MicroRNA and diseases of the nervous system

Neurosurgery

Volumn 69, Issue 2, 2011, Pages 440-454

  Omahen, David A ^a  

^a FOOTHILLS HOSPITAL   (Canada)

Author keywords

Brain diseases; Brain neoplasms; Gene expression regulation; MicroRNA; Nervous system RNA; Posttranscriptional; Untranslated RNA processing

Indexed keywords

DOUBLE STRANDED RNA; MICRORNA; MICRORNA 103; MICRORNA 10B; MICRORNA 123; MICRORNA 125B; MICRORNA 129; MICRORNA 136; MICRORNA 138; MICRORNA 143; MICRORNA 148A; MICRORNA 150; MICRORNA 155; MICRORNA 199B; MICRORNA 206; MICRORNA 21; MICRORNA 210; MICRORNA 214; MICRORNA 25; MICRORNA 26A; MICRORNA 26B; MICRORNA 32; MICRORNA 423; MICRORNA 449; MICRORNA 503; MICRORNA 672; MICRORNA 9; SMALL UNTRANSLATED RNA; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNTRANSLATED RNA;

ALZHEIMER DISEASE; AUTISM; BIPOLAR DISORDER; BRAIN ISCHEMIA; CANCER STEM CELL; DEGENERATIVE DISEASE; DENTATORUBROPALLIDOLUYSIAN ATROPHY; DEPRESSION; DIGEORGE SYNDROME; DOWN SYNDROME; FRAGILE X SYNDROME; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION; GILLES DE LA TOURETTE SYNDROME; GLIOBLASTOMA; HUMAN; HUNTINGTON CHOREA; HYPOPHYSIS ADENOMA; IN VIVO STUDY; MEDULLOBLASTOMA; MENTAL DISEASE; MOLECULAR BIOLOGY; MOLECULARLY TARGETED THERAPY; NERVOUS SYSTEM TUMOR; NEUROLOGY; NEUROMODULATION; NONHUMAN; OLIGODENDROGLIOMA; PARKINSON DISEASE; PRION DISEASE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; PROTEIN TARGETING; RETT SYNDROME; REVIEW; SCHIZOPHRENIA; SLEEP DEPRIVATION; SPINOCEREBELLAR DEGENERATION; STROKE; TRAUMATIC BRAIN INJURY; TREATMENT RESPONSE;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; MOLECULAR BIOLOGY; NERVOUS SYSTEM DISEASES;

EID: 79960374394     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e318215a3b3     Document Type: Review

References (194)

