The role of PEG architecture and molecular weight in the gene transfection performance of PEGylated poly(dimethylaminoethyl methacrylate) based cationic polymers

Biomaterials

Volumn 32, Issue 9, 2011, Pages 2369-2378

  Venkataraman, Shrinivas ^a   Ong, Wei Lin ^b   Ong, Zhan Yuin ^a,c   Joachim Loo, Say Chye ^b   Rachel Ee, Pui Lai ^c   Yang, Yi Yan ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cationic polymers; Gene transfection; Macromolecular architecture; PEGylation; Reversible addition fragmentation chain transfer (RAFT) polymerization

Indexed keywords

CATIONIC POLYMERS; GENE TRANSFECTION; MACROMOLECULAR ARCHITECTURE; PEGYLATION; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION;

ARCHITECTURE; BLOCK COPOLYMERS; CATIONIC POLYMERIZATION; CELL CULTURE; COMPLEXATION; COPOLYMERIZATION; CYTOTOXICITY; DNA; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; MACROMOLECULES; MOLECULAR WEIGHT; PLASTIC PRODUCTS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TOPOLOGY; ZETA POTENTIAL;

POLYMERS;

COPOLYMER; MACROGOL; POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE];

ARTICLE; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DRUG COMPLEX; DRUG SYNTHESIS; EMBRYO; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER; ZETA POTENTIAL;

CATIONS; CELL DEATH; CELL SURVIVAL; DNA; GENE EXPRESSION; HEK293 CELLS; HEP G2 CELLS; HUMANS; LUCIFERASES; METHACRYLATES; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR WEIGHT; PHYSICOCHEMICAL PHENOMENA; POLYETHYLENE GLYCOLS; POLYMERS; TRANSFECTION;

EID: 78751705078     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.11.070     Document Type: Article

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