RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells

International Journal of Oncology

Volumn 35, Issue 4, 2009, Pages 851-859

  Gondi, Christopher S ^a   Talluri, Lavanya ^a   Dinh, Dzung H ^a   Gujrati, Meena ^a   Rao, Jasti S ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Human glioma; MMP 2; RNAi mediated

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; APOPTOSIS INDUCING FACTOR; CASPASE 8; GELATINASE A; I KAPPA B KINASE ALPHA; MESSENGER RNA; PROTEIN NIK; PROTEIN P73; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOLIC FRACTION; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; NICK END LABELING; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STAINING; TUMOR XENOGRAFT; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BLOTTING, WESTERN; BRAIN NEOPLASMS; CASPASE 8; CELL LINE, TUMOR; CELL SEPARATION; DNA FRAGMENTATION; DNA-BINDING PROTEINS; DOWN-REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE THERAPY; GLIOMA; HUMANS; I-KAPPA B PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MATRIX METALLOPROTEINASE 2; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; TRANSDUCTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 70449395234     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000399     Document Type: Article

References (24)

1. Lakka SS, Gondi CS and Rao JS: Proteases and glioma angiogenesis. Brain Pathol 15: 327-341, 2005.
2. Fan Y, Dutta J, Gupta N, Fan G and Gelinas C: Regulation of programmed cell death by NF-kappaB and its role in tumori-genesis and therapy. Adv Exp Med Biol 615: 223-250, 2008.
3. St-Pierre Y, Couillard J and Van TC: Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets 8: 473-489, 2004. (Pubitemid 39359652)
4. Cortes SM, Rodriguez F V, Sanchez P I and Perona R: The role of the NFkappaB signalling pathway in cancer. Clin Transl Oncol 10: 143-147, 2008.
5. Chalah A and Khosravi-Far R: The mitochondrial death pathway. Adv Exp Med Biol 615: 25-45, 2008.
6. Herzig S and Martinou JC: Mitochondrial dynamics: to be in good shape to survive. Curr Mol Med 8: 131-137, 2008.
7. Chetty C, Bhoopathi P, Joseph P, Chittivelu S, Rao JS and Lakka SS: Adenovirus-mediated siRNA against MMP-2 suppresses tumor growth and lung metastasis in mice. Mol Cancer Ther 5: 2289-2299, 2006.
8. Mohan PM, Chintala SK, Mohanam S, Gladson CL, Kim ES, Gokaslan ZL, Lakka SS, Roth JA, Fang B, Sawaya R, Kyritsis AP and Rao JS: Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Res 59: 3369-3373, 1999. (Pubitemid 29334494)
9. Mohanam S, Chandrasekar N, Yanamandra N, Khawar S, Mirza F, Dinh DH, Olivero WC and Rao JS: Modulation of invasive properties of human glioblastoma cells stably expressing amino-terminal fragment of urokinase-type plasminogen activator. Oncogene 21: 7824-7830, 2002. (Pubitemid 35398840)
10. Nakada M, Okada Y and Yamashita J: The role of matrix metalloproteinases in glioma invasion. Front Biosci 8: e261-e269, 2003. (Pubitemid 38918590)
11. Sun Y, Liu M, Yang B, Li B and Lu J: Role of siRNA silencing of MMP-2 gene on invasion and growth of laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol (In press).
12. Thorburn A: Death receptor-induced cell killing. Cell Signal 16: 139-144, 2004.
13. Shinoura N, Koike H, Furitu T, Hashimoto M, Asai A, Kirino T and Hamada H: Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: implication for gene therapy. Hum Gene Ther 11: 1123-1137, 2000. (Pubitemid 30331579)
14. Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F and Salvesen GS: Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem (In press).
15. Kargiotis O, Chetty C, Gondi CS, Tsung AJ, Dinh DH, Gujrati M, Lakka SS, Kyritsis AP and Rao JS: Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma. Oncogene 27: 4830-4840, 2008.
16. Rangaswami H, Bulbule A and Kundu GC: Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. J Biol Chem 279: 38921-38935, 2004. (Pubitemid 39296053)
17. Cho SG and Choi EJ: Apoptotic signaling pathways: caspases and stress-activated protein kinases. J Biochem Mol Biol 35: 24-27, 2002. (Pubitemid 35216579)
18. Levicar N, Nuttall RK and Lah TT: Proteases in brain tumour progression. Acta Neurochir (Wien) 145: 825-838, 2003.
19. Suenaga N, Mori H, Itoh Y and Seiki M: CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase. Oncogene 24: 859-868, 2005. (Pubitemid 40216094)
20. Mori H, Tomari T, Koshikawa N, Kajita M, Itoh Y, Sato H, Tojo H, Yana I and Seiki M: CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J 21: 3949-3959, 2002. (Pubitemid 34857428)
21. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM and Kroemer G: Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446, 1999. (Pubitemid 29078912)
22. Gondi CS, Kandhukuri N, Dinh DH, Gujrati M and Rao JS: Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway. Int J Oncol 31: 19-27, 2007.
23. La Ferla-Bruhl K, Westhoff MA, Karl S, Kasperczyk H, Zwacka RM, Debatin KM and Fulda S: NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition. Oncogene 26: 571-582, 2007. (Pubitemid 46160970)
24. Rossi M, Sayan AE, Terrinoni A, Melino G and Knight RA: Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Ann NY Acad Sci 1028: 143-149, 2004. (Pubitemid 40361818)