1. Orphanides G, Reinberg D. A unified theory of gene expression. Cell. 2002; 108(4):439-451.
2. Mattick JS, Makunin IV. Small regulatory RNAs in mammals. Hum Mol Genet. 2005;14(spec No 1):R121-R132.
3. Nelson PT, Keller JN. RNA in brain disease: No longer just "the messenger in the middle." J Neuropathol Exp Neurol. 2007;66(6):461-468.
4. Hannon GJ, Rivas FV, Murchison EP, Steitz JA. The expanding universe of noncoding RNAs. Cold Spring Harb Symp Quant Biol. 2006;71:551-564.
5. Naqvi AR, Islam MN, Choudhury NR, Haq QM. The fascinating world of RNA interference. Int J Biol Sci. 2009;5(2):97-117.
6. Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell. 1990;2(4):279-289.
7. van der Krol AR, Mur LA, Beld M, Mol JN, Stuitje AR. Flavonoid genes in petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell. 1990;2(4):291-299.
8. Romano N, Macino G. Quelling: Transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol Microbiol. 1992;6(22):3343-3353.
9. Kim VN. Small RNAs: Classification, biogenesis, and function. Mol Cells. 2005;19(1):1-15.
10. Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol. 2009;10(2):141-148.
11. Herr AJ, Baulcombe DC. RNA silencing pathways in plants. Cold Spring Harb Symp Quant Biol. 2004;69:363-370.
12. Horiguchi G. RNA silencing in plants: A shortcut to functional analysis. Differentiation. 2004;72(2-3):65-73.
13. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391(6669):806-811.
14. Grimm D. Small silencing RNAs: State-of-the-art. Adv Drug Deliv Rev. 2009;61(9):672-703.
15. Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 2001;15(2):188-200.
16. Pei Y, Tuschl T. On the art of identifying effective and specific siRNAs. Nat Methods. 2006;3(9):670-676.
17. Janowski BA, Huffman KE, Schwartz JC, et al. Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nat Chem Biol. 2005;1(4):216-222.
18. Bramsen JB, Laursen MB, Nielsen AF, et al. A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res. 2009;37(9):2867-2881.
19. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993; 75(5):843-854.
20. Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 2008;39(3):959-966.
21. Asirvatham AJ, Magner WJ, Tomasi TB. miRNA regulation of cytokine genes. Cytokine. 2009;45(2):58-69.
22. Barbato C, Giorgi C, Catalanotto C, Cogoni C. Thinking about RNA? MicroRNAs in the brain. Mamm Genome. 2008;19(7-8):541-551.
23. Lai EC. microRNAs: Runts of the genome assert themselves. Curr Biol. 2003;13(23):R925-R936.
24. Yousef M, Showe L, Showe M. A study of microRNAs in silico and in vivo: Bioinformatics approaches to microRNA discovery and target identification. FEBS J. 2009;276(8):2150-2156.
25. Kim S. A study of microRNAs in silico and in vivo. FEBS J. 2009;276(8):2139.
26. Brennecke J, Stark A, Russell RB, Cohen SM. Principles of microRNA-target recognition. PLoS Biol. 2005;3(3):e85.
27. Kim S, Hwang do W, Lee DS. A study of microRNAs in silico and in vivo: Bioimaging of microRNA biogenesis and regulation. FEBS J. 2009;276(8): 2165-2174.
28. Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science. 2007;316(5825):744-747.
29. Blow MJ, Grocock RJ, van Dongen S, et al. RNA editing of human microRNAs. Genome Biol. 2006;7(4):R27.
30. Pang JC, Kwok WK, Chen Z, Ng HK. Oncogenic role of microRNAs in brain tumors. Acta Neuropathol. 2009;117(6):599-611.
31. Mendes ND, Freitas AT, Sagot MF. Current tools for the identification of miRNA genes and their targets. Nucleic Acids Res. 2009;37(8):2419-2433.
32. Garzon R, Calin GA, Croce CM. MicroRNAs in Cancer. Annu Rev Med. 2009;60:167-179.
33. Lynam-Lennon N, Maher SG, Reynolds JV. The roles of microRNA in cancer and apoptosis. Biol Rev Camb Philos Soc. 2009;84(1):55-71.
34. Smalheiser NR, Torvik VI. Mammalian microRNAs derived from genomic repeats. Trends Genet. 2005;21(6):322-326.
35. Lee YS, Dutta A. MicroRNAs in cancer. Annu Rev Pathol. 2009;4:199-227.
36. Lim LP, Lau NC, Weinstein EG, et al. The microRNAs of Caenorhabditis elegans. Genes Dev. 2003;17(8):991-1008.
37. Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA. 2005;11(3):241-247.
38. Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA. 2004;10(12):1957-1966.
39. Weber B, Stresemann C, Brueckner B, Lyko F. Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle. 2007;6(9): 1001-1005.
40. Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing. Nature. 2007;448(7149):83-86.
41. Peters L, Meister G. Argonaute proteins: Mediators of RNA silencing. Mol Cell. 2007;26(5):611-623.
42. Guil S, Esteller M. DNA methylomes, histone codes and miRNAs: Tying it all together. Int J Biochem Cell Biol. 2009;41(1):87-95.
43. Ko MH, Kim S, Hwang do W, Ko HY, Kim YH, Lee DS. Bioimaging of the unbalanced expression of microRNA9 and microRNA9* during the neuronal differentiation of P19 cells. FEBS J. 2008;275(10):2605-2616.
44. Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009;11(3): 228-234.
45. Esquela-Kerscher A, Slack FJ. Oncomirs: MicroRNAs with a role in cancer. Nat Rev Cancer. 2006;6(4):259-269.
46. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell. 2003;115(7):787-798.
47. Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009;10(2):126-139.
48. Lytle JR, Yario TA, Steitz JA. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad SciU S A. 2007;104(23):9667-9672.
49. Eulalio A, Behm-Ansmant I, Izaurralde E. P bodies: At the crossroads of posttranscriptional pathways. Nat Rev Mol Cell Biol. 2007;8(1):9-22.
50. Eulalio A, Behm-Ansmant I, Schweizer D, Izaurralde E. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol. 2007;27(11):3970-3981.
51. Jakymiw A, Lian S, Eystathioy T, et al. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol. 2005;7(12):1267-1274.
52. Kosik KS. The neuronal microRNA system. Nat Rev Neurosci. 2006;7(12): 911-920.
53. Chendrimada TP, Finn KJ, Ji X, et al. MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007;447(7146):823-828.
54. Leung AK, Sharp PA. Function and localization of microRNAs in mammalian cells. Cold Spring Harb Symp Quant Biol. 2006;71:29-38.
55. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 2009;10(10):704-714.
56. Matzke MA, Birchler JA. RNAi-mediated pathways in the nucleus. Nat Rev Genet. 2005;6(1):24-35.
57. Kim DH, Villeneuve LM, Morris KV, Rossi JJ. Argonaute-1 directs siRNAmediated transcriptional gene silencing in human cells. Nat Struct Mol Biol. 2006;13(9):793-797.
58. Morris KV, Chan SW, Jacobsen SE, Looney DJ. Small interfering RNA-induced transcriptional gene silencing in human cells. Science. 2004;305(5688): 1289-1292.
59. Kim DH, Saetrom P, Snove O Jr, Rossi JJ. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci U S A. 2008;105(42): 16230-16235.
60. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20.
61. Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A. 2007;104(40):15805-15810.
62. Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006;9(6):435-443.
63. Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci U S A. 2008;105(5):1608-1613.
64. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: MicroRNAs can up-regulate translation. Science. 2007;318(5858):1931-1934.
65. Li LC, Okino ST, Zhao H, et al. Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci U S A. 2006;103(46):17337-17342.
66. Gilad S, Meiri E, Yogev Y, et al. Serum microRNAs are promising novel biomarkers. PLoS One. 2008;3(9):e3148.
67. Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008; 18(10):997-1006.
68. Wang WX, Wilfred BR, Baldwin DA, et al. Focus on RNA isolation: Obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue. Biochim Biophys Acta. 2008;1779(11):749-757.
69. Li W, Ruan K. MicroRNA detection by microarray. Anal Bioanal Chem. 2009;394(4):1117-1124.
70. Barbarotto E, Schmittgen TD, Calin GA. MicroRNAs and cancer: Profile, profile, profile. Int J Cancer. 2008;122(5):969-977.
71. Ciafre SA, Galardi S, Mangiola A, et al. Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun. 2005;334(4):1351-1358.
72. Yin JQ, Zhao RC, Morris KV. Profiling microRNA expression with microarrays. Trends Biotechnol. 2008;26(2):70-76.
73. Ying S-Y, Miller J, Lin S-L. Non-coding RNAs: Development of man-made vector-based intronic microRNAs (miRNAs). In: Appasani K, ed. MicroRNAs: From Basic Science to Disease Biology. New York, NY: Cambridge University Press; 2008:22-41.
74. Sethupathy P, Corda B, Hatzigeorgiou AG. TarBase: A comprehensive database of experimentally supported animal microRNA targets. RNA. 2006;12(2): 192-197.
75. Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ. miRBase: Tools for microRNA genomics. Nucleic Acids Res. 2008;36(Database issue):D154-D158.
76. Lin S, Chang D, Wu D, Ying SY. A novel RNA splicing-mediated gene silencing mechanism potential for genome evolution. Biochem Biophys Res Commun. 2003;310(3):754-760.
77. Nicoloso MS, Calin GA. MicroRNA involvement in brain tumors: From bench to bedside. Brain Pathol. 2008;18(1):122-129.
78. Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435(7043):834-838.
79. Berezikov E, Thuemmler F, van Laake LW, et al. Diversity of microRNAs in human and chimpanzee brain. Nat Genet. 2006;38(12):1375-1377.
80. Conaco C, Otto S, Han JJ, Mandel G. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci U S A. 2006; 103(7):2422-2427.
81. Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027):769-773.
82. Kim J, Krichevsky A, Grad Y, et al. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A. 2004;101(1):360-365.
