) Journal of Gene Medicine , vol.6 , Issue.1 , pp. 76-84
    • Itaka, K.1    Harada, A.2    Yamasaki, Y.3    Nakamura, K.4    Kawaguchi, H.5    Kataoka, K.6
  • 26
    • 0033122034 scopus 로고    scopus 로고
    • Transfection and Physical Properties of Various Saccharide, Poly(ethylene glycol), and Antibody-Derivatized Polyethylenimines (PEI)
    • P Erbacher T Bettinger P Belguise-Valladier S Zou JL Coll JP Behr, et al. 1999 Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI) J Gene Med 1 210 222 10738569 10.1002/(SICI)1521-2254(199905/06)1:3<210::AID-JGM30>3.0.CO;2-U 1:STN:280:DC%2BD3c3gtlSmtA%3D%3D (Pubitemid 129631076)
    • (1999) Journal of Gene Medicine , vol.1 , Issue.3 , pp. 210-222
    • Erbacher, P.1    Bettinger, T.2    Belguise-Valladier, P.3    Zou, S.4    Coll, J.-L.5    Behr, J.-P.6    Remy, J.-S.7
  • 27
    • 0033084717 scopus 로고    scopus 로고
    • Polycation-Based DNA Complexes for Tumor-Targeted Gene Delivery in vivo
    • R Kircheis S Schuller S Brunner M Ogris KH Heider W Zauner, et al. 1999 Polycation-based DNA complexes for tumor-targeted gene delivery in vivo J Gene Med 1 111 120 10738575 10.1002/(SICI)1521-2254(199903/04)1:2<111::AID- JGM22>3.0.CO;2-Y 1:CAS:528:DyaK1MXjvVCmtLk%3D (Pubitemid 129631068)
    • (1999) Journal of Gene Medicine , vol.1 , Issue.2 , pp. 111-120
    • Kircheis, R.1    Schuller, S.2    Brunner, S.3    Ogris, M.4    Heider, K.-H.5    Zauner, W.6    Wagner, E.7
  • 28
    • 0142072936 scopus 로고    scopus 로고
    • Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer
    • DOI 10.1021/bc0256087
    • M Kursa GF Walker V Roessler M Ogris W Roedl R Kircheis, et al. 2003 Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer Bioconjug Chem 14 222 231 12526712 10.1021/bc0256087 1:CAS:528:DC%2BD38Xpt1aju7g%3D (Pubitemid 36169036)
    • (2003) Bioconjugate Chemistry , vol.14 , Issue.1 , pp. 222-231
    • Kursa, M.1    Walker, G.F.2    Roessler, V.3    Ogris, M.4    Roedl, W.5    Kircheis, R.6    Wagner, E.7
  • 29
    • 22644444670 scopus 로고    scopus 로고
    • PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice
    • DOI 10.1021/bc049743q
    • T Merdan K Kunath H Petersen U Bakowsky KH Voigt J Kopecek, et al. 2005 Pegylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice Bioconjug Chem 16 785 792 16029019 10.1021/bc049743q 1:CAS:528:DC%2BD2MXltVCitbc%3D (Pubitemid 41026164)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.4 , pp. 785-792
    • Merdan, T.1    Kunath, K.2    Petersen, H.3    Bakowsky, U.4    Voigt, K.H.5    Kopecek, J.6    Kissel, T.7
  • 30
    • 14044252938 scopus 로고    scopus 로고
    • Toward synthetic viruses: Endosomal pH-Triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
    • DOI 10.1016/j.ymthe.2004.11.006, PII S1525001604015321
    • GF Walker C Fella J Pelisek J Fahrmeir S Boeckle M Ogris, et al. 2005 Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo Mol Ther 11 418 425 15727938 10.1016/j.ymthe.2004.11.006 1:CAS:528:DC%2BD2MXhsVOju74%3D (Pubitemid 40277318)
    • (2005) Molecular Therapy , vol.11 , Issue.3 , pp. 418-425
    • Walker, G.F.1    Fella, C.2    Pelisek, J.3    Fahrmeir, J.4    Boeckle, S.5    Ogris, M.6    Wagner, E.7
  • 31
    • 41149086686 scopus 로고    scopus 로고
    • Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver
    • DOI 10.1021/bc700388u
    • RS Burke SH Pun 2008 Extracellular barriers to in vivo PEI and pegylated PEI polyplex-mediated gene delivery to the liver Bioconjug Chem 19 693 704 18293906 10.1021/bc700388u 1:CAS:528:DC%2BD1cXitlOmsL4%3D (Pubitemid 351431402)
    • (2008) Bioconjugate Chemistry , vol.19 , Issue.3 , pp. 693-704
    • Burke, R.S.1    Pun, S.H.2
  • 32
