MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

Nature Genetics

Volumn 36, Issue 10, 2004, Pages 1079-1083

  Mansfield, Jennifer H ^a   Harfe, Brian D ^b,c   Nissen, Robert ^d   Obenauer, John ^c   Srineel, Jalagani ^e   Chaudhuri, Aadel ^c   Farzan Kashani, Raphael ^c   Zuker, Michael ^e   Pasquinelli, Amy E ^a,f,h   Ruvkun, Gary ^a,f   Sharp, Phillip A ^c,g   Tabin, Clifford J ^a   McManus, Michael T ^c,h,i  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; UNTRANSLATED RNA; HOMEODOMAIN PROTEIN; HOXB8 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; EMBRYO; EMBRYO DEVELOPMENT; HOMEOBOX; HOX GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE SPECIFICITY; TRANSGENE; VERTEBRATE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; LACTOSE OPERON; MOLECULAR GENETICS; MORPHOGENESIS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; REPORTER GENE; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE;

ANIMALIA; CAENORHABDITIS ELEGANS; VERTEBRATA;

ANIMALS; BASE SEQUENCE; BODY PATTERNING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, REPORTER; HOMEODOMAIN PROTEINS; LAC OPERON; MICE; MICE, TRANSGENIC; MICRORNAS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 6944246368     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1421     Document Type: Article

References (27)

1. Griffiths-Jones, S. The microRNA Registry. Nucleic Acids Res. 32, D109-D111 (2004).
2. Lee, R.C. & Ambros, V. An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864 (2001).
3. Lagos-Quintana, M. et al. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735-739 (2002).
4. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853-858 (2001).
5. Krichevsky, A.M., King, K.S., Donahue, C.P., Khrapko, K. & Kosik, K.S. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA 9, 1274-1281 (2003).
6. Chen, X. A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Science 303, 2022-2025 (2004).
7. Juarez, M.T., Kui, J.S., Thomas, J., Heller, B.A. & Timmermans, M.C. microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity. Nature 428, 84-88 (2004).
8. Johnson, S.M., Lin, S.Y. & Slack, F.J. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev. Biol. 259, 364-379 (2003).
9. Brennecke, J., Hipfner, D.R., Stark, A., Russell, R.B. & Cohen, S.M. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113, 25-36 (2003).
10. Hutvagner. G. & Zamore, P.D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
11. Reinhart, B.J. et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901-906 (2000).
12. Pasquinelli, A.E. et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408, 86-89 (2000).
13. Lagos-Quintana, M., Rauhut, R., Meyer, J., Borkhardt, A. & Tuschl, T. New microRNAs from mouse and human. RNA 9, 175-179 (2003).
14. Lim, L.P., Glasner, M.E., Yekta, S., Burge, C.B. & Bartel, D.P. Vertebrate microRNA genes. Science 299, 1540 (2003).
15. Yekta, S., Shih, I.H. & Bartel, D.P. MicroRNA-directed cleavage of HOXB8 mRNA. Science 304, 594-596 (2004).
16. Whiting, J. et al. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 11, 2048-2059 (1991).
17. Brend, T., Gilthorpe, J., Summerbell, D. & Rigby, P.W. Multiple levels of transcriptional and post-transcriptional regulation are required to define the domain of Hoxb4 expression. Development 130, 2717-2728 (2003).
18. Erselius, J.R., Goulding, M.D. & Gruss, P. Structure and expression pattern of the murine Hox-3.2 gene. Development 110, 629-642 (1990).
19. van den Akker, E. et al. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development 123, 1911-1921 (2001).
20. Bartel, D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
21. Llave, C., Xie, Z., Kasschau, K.D. & Carrington, J.C. Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science 297, 2053-2056 (2002).
22. Kasschau, K.D. et al. P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA function. Dev. Cell 4, 205-217 (2003).
23. Niwa, H., Yamamura, K. & Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-199 (1991).
24. Chung, J.H., Whiteley, M. & . Felsenfeld, G. A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74, 505-514 (1993).
25. Araki, K., Araki, M., Miyazaki, J. & Vassalli, P. Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Natl. Acad. Sci. USA 92, 160-164 (1995).
26. Dietrich, S., Schubert, F.R. & Lumsden, A. Control of dorsoventral pattern in the chick paraxial mesoderm. Development 124, 3895-3908 (1997).
27. Hamburger, V. & Hamilton, H.L. A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49-92 (1951).