83. Cheng LC, Tavazoie M, Doetsch F. Stem cells: From epigenetics to microRNAs. Neuron. 2005;46(3):363-367.
84. Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA. 2003;9(10):1274-1281.
85. Miska EA, Alvarez-Saavedra E, Townsend M, et al. Microarray analysis of micro- RNA expression in the developing mammalian brain. Genome Biol. 2004;5(9):R68.
86. Hebert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci. 2009;32(4):199-206.
87. Johnson R, Zuccato C, Belyaev ND, Guest DJ, Cattaneo E, Buckley NJ. A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol Dis. 2008;29(3):438-445.
88. Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative premRNA splicing. Mol Cell. 2007;27(3):435-448.
89. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brainexpressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004;5(3):R13.
90. Smirnova L, Grafe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21(6):1469-1477.
91. Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129(7):1401-1414.
92. Liang Y, Ridzon D, Wong L, Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 2007;8:166.
93. Johnston RJ Jr, Chang S, Etchberger JF, Ortiz CO, Hobert O. MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc Natl Acad Sci U S A. 2005;102(35):12449-12454.
94. Mansfield JH, Harfe BD, Nissen R, et al. MicroRNA-responsive "sensor" transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36(10):1079-1083.
95. Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific Micro- RNAs. Dev Cell. 2003;5(2):351-358.
96. He L, Hannon GJ. MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5(7):522-531.
97. Abu-Elneel K, Liu T, Gazzaniga FS, et al. Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics. 2008;9(3):153-161.
98. Kuss AW, Chen W. MicroRNAs in brain function and disease. Curr Neurol Neurosci Rep. 2008;8(3):190-197.
99. Corbin R, Olsson-Carter K, Slack F. The role of microRNAs in synaptic development and function. BMB Rep. 2009;42(3):131-135.
100. Hernandez PJ, Abel T. The role of protein synthesis in memory consolidation: Progress amid decades of debate. Neurobiol Learn Mem. 2008;89(3):293-311.
101. Ashraf SI, Kunes S. A trace of silence: Memory and microRNA at the synapse. Curr Opin Neurobiol. 2006;16(5):535-539.
102. Lugli G, Larson J, Martone ME, Jones Y, Smalheiser NR. Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner. J Neurochem. 2005;94(4): 896-905.
103. Schratt GM, Tuebing F, Nigh EA, et al. A brain-specific microRNA regulates dendritic spine development. Nature. 2006;439(7074):283-289.
104. Simon DJ, Madison JM, Conery AL, et al. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008; 133(5):903-915.
105. Negrini M, Nicoloso MS, Calin GA. MicroRNAs and cancer: New paradigms in molecular oncology. Curr Opin Cell Biol. 2009;21(3):470-479.
106. Lavon I, Zrihan D, Granit A, et al. Gliomas display a microRNA expression profile reminiscent of neural precursor cells. Neuro Oncol. 2010;12(5):422-433.
107. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20(16):2202-2207.
108. Silber J, Lim DA, Petritsch C, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008;6:14.
109. Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RH, Mourelatos Z. RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA. 2006;12(2):187-191.
110. Uziel T, Karginov FV, Xie S, et al. The miR-17;92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci U S A. 2009;106(8):2812-2817.
111. Bottoni A, Piccin D, Tagliati F, Luchin A, Zatelli MC, degli Uberti EC. miR-15a and miR-16-1 down-regulation in pituitary adenomas. J Cell Physiol. 2005; 204(1):280-285.
112. Godlewski J, Nowicki MO, Bronisz A, et al. Targeting of the Bmi-1 oncogene/ stem cell renewal factor by microRNA-128 inhibits glioma proliferation and selfrenewal. Cancer Res. 2008;68(22):9125-9130.
113. Ferretti E, De Smaele E, Miele E, et al. Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 2008;27(19):2616-2627.
114. Ferretti E, De Smaele E, Po A, et al. MicroRNA profiling in human medulloblastoma. Int J Cancer. 2009;124(3):568-577.
115. Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004;101(9):2999-3004.
116. Waldman SA, Terzic A. A study of microRNAs in silico and in vivo: Diagnostic and therapeutic applications in cancer. FEBS J. 2009;276(8):2157- 2164.
117. Calin GA, Croce CM. MicroRNA-cancer connection: The beginning of a new tale. Cancer Res. 2006;66(15):7390-7394.
118. Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120(5):635-647.
119. Mathupala SP, Mittal S, Guthikonda M, Sloan AE. MicroRNA and brain tumors: A cause and a cure? DNA Cell Biol. 2007;26(5):301-310.
120. Gal H, Pandi G, Kanner AA, et al. MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochem Biophys Res Commun. 2008;376(1):86-90.