    • 39449113001 scopus 로고    scopus 로고
    • PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy
    • DOI 10.1080/10611860701849058, PII 790598183
    • A Malek F Czubayko A Aigner 2008 PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and sirna-induced gene targeting efficacy J Drug Target 16 124 139 18274933 10.1080/10611860701849058 1:CAS:528:DC%2BD1cXhvVenurY%3D (Pubitemid 351266549)
    • (2008) Journal of Drug Targeting , vol.16 , Issue.2 , pp. 124-139
    • Malek, A.1    Czubayko, F.2    Aigner, A.3
  • 33
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • 7700380 10.1038/374546a0 1:CAS:528:DyaK2MXkvVKqtr8%3D
    • AM Krieg AK Yi S Matson TJ Waldschmidt GA Bishop R Teasdale, et al. 1995 CpG motifs in bacterial DNA trigger direct B-cell activation Nature 374 546 549 7700380 10.1038/374546a0 1:CAS:528:DyaK2MXkvVKqtr8%3D
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3    Waldschmidt, T.J.4    Bishop, G.A.5    Teasdale, R.6
  • 34
    • 61749098024 scopus 로고    scopus 로고
    • Immunotherapeutic applications of CpG oligodeoxynucleotide tlr9 agonists
    • 19211030 10.1016/j.addr.2008.12.008 1:CAS:528:DC%2BD1MXjtFKltb4%3D
    • J Vollmer AM Krieg 2009 Immunotherapeutic applications of CpG oligodeoxynucleotide tlr9 agonists Adv Drug Deliv Rev 61 195 204 19211030 10.1016/j.addr.2008.12.008 1:CAS:528:DC%2BD1MXjtFKltb4%3D
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 195-204
    • Vollmer, J.1    Krieg, A.M.2
  • 35
    • 55549114663 scopus 로고    scopus 로고
    • 5′-triphosphate-siRNA: Turning gene silencing and Rig-i activation against melanoma
    • 18978796 10.1038/nm.1887 1:CAS:528:DC%2BD1cXhtlCjtLzF
    • H Poeck R Besch C Maihoefer M Renn D Tormo S Morskaya, et al. 2008 5′-triphosphate-siRNA: turning gene silencing and Rig-i activation against melanoma Nat Med 14 1256 1263 18978796 10.1038/nm.1887 1:CAS:528: DC%2BD1cXhtlCjtLzF
    • (2008) Nat Med , vol.14 , pp. 1256-1263
    • Poeck, H.1    Besch, R.2    Maihoefer, C.3    Renn, M.4    Tormo, D.5    Morskaya, S.6
  • 37
    • 41349102954 scopus 로고    scopus 로고
    • TLR3: Interferon induction by double-stranded rna including poly(i:C)
    • 18262679 10.1016/j.addr.2007.11.005 1:CAS:528:DC%2BD1cXksVagsL8%3D
    • M Matsumoto T Seya 2008 TLR3: interferon induction by double-stranded rna including poly(i:C) Adv Drug Deliv Rev 60 805 812 18262679 10.1016/j.addr.2007. 11.005 1:CAS:528:DC%2BD1cXksVagsL8%3D
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 805-812
    • Matsumoto, M.1    Seya, T.2
  • 38
    • 70350448730 scopus 로고    scopus 로고
    • Brain tumor immunotherapy with type-1 polarizing strategies
    • 19769732 10.1111/j.1749-6632.2009.04932.x 1:CAS:528:DC%2BD1MXhtlehs7rL
    • H Okada 2009 Brain tumor immunotherapy with type-1 polarizing strategies Ann NY Acad Sci 1174 18 23 19769732 10.1111/j.1749-6632.2009.04932.x 1:CAS:528:DC%2BD1MXhtlehs7rL
    • (2009) Ann NY Acad Sci , vol.1174 , pp. 18-23
    • Okada, H.1
  • 39
    • 57349097681 scopus 로고    scopus 로고
    • A north american brain tumor consortium phase ii study of poly-iclc for adult patients with recurrent anaplastic gliomas
    • 18850068 10.1007/s11060-008-9705-3 1:CAS:528:DC%2BD1MXjvFehsQ%3D%3D
    • N Butowski KR Lamborn BL Lee MD Prados T Cloughesy LM DeAngelis, et al. 2009 A north american brain tumor consortium phase ii study of poly-iclc for adult patients with recurrent anaplastic gliomas J Neurooncol 91 183 189 18850068 10.1007/s11060-008-9705-3 1:CAS:528:DC%2BD1MXjvFehsQ%3D%3D
    • (2009) J Neurooncol , vol.91 , pp. 183-189
    • Butowski, N.1    Lamborn, K.R.2    Lee, B.L.3    Prados, M.D.4    Cloughesy, T.5    Deangelis, L.M.6
  • 40
