Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing αvβ 3 and αvβ5 integrins

Bioconjugate Chemistry

Volumn 18, Issue 5, 2007, Pages 1415-1423

  Oba, Makoto ^a   Fukushima, Shigeto ^b,c   Kanayama, Naoki ^c,d   Aoyagi, Kazuhiro ^c   Nishiyama, Nobuhiro ^a   Koyama, Hiroyuki ^a   Kataoka, Kazunori ^a,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON KAYAKU CO LTD   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; CYTOLOGY; GENE TRANSFER; GENES; GLYCOPROTEINS; LANTHANUM COMPOUNDS; LIGANDS; MICELLES; PEPTIDES; POLYETHYLENE OXIDES; SOLUTIONS;

CONJUGATED BLOCK COPOLYMERS; GENE DELIVERY SYSTEMS; HELA CELL; INTEGRIN RECEPTORS; INTEGRINS; PERINUCLEAR REGION; PLASMID DNA; POLYPLEX MICELLES; RGD PEPTIDE; TRANSFECTION EFFICIENCY;

POLYETHYLENE GLYCOLS;

ALPHAVBETA5 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; COPOLYMER; CYCLOPEPTIDE; LIGAND; MACROGOL; PLASMID DNA; POLYLYSINE; VITRONECTIN RECEPTOR;

ANGIOGENESIS; AQUEOUS SOLUTION; ARTICLE; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; FLOW CYTOMETRY; GEL PERMEATION CHROMATOGRAPHY; GENE DELIVERY SYSTEM; GENE TARGETING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; LIGHT SCATTERING; MICELLE; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PEPTIDE SYNTHESIS;

EID: 34648843428     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0700133     Document Type: Article

References (32)

1. Pedroso de Lima, M. C., Simoes, S., Pires, P., Faneca, H., and Düzgunes, N. (2001) Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications. Adv. Drug Delivery Rev. 47, 277-294.
2. Merdan, T., Kopecek, J., and Kissel, T. (2002) Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Delivery Rev. 54, 715-758.
3. Kakizawa, Y., and Kataoka, K. (2002) Block copolymer micelles for delivery of gene and related compounds. Adv. Drug Delivery Rev. 54, 203-222.
4. Itaka, K., Harada, A., Nakamura, K., Kawaguchi, H., and Kataoka, K. (2002) Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. Biomacromolecules 3, 841-845.
5. Harada-Shiba, M., Yamauchi, K., Harada, A., Takamisawa, I., Shimokado, K., and Kataoka, K. (2002) Polyion complex micelles as vectors in gene therapy-pharmacokinetics and in vivo gene transfer. Gene Ther. 9, 407-414.
6. Wakebayashi, D., Nishiyama, N., Yamasaki, Y., Itaka, K., Kanayama, N., Harada, A., Nagasaki, Y., and Kataoka, K. (2004) Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. J. Controlled Release 95, 653-664.
7. Suh, W., Han, S.-O., Yu, L., and Kim, S. W. (2002) An angiogenic, endothelial-cell-targeted polymeric gene carrier. Mol. Ther. 6, 664-672.
8. Ogris, M., Walker, G., Blessing, T., Kircheis, R., Wolschek, M., and Wagner, E. (2003) Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J. Controlled Release 91, 173-181.
9. Miyata, K., Kakizawa, Y., Nishiyama, N., Yamasaki, Y., Watanabe, T., Kohara, M., and Kataoka, K. (2005) Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J. Controlled Release 109, 15-23.
10. 3 antagonist. J. Am. Chem. Soc. 118, 7461-7472.
11. 3 for angiogenesis. Science 264, 569-571.
12. Akiyama, Y., Harada, A., Nagasaki, Y., and Kataoka, K. (2000) Synthesis of poly(ethylene glycol)-block-poly(ethylenimine) possessing an acetal group at the PEG end. Macromolecules 33, 5841-5845.
13. Harada, A., and Kataoka, K. (1995) Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely charged block copolymers with poly(ethylene glycol) segments. Macromolecules 28, 294-299.
14. Nagasaki, Y., Kutsuna, T., Iijima, M., Kato, M., and Kataoka, K. (1995) Formyl-ended heterobifunctional poly(ethylene oxide): synthesis of poly(ethylene oxide) with a formyl group at one end and a hydroxyl group at the other end. Bioconjugate Chem. 6, 231-233.
15. Poche, D. S., Moore, M. J., and Bowles, J. L. (1999) An unconventional method for purifying N-carboxyanhydride derivatives of γ-alkyl-L-glutamates. Synth. Commun. 29, 843-854.
16. Zhang, L., Torgerson, T. R., Liu, X.-Y., Timmons, S., Colosia, A. D., Hawiger, J., and Tam, J. P. (1998) Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. Proc. Natl. Acad. Sci. U.S.A. 95, 9184-9189.
17. LePecq, J.-B., and Paoletti, C. (1967) A fluorescent complex between ethidium bromide and nucleic acids. J. Mol. Biol. 27, 87-106.
18. Itaka, K., Yamauchi, K., Harada, A., Nakamura, K., Kawaguchi, H., and Kataoka, K. (2003) Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials 24, 4495-4506.
19. Wakebayashi, D., Nishiyama, N., Itaka, K., Miyata, K., Yamasaki, Y., Harada, A., Koyama, H., Nagasaki, Y., and Kataoka, K. (2004) Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficiency. Biomacromolecules 5, 2128-2136.
20. Pierschbacher, M. D., and Ruoslahti, E. (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30-33.
21. Pierschbacher, M. D., and Ruoslahti, E. (1984) Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc. Natl. Acad. Sci. U.S.A. 81, 5985-5988.
22. 3 integrin antagonists. J. Med. Chem. 42, 3033-3040.
23. Allen, T. M. (2002) Ligand-targeted therapeutics in anticancer therapy. Nat. Rev. 2, 750-763.
24. Kim, W. J., Yockman, J. W., Lee, M., Jeong, J. H., Kim, Y.-H., and Kim, S. W. (2005) Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. J. Controlled Release 106, 224-234.
25. Kim, W. J., Yockman, J. W., Jeong, J. H., Christensen, L. V., Lee, M., Kim, Y.-H., and Kim, S. W. (2006) Anti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing mice. J. Controlled Release 114, 381-388.
26. 5: homology modeling and ligand binding. J. Med. Chem. 47, 4166-4177.
27. Bretscher, M. S. (1996) Moving membrane up to the front of migrating cells. Cell 85, 465-467.
28. 3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr. Biol. 11, 1392-1402.
29. Suh, J., Wirtz, D., and Hanes, J. (2003) Efficient active transport of gene nanocarriers to the cell nucleus. Proc. Natl. Acad. Sci. U.S.A. 100, 3878-3882.
30. Kulkarni, R. P., Wu, D. D., Davis, M. E., and Fraser, S. E. (2005) Quantitating intracellular transport of polyplexes by spatio-temporal image correlation spectroscopy. Proc. Natl. Acad. Sci. U.S.A. 102, 7523-7528.
31. Rejmna, J., Bragonzi, A., and Conese, M. (2005) Role of clathrin-and caveolae-mediated endocytosis in gene transfer mediated by lipo-and polyplexes. Mol. Ther. 12, 468-474.
32. Gersdorff, K., Sanders, N. N., Vandenbroucke, R., Smedt, S. C., Wagner, E., and Ogris, M. (2006) The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type. Mol. Ther. 14, 745-753.