121. Malzkorn B, Wolter M, Liesenberg F, et al. Identification and functional characterization of micrornas involved in the malignant progression of gliomas. Brain Pathol. 2010;20(3):539-550.
122. Nass D, Rosenwald S, Meiri E, et al. MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors. Brain Pathol. 2009;19(3):375-383.
123. Bottoni A, Zatelli MC, Ferracin M, et al. Identification of differentially expressed microRNAs by microarray: A possible role for microRNA genes in pituitary adenomas. J Cell Physiol. 2007;210(2):370-377.
124. Vreugdenhil E, Verissimo CS, Mariman R, et al. MicroRNA 18 and 124a downregulate the glucocorticoid receptor: Implications for glucocorticoid responsiveness in the brain. Endocrinology. 2009;150(5):2220-2228.
125. Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A. 2006;103(7):2257-2261.
126. Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005;65(14):6029-6033.
127. Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res. 2007;67(19):8994-9000.
128. Krichevsky AM, Gabriely G. miR-21: A small multi-faceted RNA. J Cell Mol Med. 2009;13(1):39-53.
129. Ohgaki H, Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am J Pathol. 2007;170(5):1445-1453.
130. Huse JT, Brennan C, Hambardzumyan D, et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 2009;23(11):1327-1337.
131. Gillies JK, Lorimer IA. Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle. 2007;6(16):2005-2009.
132. le Sage C, Nagel R, Egan DA, et al. Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J. 2007;26(15):3699-3708.
133. Gonzalez T, Seoane M, Caamano P, Vinuela J, Dominguez F, Zalvide J. Inhibition of Cdk4 activity enhances translation of p27kip1 in quiescent Rbnegative cells. J Biol Chem. 2003;278(15):12688-12695.
134. Novakova J, Slaby O, Vyzula R, Michalek J. MicroRNA involvement in glioblastoma pathogenesis. Biochem Biophys Res Commun. 2009;386(1):1-5.
135. Bommer GT, Gerin I, Feng Y, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol. 2007;17(15):1298-1307.
136. Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumourassociated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008;141(5):672-675.
137. Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10(12):1470-1476.
138. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosomemediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.
139. Wurdinger T, Tannous BA, Saydam O, et al. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell. 2008; 14(5):382-393.
140. Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable bloodbased markers for cancer detection. Proc Natl Acad Sci U S A. 2008; 105(30):10513-10518.
141. Ng EK, Chong WW, Jin H, et al. Differential expression of microRNAs in plasma of patients with colorectal cancer: A potential marker for colorectal cancer screening. Gut. 2009;58(10):1375-1381.
142. Calin GA, Ferracin M, Cimmino A, et al. AMicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353(17):1793-1801.
143. Barik S. Silence of the transcripts: RNA interference in medicine. J Mol Med. 2005;83(10):764-773.
144. Mathupala SP, Guthikonda M, Sloan AE. RNAi based approaches to the treatment of malignant glioma. Technol Cancer Res Treat. 2006;5(3):261-269.
145. Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease? Gene Ther. 2006;13(6):496-502.
146. Dharap A, Bowen K, Place R, Li LC, Vemuganti R. Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab. 2009;29(4):675-687.
147. Redell JB, Liu Y, Dash PK. Traumatic brain injury alters expression of hippocampal microRNAs: Potential regulators of multiple pathophysiological processes. J Neurosci Res. 2009;87(6):1435-1448.
148. Van Den Heuvel C, Thornton E, Vink R. Traumatic brain injury and Alzheimer's disease: A review. Prog Brain Res. 2007;161:303-316.
149. Dean B, Boer S, Gibbons A, Money T, Scarr E. Recent advances in postmortem pathology and neurochemistry in schizophrenia. Curr Opin Psychiatry. 2009; 22(2):154-160.
150. Perkins DO, Jeffries CD, Jarskog LF, et al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol. 2007;8(2):R27.
151. Hansen T, Olsen L, Lindow M, et al. Brain expressed microRNAs implicated in schizophrenia etiology. PLoS One. 2007;2(9):e873.
152. Zhou R, Yuan P, Wang Y, et al. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology. 2009;34(6):1395-1405.
153. Cheng HY, Papp JW, Varlamova O, et al. microRNA modulation of circadianclock period and entrainment. Neuron. 2007;54(5):813-829.
154. Fiore R, Siegel G, Schratt G. MicroRNA function in neuronal development, plasticity and disease. Biochim Biophys Acta. 2008;1779(8):471-478.
155. Abelson JF, Kwan KY, O'Roak BJ, et al. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005;310(5746):317-320.