    • 67349117313 scopus 로고    scopus 로고
    • Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
    • 19200817 10.1016/j.vaccine.2009.01.071 1:CAS:528:DC%2BD1MXmtlKgu7Y%3D
    • B Jasani H Navabi M Adams 2009 Ampligen: a potential toll-like 3 receptor adjuvant for immunotherapy of cancer Vaccine 27 3401 3404 19200817 10.1016/j.vaccine.2009.01.071 1:CAS:528:DC%2BD1MXmtlKgu7Y%3D
    • (2009) Vaccine , vol.27 , pp. 3401-3404
    • Jasani, B.1    Navabi, H.2    Adams, M.3
  • 41
    • 0024792330 scopus 로고
    • Antibody targeted liposomes containing poly(rI) · poly(rC) exert a specific antiviral and toxic effect on cells primed with interferons α/β or γ
    • DOI 10.1016/0005-2736(89)90449-5
    • PG Milhaud P Machy B Lebleu L Leserman 1989 Antibody targeted liposomes containing poly(rI). Poly(rC) exert a specific antiviral and toxic effect on cells primed with interferons alpha/beta or gamma Biochim Biophys Acta 987 15 20 2557080 10.1016/0005-2736(89)90449-5 1:CAS:528:DyaK3cXhsVGgurk%3D (Pubitemid 20008992)
    • (1989) Biochimica et Biophysica Acta - Biomembranes , vol.987 , Issue.1 , pp. 15-20
    • Milhaud, P.G.1    Machy, P.2    Lebleu, B.3    Leserman, L.4
  • 42
    • 0026925151 scopus 로고
    • Interferon production of l929 and hela cells enhanced by polyriboinosinic acid-polyribocytidylic acid pH-sensitive liposomes
    • 1384719 10.1021/bc00017a008 1:CAS:528:DyaK38XlsFOms78%3D
    • PG Milhaud B Compagnon A Bienvenue JR Philippot 1992 Interferon production of l929 and hela cells enhanced by polyriboinosinic acid-polyribocytidylic acid pH-sensitive liposomes Bioconjug Chem 3 402 407 1384719 10.1021/bc00017a008 1:CAS:528:DyaK38XlsFOms78%3D
    • (1992) Bioconjug Chem , vol.3 , pp. 402-407
    • Milhaud, P.G.1    Compagnon, B.2    Bienvenue, A.3    Philippot, J.R.4
  • 43
    • 0141676278 scopus 로고    scopus 로고
    • Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: Poly C in a murine lung metastasis model
    • DOI 10.1038/sj.cgt.7700617
    • F Sakurai T Terada M Maruyama Y Watanabe F Yamashita Y Takakura, et al. 2003 Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: Poly C in a murine lung metastasis model Cancer Gene Ther 10 661 668 12944985 10.1038/sj.cgt.7700617 1:CAS:528: DC%2BD3sXmslSisbk%3D (Pubitemid 37129454)
    • (2003) Cancer Gene Therapy , vol.10 , Issue.9 , pp. 661-668
    • Sakurai, F.1    Terada, T.2    Maruyama, M.3    Watanabe, Y.4    Yamashita, F.5    Takakura, Y.6    Hashida, M.7
  • 44
    • 33750976822 scopus 로고    scopus 로고
    • DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions
    • DOI 10.1016/j.jconrel.2006.07.002, PII S0168365906003300
    • J Kloeckner S Boeckle D Persson W Roedl M Ogris K Berg, et al. 2006 DNA polyplexes based on degradable oligoethylenimine-derivatives: combination with EGF receptor targeting and endosomal release functions J Control Release 116 115 122 16959361 10.1016/j.jconrel.2006.07.002 1:CAS:528:DC%2BD28Xht12jtLzN (Pubitemid 44854278)
    • (2006) Journal of Controlled Release , vol.116 , Issue.2 SPEC. ISS. , pp. 115-122
    • Kloeckner, J.1    Boeckle, S.2    Persson, D.3    Roedl, W.4    Ogris, M.5    Berg, K.6    Wagner, E.7
  • 46
    • 34547657290 scopus 로고    scopus 로고
    • Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes
    • DOI 10.1080/10611860701498203, PII 780334291
    • AA Kale VP Torchilin 2007 Enhanced transfection of tumor cells in vivo using "Smart" Ph-sensitive tat-modified pegylated liposomes J Drug Target 15 538 545 17671900 10.1080/10611860701498203 1:CAS:528: DC%2BD2sXosVSktLw%3D (Pubitemid 47209054)
    • (2007) Journal of Drug Targeting , vol.15 , Issue.7-8 , pp. 538-545
    • Kale, A.A.1    Torchilin, V.P.2
