Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics

FASEB Journal

Volumn 19, Issue 14, 2005, Pages 1978-1985

  Li, Zonghai ^a,c   Zhao, Ruijiao ^a   Wu, Xianghua ^a,c   Sun, Ye ^b   Yao, Ming ^a   Li, Jinjun ^a   Xu, Yuhong ^a,b,d   Gu, Jianren ^a,c,d  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d SHANGHAI CANCER INSTITUTE   (China)

Author keywords

EGFR; Peptide ligand; Peptide synthesis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; PEPTIDE; POLYETHYLENEIMINE;

AMINO ACID SEQUENCE; ANALYTIC METHOD; APOPTOSIS; ARTICLE; CELL MIGRATION; GENE DELIVERY SYSTEM; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOGENICITY; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PRIORITY JOURNAL; SCATCHARD PLOT; TUMOR XENOGRAFT;

CELL LINE, TUMOR; DEOXYRIBONUCLEASES; DRUG DELIVERY SYSTEMS; EPIDERMAL GROWTH FACTOR; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INFUSIONS, INTRAVENOUS; IODIDES; K562 CELLS; KINETICS; LIGANDS; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEINS V-ERBB; PEPTIDE LIBRARY; PEPTIDES; POLYETHYLENEIMINE; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION;

EID: 28744436511     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4058com     Document Type: Article

References (28)

1. Woodburn, J. R. (1999) The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol. Ther. 82, 241-250
2. Salomon, D. S., Brandt, R., Ciardiello, F., and Normarmo, N. (1995) Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19, 183-232
3. Michael, S. I., Hong, J. S., Curiel, D. T., and Engler, J. A. (1995) Addition of a short peptide ligand to the adenovirus fiber protein. Gene Ther. 2, 660-668
4. Jong, M. D., Kwekkeboom, D., Valkema, R., and Krenning, E. P. (2003) Radiolabelled peptides for tumour therapy: current status and future directions plenary lecture at the EANM 2002. Eur. J. Nucl. Med. Mol. Imag. 30, 463-469
5. Halin, C., Gafner, V., Villani, M. E., Borsi, L., Berndt, A., Kosmehl, H., Zardi L., and Neri, D. (2003) Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha. Cancer Res. 63, 3202-3210
6. Langer, M., and Beck-Sickinger, A. G. (2001) Peptides as carrier for tumor diagnosis and treatment. Curr. Med. Chem. Anti-Canc. Agents 1, 71-93
7. White, S. J., Nicklin, S. A., Sawamura, T., and Baker, A. H. (2001) Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension 37, 449-455
8. Rajotte, D., and Ruoslahti, E. (1999) Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display. J. Biol. Chem. 274, 11593-11598
9. Binetruy-Tournaire, R., Demangel, C., Malavaud, B., Vassy, R., Rouyre, S., Kraemer, M., Plouet, J., Derbin, C., Perret, G., and Mazie, J. C. (2000) Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis. EMBO J. 19, 1525-1533
10. Hansen, M. B., Nielsen, S. E., and Berg, K. (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210
11. Chiua, S. J., Uenob, N. T., and Leea, R. J. (2004) Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, HerceptinR) conjugated polyethylenimine. J. Control. Release 97, 357-369
12. Lin, C. R., Chen, W. S., Lazar, C. S., Carpenter, C. D., Gill, G. N., Evans, R. M., and Rosenfeld, M. G. (1986) Protein Kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms. Cell 44, 839-848
13. Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J. H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., and Yokoyama, S. (2002) Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110, 775-787
14. Opresko, L. K., Chang, C. P., Will, B. H., Burke, P. M., Gill, G. N., and Wiley, H. S. (1995) Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain. J. Biol. Chem. 270, 4325-4333
15. Mamot, C., Drummond, D. C., Greiser, U., Hong, K., Kirpotin, D. B., Marks, J. D., and Park, J. W. (2003) Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells. Cancer Res. 63, 3154-3161
16. Blessing, T., Kursa, M., Holzhauser, R., Kircheis, R., and Wagner, E. (2000) Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug. Chem. 12, 529-537
17. Kursa, M., Walker, G. F., Roessler, V., Ogris, M., Roedl, W., Kircheis, R., and Wagner, E. (2003) Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug. Chem. 14, 222-231
18. Wolschek, M. F., Thallinger, C., Kursa, M., Allen, M., Lichtenberger, C., Kircheis, R., Lucas, T., Willheim, M., Reinisch, W., Gangl, A., Wagner, E., and Jansen, B. (2002) Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology 36, 1106-1114
19. Li, S., Tan, Y., Viroonchatapan, E., Pitt, B. R., and Huang, L. (2000) Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Am. J. Physiol. 278, L504-L511
20. Kunath, K., Merdan, T., Hegener, O., Haberlein, H., and Kissel, T. (2003) Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J. Gene Med. 5, 588-599
21. Safiejko-Mroczka, B., and Bell, P. B., Jr. (1996) Bifunctional protein crosslinking reagents improve labeling of cytoskeletal proteins for qualitative and quantitative fluorescence microscopy. J. Histochem. Cytochem. 44, 641-656
22. Gosselin, M. A., Guo, W. J., and Lee, R. J. (2002) Incorporation of reversibly cross-linked polyplexes into LPDII vectors for gene delivery. Bioconjug. Chem. 13, 1044-1053
23. Gosselin, M. A., Guo, W. J., and Lee, R. J. (2001) Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug. Chem. 12, 989-994
24. Balasubramanlam, R. P., Bennett, A. M., Aberle, J. G., Malone, J. G., Nantz, M. H., and Malone, R. W. (1996) Structural and functional analysis of cationic transfection lipids: The hydrophobic domain. Gene Ther. 3, 163-172
25. Zou, Y., Zong, G., Ling, Y. H., and Perez-soler, R. (2000) Development of cationic liposome formulations for intratracheal gene therapy of early lung cancer. Cancer Gene Ther. 7, 683-696
26. Solodin, I., Brown, C. S., Bruno, M. S., Chow, C. Y., Jang, E. H., Debs, R. J., and Heath, T. D. (1995) A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery. Biochemistry 34, 13537-13544
27. Lee, E. R., Marshal, J., Siegel, C. S., Jiang, C., Yew, N. S., Nichols, M. R., Nietupski, J. B., Ziegler, R. J., Lane, M. B., Wang, K. X., Wan, N. C., Scheule, R. K., Harris, D. J., Smith, A. E., and Cheng, S. H. (1996) Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Gene Ther. 7, 1701-1717
28. Gorman, C. M., Aikawa, M., Fox, B., Fox, E., Lapuz, C., Michaud, B., Nguyen, H., Roche, E., Sawa, T., and Wiener-Kronish, J. P. (1997) Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC. Gene Ther. 4, 983-992