156. Sethi P, Lukiw WJ.Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci Lett. 2009;459(2):100-104.
157. Cogswell JP, Ward J, Taylor IA, et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis. 2008;14(1):27-41.
158. Lukiw WJ. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport. 2007;18(3):297-300.
159. Rademakers R, Eriksen JL, Baker M, et al. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008;17(23):3631-3642.
160. Saba R, Goodman CD, Huzarewich RL, Robertson C, Booth SA. A miRNA signature of prion induced neurodegeneration. PLoS One. 2008;3(11):e3652.
161. Harper SQ. Progress and challenges in RNA interference therapy for Huntington disease. Arch Neurol. 2009;66(8):933-938.
162. Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J Neurosci. 2008;28(53):14341-14346.
163. Kim J, Inoue K, Ishii J, et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 2007;317(5842):1220-1224.
164. Weinberg MS, Wood MJ. Short non-coding RNA biology and neurodegenerative disorders: Novel disease targets and therapeutics. Hum Mol Genet. 2009;18(R1):R27-R39.
165. Orr HT, Zoghbi HY. Trinucleotide repeat disorders. Annu Rev Neurosci. 2007;30:575-621.
166. Schaefer A, O'Carroll D, Tan CL, et al. Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med. 2007;204(7):1553-1558.
167. Karres JS, Hilgers V, Carrera I, Treisman J, Cohen SM. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell. 2007;131(1):136-145.
168. Mishra PJ, Merlino G. MicroRNA reexpression as differentiation therapy in cancer. J Clin Invest. 2009;119(8):2119-2123.
169. Taulli R, Bersani F, Foglizzo V, et al. The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest. 2009;119(8):2366-2378.
170. Li Y, Guessous F, Zhang Y, et al. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 2009;69(19):7569-7576.
171. Chen G, Zhu W, Shi D, et al. MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol Rep. 2010;23(4): 997-1003.
172. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with "antagomirs." Nature. 2005;438(7068):685-689.
173. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13(5):613-618.
174. Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells. Nat Methods. 2007;4(9):721-726.
175. Haraguchi T, Ozaki Y, Iba H. Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res. 2009;37(6):e43.
176. Zhou X, Ren Y, Moore L, et al. Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest. 2010;90(2):144-155.
177. Gondi CS, Talluri L, Dinh DH, Gujrati M, Rao JS. RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells. Int J Oncol. 2009;35(4):851-859.
178. Kang C, Pu P, Jiang H. Silencing epidermal growth factor receptor by RNA interference in glioma. Methods Mol Biol. 2009;542:335-349.
179. Feng X, Zhang B, Wang J, Xu X, Lin N, Liu H. Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy. Med Oncol. 2011;28(1):24-30.
180. Kelly EJ, Russell SJ. MicroRNAs and the regulation of vector tropism. Mol Ther. 2009;17(3):409-416.
181. Bell JC, Kirn D. MicroRNAs fine-tune oncolytic viruses. Nat Biotechnol. 2008;26(12):1346-1348.
182. Edge RE, Falls TJ, Brown CW, Lichty BD, Atkins H, Bell JC. A let-7 MicroRNA- sensitive vesicular stomatitis virus demonstrates tumor-specific replication. Mol Ther. 2008;16(8):1437-1443.
183. Poeck H, Besch R, Maihoefer C, et al. 5#-Triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma. Nat Med. 2008;14(11): 1256-1263.
184. Burchard J, Jackson AL, Malkov V, et al. MicroRNA-like off-target transcript regulation by siRNAs is species specific. RNA. 2009;15(2):308-315.
185. Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol. 2003;21(6):635-637.
186. Jackson AL, Burchard J, Leake D, et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA. 2006;12(7): 1197-1205.
187. Jackson AL, Burchard J, Schelter J, et al. Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA. 2006;12(7):1179-1187.
188. Jackson AL, Linsley PS. Noise amidst the silence: Off-target effects of siRNAs? Trends Genet. 2004;20(11):521-524.
189. Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol. 2004;22(3):326-330.
190. Ui-Tei K, Naito Y, Nishi K, Juni A, Saigo K. Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect. Nucleic Acids Res. 2008;36(22): 7100-7109.
191. Kleinman ME, Yamada K, Takeda A, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008;452(7187):591-597.
192. Robbins M, Judge A, Ambegia E, et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum Gene Ther. 2008;19(10):991-999.
193. Dou T, Wu Q, Chen X, et al. A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population. J Cancer Res Clin Oncol. 2010;136(12):1853-1859.
194. Kim H, Huang W, Jiang X, Pennicooke B, Park PJ, Johnson MD. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci U S A. 2010;107(5):2183-2188.