  • 47
    • 33845625261 scopus 로고    scopus 로고
    • Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
    • DOI 10.1038/sj.gt.3302843, PII 3302843
    • H Hatakeyama H Akita K Kogure M Oishi Y Nagasaki Y Kihira, et al. 2007 Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid Gene Ther 14 68 77 16915290 10.1038/sj.gt.3302843 1:CAS:528:DC%2BD28XhtlaqsL%2FL (Pubitemid 44942867)
    • (2007) Gene Therapy , vol.14 , Issue.1 , pp. 68-77
    • Hatakeyama, H.1    Akita, H.2    Kogure, K.3    Oishi, M.4    Nagasaki, Y.5    Kihira, Y.6    Ueno, M.7    Kobayashi, H.8    Kikuchi, H.9    Harashima, H.10
  • 48
    • 0037057855 scopus 로고    scopus 로고
    • Nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
    • 12383945 1:CAS:528:DC%2BD38Xns1ahu7Y%3D
    • C Rudolph U Schillinger C Plank A Gessner P Nicklaus R Muller, et al. 2002 Nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine Biochim Biophys Acta 1573 75 12383945 1:CAS:528:DC%2BD38Xns1ahu7Y%3D
    • (2002) Biochim Biophys Acta , vol.1573 , pp. 75
    • Rudolph, C.1    Schillinger, U.2    Plank, C.3    Gessner, A.4    Nicklaus, P.5    Muller, R.6
  • 49
    • 33748673542 scopus 로고    scopus 로고
    • pH-responsive shielding of non-viral gene vectors
    • DOI 10.1517/17425247.3.5.563
    • M Meyer E Wagner 2006 pH-responsive shielding of non-viral gene vectors Expert Opin Drug Deliv 3 563 571 16948553 10.1517/17425247.3.5.563 1:CAS:528:DC%2BD28XovF2gu7s%3D (Pubitemid 44383485)
    • (2006) Expert Opinion on Drug Delivery , vol.3 , Issue.5 , pp. 563-571
    • Meyer, M.1    Wagner, E.2
  • 50
    • 34547153677 scopus 로고    scopus 로고
    • An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes
    • DOI 10.1021/bc060327a
    • V Knorr L Allmendinger GF Walker FF Paintner E Wagner 2007 An acetal-based pegylation reagent for pH-sensitive shielding of DNA polyplexes Bioconjug Chem 18 1218 1225 17477500 10.1021/bc060327a 1:CAS:528: DC%2BD2sXkvVCltrk%3D (Pubitemid 47122645)
    • (2007) Bioconjugate Chemistry , vol.18 , Issue.4 , pp. 1218-1225
    • Knorr, V.1    Allmendinger, L.2    Walker, G.F.3    Paintner, F.F.4    Wagner, E.5
  • 51
    • 37549032712 scopus 로고    scopus 로고
    • Breaking the bonds: Non-viral vectors become chemically dynamic
    • 17955026 10.1038/sj.mt.6300326 1:CAS:528:DC%2BD2sXhsVKku77L
    • JA Wolff DB Rozema 2008 Breaking the bonds: non-viral vectors become chemically dynamic Mol Ther 16 8 15 17955026 10.1038/sj.mt.6300326 1:CAS:528:DC%2BD2sXhsVKku77L
    • (2008) Mol Ther , vol.16 , pp. 8-15
    • Wolff, J.A.1    Rozema, D.B.2
  • 52
    • 0029837306 scopus 로고    scopus 로고
    • Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors
    • Y Han CG Caday A Nanda WK Cavenee HJ Huang 1996 Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors Cancer Res 56 3859 3861 8752145 1:CAS:528:DyaK28XltlSnsLk%3D (Pubitemid 26284726)
    • (1996) Cancer Research , vol.56 , Issue.17 , pp. 3859-3861
    • Han, Y.1    Caday, C.G.2    Nanda, A.3    Cavenee, W.K.4    Huang, H.-J.S.5
  • 53
    • 1242270605 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and tumor response to radiation: In vivo preclinical studies
    • DOI 10.1016/j.ijrobp.2003.08.035
    • L Milas Z Fan NH Andratschke KK Ang 2004 Epidermal growth factor receptor and tumour response to radiation: in vivo preclinical studies Int J Radiat Oncol Biol Phys 58 966 971 14967457 10.1016/j.ijrobp.2003.08.035 1:CAS:528:DC%2BD2cXhtVyhu7k%3D (Pubitemid 38221157)
    • (2004) International Journal of Radiation Oncology Biology Physics , vol.58 , Issue.3 , pp. 966-971
    • Milas, L.1    Fan, Z.2    Andratschke, N.H.3    Ang, K.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.